P Tessari

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Slow versus fast proteins in the stimulation of beta-cell response and the activation of the entero-insular axis in type 2 diabetes
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Diabetes Metab Res Rev 23:378-85. 2007
  2. pmc Roles of insulin, age, and asymmetric dimethylarginine on nitric oxide synthesis in vivo
    Paolo Tessari
    Metabolism Division, Department of Medicine, University of Padova, Padova, Italy
    Diabetes 62:2699-708. 2013
  3. ncbi request reprint Postprandial body protein synthesis and amino acid catabolism measured with leucine and phenylalanine-tyrosine tracers
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 284:E1037-42. 2003
  4. doi request reprint Phenylalanine and tyrosine kinetics in compensated liver cirrhosis: effects of meal ingestion
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Am J Physiol Gastrointest Liver Physiol 295:G598-604. 2008
  5. ncbi request reprint Insulin in methionine and homocysteine kinetics in healthy humans: plasma vs. intracellular models
    Paolo Tessari
    Dept of Clinical and Experimental Medicine, Chair of Metabolism, Policlinico Universitario, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 288:E1270-6. 2005
  6. doi request reprint Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Acta Diabetol 45:143-5. 2008
  7. ncbi request reprint Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Diabetes 54:2968-76. 2005
  8. ncbi request reprint Albumin and fibrinogen synthesis and insulin effect in type 2 diabetic patients with normoalbuminuria
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Chair of Metabolism, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Diabetes Care 29:323-8. 2006
  9. ncbi request reprint Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes
    P Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, University of Padua, Padua, Italy
    Diabetologia 49:1955-61. 2006
  10. ncbi request reprint Acute effect of insulin on nitric oxide synthesis in humans: a precursor-product isotopic study
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, Policlinico Universitario, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 293:E776-82. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Slow versus fast proteins in the stimulation of beta-cell response and the activation of the entero-insular axis in type 2 diabetes
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Diabetes Metab Res Rev 23:378-85. 2007
    ..We tested whether ingestion of whey protein can induce greater post-prandial amino acid (AA) levels in the plasma and a higher beta-cell response than casein ingestion in type 2 diabetes mellitus patients...
  2. pmc Roles of insulin, age, and asymmetric dimethylarginine on nitric oxide synthesis in vivo
    Paolo Tessari
    Metabolism Division, Department of Medicine, University of Padova, Padova, Italy
    Diabetes 62:2699-708. 2013
    ..We conclude that whole-body NOx production is decreased in aging and T2DM. Age, ADMA concentration, and T2DM, but not insulin resistance, appear as negative regulators of whole-body NOx production. ..
  3. ncbi request reprint Postprandial body protein synthesis and amino acid catabolism measured with leucine and phenylalanine-tyrosine tracers
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 284:E1037-42. 2003
    ....
  4. doi request reprint Phenylalanine and tyrosine kinetics in compensated liver cirrhosis: effects of meal ingestion
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Am J Physiol Gastrointest Liver Physiol 295:G598-604. 2008
    ....
  5. ncbi request reprint Insulin in methionine and homocysteine kinetics in healthy humans: plasma vs. intracellular models
    Paolo Tessari
    Dept of Clinical and Experimental Medicine, Chair of Metabolism, Policlinico Universitario, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 288:E1270-6. 2005
    ..Use of plasma homocysteine as a surrogate of intracellular methionine enrichment, after acute perturbations such as insulin infusion, needs to be critically reassessed...
  6. doi request reprint Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Acta Diabetol 45:143-5. 2008
    ....
  7. ncbi request reprint Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Diabetes 54:2968-76. 2005
    ..In conclusion, pathways of homocysteine disposal are impaired in type 2 diabetes with nephropathy, both in postabsorptive and insulin-stimulated states, possibly accounting for the hyperhomocysteinemia of this condition...
  8. ncbi request reprint Albumin and fibrinogen synthesis and insulin effect in type 2 diabetic patients with normoalbuminuria
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Chair of Metabolism, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Diabetes Care 29:323-8. 2006
    ..In type 2 diabetes, fibrinogen production is increased both in the postabsorptive state and in response to hyperinsulinemia. No data exist on the rate of albumin synthesis and its response to insulin in type 2 diabetes...
  9. ncbi request reprint Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes
    P Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, University of Padua, Padua, Italy
    Diabetologia 49:1955-61. 2006
    ....
  10. ncbi request reprint Acute effect of insulin on nitric oxide synthesis in humans: a precursor-product isotopic study
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, Policlinico Universitario, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 293:E776-82. 2007
    ..13 +/- 0.35% (P < 0.003). In conclusion, whole body NO(x) synthesis can be directly measured over a short observation time with stable isotope methods in humans. Insulin acutely stimulates NO(x) synthesis from arginine...
  11. doi request reprint Hepatic lipid metabolism and non-alcoholic fatty liver disease
    P Tessari
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padua, Italy
    Nutr Metab Cardiovasc Dis 19:291-302. 2009
    ..However, both "hits" may be caused by the same factors. The aim of this article is to overview the biochemical steps of fat regulation in the liver and the alterations occurring in the pathogenesis of NAFLD and NASH...
  12. ncbi request reprint Protein metabolism in liver cirrhosis: from albumin to muscle myofibrils
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Policlinico Universitario, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Curr Opin Clin Nutr Metab Care 6:79-85. 2003
    ..An understanding of the causes and mechanisms leading to protein wasting in cirrhosis may help in the development of nutritional interventions and new therapies...
  13. doi request reprint Insulin resistance of amino acid and protein metabolism in type 2 diabetes
    Paolo Tessari
    Dept of Clinical and Experimental Medicine, Metabolism Division, University of Padova, Italy
    Clin Nutr 30:267-72. 2011
    ..Furthermore, the effects of interaction between diabetes (with the associated insulin resistance) and older age in the pathogenesis of sarcopenia in the elderly deserve more specific studies...
  14. pmc Nitric oxide synthesis is reduced in subjects with type 2 diabetes and nephropathy
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, University of Padova, Italy
    Diabetes 59:2152-9. 2010
    ..However, whether the decreased NOx excretion in type 2 diabetes is caused by a defective NOx production from arginine in response to hyperinsulinemia has never been studied...
  15. doi request reprint Fibrinogen kinetics and protein turnover in obese non-diabetic males: effects of insulin
    P Tessari
    Department of Clinical and Experimental Medicine, Chair of Metabolism, Policlinico Universitario, Via Giustiniani 2, Padua, Italy
    Diabetes Metab Res Rev 26:50-8. 2010
    ..Although hyperfibrinogenemia and insulin resistance are common in obesity and diabetes mellitus, the impact of obesity per se on fibrinogen turnover and the insulin effects on fibrinogen and protein kinetics is unknown...
  16. ncbi request reprint Impairment of albumin and whole body postprandial protein synthesis in compensated liver cirrhosis
    P Tessari
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padova, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 282:E304-11. 2002
    ..032). Thus mixed meal ingestion did not stimulate either albumin FSR or whole body protein synthesis in compensated liver cirrhosis. The mechanism(s) maintaining normoalbuminemia at this disease stage need to be further investigated...
  17. doi request reprint Effect of liver cirrhosis on phenylalanine and tyrosine metabolism
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Curr Opin Clin Nutr Metab Care 13:81-6. 2010
    ..The purpose of the present review is both to examine hydroxylation from a biochemical standpoint and to report data measured in vivo under physiological conditions, as well as in liver and kidney disease...
  18. ncbi request reprint Effects of wine intake on postprandial plasma amino acid and protein kinetics in type 1 diabetes
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Am J Clin Nutr 75:856-66. 2002
    ..Alcohol may impair protein turnover and insulin sensitivity in vivo...
  19. doi request reprint Middle age is not associated with altered fibrinogen concentration and production in males
    Paolo Tessari
    Metabolism Division, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Acta Diabetol 47:155-9. 2010
    ..Factor(s) different from age per se are likely to be involved in the dysfibrinogenemia possibly occurring with ageing. Protein turnover is already reduced in middle-age males...
  20. ncbi request reprint Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padova, Padova, Italy
    J Proteome Res 6:976-86. 2007
    ..These changes of chaperone-like proteins in fibroblasts may highlight those of the kidney and be patho-physiologically related to the development of nephropathy in T1DM...
  21. ncbi request reprint Insulin infusion normalizes fasting and post-prandial albumin and fibrinogen synthesis in Type 1 diabetes mellitus
    D Bruttomesso
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padova, Padova, Italy
    Diabet Med 18:915-20. 2001
    ..CONCLUSIONS: Albumin and fibrinogen FSR in T1DM can be maintained within near-normal ranges by insulin infusion under post-absorptive and post-prandial conditions...
  22. doi request reprint Fibrinogen kinetics and protein turnover in hypertension: Effects of insulin
    E Kiwanuka
    Metabolism Division, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 19:789-96. 2009
    ....
  23. ncbi request reprint Glucose kinetics and splanchnic uptake following mixed meal ingestion in cirrhotic-diabetic subjects
    E Kiwanuka
    Department of Clinical and Experimental Medicine, Padua, Italy
    Diabetes Nutr Metab 14:315-24. 2001
    ....
  24. ncbi request reprint Phenylalanine hydroxylation across the kidney in humans rapid communication
    P Tessari
    Department of Clinical Experimental Medicine, University of Padova, Italy
    Kidney Int 56:2168-72. 1999
    ..Phenylalanine hydroxylation across the kidney in humans...
  25. ncbi request reprint Plasma protein synthesis in patients with low-grade nephrotic proteinuria
    M Zanetti
    Departments of Metabolic Diseases and Internal Medicine, University of Padova, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 280:E591-7. 2001
    ..These findings suggest that low-grade nephrotic proteinuria is characterized by simultaneous multiple alterations in turnover rates of albumin, fibrinogen, and VLDL apoB-100. Their pathogenesis, however, appears to be multifactorial...
  26. ncbi request reprint Insulin acutely increases fibrinogen production in individuals with type 2 diabetes but not in individuals without diabetes
    Rocco Barazzoni
    Department of Clinical and Experimental Medicine, University of Padova, Padua, Italy
    Diabetes 52:1851-6. 2003
    ..Unchanged fibrinogen production in nondiabetic individuals suggests a role of plasma amino acids in regulating fibrinogen production in humans...
  27. ncbi request reprint Interorgan amino acid exchange
    P Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Curr Opin Clin Nutr Metab Care 3:51-7. 2000
    ..An interorgan cooperation between the kidney and splanchnic organs for leucine-ketoisocaproate metabolism has also been demonstrated...
  28. ncbi request reprint A rapid method to determine plasma homocysteine concentration and enrichment by gas chromatography/mass spectrometry
    Anna Valerio
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Rapid Commun Mass Spectrom 19:561-7. 2005
    ..We suggest applying this method to the measurement of the 'in vivo' rate of production of homocysteine (by the plasma 13C-homocysteine enrichment) from its precursor (13C-methionine)...
  29. ncbi request reprint L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled 15N arginine approach
    Angelo Avogaro
    Department of Metabolic Disease, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes 52:795-802. 2003
    ..From our data, it appears that noncomplicated type 2 diabetic patients have a decreased conversion of arginine to NO...
  30. ncbi request reprint Role of insulin in age-related changes in macronutrient metabolism
    P Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Eur J Clin Nutr 54:S126-30. 2000
    ..The degree of physical activity probably interacts with these changes, possibly playing a causative role. The possible interaction between insulin and exercise in the maintenance of muscle mass in the elderly needs to be studied further...
  31. doi request reprint Kinetics of albumin homocysteinylation measured with matrix-assisted laser/desorption ionization mass spectrometry versus with a radioactive tracer
    Elisabetta Callegher
    Department of Clinical and Experimental Medicine, Division of Metabolic Disease, University of Padova
    Rapid Commun Mass Spectrom 23:3837-42. 2009
    ..Although the results of the two methods were rather similar, the radioactive method appears to be more sensitive than the MALDI-MS technique...
  32. ncbi request reprint Rapid, simple and effective technical procedure for the regeneration of IgG and HSA affinity columns for proteomic analysis
    R Millioni
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padova, Padova, Italy
    Amino Acids 34:507-9. 2008
    ..We applied an affinity chromatography kit to remove albumin and the immunoglobulin chains from plasma and propose a simple and effective technical procedure for the regeneration of these affinity columns...
  33. ncbi request reprint Proteome analysis of cultured fibroblasts from type 1 diabetic patients and normal subjects
    Lucia Puricelli
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Padova, Via Giustiniani 2, 35128 Padova, Italy
    J Clin Endocrinol Metab 91:3507-14. 2006
    ..Cultured fibroblasts are a useful in vitro model for proteome analysis and study of the molecular mechanisms involved in diabetes...
  34. doi request reprint Glycolytic enzyme expression and pyruvate kinase activity in cultured fibroblasts from type 1 diabetic patients with and without nephropathy
    Elisabetta Iori
    Department of Clinical and Experimental Medicine, Chair of Metabolism, 35128 Padova, Italy
    Biochim Biophys Acta 1782:627-33. 2008
    ..In conclusion, this study reports novel alterations of enzymes involved in glucose metabolism that may be associated with the pathophysiology of insulin resistance and of renal damage in T1DM(DN+) patients...
  35. doi request reprint Effects of chronic metabolic acidosis on splanchnic protein turnover and oxygen consumption in human beings
    Paolo Tessari
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Gastroenterology 138:1557-65. 2010
    ..We investigated the effects of chronic metabolic acidosis (CMA) on splanchnic protein dynamics and oxygen consumption in human beings by using a leucine tracer and mass-balance techniques...
  36. doi request reprint SDS-PAGE and two-dimensional maps in a radial gel format
    Renato Millioni
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padova, Padova, Italy
    Electrophoresis 31:465-70. 2010
    ..When used in a mono-dimensional, SDS-PAGE format, this system allows the simultaneous running of 62 sample tracks. Examples are given of separation of plasma and urinary proteins...
  37. doi request reprint The effects of rosiglitazone and high glucose on protein expression in endothelial cells
    Renato Millioni
    Department of Clinical and Experimental Medicine, Chair of Metabolism, University of Padova, Padova, Italy
    J Proteome Res 9:578-84. 2010
    ..These mechanisms may foster new investigations on the overall vascular effects of this compound, and help to discriminate between desired and adverse effects...
  38. ncbi request reprint Role of blood cells in leucine kinetics across the human kidney
    Giacomo Garibotto
    Nephrology Division, Department of Internal Medicine, University of Genoa, 16132 Genoa
    Am J Physiol Renal Physiol 283:F1430-7. 2002
    ..These data also emphasize the need for complete whole blood arteriovenous measurements to accurately estimate protein turnover across the kidney...
  39. ncbi request reprint Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis
    Giacomo Garibotto
    Division of Nephrology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy
    J Am Soc Nephrol 15:1606-15. 2004
    ..The latter effect, which is likely induced by the increase in ammonia excretion and partition into the urine, is potentially responsible for kidney hypertrophy...
  40. ncbi request reprint The metabolic conversion of phenylalanine into tyrosine in the human kidney: does it have nutritional implications in renal patients?
    Giacomo Garibotto
    Division of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy
    J Ren Nutr 12:8-16. 2002
    ..This mechanism could in part account for the increased protein requirements in dialysis-treated end-stage renal disease patients, as compared with predialysis patients...