Gian M Tiboni

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi request reprint Influence of cigarette smoking on vitamin E, vitamin A, beta-carotene and lycopene concentrations in human pre-ovulatory follicular fluid
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Universita G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 17:389-93. 2004
  2. doi request reprint Impact of estrogen replacement on letrozole-induced embryopathic effects
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara Ospedale SS Annunziata, 66013 Chieti, Italy
    Hum Reprod 24:2688-92. 2009
  3. ncbi request reprint Inhibition of nitric oxide synthesis enhances teratogenic effects induced by valproic Acid
    Gian Mario Tiboni
    Department of Medicine and Aging Sciences, Faculty of Medicine, University G d Annunzio of Chieti Pescara, Ortona, Italy
    In Vivo 27:513-8. 2013
  4. pmc Assisted reproduction outcomes after embryo transfers requiring a malleable stylet
    Gian Mario Tiboni
    Unità di Procreazione Medicalmente Assistita, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita, G D Annunzio, Chieti Pescara, Ospedale, Bernabeo, Ortona, Chieti, Italy
    J Assist Reprod Genet 29:585-8. 2012
  5. ncbi request reprint Production of axial skeletal malformations with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the mouse
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Italy
    Birth Defects Res B Dev Reprod Toxicol 80:28-33. 2007
  6. doi request reprint Effects of the aromatase inhibitor letrozole on in utero development in rats
    G M Tiboni
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale Clinicizzato SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Hum Reprod 23:1719-23. 2008
  7. ncbi request reprint Progestational agents prevent preterm birth induced by a nitric oxide synthesis inhibitor in the mouse
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale SS Annunziata, 66013 Chieti, Italy
    In Vivo 22:447-50. 2008
  8. doi request reprint Teratogenic effects in mouse fetuses subjected to the concurrent in utero exposure to miconazole and metronidazole
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G d Annunzio di Chieti Pescara, Italy
    Reprod Toxicol 26:254-61. 2008
  9. doi request reprint Fluconazole alters CYP26 gene expression in mouse embryos
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G d Annunzio di Chieti Pescara, Italy
    Reprod Toxicol 27:199-202. 2009
  10. doi request reprint Cytogenetic findings and reproductive outcome of infertile couples referred to an assisted reproduction program
    Gian Mario Tiboni
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Italy
    Gynecol Endocrinol 27:669-74. 2011

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Influence of cigarette smoking on vitamin E, vitamin A, beta-carotene and lycopene concentrations in human pre-ovulatory follicular fluid
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Universita G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 17:389-93. 2004
    ..05) lower fertilization rate in comparison to non-smokers, (55.9 % vs. 71.5 % , respectively). It is postulated that follicular depletion of the antioxidant beta-carotene occurs in response to oxidative stress imposed by cigarette smoke...
  2. doi request reprint Impact of estrogen replacement on letrozole-induced embryopathic effects
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara Ospedale SS Annunziata, 66013 Chieti, Italy
    Hum Reprod 24:2688-92. 2009
    ..In order to gain insight on this hypothesis, the present study tested the capacity of estrogen replacement in preventing letrozole-mediated embryopathy...
  3. ncbi request reprint Inhibition of nitric oxide synthesis enhances teratogenic effects induced by valproic Acid
    Gian Mario Tiboni
    Department of Medicine and Aging Sciences, Faculty of Medicine, University G d Annunzio of Chieti Pescara, Ortona, Italy
    In Vivo 27:513-8. 2013
    ..The mechanism of valproic acid (VPA)-induced teratogenicity is poorly known. This study was carried out to probe into the potential consequences of nitric oxide (NO) deprivation on VPA teratogenicity...
  4. pmc Assisted reproduction outcomes after embryo transfers requiring a malleable stylet
    Gian Mario Tiboni
    Unità di Procreazione Medicalmente Assistita, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita, G D Annunzio, Chieti Pescara, Ospedale, Bernabeo, Ortona, Chieti, Italy
    J Assist Reprod Genet 29:585-8. 2012
    ..This retrospective case-control study was undertaken to assess the impact of a malleable stylet application on embryo transfer (ET) outcome...
  5. ncbi request reprint Production of axial skeletal malformations with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the mouse
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Italy
    Birth Defects Res B Dev Reprod Toxicol 80:28-33. 2007
    ..To test whether the differentiating embryo is susceptible to the teratogenic effects of the nitric oxide (NO) synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME)...
  6. doi request reprint Effects of the aromatase inhibitor letrozole on in utero development in rats
    G M Tiboni
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale Clinicizzato SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Hum Reprod 23:1719-23. 2008
    ..As information regarding possible adverse effects on gestation outcome is limited, the present study was undertaken to evaluate the developmental toxicity potential of letrozole in the rat...
  7. ncbi request reprint Progestational agents prevent preterm birth induced by a nitric oxide synthesis inhibitor in the mouse
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale SS Annunziata, 66013 Chieti, Italy
    In Vivo 22:447-50. 2008
    ..The present study tested the ability of progestational agents to prevent preterm birth induced by L-NAME...
  8. doi request reprint Teratogenic effects in mouse fetuses subjected to the concurrent in utero exposure to miconazole and metronidazole
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G d Annunzio di Chieti Pescara, Italy
    Reprod Toxicol 26:254-61. 2008
    ..No significant synergism was noted when drugs were co-administered on GD 10. This study shows that a teratogenic interaction can result from miconazole-metronidazole concomitant exposure...
  9. doi request reprint Fluconazole alters CYP26 gene expression in mouse embryos
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G d Annunzio di Chieti Pescara, Italy
    Reprod Toxicol 27:199-202. 2009
    ..This study demonstrates the capacity of fluconazole to alter CYP26 gene expression in mouse embryos...
  10. doi request reprint Cytogenetic findings and reproductive outcome of infertile couples referred to an assisted reproduction program
    Gian Mario Tiboni
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Italy
    Gynecol Endocrinol 27:669-74. 2011
    ..This with the aim of identifying patients that would possibly benefit from pre-implantation genetic diagnosis...
  11. doi request reprint Effectiveness of a low gonadotrophin-releasing hormone antagonist dose in preventing premature luteinizing hormone rise during controlled ovarian stimulation
    Gian Mario Tiboni
    Dipartimento di Medicina e Scienze dell Invecchiamento, Sezione di Scienze della Riproduzione, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Italy
    Gynecol Endocrinol 27:885-9. 2011
    ..In conclusion, our results suggest that a cetrorelix dose of 0.125 mg/day is effective as the standard dose (0.25 mg/day) in preventing premature LH rise during controlled ovarian stimulation...
  12. ncbi request reprint Ovulation inducing agents and cancer risk: review of literature
    Gianna Gabriella Impicciatore
    Sezione di Scienze della Riproduzione, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G D Annunzio Chieti Pescara, Italy
    Curr Drug Saf 6:250-8. 2011
    ..A possible trend towards an increased risk has been reported by some authors for endometrial cancer. Altogether, current data should be thus regarded as a signal for the need of further studies rather than being definitive in them...
  13. ncbi request reprint Impact of a single endometrial injury on assisted reproductive technology outcome: a preliminary observational study
    Gian Mario Tiboni
    Section of Reproductive Sciences, Department of Medicine and Sciences of the Aging, Faculty of Medicine and Surgery, University G D Annunzio, Chieti Pescara, Italy
    J Reprod Med 56:504-6. 2011
    ....
  14. ncbi request reprint Extrapituitary actions of GnRH antagonists: prospects for in vitro fertilization programs
    Gianna Gabriella Impicciatore
    Sezione di Scienze della Riproduzione, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale G Bernabeo, Contrada S Andrea, Ortona, Italy
    Curr Pharm Des 18:264-9. 2012
    ..This review summarizes current research in the area, especially focusing on the possible impact of GnRH-ant on steroidogenesis, folliculogenesis and endometrial receptivity...
  15. ncbi request reprint Defining critical periods for itraconazole-induced cleft palate, limb defects and axial skeletal malformations in the mouse
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale SS Annunziata, Via dei Vestini, Chieti, Italy
    Toxicol Lett 167:8-18. 2006
    ..Exposure on gestation day 12 did not yield significant teratogenic responses. Cleft palate was the most sensitive teratogenic response, being the only developmental lesion associated to exposure to itraconazole at 150 mg/kg b.w...
  16. ncbi request reprint Teratological consequences of nitric oxide synthesis inhibition
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Via dei Vestini, 66013 Chieti, Italy
    Curr Pharm Des 10:2759-67. 2004
    ..Several observations have led to the proposal that hypoxia and possible consequential generation of reactive oxygen species are involved in the causation of NOS inhibitors induced limb defects...
  17. ncbi request reprint Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita, Ospedale Via dei Vestini, 66013 Chieti, Italy
    Toxicol Lett 145:219-29. 2003
    ..These results further argue against a role for CYP system in teratogenic bioactivation of PHT...
  18. ncbi request reprint The nitric oxide synthesis inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME) causes limb defects in mouse fetuses: protective effect of acute hyperoxia
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti, Italy
    Pediatr Res 54:69-76. 2003
    ..This study characterizes for the first time the teratogenic capacity of l-NAME in the mouse. Results obtained with hyperoxia fit the hypothesis that hypoxic tissue damage may play a contributory role in l-NAME-induced limb defects...
  19. ncbi request reprint The soluble guanylate cyclase inhibitor methylene blue evokes preterm delivery and fetal growth restriction in a mouse model
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento Facoltà di Medicina e Chirurgia, Universita G D Annunzio, Ospedale Clinicizzato SS Annunziata, Via dei Vestini, 66013, Chieti, Italy
    In Vivo 15:333-7. 2001
    ..The present study was undertaken to test whether methylene blue a soluble guanylate cyclase inhibitor, can initiate delivery in the mouse. The potential adverse effects of methylene blue on the fetal growth process were also investigated...
  20. ncbi request reprint Transplacental exposure to methylene blue initiates teratogenesis in the mouse: preliminary evidence for a mechanistic implication of cyclic GMP pathway disruption
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Ospedale Clinicizzato SS Annunziata, 66013 Chieti, Italy
    Teratology 64:213-20. 2001
    ..The vital dye methylene blue (MB) has been shown to be teratogenic when injected into the amnion in the second trimester. On the other hand, the teratogenic potential of transplacental exposure to MB has not been determined...
  21. ncbi request reprint Inhibition of nitric oxide synthesis causes preterm delivery in the mouse
    G M Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti, Italy
    Hum Reprod 15:1838-42. 2000
    ..05 versus positive control value) protection from L-NAME-initiated preterm delivery. This is the first report to reveal that an inhibitor of NO synthesis initiates preterm delivery in a mouse model...
  22. ncbi request reprint Murine teratology of fluconazole: evaluation of developmental phase specificity and dose dependence
    Gian M Tiboni
    Division of Obstetrics and Gynecology, Department of Medicine and Science, Faculty of Medicine and Surgery, University G D Annunzio, Chieti Pescara Hospital SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Pediatr Res 58:94-9. 2005
    ..Besides showing that fluconazole operates under a strict dose-response mechanism, the study identified 175 mg/kg as the lowest observed adverse effect level for cleft palate induction, with 7.6% of the exposed fetuses being affected...
  23. ncbi request reprint Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin
    G M Tiboni
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Ospedale SS Annunziata, Chieti, Italy
    Teratology 59:81-7. 1999
    ..Although the mechanistic nature of teratological interaction between FCZ and PHT remains to be established, these results may not support CYP system-mediated metabolic conversion as the mechanistic component of PHT teratogenesis...
  24. ncbi request reprint Serological testing for celiac disease in women undergoing assisted reproduction techniques
    Gian Mario Tiboni
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G d Annunzio Chieti Pescara and Servizio Laboratorio Analisi, Ospedale SS Annunziata, Chieti, Italy
    Hum Reprod 21:376-9. 2006
    ..Nevertheless, robust evidence has not yet been provided. The present study evaluated, for the first time, the prevalence of celiac disease in women undergoing assisted reproduction techniques (ART)...
  25. ncbi request reprint Purification and characterization of three Pi class glutathione transferase from monkey (Macaca fascicularis) placenta
    C Di Ilio
    Istituto di Scienze Biochimiche, Facolta di Medicina e Chirurgia, Università di Chieti G d Annunzio, Italia
    Comp Biochem Physiol B Biochem Mol Biol 114:377-82. 1996
    ..43 +/- 0.13 min subunit, whereas the GST II is an heterodimer of the 29.60 +/- 0.10 min and 32.43 +/- 0.13 min subunits. Our results strongly suggest that unlike human, multiple forms of pi class GST exist in monkey placenta...
  26. ncbi request reprint Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques
    E Clementini
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti and ITOI CNR, Bologna, Italy
    Hum Reprod 20:437-42. 2005
    ..This study analyses the prevalence of karyotype changes and Yq11 microdeletions among couples referred for assisted reproduction techniques...
  27. ncbi request reprint Pampiniform plexus and oxidative stress during chronic hypoxia and hyperoxia
    V Verratti
    Department of Medicine and Aging Science, University of Chieti, Via dei Vestini 31, Chieti, Italy
    Int J Immunopathol Pharmacol 21:353-7. 2008
    ....
  28. doi request reprint Molecular aspects of azoles-induced teratogenesis
    Francesca Marotta
    Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G D Annunzio Chieti Pescara, Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Expert Opin Drug Metab Toxicol 6:461-82. 2010
    ..Azoles are teratogenic in animal models and are under investigation for potential human developmental toxic effects. Rational approaches to prevent teratogenic effects require knowledge of the underlying mechanisms...
  29. ncbi request reprint Aromatase inhibitors and teratogenesis
    Gian Mario Tiboni
    Fertil Steril 81:1158-9; author reply 1159. 2004
  30. ncbi request reprint Proteome analysis of human follicular fluid
    Stefania Angelucci
    Department of Biomedical Science, G D Annunzio University, Chieti Pescara Italy and Center of Excellence on Aging G d Annunzio University Foundation, Chieti, Italy
    Biochim Biophys Acta 1764:1775-85. 2006
    ..This indicates that during maturation the human follicle is well protected against toxic injury due to oxidative stress...
  31. ncbi request reprint Levels of apoptosis in human granulosa cells seem to be comparable after therapy with a gonadotropin-releasing hormone agonist or antagonist
    Franca Giampietro
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Università G D Annunzio Chieti Pescara, Chieti, Italy
    Fertil Steril 85:412-9. 2006
    ..To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix...
  32. doi request reprint The role of toxicology to characterize biomarkers for agrochemicals with potential endocrine activities
    Alberto Mantovani
    Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy
    Reprod Toxicol 26:1-7. 2008
    ....
  33. doi request reprint Pesticides and fertility: an epidemiological study in Northeast Italy and review of the literature
    Maurizio Clementi
    North East Registry of Congenital Malformations, Genetica Clinica ed Epidemiologica, Dipartimento Pediatria, Universita di Padova, Italy
    Reprod Toxicol 26:13-8. 2008
    ....
  34. ncbi request reprint Screening of mutations in the CFTR gene in 1195 couples entering assisted reproduction technique programs
    Liborio Stuppia
    Dipartimento di Scienze Biomediche, Universita G D Annunzio, Chieti Pescara, Italy
    Eur J Hum Genet 13:959-64. 2005
    ..In order to improve genetic counselling of these couples, the TG-M470V-5T association was analyzed, and a statistically significant relationship between 12TG-V470 and CBAVD was detected...