Danilo Toni

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi request reprint Acute stroke trials: the problems of local investigators?
    D Toni
    Department of Neurological Sciences, University La Sapienza, Viale dell Universita 30, I 00182 Rome, Italy
    Eur Neurol 49:109-14. 2003
  2. doi request reprint Intravenous thrombolysis in young stroke patients: results from the SITS-ISTR
    D Toni
    Department of Neurology and Psychiatry, La Sapienza University of Rome, Italy
    Neurology 78:880-7. 2012
  3. ncbi request reprint Specific therapies for ischaemic stroke: rTPA and others
    D Toni
    Unità di Trattamento Neurovascolare, University La Sapienza, Viale dell Universita 30, I 00185 Rome, Italy
    Neurol Sci 26:S26-8. 2005
  4. ncbi request reprint The SITS-MOST registry
    D Toni
    Unità di Trattamento Neurovascolare, University of Rome La Sapienza, Italy
    Neurol Sci 27:S260-2. 2006
  5. ncbi request reprint Intravenous thrombolysis with rt-PA in acute ischemic stroke patients aged older than 80 years in Italy
    Danilo Toni
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
    Cerebrovasc Dis 25:129-35. 2008
  6. ncbi request reprint Treatment of cerebrovascular diseases: state of the art and perspectives
    D Toni
    Department of Neurological Sciences, University La Sapienza, Rome, Italy
    J Cardiovasc Pharmacol 38:S83-6. 2001
  7. doi request reprint Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T Acute Stroke Unit, Department of Neuroscience, Hospital Universitari Germas Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain M G, A D International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, University Hospital, Plzen, Czech Republic P S and Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland J O
    Stroke 45:176-84. 2014
  8. doi request reprint TESPI (Thrombolysis in Elderly Stroke Patients in Italy): a randomized controlled trial of alteplase (rt-PA) versus standard treatment in acute ischaemic stroke in patients aged more than 80 years where thrombolysis is initiated within three hours after s
    Svetlana Lorenzano
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, Policlinico Umberto I Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy
    Int J Stroke 7:250-7. 2012
  9. ncbi request reprint Determinants of plasma levels of brain natriuretic peptide after acute ischemic stroke or TIA
    Emanuele Di Angelantonio
    Department of Neurological Sciences, University of Rome La Sapienza, Italy
    J Neurol Sci 260:139-42. 2007
  10. ncbi request reprint Which model of stroke unit is better for stroke patient management?
    Svetlana Lorenzano
    Neurovascular Treatment Unit, Department of Neurological Sciences, University of Rome, La Sapienza, Rome, Italy
    Clin Exp Hypertens 28:377-82. 2006

Detail Information

Publications34

  1. ncbi request reprint Acute stroke trials: the problems of local investigators?
    D Toni
    Department of Neurological Sciences, University La Sapienza, Viale dell Universita 30, I 00182 Rome, Italy
    Eur Neurol 49:109-14. 2003
    ..It is just a greater involvement of these latter, possibly free from bureaucratic laces, which might help a balance to be struck between academic and industrial aims...
  2. doi request reprint Intravenous thrombolysis in young stroke patients: results from the SITS-ISTR
    D Toni
    Department of Neurology and Psychiatry, La Sapienza University of Rome, Italy
    Neurology 78:880-7. 2012
    ..To assess safety and efficacy of thrombolysis in 18- to 50-year-old patients compared to those aged 51 to 80 years recorded in the Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR)...
  3. ncbi request reprint Specific therapies for ischaemic stroke: rTPA and others
    D Toni
    Unità di Trattamento Neurovascolare, University La Sapienza, Viale dell Universita 30, I 00185 Rome, Italy
    Neurol Sci 26:S26-8. 2005
    ..However, some studies have brought new light and new doubts on the roles of these traditional therapies...
  4. ncbi request reprint The SITS-MOST registry
    D Toni
    Unità di Trattamento Neurovascolare, University of Rome La Sapienza, Italy
    Neurol Sci 27:S260-2. 2006
    ....
  5. ncbi request reprint Intravenous thrombolysis with rt-PA in acute ischemic stroke patients aged older than 80 years in Italy
    Danilo Toni
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
    Cerebrovasc Dis 25:129-35. 2008
    ..However, little information exists on its use in elderly patients, in particular those aged >80 years, who at present are excluded from treatment...
  6. ncbi request reprint Treatment of cerebrovascular diseases: state of the art and perspectives
    D Toni
    Department of Neurological Sciences, University La Sapienza, Rome, Italy
    J Cardiovasc Pharmacol 38:S83-6. 2001
    ....
  7. doi request reprint Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T Acute Stroke Unit, Department of Neuroscience, Hospital Universitari Germas Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain M G, A D International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, University Hospital, Plzen, Czech Republic P S and Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland J O
    Stroke 45:176-84. 2014
    ..In this large cohort study, we evaluated whether thrombolytic treatment has a within-day and weekly variability corresponding to circadian and weekly patterns of ischemic stroke onset, and whether these have impact on clinical outcome...
  8. doi request reprint TESPI (Thrombolysis in Elderly Stroke Patients in Italy): a randomized controlled trial of alteplase (rt-PA) versus standard treatment in acute ischaemic stroke in patients aged more than 80 years where thrombolysis is initiated within three hours after s
    Svetlana Lorenzano
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, Policlinico Umberto I Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy
    Int J Stroke 7:250-7. 2012
    ..This article describes the design of the Thrombolysis in Elderly Stroke Patients in Italy (TESPI) trial planned to fill the lack of controlled data on i.v. thrombolysis in this age category of stroke patients...
  9. ncbi request reprint Determinants of plasma levels of brain natriuretic peptide after acute ischemic stroke or TIA
    Emanuele Di Angelantonio
    Department of Neurological Sciences, University of Rome La Sapienza, Italy
    J Neurol Sci 260:139-42. 2007
    ..These results encourage further investigation of plasma BNP concentration as a potential marker of the presence of left atrial sources of emboli...
  10. ncbi request reprint Which model of stroke unit is better for stroke patient management?
    Svetlana Lorenzano
    Neurovascular Treatment Unit, Department of Neurological Sciences, University of Rome, La Sapienza, Rome, Italy
    Clin Exp Hypertens 28:377-82. 2006
    ....
  11. doi request reprint Safe implementation of thrombolysis in stroke-monitoring study in Italy
    S Lorenzano
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Eur J Neurol 17:163-7. 2010
    ..v. alteplase within 3 h of ischaemic stroke outside the setting of clinical trials...
  12. ncbi request reprint Focal cerebral ischaemia induces corticotropin releasing factor (CRF) vascular immunoreactivity in rat occluded hemisphere
    M De Michele
    Wellcome Surgical Institute, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow G61 1QH, UK
    Regul Pept 143:69-75. 2007
    ..These data provide morphologic support for a role of CRF in the pathophysiology of cerebral ischaemia...
  13. doi request reprint The need for emergency surgical treatment in carotid-related stroke in evolution and crescendo transient ischemic attack
    Laura Capoccia
    Vascular Surgery Division, Department of Surgery Paride Stefanini, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
    J Vasc Surg 55:1611-7. 2012
    ..The purpose of this study was to examine the safety of emergency carotid endarterectomy (CEA) in patients with carotid stenosis and unstable neurological symptoms...
  14. doi request reprint An observational study on electrolyte disorders in the acute phase of ischemic stroke and their prognostic value
    Luisa Fofi
    Clinical Trial Center, IRCCS San Raffaele Pisana, via della Pisana 235, Rome, Italy
    J Clin Neurosci 19:513-6. 2012
    ..Our work suggests an association between serum sodium alterations and mortality, and between high sodium levels and neurological clinical impairment, in the acute phase of an ischemic stroke...
  15. pmc An emergency clinical pathway for stroke patients--results of a cluster randomised trial (isrctn41456865)
    Assunta De Luca
    Public Health Agency of the Latium Region, Rome, Italy
    BMC Health Serv Res 9:14. 2009
    ..Emergency Clinical Pathways (ECP) for stroke have never been tested in randomized controlled trials (RCTs)...
  16. doi request reprint Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register
    Svetlana Lorenzano
    From the Emergency Department Stroke Unit, Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L, A F, D T Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden N A, N W International Clinical Research Center, Neurology Department, St Anne s Hospital, Brno, Czech Republic R M Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland T T and Stroke Research Offices, Royal Infirmary, Keele University, North Staffordshire, United Kingdom C R
    Stroke 44:3401-6. 2013
    ..We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register...
  17. doi request reprint Stroke prediction after transient ischemic attacks in patients admitted to a stroke unit
    Francesca Tari Capone
    Department of Neuroscience, Mental Health and Sensory Organs, University of Rome La Sapienza, Italy
    Eur Neurol 67:34-8. 2012
    ..Transient ischemic attacks (TIAs) bear a presumed high risk of early recurrence of stroke. Data in the literature, however, are inconsistent, as recurrence rates range from 9.5 to 20%, at 90 days...
  18. ncbi request reprint Emergency and early carotid endarterectomy in patients with acute ischemic stroke selected with a predefined protocol. A prospective pilot study
    E Sbarigia
    Vascular Surgery Section, La Sapienza University, Rome, Italy
    Int Angiol 22:426-30. 2003
    ..The aim of this study was to verify the safety and feasibility of early CEA in a consecutive series of patients with acute ischemic stroke observed in an emergency Department Stroke Unit...
  19. ncbi request reprint Early spontaneous improvement and deterioration of ischemic stroke patients. A serial study with transcranial Doppler ultrasonography
    D Toni
    Department of Neurological Sciences, University La Sapienza, Rome, Italy
    Stroke 29:1144-8. 1998
    ..The purpose of our study was to investigate whether emergency transcranial Doppler (TCD) findings and their modifications over the first 48 hours are related to early neurological changes in acute ischemic stroke patients...
  20. pmc Prognostic significance of admission levels of troponin I in patients with acute ischaemic stroke
    E Di Angelantonio
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita 30, 00185 Rome, Italy
    J Neurol Neurosurg Psychiatry 76:76-81. 2005
    ..Markers of myocardial injury on admission deserve investigation as potential predictors of poor outcome from stroke...
  21. ncbi request reprint Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat
    Manuela De Michele
    Department of Neuroscience, University La Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
    Regul Pept 134:38-45. 2006
    ..Gal immunoreactivity was also detected in myelinated fibers 4 and 24 h after focal ischemia. Gal may be a peptide with neurotrophic and plasticity functions under stress conditions...
  22. ncbi request reprint Spontaneous multiple cervical artery dissection: two case reports and a review of the literature
    Federica Pace
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    J Emerg Med 27:133-8. 2004
    ..We describe two cases of multiple spontaneous CADs presenting as transient ischemic attack (TIA), in which only a specific diagnostic flow-chart allowed us to recognize multiple vessel involvement and start the appropriate therapy...
  23. ncbi request reprint Early carotid endarterectomy after ischemic stroke: the results of a prospective multicenter Italian study
    E Sbarigia
    I Cattedra di Chirurgia Vascolare, Universita di Roma La Sapienza, Viale del Policlinico, Rome, Italy
    Eur J Vasc Endovasc Surg 32:229-35. 2006
    ..To evaluate safety of early carotid endarterectomy (CEA) in patients with acute brain ischemia presenting to the emergency department stroke units (EDSU)...
  24. ncbi request reprint Computed tomography findings in the first few hours of ischemic stroke: implications for the clinician
    M Fiorelli
    Department of Neurological Sciences, University La Sapienza, Rome, Italy
    J Neurol Sci 173:10-7. 2000
    ....
  25. doi request reprint Diffusion-weighted MRI in patients with non-diagnostic CT in the post-acute phase of cerebral ischemia
    P Totaro
    Section of Neuroradiology, Department of Neurological Sciences, La Sapienza University, Rome, Italy
    Eur Neurol 63:94-100. 2010
    ..The aim of our work was to evaluate the diagnostic value of diffusion-weighted imaging (DWI) in the post-acute phase of cerebral ischemia in patients in whom CT did not yield a definitive diagnosis...
  26. ncbi request reprint Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Lancet 369:275-82. 2007
    ..Under European Union regulations, SITS-MOST was required to assess the safety profile of alteplase in clinical practice by comparison with results in randomised controlled trials...
  27. doi request reprint Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  28. ncbi request reprint Acute treatment of ischaemic stroke. European Stroke Initiative
    Danilo Toni
    Cerebrovasc Dis 17:30-46. 2004
  29. ncbi request reprint Can the time window for administration of thrombolytics in stroke be increased?
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, 300 Waterdale Road, West Heidelberg, Victoria 3081, Australia
    CNS Drugs 17:995-1011. 2003
    ..Should these means of extending the time window for thrombolysis prove successful, a more widespread use of this form of acute stroke therapy will be possible...
  30. ncbi request reprint The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia
    Donatella Colaizzo
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Blood Coagul Fibrinolysis 17:93-6. 2006
    ..07; 95% CI, 0.01-0.61). Our data show an association between the COX-2 G/C-765 gene polymorphism and cerebrovascular ischemia, suggesting that the COX-2 gene is a susceptibility locus for the risk of cerebrovascular ischemic disease...
  31. pmc Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    ..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel...
  32. ncbi request reprint Transforming guidelines in routine practice
    Maria Luisa Sacchetti
    Stroke 39:e22; author reply e23. 2008
  33. doi request reprint Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
    Nils Wahlgren
    Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet 372:1303-9. 2008
    ..5 h versus those treated within 3 h, who were recorded in the in the Safe Implementation of Treatments in Stroke (SITS), a prospective internet-based audit of the International Stroke Thrombolysis Registry (ISTR)...