Affiliation: University of Brescia
- Pregnancy complications of the antiphospholipid syndromeA Tincani
Servizio di Reumatologia, Allergologia e Immunologia Clinica, Spedali Civili di Brescia, P le Spedali Civili, 1 25123 Brescia, Italy
Autoimmunity 36:27-32. 2003..In fact, despite the high number of complications and preterm delivery, today a successful outcome can be achieved in the large majority of the cases...
- Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations--a cooperative project of the European Antiphospholipid ForumA Tincani
Clinical Immunology Unit, Brescia Hospital, Italy
Thromb Haemost 86:575-83. 2001..Our data show that aCL ELISA standardization is necessary in order to obtain comparable results in different laboratories...
- Anti beta2-glycoprotein I antibodies: clinical significanceA Tincani
Clinical Immunology Unit, Ospedale Civile di Brescia, Italy
Lupus 7:S107-9. 1998..This observation suggests that anti beta2GPI may also modify the immunogenicity of apoptotic bodies and of the autoantigens that they contain...
- [Role of anti-prothrombin in antiphospholipid syndrome]M Cinquini
Servizio di Reumatologia, Allergologia ed Immunologia Clinica, Spedali Civili di Brescia, Cattedra di Allergologia ed Immunologia Clinica dell Università degli Studi di Brescia
Reumatismo 54:243-50. 2002..2% with one test (LAC) to 81.1% with the application of LAC, aCL, a(beta)2GPI and aPT...
- The immune development in a child born to a cyclosporin A-treated woman with systemic lupus erythematosus/polymyositisP Airo
Division of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy
Lupus 11:454-7. 2002..Lymphocyte phenotypical and functional studies, as well as response to vaccination, were also normal...
- Pregnancy in patients with rheumatic diseases: psychological implication of a chronic disease and neuropsychological evaluation of the childrenF Neri
Pediatric Neuropsychiatry Institute, University of Brescia, Italy
Lupus 13:666-8. 2004..Therefore, psychological support seems to be an important help in the counseling of patients with rheumatic disease and in the future life of their children...
- Treatment of pregnant patients with antiphospholipid syndromeA Tincani
Rheumatology Allergy and Clinical Immunology, Brescia Hospital, Brescia, Italy
Lupus 12:524-9. 2003..The experts usually advised barrier methods of contraception, intrauterine device (if the patient is not taking corticosteroids) or progestins. Oral contraception with oestrogens was usually avoided...
- Alterations in the immune system of children from mothers treated with immunosuppressive agents during pregnancyR Cimaz
Clinica Pediatrica, ICP, Via Commenda 9, Milan 20122, Italy
Toxicol Lett 149:155-62. 2004..Although our results are preliminary, we conclude that prenatal exposure to immunosuppressive drugs does not have a profound effect to the developing immune system. More data and a longer follow-up are needed to confirm these results...
- Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome)A Tincani
Rheumatology and Clinical Immunology, Brescia Hospital and University, Italy
Lupus 15:156-60. 2006..Nowadays, owing to our increasing knowledge of the disease pathophysiological mechanisms and the development of combined medical-obstetric clinics, pregnancy outcome in patients with AD has notably improved...
- [Rare autoimmune rheumatic illnesses during pregnancy. Systemic sclerosis, polymyositis/dermatomyositis and vasculitis]A Doria
Division of Rheumatology, Department of Medical and Surgical Sciences, University of Padova, Padova
Z Rheumatol 65:200, 202-6, 208. 2006..However, it is important to note that data on pregnancy outcome are very limited and, in the absence of prospective studies, most of the information derives from case reports and retrospective studies...
- Neuropsychological development of children born to patients with systemic lupus erythematosusF Neri
Pediatric Neuropsychiatry Institute, University of Brescia, Brescia, Italy
Lupus 13:805-11. 2004..In conclusion, maternal SLE does not impair intelligence levels, but may increase the occurrence of LD particularly in male children (2/8 males examined, 25%). Both maternal aPL and genetic background may have pathogenetic implications...
- EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including TherapeuticsG Bertsias
Department of Internal Medicine, University of Crete School of Medicine, 71003, Heraklion, Greece
Ann Rheum Dis 67:195-205. 2008..Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE...
- Neuropsychological development of children born to patients with antiphospholipid syndromeR Nacinovich
University of Brescia, Brescia, Italy
Arthritis Rheum 59:345-51. 2008....
- Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disordersR Cimaz
hospices civils de Lyon université Lyon 1, Lyon, France
Lupus 16:129-32. 2007..Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used...
- International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)S Miyakis
St George Hospital, University of New South Wales, Sydney, Australia
J Thromb Haemost 4:295-306. 2006..Based on this, we propose amendments to the Sapporo criteria. We also provide definitions on features of APS that were not included in the updated criteria...
- The antiphospholipid antibody syndrome: diagnosis, skin manifestations and current therapyR A Asherson
Rheumatic Disease Unit, University of Cape Town School of Health Sciences, Cape Town and the Rosebank Clinic, Johannesburg, South Africa
Clin Exp Rheumatol 24:S46-51. 2006..High dose intravenous steroids and parenteral anticoagulation should be supplemented by intravenous gammaglobulin and repeated plasma exchanges using fresh frozen plasma early on in the course of the syndrome...
- Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the "Euro-Lupus Project"Ricard Cervera
Department of Autoimmune Diseases, Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
Autoimmun Rev 5:180-6. 2006..The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors...
- Normal neuropsychological development in children with congenital complete heart block who may or may not be exposed to high-dose dexamethasone in uteroA Brucato
Department of Internal Medicine and Rheumatology, Niguarda Hospital, Milano, Italy
Ann Rheum Dis 65:1422-6. 2006..Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies may also be associated with learning disabilities in offspring...
- Inflammatory molecules: a target for treatment of systemic autoimmune diseasesA Tincani
Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Italy
Autoimmun Rev 7:1-7. 2007..Increasing understanding of the role of inflammatory mediators in inflammation and diseases is opening new avenues for the treatment of inflammatory-based diseases through selective targeting of cytokines and lipid mediators...
- Contraception in adolescents with systemic lupus erythematosusA Tincani
Department of Rheumatology and Clinical Immunology, Brescia Hospital and University of Brescia, Brescia, Italy
Lupus 16:600-5. 2007..In patients with aPL, fewer options are available, and the selection of the preferred form of contraception should be made on an individual basis...
- Antiprothrombin antibodies: a comparative analysis of homemade and commercial methods. A collaborative study by the Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA)A Tincani
Reumatologia e Immunologia Clinica, Ospedale Civile e Università di Brescia, Italy
Clin Exp Rheumatol 25:268-74. 2007..The purpose of this study was to compare the performance of different assays on a set of well-characterized serum samples...
- Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupusA Tincani
Reumatologia e Immunologia Clinica, Ospedale Civile, Piazza Spedali Civili 1, 25125 Brescia, Italy
Rheumatology (Oxford) 45:iv8-13. 2006....
- Electrocardiographic abnormalities in infants born from mothers with autoimmune diseases--a multicentre prospective studyM Gerosa
Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Via Spagnoletto, 3, 20149 Milan, Italy
Rheumatology (Oxford) 46:1285-9. 2007..To assess the prevalence of congenital heart block (CHB) and electrocardiographic (ECG) abnormalities in infants of anti-Ro/SSA-positive women...
- Impact of in utero environment on the offspring of lupus patientsA Tincani
Spedali Civili and University of Brescia, Brescia, Italy
Lupus 15:801-7. 2006..Fetal consequence of maternal treatment need to be considered choosing non teratogenic drugs, but the withdrawal of medications just because the patient is pregnant should be avoided to avoid SLE flares...
- Inflammatory response and the endotheliumP L Meroni
Department of Internal Medicine, University of Milan, Istituto Auxologico Italiano, Milan, Italy
Thromb Res 114:329-34. 2004..As shown in antiphospholipid syndrome experimental animal models, a two-hit hypothesis is suggested...
- Prevalence and pattern of cognitive impairment in systemic lupus erythematosus patients with and without overt neuropsychiatric manifestationsR Monastero
2nd Department of Neurology, Institute of Neuropsychiatry, University of Palermo, Palermo, Italy
J Neurol Sci 184:33-9. 2001..This study shows that cognitive impairment occurs frequently in both nSLE and NPSLE subjects. The higher frequency in NPSLE may be related to coexisting depressive disturbances...
- Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 womenA Brucato
Niguarda Hospital, Milan, Italy
Arthritis Rheum 44:1832-5. 2001..Additional electrocardiographic abnormalities such as sinus bradycardia and prolongation of the QT interval may be present in their children...
- Pregnancy and neonatal outcome in primary antiphospholipid syndromeA Tincani
Department of Obstetrics and Gynecology, Neonatal Intensive Care Unit, Rheumatology and Clinical Immunology, University Hospital, Brescia, Italy
Lupus 11:649. 2002
- Pathogenetic associations of maternal anti-Ro/SSA antibodiesA Brucato
Lupus 11:650. 2002
- Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: prospective evaluation in a large cohort of Italian patientsR Gerli
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Rheumatology (Oxford) 41:1357-66. 2002....
- Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled studyA Brucato
Lupus 11:716-21. 2002..The general outcome of these pregnancies is now very good, ifprospectively followed by multidisciplinary teams with ample experience in this field...
- Lessons from the "Euro-Lupus Cohort"Ricard Cervera
Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
Ann Med Interne (Paris) 153:530-6. 2002..The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors...
- Venous thromboembolism in the antiphospholipid syndrome: management guidelines for secondary prophylaxisP L Meroni
Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
Lupus 12:504-7. 2003..Until such information becomes available, individualized treatment according to the patient's individual risk factors for both bleeding and thrombosis is the general practice...
- Cardiac disease in the antiphospholipid syndrome: recommendations for treatment. Committee consensus reportM Lockshin
Hospital for Special Surgery, Barbara Volcker Center for Women and Rheumatic Diseases, New York, NY 10021, USA
Lupus 12:518-23. 2003..Pulmonary hypertension: the Committee recommends intensive anticoagulation with warfarin and clinical trials of bosentan, epoprostenol and other new agents...
- HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosusG D Sebastiani
UO Complessa di Reumatologia, Azienda Ospedaliera San Camillo Forlanini, Roma, Italy
Lupus 12:560-3. 2003..In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE...
- Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndromeY Shoenfeld
Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
J Clin Immunol 23:377-83. 2003..Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes...
- Should our approach to the anticardiolipin assay change 20 years after its discovery?P L Meroni
Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
J Thromb Haemost 2:1074-6. 2004
- European register of babies born to mothers with antiphospholipid syndromeM C Boffa
Department of Internal Medicine, Hopital de la Pitie, Paris, France
Lupus 13:713-7. 2004..A descriptive and a case control study of babies with versus without APL at birth will be possible after the inclusion of 300 cases...
- Neonatal outcome in patients with rheumatic diseaseM Motta
Neonatology and Neonatal Intensive Care, Spedali Civili, Brescia, Italy
Lupus 13:718-23. 2004..Finally, mothers disease and/or treatment could be related to neuropsychological alteration reported in some of their children...
- Pathogenic anti-nucleosome antibodiesS Muller
CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunologie et Chimie Thérapeutiques, Strasbourg, France
Lupus 17:431-6. 2008..Recent studies reported anti-nucleosome antibodies also in primary anti-phospholipid syndrome and particularly in patients with associated lupus-like disease...