Gianluca Tell

Summary

Affiliation: University of Udine
Country: Italy

Publications

  1. pmc The many functions of APE1/Ref-1: not only a DNA repair enzyme
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Antioxid Redox Signal 11:601-20. 2009
  2. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
  3. pmc Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
    Lisa Lirussi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 23:4079-96. 2012
  4. pmc Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 9:1058-74. 2009
  5. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
  6. ncbi request reprint Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
    J Mol Med (Berl) 85:1099-112. 2007
  7. pmc Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
    Carlo Vascotto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 22:3887-901. 2011
  8. doi request reprint A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 10:1645-57. 2010
  9. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009
  10. doi request reprint Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem J 452:545-57. 2013

Collaborators

Detail Information

Publications35

  1. pmc The many functions of APE1/Ref-1: not only a DNA repair enzyme
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Antioxid Redox Signal 11:601-20. 2009
    ....
  2. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
    ..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms...
  3. pmc Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
    Lisa Lirussi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 23:4079-96. 2012
    ..They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo...
  4. pmc Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 9:1058-74. 2009
    ..Overall, our data show that APE1 acts as a hub in coordinating different and vital functions in mammalian cells, highlighting the molecular determinants of the multifunctional nature of APE1 protein...
  5. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
    ..Thus, the data open new perspectives in the comprehension of the many functions exerted by APE1 in controlling cell response to oxidative stress...
  6. ncbi request reprint Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
    J Mol Med (Berl) 85:1099-112. 2007
    ..These findings describe a new molecular pathway involved in the cytotoxic effects of UCB...
  7. pmc Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
    Carlo Vascotto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 22:3887-901. 2011
    ....
  8. doi request reprint A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 10:1645-57. 2010
    ..This study sheds light on the mechanisms of bilirubin-induced neurotoxicity and might help to design a strategy to prevent or ameliorate the neuronal damages leading to bilirubin encephalopathy...
  9. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009
    ..Strains carrying deletions in genes encoding potential drug targets show a variation of the intensity of their corresponding barcodes on the hybridization array over the time...
  10. doi request reprint Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem J 452:545-57. 2013
    ..Although required, however, this region is not sufficient itself to stably interact with DNA or NPM1...
  11. ncbi request reprint Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006
    ..Accordingly, these two receptors resulted significantly upregulated in sample biopsies from different thyroid tumors...
  12. doi request reprint Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 424:34-9. 2012
    ..Our findings reveal a profound deregulation of APE1 acetylation status in TNBC, opening new perspectives for future improvements on treatment and prognosis of this molecular subtype of breast carcinomas...
  13. ncbi request reprint Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Italy
    Curr Pharm Des 15:2908-14. 2009
    ..We then elucidate some of the molecular pathways that govern these effects...
  14. doi request reprint Nucleophosmin is overexpressed in thyroid tumors
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
    Biochem Biophys Res Commun 397:499-504. 2010
    ..It seems as a result of a dysregulation occurring at protein and not transcriptional level related to an increase of p-Akt levels of transformed thyrocytes...
  15. doi request reprint Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes
    Nicoletta Bivi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Proteomics 74:1113-22. 2011
    ..In conclusion, these findings unveil novel functions targeted by N-BPs in osteocytes and could be useful to design novel pharmaceutical compounds...
  16. pmc Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 38:8239-56. 2010
    ....
  17. ncbi request reprint Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines
    Milena Romanello
    Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Bone 39:739-53. 2006
    ..These findings show that bisphosphonates, by inducing ATP release, may also act through nucleotide receptors signaling leading to ERKs activation and may exert their mitogenic role on osteoblasts through the involvement of Hsp90...
  18. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005
    ..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions...
  19. doi request reprint Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
    J Proteome Res 8:1131-42. 2009
    ..Data validated using gel imaging in combination with the GLaD post digestion isotopic labeling method provide the molecular basis for understanding the role of bisphosphonates as antiapoptotic drugs for osteocytes...
  20. ncbi request reprint Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 212:223-35. 2007
    ..These data, suggesting that GD cells display an impairment in the cellular redox state and in the adaptive cellular response to oxidative stress, may open new perspectives in the comprehension of GD pathogenesis...
  21. pmc Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines
    Laura Cesaratto
    Dipartimento di Scienze Mediche e Biologiche, Universita di Udine, Udine, Italy Fondazione Italiana Fegato, Area Science Park, Basovizza, Trieste, Italy
    PLoS ONE 8:e70909. 2013
    ..The efficacy of the inhibition of APE1 redox activity in blocking TNF-α and FAs induced inflammatory response opens new perspectives for treatment of inflammatory-based liver diseases. ..
  22. ncbi request reprint Oxidized transthyretin in amniotic fluid as an early marker of preeclampsia
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    J Proteome Res 6:160-70. 2007
    ....
  23. doi request reprint Alterations in the redox state and liver damage: hints from the EASL Basic School of Hepatology
    Gianluca Tell
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Hepatol 58:365-74. 2013
    ..In parallel, understanding how alteration of the redox balance may be associated with liver damage may help define sensitive and ideally early biomarkers of the disorder...
  24. doi request reprint Expression of Dicer and Drosha in triple-negative breast cancer
    Nadia Passon
    Dipartimento di Scienze Mediche e Biologiche, Universita di Udine, Udine, Italy
    J Clin Pathol 65:320-6. 2012
    ..The main purpose of this study was a detailed investigation of Dicer and Drosha expression and localisation in triple-negative breast cancers...
  25. doi request reprint Two novel NPM1 mutations in a therapy-responder AML patient
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Facolta di Medicina, Universita di Udine, Udine, Italy
    Hematol Oncol 28:151-5. 2010
    ..Cells' transfection studies indicate that the presence of one of these mutations is associated to an abnormal nucleolar structure, suggesting that NPM1 may contribute to the control of nucleolar integrity...
  26. ncbi request reprint Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response
    Adalberto Costessi
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Bone 36:418-32. 2005
    ....
  27. ncbi request reprint Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 6:3455-65. 2006
    ..Our data represent the first global approach in the study of I/R injury in liver...
  28. doi request reprint Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100, Udine, Italy
    Cell Mol Life Sci 67:3589-608. 2010
    ..This survey intends to give an overview of the multifunctional roles of APE1 and their regulation in the context of considering this protein a promising tool for anticancer therapy...
  29. ncbi request reprint PTEN and Egr-1 expression in thyroid proliferative lesions
    Carla Di Loreto
    Anatomic Pathology, University of Udine, Udine, Italy
    Cancer Lett 224:105-9. 2005
    ..75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively)...
  30. ncbi request reprint Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissues
    Erika Codarin
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    J Proteome Res 8:2273-84. 2009
    ..These data may provide novel candidate biomarkers for HCC and useful insights for understanding the mechanisms of HCC pathogenesis and progression...
  31. ncbi request reprint Molecular analysis of a human PAX6 homeobox mutant
    Angela Valentina D'Elia
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
    Eur J Hum Genet 14:744-51. 2006
    ..Thus, we suggest that the R242T human phenotype could be due to abnormal increase of PAX6 protein, in keeping with the reported sensitivity of the eye phenotype to increased PAX6 dosage...
  32. ncbi request reprint Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltration
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, Molecular Biology Section, University of Udine, Udine, Italy
    Biotechnol Lett 29:65-72. 2007
    ....
  33. pmc Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 30:366-71. 2010
    ..In this review, we introduce questions and speculations concerning the role of APE1 in RNA metabolism and discuss the implications of these findings in a broader evolutionary context...
  34. ncbi request reprint The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Antioxid Redox Signal 7:367-84. 2005
    ..In the present review, we tried to put together a growing body of information concerning APE1/Ref-1's different functions, shedding new light on present and future directions to understand fully this unique molecule...
  35. ncbi request reprint Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: a proteomics study
    Angela Risso
    Centro d Eccellenza MATI Microgravity, Ageing, Training, Immobility, Udine, Italy
    Proteomics 5:1827-37. 2005
    ..Seven proteins with modified expression values were identified; they are involved in nucleic acids processing, proteasome regulation and cytoskeleton structure...