Gianluca Tell

Summary

Affiliation: University of Udine
Country: Italy

Publications

  1. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005
  2. pmc The many functions of APE1/Ref-1: not only a DNA repair enzyme
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Antioxid Redox Signal 11:601-20. 2009
  3. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
  4. doi Nucleophosmin delocalization in thyroid tumour cells
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocr Pathol 22:18-23. 2011
  5. ncbi Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
    J Mol Med (Berl) 85:1099-112. 2007
  6. pmc Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
    Lisa Lirussi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 23:4079-96. 2012
  7. pmc Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 9:1058-74. 2009
  8. ncbi Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Mol Cell Endocrinol 214:117-25. 2004
  9. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
  10. ncbi Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006

Collaborators

Detail Information

Publications57

  1. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005
    ..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions...
  2. pmc The many functions of APE1/Ref-1: not only a DNA repair enzyme
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Antioxid Redox Signal 11:601-20. 2009
    ....
  3. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
    ..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms...
  4. doi Nucleophosmin delocalization in thyroid tumour cells
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocr Pathol 22:18-23. 2011
    ..Either presence of the histone deacetylase inhibitor trichostatin A or absence of thyroid-stimulating hormone induces NPM nuclear localization in non-tumorigenic thyroid cell lines...
  5. ncbi Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
    J Mol Med (Berl) 85:1099-112. 2007
    ..These findings describe a new molecular pathway involved in the cytotoxic effects of UCB...
  6. pmc Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
    Lisa Lirussi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 23:4079-96. 2012
    ..They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo...
  7. pmc Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 9:1058-74. 2009
    ..Overall, our data show that APE1 acts as a hub in coordinating different and vital functions in mammalian cells, highlighting the molecular determinants of the multifunctional nature of APE1 protein...
  8. ncbi Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Mol Cell Endocrinol 214:117-25. 2004
    ..These findings, together with other published data, suggest that a network of functional interactions between transcriptional regulators is present in TFC...
  9. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
    ..Thus, the data open new perspectives in the comprehension of the many functions exerted by APE1 in controlling cell response to oxidative stress...
  10. ncbi Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006
    ..Accordingly, these two receptors resulted significantly upregulated in sample biopsies from different thyroid tumors...
  11. ncbi Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells
    Gianluca Tell
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocrinology 145:4660-6. 2004
    ..Thus, modification of the Egr-1-dependent mechanisms may play a role in the silencing of PTEN gene expression occurring during thyroid cell transformation...
  12. doi Nucleophosmin is overexpressed in thyroid tumors
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
    Biochem Biophys Res Commun 397:499-504. 2010
    ..It seems as a result of a dysregulation occurring at protein and not transcriptional level related to an increase of p-Akt levels of transformed thyrocytes...
  13. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009
    ..Strains carrying deletions in genes encoding potential drug targets show a variation of the intensity of their corresponding barcodes on the hybridization array over the time...
  14. pmc The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the pax protein family
    Luca Codutti
    Dipartimento di Scienze e Tecnologie Biomediche, Universita Degli Studi di Udine, P le Kolbe 4, 33100 Udine, Italy
    J Biol Chem 283:33321-8. 2008
    ..Finally, sequence conservation suggests that our findings could be a general feature of the Pax family transcription factors...
  15. ncbi Effects of histone acetylation on sodium iodide symporter promoter and expression of thyroid-specific transcription factors
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Policlinico Universitario di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocrinology 146:3967-74. 2005
    ..We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors...
  16. ncbi Galectin-3 expression in non-small cell lung carcinoma
    Fabio Puglisi
    Clinical Oncology, University of Udine, Italy
    Cancer Lett 212:233-9. 2004
    ..In the present study, concomitant expression of nuclear galectin-3 and TTF-1 was independently associated with a worse clinical outcome (HR 2.0; P = 0.01)...
  17. ncbi Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
    Endocrinology 145:1290-3. 2004
    ..However, restoring the PAX8-APE/Ref-1 expression in tumor cells may not be sufficient to obtain adequate levels of NIS gene expression...
  18. ncbi Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response
    Adalberto Costessi
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Bone 36:418-32. 2005
    ....
  19. doi Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem J 452:545-57. 2013
    ..Although required, however, this region is not sufficient itself to stably interact with DNA or NPM1...
  20. doi Down-regulation of SM22/transgelin gene expression during H9c2 cells differentiation
    Elisa Bregant
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Mol Cell Biochem 327:145-52. 2009
    ..Moreover, a differential expression of this protein in different districts of the human heart embryo was detected. Therefore, these data suggest that SM22 expression is regulated during heart development...
  21. pmc Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
    Carlo Vascotto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 22:3887-901. 2011
    ....
  22. doi A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 10:1645-57. 2010
    ..This study sheds light on the mechanisms of bilirubin-induced neurotoxicity and might help to design a strategy to prevent or ameliorate the neuronal damages leading to bilirubin encephalopathy...
  23. ncbi PTEN and Egr-1 expression in thyroid proliferative lesions
    Carla Di Loreto
    Anatomic Pathology, University of Udine, Udine, Italy
    Cancer Lett 224:105-9. 2005
    ..75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively)...
  24. pmc Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 38:8239-56. 2010
    ....
  25. ncbi Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines
    Milena Romanello
    Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Bone 39:739-53. 2006
    ..These findings show that bisphosphonates, by inducing ATP release, may also act through nucleotide receptors signaling leading to ERKs activation and may exert their mitogenic role on osteoblasts through the involvement of Hsp90...
  26. doi Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 424:34-9. 2012
    ..Our findings reveal a profound deregulation of APE1 acetylation status in TNBC, opening new perspectives for future improvements on treatment and prognosis of this molecular subtype of breast carcinomas...
  27. ncbi Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Italy
    Curr Pharm Des 15:2908-14. 2009
    ..We then elucidate some of the molecular pathways that govern these effects...
  28. doi Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes
    Nicoletta Bivi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Proteomics 74:1113-22. 2011
    ..In conclusion, these findings unveil novel functions targeted by N-BPs in osteocytes and could be useful to design novel pharmaceutical compounds...
  29. ncbi Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers
    Barbara Dapas
    Department of Biomedical Sciences and Technologies, University of Udine, Italy
    Eur J Biochem 270:3251-62. 2003
    ..These results suggest the involvement of eEF1A, associated with the nuclear-enriched fraction, in the growth and maintenance of tumour cells, possibly modulated by post-translational processing of the polypeptide chain...
  30. pmc A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells
    Igor Paron
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Biochem J 378:929-37. 2004
    ..These results indicate that a combination of different approaches is required for a complete functional understanding of the biological events triggered by oxidative stress...
  31. ncbi Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 6:3455-65. 2006
    ..Our data represent the first global approach in the study of I/R injury in liver...
  32. ncbi Molecular analysis of a human PAX6 homeobox mutant
    Angela Valentina D'Elia
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
    Eur J Hum Genet 14:744-51. 2006
    ..Thus, we suggest that the R242T human phenotype could be due to abnormal increase of PAX6 protein, in keeping with the reported sensitivity of the eye phenotype to increased PAX6 dosage...
  33. doi Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
    J Proteome Res 8:1131-42. 2009
    ..Data validated using gel imaging in combination with the GLaD post digestion isotopic labeling method provide the molecular basis for understanding the role of bisphosphonates as antiapoptotic drugs for osteocytes...
  34. pmc SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
    Giulia Antoniali
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy Proteomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, 80147 Naples, Italy Department of Biomedical and Pharmaceutical Sciences, University of Salerno, 84084 Fisciano Salerno, Italy Department of Pharmacy, University of Naples Federico II, 80134 Naples, Italy Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy
    Mol Biol Cell 25:532-47. 2014
    ..These findings provide new insights into the role of nCaRE sequences in the transcriptional regulation of mammalian genes. ..
  35. ncbi The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Antioxid Redox Signal 7:367-84. 2005
    ..In the present review, we tried to put together a growing body of information concerning APE1/Ref-1's different functions, shedding new light on present and future directions to understand fully this unique molecule...
  36. doi Two novel NPM1 mutations in a therapy-responder AML patient
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Facolta di Medicina, Universita di Udine, Udine, Italy
    Hematol Oncol 28:151-5. 2010
    ..Cells' transfection studies indicate that the presence of one of these mutations is associated to an abnormal nucleolar structure, suggesting that NPM1 may contribute to the control of nucleolar integrity...
  37. ncbi Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 212:223-35. 2007
    ..These data, suggesting that GD cells display an impairment in the cellular redox state and in the adaptive cellular response to oxidative stress, may open new perspectives in the comprehension of GD pathogenesis...
  38. ncbi Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: a proteomics study
    Angela Risso
    Centro d Eccellenza MATI Microgravity, Ageing, Training, Immobility, Udine, Italy
    Proteomics 5:1827-37. 2005
    ..Seven proteins with modified expression values were identified; they are involved in nucleic acids processing, proteasome regulation and cytoskeleton structure...
  39. doi Expression of Dicer and Drosha in triple-negative breast cancer
    Nadia Passon
    Dipartimento di Scienze Mediche e Biologiche, Universita di Udine, Udine, Italy
    J Clin Pathol 65:320-6. 2012
    ..The main purpose of this study was a detailed investigation of Dicer and Drosha expression and localisation in triple-negative breast cancers...
  40. doi Alterations in the redox state and liver damage: hints from the EASL Basic School of Hepatology
    Gianluca Tell
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Hepatol 58:365-74. 2013
    ..In parallel, understanding how alteration of the redox balance may be associated with liver damage may help define sensitive and ideally early biomarkers of the disorder...
  41. pmc Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines
    Laura Cesaratto
    Dipartimento di Scienze Mediche e Biologiche, Universita di Udine, Udine, Italy
    PLoS ONE 8:e70909. 2013
    ..The efficacy of the inhibition of APE1 redox activity in blocking TNF-α and FAs induced inflammatory response opens new perspectives for treatment of inflammatory-based liver diseases. ..
  42. ncbi Oxidized transthyretin in amniotic fluid as an early marker of preeclampsia
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    J Proteome Res 6:160-70. 2007
    ....
  43. ncbi Combining RNAi and in vivo confocal microscopy analysis of the photoconvertible fluorescent protein Dendra2 to study a DNA repair protein
    Gianluca Tell
    Department of Medical and Biological Sciences, University of Udine, Udine, Italy
    Biotechniques 55:198-203. 2013
    ..In conclusion, we combined RNAi and in vivo confocal microscopy to study a DNA repair protein demonstrating the feasibility and the advantage of this approach for the study of the cellular dynamic of a DNA repair protein. ..
  44. ncbi Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulation
    Igor Paron
    Dipartimento di Scienze e Tecnologie Biomediche, P le Kolbe 1, Universita Degli Studi di Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 302:545-53. 2003
    ....
  45. ncbi Functional analysis of a novel RUNX2 missense mutation found in a family with cleidocranial dysplasia
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    J Hum Genet 50:679-83. 2005
    ..Computer modeling indicated that the G192R mutation perturbs not only loop 9, but also other parts of the runt domain, suggesting impairment of the interaction with CBFbeta...
  46. ncbi Expression and prognostic significance of APE1/Ref-1 and NPM1 proteins in high-grade ovarian serous cancer
    Ambrogio P Londero
    Dept of Experimental Clinical and Medical Science, Clinic of Obstetrics and Gynecology, University of Udine, Piazzale SM della Misericordia, 15 33100 Udine, Italy
    Am J Clin Pathol 141:404-14. 2014
    ....
  47. doi Thyroid tumors: novel insights from proteomic studies
    Giuseppe Damante
    Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 1, 33100 Udine, Italy
    Expert Rev Proteomics 6:363-76. 2009
    ..In this review, we describe the most relevant results that have been obtained for tumors derived from thyroid follicular cells using various proteomic approaches...
  48. ncbi Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissues
    Erika Codarin
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    J Proteome Res 8:2273-84. 2009
    ..These data may provide novel candidate biomarkers for HCC and useful insights for understanding the mechanisms of HCC pathogenesis and progression...
  49. pmc Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, Udine 33100, Italy
    Mol Biol Cell 25:1641-52. 2014
    ..Finally, based on the use of APE1 as a representative protein of the BER pathway, our data suggest a function for BER proteins in the regulation of ribogenesis. ..
  50. pmc The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate
    Rossana Domenis
    Department of Medical and Biological Sciences, University of Udine, Udine, Italy
    PLoS ONE 9:e89232. 2014
    ..These findings provide a molecular basis for the redox-mediated hypothesis of neuronal differentiation program...
  51. pmc Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 30:366-71. 2010
    ..In this review, we introduce questions and speculations concerning the role of APE1 in RNA metabolism and discuss the implications of these findings in a broader evolutionary context...
  52. ncbi The importance of redox state in liver damage
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Ann Hepatol 3:86-92. 2004
    ....
  53. ncbi H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line
    Barbara Frossi
    Immunology Section, Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 193:180-6. 2002
    ..These findings indicate that the APE/Ref-1 translocates to mitochondria in response to oxidative stress and thereby it might exert a protective function...
  54. pmc Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example
    Giulia Antoniali
    Department of Medical and Biological Sciences, University of Udine, Udine, Italy
    Antioxid Redox Signal 20:621-39. 2014
    ..During the evolution of these key enzymes, the acquisition of unfolded domains significantly amplified the possibility to interact with different partners and substrates, possibly explaining their phylogenetic gain of functions...
  55. doi Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100, Udine, Italy
    Cell Mol Life Sci 67:3589-608. 2010
    ..This survey intends to give an overview of the multifunctional roles of APE1 and their regulation in the context of considering this protein a promising tool for anticancer therapy...
  56. ncbi Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltration
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, Molecular Biology Section, University of Udine, Udine, Italy
    Biotechnol Lett 29:65-72. 2007
    ....
  57. ncbi Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors
    Angela V D'Elia
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, 33100 Udine, Italy
    J Clin Endocrinol Metab 87:1376-83. 2002
    ..These findings suggest that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis...