M Tonini

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Review article: cardiac adverse effects of gastrointestinal prokinetics
    M Tonini
    Department of Internal Medicine and Therapeutics, Section of Experimental and Clinical Pharmacology, University of Pavia, Pavia, Italy
    Aliment Pharmacol Ther 13:1585-91. 1999
  2. ncbi request reprint Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Digestion 76:171-8. 2007
  3. ncbi request reprint Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon
    M Tonini
    Department of Internal Medicine and Therapeutics, Division of Clinical and Experimental Pharmacology, University of Pavia, Italy
    Gastroenterology 120:938-45. 2001
  4. ncbi request reprint Drugs acting on serotonin receptors for the treatment of functional GI disorders
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Dig Dis 24:59-69. 2006
  5. pmc Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations
    M Tonini
    Department of Internal Medicine and Therapeutics, Division of Experimental and Clinical Pharmacology, University of Pavia, Italy
    Br J Pharmacol 129:12-20. 2000
  6. pmc 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle
    E Messori
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Br J Pharmacol 115:677-83. 1995
  7. ncbi request reprint 5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Piazza Botta 10 11, 27100 Pavia, Italy
    Dig Liver Dis 35:244-50. 2003
  8. pmc The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors
    A Lucchelli
    Institute of Pharmacology, School of Pharmacy, University of Pavia, Italy
    Br J Pharmacol 114:1017-25. 1995
  9. pmc Role of carbon monoxide in electrically induced non-adrenergic, non-cholinergic relaxations in the guinea-pig isolated whole trachea
    A Dellabianca
    Department of Preventive, Occupational and Community Medicine, University of Pavia, Pavia, Italy
    Br J Pharmacol 150:220-6. 2007
  10. pmc A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea
    A Lucchelli
    Institute of Pharmacology, School of Pharmacy, University of Pavia, Italy
    Br J Pharmacol 112:763-8. 1994

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Review article: cardiac adverse effects of gastrointestinal prokinetics
    M Tonini
    Department of Internal Medicine and Therapeutics, Section of Experimental and Clinical Pharmacology, University of Pavia, Pavia, Italy
    Aliment Pharmacol Ther 13:1585-91. 1999
    ..g. ketoconazole, itraconazole, miconazole and fluconazole) and macrolide antibacterials (e.g. erythromycin, clarithrod-mycin and troleandomycin), which can inhibit cisapride metabolism by interfering with the CYP3A4 isoenzyme...
  2. ncbi request reprint Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Digestion 76:171-8. 2007
    ..The use of PPIs with the strongest antisecretory properties might reveal to be more adequate and cost-effective, particularly for this indication...
  3. ncbi request reprint Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon
    M Tonini
    Department of Internal Medicine and Therapeutics, Division of Clinical and Experimental Pharmacology, University of Pavia, Italy
    Gastroenterology 120:938-45. 2001
    ..The aim of this study was to test the hypothesis that colonic propulsion is regulated by an interplay between tachykinergic and cholinergic transmission...
  4. ncbi request reprint Drugs acting on serotonin receptors for the treatment of functional GI disorders
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Dig Dis 24:59-69. 2006
    ....
  5. pmc Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations
    M Tonini
    Department of Internal Medicine and Therapeutics, Division of Experimental and Clinical Pharmacology, University of Pavia, Italy
    Br J Pharmacol 129:12-20. 2000
    ..The difference between NO and VIP release suggests that in human fundus accommodation is initiated by NO. British Journal of Pharmacology (2000) 129, 12 - 20..
  6. pmc 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle
    E Messori
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Br J Pharmacol 115:677-83. 1995
    ..On the other hand, the potentiating effect caused by micromolar concentrations of 5-HT mostly involves cholinergic transmission and is mediated by the 5-HT3 receptors...
  7. ncbi request reprint 5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Piazza Botta 10 11, 27100 Pavia, Italy
    Dig Liver Dis 35:244-50. 2003
    ..However, for other benzamide derivatives, such as cisapride and mosapride, agonism towards serotonin 5-HT4 receptors is considered the main mechanism leading to gastrointestinal prokinesia...
  8. pmc The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors
    A Lucchelli
    Institute of Pharmacology, School of Pharmacy, University of Pavia, Italy
    Br J Pharmacol 114:1017-25. 1995
    ..The interaction of antidepressants with central and peripheral 5-HT3 and 5-HT4 receptors may be relevant for both potential therapeutic action and adverse effects at gastrointestinal level...
  9. pmc Role of carbon monoxide in electrically induced non-adrenergic, non-cholinergic relaxations in the guinea-pig isolated whole trachea
    A Dellabianca
    Department of Preventive, Occupational and Community Medicine, University of Pavia, Pavia, Italy
    Br J Pharmacol 150:220-6. 2007
    ..This study was designed to assess the participation of CO, and to investigate the localization of haem oxygenase-2 (HO-2), the CO-producing enzyme, in tracheal neurons...
  10. pmc A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea
    A Lucchelli
    Institute of Pharmacology, School of Pharmacy, University of Pavia, Italy
    Br J Pharmacol 112:763-8. 1994
    ..The second phase is mediated by 5-HT2Areceptors, which are probably located at both the neural and muscular level. No evidence for the participation of 5-HT1 receptors in the 5-HT response has been obtained...
  11. ncbi request reprint Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine
    M Tonini
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Naunyn Schmiedebergs Arch Pharmacol 358:686-9. 1998
    ..These results demonstrate that endomorphins selectively activate mu-opioid receptors located on excitatory myenteric plexus neurons, and that they act as full agonists...
  12. doi request reprint Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons
    B Balestra
    Department of Forensic Medicine, Pharmacology and Toxicology, University of Pavia, Pavia, Italy
    Neurogastroenterol Motil 24:1118-e570. 2012
    ..Mediators released in the mucosal milieu have been suggested to be involved in visceral hypersensitivity and abdominal pain in patients with irritable bowel syndrome (IBS). However, their impact on myenteric neurons remains unsettled...
  13. ncbi request reprint Calcium entry blockade as a mechanism for chlordimeform-induced inhibition of motor activity in the isolated guinea-pig ileum
    S M Candura
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Pharmacol Toxicol 71:426-33. 1992
    ..On the whole, these results indicate that chlordimeform-induced depression of motor activity in the guinea-pig ileum is, at least in part, related to inhibition of transmembrane Ca2+ fluxes responsible for smooth muscle contraction...
  14. ncbi request reprint Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons
    T Coccini
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Eur J Pharmacol 198:105-8. 1991
    ..Rimcazole and BMY 14802 may provide useful tools for the characterization of peripheral non-opioid sigma receptors...
  15. doi request reprint Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease
    F Blandini
    Interdepartmental Research Center for Parkinson s Disease CRIMP, Neurological Institute C Mondino, Pavia, Pavia, Italy
    Neurosci Lett 467:203-7. 2009
    ....
  16. ncbi request reprint Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders
    A Agazzi
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Dig Liver Dis 35:590-5. 2003
    ....
  17. ncbi request reprint Clinical pharmacology and safety profile of esomeprazole, the first enantiomerically pure proton pump inhibitor
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Italy
    Dig Liver Dis 33:600-6. 2001
    ..The superior acid control achieved by esomeprazole is mainly due to an advantageous metabolism compared with racemate omeprazole, leading to improved bioavailability and to enhanced delivery of the drug to the gastric proton pump...
  18. ncbi request reprint The interaction of antidepressant drugs with enteric 5-HT7 receptors
    A Lucchelli
    Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Italy
    Naunyn Schmiedebergs Arch Pharmacol 362:284-9. 2000
    ..This evidence extends our previous findings demonstrating the interaction of antidepressants with other 5-HT receptors, namely 5-HT3 and 5-HT4 receptors...
  19. pmc Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype
    G D'Agostino
    Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Italy
    Br J Pharmacol 129:493-500. 2000
    ....
  20. ncbi request reprint Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics
    M Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Aliment Pharmacol Ther 19:379-90. 2004
    ..A knowledge of central and peripheral D2 receptor pharmacology can help the clinician to choose between the antidopaminergic prokinetics to obtain a more favourable risk/benefit ratio...
  21. ncbi request reprint 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Gastroenterology 129:1557-66. 2005
    ..In this study, we evaluated the expression of 5-HT7 receptors in the guinea pig ileum and their role in peristalsis and accommodation of the circular muscle...
  22. ncbi request reprint Characterization of prejunctional serotonin receptors modulating [3H]acetylcholine release in the human detrusor
    Gianluigi D'Agostino
    Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Viale Taramelli 14, I 27100 Pavia, Italy
    J Pharmacol Exp Ther 316:129-35. 2006
    ....
  23. ncbi request reprint Progress with novel pharmacological strategies for gastro-oesophageal reflux disease
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Drugs 64:347-61. 2004
    ..A better understanding of TLOSR pathophysiology is a necessary step for the further development of novel drugs effective for anti-reflux therapy...
  24. pmc Isolated porcine bronchi provide a reliable model for development of bronchodilator anti-muscarinic agents for human use
    G D'Agostino
    Department of Experimental and Applied Pharmacology, University of Pavia, Italy
    Br J Pharmacol 154:1611-8. 2008
    ..This study was designed to characterize the mAChRs in a bronchial preparation from pigs, animals considered to provide close models of human biology...
  25. doi request reprint Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin
    O Pastoris
    Department of Physiological and Pharmacological Sciences, University of Pavia, Piazza Botta 11, 27100, Pavia, Italy
    Naunyn Schmiedebergs Arch Pharmacol 378:421-9. 2008
    ..Indomethacin-induced mucosal injuries were reduced by esomeprazole. Thus, in addition to inhibiting acid secretion, the gastroprotective effect of esomeprazole can be ascribed to a reduction in gastric oxidative injury...
  26. ncbi request reprint [Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders]
    Elisabetta Cervio
    Dipartimento di Scienze Fisiologiche e Farmacologiche, Universita, Pavia
    Recenti Prog Med 98:69-73. 2007
    ..Since an exaggerated accommodation of the gut wall may contribute to abdominal distension and bloating, 5-HT7 receptor ligands may offer innovative opportunities for the pharmacological treatment of functional bowel disorders...
  27. ncbi request reprint Novel therapeutic targets for enteric nervous system disorders
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Trends Pharmacol Sci 28:473-81. 2007
    ....
  28. ncbi request reprint Facilitation of acetylcholine signaling by the dithiocarbamate fungicide propineb
    Marina Marinovich
    Laboratory of Toxicology and Section of Theoretical Pharmacology and Receptor Modeling, Department Pharmacological Sciences, University of Milan, Italy
    Chem Res Toxicol 15:26-32. 2002
    ..In LMMPs, the potentiation of cholinergic transmission is partly dependent on the activation of ganglionic nicotinic receptors. Other targets relevant to cholinergic transmission seem not to be affected by propineb...
  29. ncbi request reprint N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery
    Simona Patierno
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 90073, USA
    Gastroenterology 128:2009-19. 2005
    ..We tested the hypothesis that N-methyl-D-aspartate (NMDA) receptors mediate surgery-induced opioid release in enteric neurons...
  30. ncbi request reprint Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum
    Anthony Ho
    Division of Digestive Diseases, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA
    J Comp Neurol 458:404-11. 2003
    ....
  31. ncbi request reprint Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Am J Gastroenterol 97:2454-9. 2002
    ..The immunosuppressive approach deserves further investigation in patients with severe gut motor abnormalities attributable to idiopathic myenteric ganglionitis...
  32. ncbi request reprint Prokinetics in the treatment of acute intestinal pseudo-obstruction
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna I 40138, Italy
    IDrugs 7:160-5. 2004
    ..New colokinetic agents, including 5-HT(4) receptor agonists and motilides, may represent other useful therapeutic options for Ogilvie's syndrome...
  33. ncbi request reprint Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, and CRBA, University of Bologna, St Orsola Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 132:26-37. 2007
    ..However, the underlying mechanisms remain unknown. We assessed the effect of mast cell mediators released from the colonic mucosa of IBS patients on the activation of rat sensory neurons in vitro...
  34. ncbi request reprint Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon
    Luciano Onori
    Dept of Internal Medicine and Public Health, Univ of L Aquila, Italy
    Am J Physiol Gastrointest Liver Physiol 285:G325-31. 2003
    ..In the presence of L-NNA, the inhibitory effect of septide was reverted into a prokinetic effect, which is probably mediated by the activation of postjunctional excitatory NK1 receptors...
  35. ncbi request reprint Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Gastroenterology 125:70-9. 2003
    ....
  36. ncbi request reprint Enteric neuroplasticity evoked by inflammation
    Valentina Vasina
    Department of Pharmacology, University of Bologna, St Orsola Malpighi Hospital, Italy
    Auton Neurosci 126:264-72. 2006
    ..A better comprehension of ENS plasticity during inflammation could be instrumental to develop new therapeutic options for patients with IBD and inflammatory enteric neuropathies...
  37. ncbi request reprint Galanin receptors in the rat gastrointestinal tract
    Laura Anselmi
    CURE, Digestive Diseases Research Center, Digestive Diseases Division, VAGLAHS, Los Angeles, CA 90073, USA
    Neuropeptides 39:349-52. 2005
    ..Furthermore, this study confirms the presence of functional GalRs and suggests that galanin modulates transmitter release from myenteric neurons through inhibition of voltage-dependent calcium channels involving a G(i/o)-coupled GalR...
  38. ncbi request reprint Alterations in colonic motility and relationship to pain in colonic diverticulosis
    Gabrio Bassotti
    Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Clin Gastroenterol Hepatol 3:248-53. 2005
    ....
  39. ncbi request reprint Neurology and neuropathology of the pancreatic innervation
    Beatrice Salvioli
    JOP 3:26-33. 2002