Research Topics
Genomes and Genes | Gianluca TellSummaryAffiliation: University of Udine Country: Italy Publications
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Detail Information
Publications
The many functions of APE1/Ref-1: not only a DNA repair enzymeGianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Antioxid Redox Signal 11:601-20. 2009....- APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control processCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
Mol Cell Biol 29:1834-54. 2009..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms... 
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cellsCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Proteomics 9:1058-74. 2009..Overall, our data show that APE1 acts as a hub in coordinating different and vital functions in mammalian cells, highlighting the molecular determinants of the multifunctional nature of APE1 protein...- APE1/Ref-1 regulates PTEN expression mediated by Egr-1Damiano Fantini
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Free Radic Res 42:20-9. 2008..Thus, the data open new perspectives in the comprehension of the many functions exerted by APE1 in controlling cell response to oxidative stress... 
Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathwayLaura Cesaratto
Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
J Mol Med (Berl) 85:1099-112. 2007..These findings describe a new molecular pathway involved in the cytotoxic effects of UCB...- Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionCarlo Vascotto
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
Mol Biol Cell 22:3887-901. 2011.... - Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collectionNicoletta Bivi
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
Genome Biol 10:R93. 2009..Strains carrying deletions in genes encoding potential drug targets show a variation of the intensity of their corresponding barcodes on the hybridization array over the time... - A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 proteinMarta Deganuto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Proteomics 10:1645-57. 2010..This study sheds light on the mechanisms of bilirubin-induced neurotoxicity and might help to design a strategy to prevent or ameliorate the neuronal damages leading to bilirubin encephalopathy... - Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathwayAlex Pines
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
J Cell Physiol 209:44-55. 2006..Accordingly, these two receptors resulted significantly upregulated in sample biopsies from different thyroid tumors... - Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancersMattia Poletto
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
Biochem Biophys Res Commun 424:34-9. 2012..Our findings reveal a profound deregulation of APE1 acetylation status in TNBC, opening new perspectives for future improvements on treatment and prognosis of this molecular subtype of breast carcinomas... - Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cellsGianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Italy
Curr Pharm Des 15:2908-14. 2009..We then elucidate some of the molecular pathways that govern these effects... - Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytesNicoletta Bivi
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
J Proteomics 74:1113-22. 2011..In conclusion, these findings unveil novel functions targeted by N-BPs in osteocytes and could be useful to design novel pharmaceutical compounds... - Nucleophosmin is overexpressed in thyroid tumorsAnnalisa Pianta
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Udine, Italy
Biochem Biophys Res Commun 397:499-504. 2010..It seems as a result of a dysregulation occurring at protein and not transcriptional level related to an increase of p-Akt levels of transformed thyrocytes... - Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATPAlex Pines
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
Nucleic Acids Res 33:4379-94. 2005..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions... - Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functionsDamiano Fantini
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
Nucleic Acids Res 38:8239-56. 2010.... - Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell linesMilena Romanello
Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P.le Kolbe 4, 33100 Udine, Italy
Bone 39:739-53. 2006..These findings show that bisphosphonates, by inducing ATP release, may also act through nucleotide receptors signaling leading to ERKs activation and may exert their mitogenic role on osteoblasts through the involvement of Hsp90... - Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonatesNicoletta Bivi
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
J Proteome Res 8:1131-42. 2009..Data validated using gel imaging in combination with the GLaD post digestion isotopic labeling method provide the molecular basis for understanding the role of bisphosphonates as antiapoptotic drugs for osteocytes... - Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stressMarta Deganuto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
J Cell Physiol 212:223-35. 2007..These data, suggesting that GD cells display an impairment in the cellular redox state and in the adaptive cellular response to oxidative stress, may open new perspectives in the comprehension of GD pathogenesis... - Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsLisa Lirussi
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
Mol Biol Cell 23:4079-96. 2012..They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo... - Oxidized transthyretin in amniotic fluid as an early marker of preeclampsiaCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
J Proteome Res 6:160-70. 2007.... - Expression of Dicer and Drosha in triple-negative breast cancerNadia Passon
Dipartimento di Scienze Mediche e Biologiche, Universita di Udine, Udine, Italy
J Clin Pathol 65:320-6. 2012..The main purpose of this study was a detailed investigation of Dicer and Drosha expression and localisation in triple-negative breast cancers... - Two novel NPM1 mutations in a therapy-responder AML patientAnnalisa Pianta
Dipartimento di Scienze e Tecnologie Biomediche, Facolta di Medicina, Universita di Udine, Udine, Italy
Hematol Oncol 28:151-5. 2010..Cells' transfection studies indicate that the presence of one of these mutations is associated to an abnormal nucleolar structure, suggesting that NPM1 may contribute to the control of nucleolar integrity... - Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' responseAdalberto Costessi
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
Bone 36:418-32. 2005.... - Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantationCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Proteomics 6:3455-65. 2006..Our data represent the first global approach in the study of I/R injury in liver... - Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissuesErika Codarin
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
J Proteome Res 8:2273-84. 2009..These data may provide novel candidate biomarkers for HCC and useful insights for understanding the mechanisms of HCC pathogenesis and progression... - PTEN and Egr-1 expression in thyroid proliferative lesionsCarla Di Loreto
Anatomic Pathology, University of Udine, Udine, Italy
Cancer Lett 224:105-9. 2005..75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively)... - Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatmentGianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100, Udine, Italy
Cell Mol Life Sci 67:3589-608. 2010..This survey intends to give an overview of the multifunctional roles of APE1 and their regulation in the context of considering this protein a promising tool for anticancer therapy... - Molecular analysis of a human PAX6 homeobox mutantCinzia Puppin
Dipartimento di Scienze e Tecnologie Biomediche, , Udine, Italy
Eur J Hum Genet 14:744-51. 2006..Thus, we suggest that the R242T human phenotype could be due to abnormal increase of PAX6 protein, in keeping with the reported sensitivity of the eye phenotype to increased PAX6 dosage... - Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltrationGianluca Tell
Department of Biomedical Sciences and Technologies, Molecular Biology Section, University of Udine, Udine, Italy
Biotechnol Lett 29:65-72. 2007.... - Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Gianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
Mol Cell Biol 30:366-71. 2010..In this review, we introduce questions and speculations concerning the role of APE1 in RNA metabolism and discuss the implications of these findings in a broader evolutionary context... - The intracellular localization of APE1/Ref-1: more than a passive phenomenon?Gianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
Antioxid Redox Signal 7:367-84. 2005..In the present review, we tried to put together a growing body of information concerning APE1/Ref-1's different functions, shedding new light on present and future directions to understand fully this unique molecule... - Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: a proteomics studyAngela Risso
Centro d Eccellenza MATI Microgravity, Ageing, Training, Immobility, Udine, Italy
Proteomics 5:1827-37. 2005..Seven proteins with modified expression values were identified; they are involved in nucleic acids processing, proteasome regulation and cytoskeleton structure...