Luca Tiano

Summary

Affiliation: University of Camerino
Country: Italy

Publications

  1. ncbi request reprint Assessment of DNA damage in Down Syndrome patients by means of a new, optimised single cell gel electrophoresis technique
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 25:187-95. 2005
  2. doi request reprint Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation
    Luca Tiano
    Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    Neurobiol Aging 33:626.e1-8. 2012
  3. ncbi request reprint Effect of tributyltin on trout blood cells: changes in mitochondrial morphology and functionality
    Luca Tiano
    Department of Biology MCA, University of Camerino, Camerino MC, Italy
    Biochim Biophys Acta 1640:105-12. 2003
  4. doi request reprint Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?
    Luca Tiano
    Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 37:386-92. 2011
  5. doi request reprint Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial
    L Tiano
    Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy
    Neurobiol Aging 32:2103-5. 2011
  6. ncbi request reprint Coenzyme Q10 and oxidative imbalance in Down syndrome: biochemical and clinical aspects
    L Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 32:161-7. 2008
  7. ncbi request reprint Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60100 Ancona, Italy
    Eur Heart J 28:2249-55. 2007
  8. doi request reprint Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status
    Francesca Bruge
    Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona, Italy
    Biofactors 38:249-56. 2012
  9. ncbi request reprint Bioenergetic and antioxidant properties of coenzyme Q10: recent developments
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, Ancona 60131, Italy
    Mol Biotechnol 37:31-7. 2007
  10. doi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
    Nutrition 26:250-4. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Assessment of DNA damage in Down Syndrome patients by means of a new, optimised single cell gel electrophoresis technique
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 25:187-95. 2005
    ....
  2. doi request reprint Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation
    Luca Tiano
    Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    Neurobiol Aging 33:626.e1-8. 2012
    ..Our results highlight an age-specific reduction in the percentage of cells showing the highest amount of oxidized bases, indicating a potential role of CoQ(10) in modulating DNA repair mechanisms...
  3. ncbi request reprint Effect of tributyltin on trout blood cells: changes in mitochondrial morphology and functionality
    Luca Tiano
    Department of Biology MCA, University of Camerino, Camerino MC, Italy
    Biochim Biophys Acta 1640:105-12. 2003
    ..Longer exposures, up to 12 h, were required to trigger an apoptotic response in erythrocytes...
  4. doi request reprint Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?
    Luca Tiano
    Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 37:386-92. 2011
    ..Results suggest that the effect of CoQ(10) treatment in DS not only reflects antioxidant efficacy, but likely modulates DNA repair mechanisms...
  5. doi request reprint Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial
    L Tiano
    Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy
    Neurobiol Aging 32:2103-5. 2011
    ..Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique...
  6. ncbi request reprint Coenzyme Q10 and oxidative imbalance in Down syndrome: biochemical and clinical aspects
    L Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 32:161-7. 2008
    ..On the contrary, lymphocyte and platelet CoQ10 content was significantly lower in DS patients, a fact that might underlie oxidative imbalance at a cellular level...
  7. ncbi request reprint Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60100 Ancona, Italy
    Eur Heart J 28:2249-55. 2007
    ..Moreover, there is a strong correlation between endothelium-bound ecSOD and the ED dilation of conduit arteries. CoQ(10) has been recently shown to improve the ED relaxation in diabetic patients...
  8. doi request reprint Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status
    Francesca Bruge
    Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona, Italy
    Biofactors 38:249-56. 2012
    ..These changes are associated with a decreased susceptibility of plasma lipoproteins to peroxidation associated with a chain-breaking antioxidant activity of the formulation...
  9. ncbi request reprint Bioenergetic and antioxidant properties of coenzyme Q10: recent developments
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, Ancona 60131, Italy
    Mol Biotechnol 37:31-7. 2007
    ..The effect was more pronounced in patients with low basal values of ecSOD. Finally, we summarize the findings, also from our laboratory, on the implications of CoQ10 in seminal fluid integrity and sperm cell motility...
  10. doi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
    Nutrition 26:250-4. 2010
    ..Moreover, for the first time CoQ(10) was found to decrease the incidence of preeclampsia in pregnancy. The ability of CoQ(10) to mitigate headache symptoms in adults was also verified in pediatric and adolescent populations...
  11. ncbi request reprint Oxidative stress, endothelial function and coenzyme Q10
    Romualdo Belardinelli
    Cardiologia Riabilitativa Lancisi, Azienda Ospedali Riuniti, Ancona, Italy
    Biofactors 32:129-33. 2008
    ..Future studies are needed to inquire whether these effects may translate into benefits in clinical practice...
  12. doi request reprint Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading
    Angelo Turi
    Department of Clinical Sciences, Unit of Obstetrics and Gynecology at G Salesi Hospital, Polytechnic University of Marche, Via F Corridoni 11, 60123 Ancona, Italy
    Arch Gynecol Obstet 285:1173-6. 2012
    ..No data are available on the presence and content of Coenzyme Q10 (CoQ10) in human follicular fluid and its role...
  13. doi request reprint Coenzyme Q(10) , endothelial function, and cardiovascular disease
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, Ancona, Italy
    Biofactors 37:366-73. 2011
    ..The effect of CoQ(10) on endothelial dysfunction in ischemic heart disease is also reviewed together with recent data highlighting that treatment with CoQ(10) increases extracellular SOD activity...
  14. doi request reprint Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial
    Giancarlo Balercia
    Department of Internal Medicine and Applied Biotechnologies, Andrology Unit, Endocrinology, Umberto I Hospital, School of Medicine, Polytechnic University of Marche, Ancona, Italy
    Fertil Steril 91:1785-92. 2009
    ..To evaluate the effectiveness of coenzyme Q(10) treatment in improving semen quality in men with idiopathic infertility...
  15. ncbi request reprint Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure
    Romualdo Belardinelli
    Lancisi Heart Institute, Department of Cardiology and Cardiac Surgery, Ancona, Italy
    Biofactors 25:137-45. 2005
    ..There is evidence that plasma CoQ(10) levels decrease in patients with advanced chronic heart failure (CHF)...
  16. doi request reprint Plasma coenzyme Q10 is increased during gestational diabetes
    Stefano Raffaele Giannubilo
    Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    Diabetes Res Clin Pract 94:230-5. 2011
    ..To determine plasma CoQ(10) concentration in the course of gestational diabetes mellitus...
  17. doi request reprint Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation
    Francesca Bruge
    Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy
    Br J Nutr 106:1058-62. 2011
    ..We conclude that regular consumption of MK-7-enriched olive oil may constitute a valid approach in order to preserve some key biochemical mechanisms controlling bone mineralisation...
  18. ncbi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of Marche, Via Ranieri, Ancona, Italy
    Curr Opin Clin Nutr Metab Care 8:641-6. 2005
    ..These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10...
  19. ncbi request reprint NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell lines
    Francesca Bruge
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 32:71-81. 2008
    ..On the other hand, this result suggests a careful re-evaluation of data concerning loss of NQO1 activity and polymorphisms in tumour cells...
  20. doi request reprint A novel Real Time PCR strategy to detect SOD3 SNP using LNA probes
    Francesca Bruge
    Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    Mutat Res 669:80-4. 2009
    ..Moreover, identification of patients with lowered vascular antioxidant defences could address pharmacogenomical approaches to the therapy of cardiovascular diseases...
  21. ncbi request reprint Oleoylethanolamide protects human sperm cells from oxidation stress: studies on cases of idiopathic infertility
    Annarina Ambrosini
    Institute of Biochemistry, Polytechnic University of Marche, 60100 Ancona, Italy
    Biol Reprod 74:659-65. 2006
    ..Results of this study support the hypothesis of a possible protective action of oleoylethanolamide against reactive oxygen species, which could explain its beneficial effects on in vitro capacitated spermatozoa...
  22. pmc Prevention of UVA-induced oxidative damage in human dermal fibroblasts by new UV filters, assessed using a novel in vitro experimental system
    Francesca Bruge
    Dipartimento Scienze Cliniche Specialistiche ed Odontostomatologiche, Universita Politecnica delle Marche, Ancona, Italy
    PLoS ONE 9:e83401. 2014
    ....
  23. ncbi request reprint Coenzyme Q10 and exercise training in chronic heart failure
    Romualdo Belardinelli
    Lancisi Heart Institute, Via Conca, 71 Torrette di Ancona, Italy
    Eur Heart J 27:2675-81. 2006
    ..However, it is not known whether oral CoQ(10) supplementation may improve cardiocirculatory efficiency and endothelial function in patients with CHF...