Affiliation: University of Turin
Tolosano E, Fagoonee S, Hirsch E, Berger F, Baumann H, Silengo L, et al
. Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood. 2002;100:4201-8 pubmed
..These data demonstrate that haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis. ..
Fiorito V, Chiabrando D, Tolosano E. Mitochondrial Targeting in Neurodegeneration: A Heme Perspective. Pharmaceuticals (Basel). 2018;11: pubmed publisher
..By reporting the body of knowledge on this topic, the review intends to stimulate future studies on the role of heme metabolism in neurodegeneration, envisioning innovative strategies in the struggle against neurodegenerative diseases. ..
Tolosano E, Fagoonee S, Morello N, Vinchi F, Fiorito V. Heme scavenging and the other facets of hemopexin. Antioxid Redox Signal. 2010;12:305-20 pubmed publisher
..In this review, the importance of heme scavenging by hemopexin, as well as the other emerging functions of this protein, are discussed. ..
Vinchi F, Gastaldi S, Silengo L, Altruda F, Tolosano E. Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload. Am J Pathol. 2008;173:289-99 pubmed publisher
..These studies highlight the importance of hemopexin in heme detoxification, thus suggesting that drugs mimicking hemopexin activity might be useful to prevent endothelial damage in patients suffering from hemolytic disorders. ..
Mercurio S, Petrillo S, Chiabrando D, Bassi Z, Gays D, Camporeale A, et al
. The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica. 2015;100:720-9 pubmed publisher
..Consistently, reduction or increase of the cytosolic heme rescued the erythroid defects in zebrafish deficient in Flvcr1a or Flvcr1b, respectively. Thus, heme export represents a tightly regulated process that controls erythropoiesis. ..
Ma B, Day J, Phillips H, Slootsky B, Tolosano E, DorÃ© S. Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J Neuroinflammation. 2016;13:26 pubmed publisher
..This study suggests that microglial cells contribute to hemoglobin-heme clearance after ICH; however, the resultant iron overloads in microglia appear to decrease Iba1 expression and to further inhibit microglial phagocytosis. ..
Ingoglia G, Sag C, Rex N, De Franceschi L, Vinchi F, Cimino J, et al
. Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress. Free Radic Biol Med. 2017;108:452-464 pubmed publisher
..Scavenging heme, Hx counteracts cardiac heme toxicity and preserves left ventricular function. Our data generate the rationale to consider the therapeutic use of Hx to limit the cardiotoxicity of free heme in hemolytic disorders. ..
Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, et al
. Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis. Cell Death Differ. 2018;25:573-588 pubmed publisher
Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, et al
. Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450. Gastroenterology. 2014;146:1325-38 pubmed publisher
..In livers of mice, Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity. These findings have important implications for drug metabolism. ..