Gianluca Tell

Summary

Affiliation: University of Udine
Country: Italy

Publications

  1. ncbi request reprint The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Antioxid Redox Signal 7:367-84. 2005
  2. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
  3. pmc Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
    Lisa Lirussi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 23:4079-96. 2012
  4. ncbi request reprint Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
    J Mol Med (Berl) 85:1099-112. 2007
  5. pmc Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 9:1058-74. 2009
  6. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
  7. ncbi request reprint Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Mol Cell Endocrinol 214:117-25. 2004
  8. ncbi request reprint Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006
  9. ncbi request reprint Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells
    Gianluca Tell
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocrinology 145:4660-6. 2004
  10. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009

Collaborators

Detail Information

Publications61

  1. ncbi request reprint The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Antioxid Redox Signal 7:367-84. 2005
    ..In the present review, we tried to put together a growing body of information concerning APE1/Ref-1's different functions, shedding new light on present and future directions to understand fully this unique molecule...
  2. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
    ..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms...
  3. pmc Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
    Lisa Lirussi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 23:4079-96. 2012
    ..They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo...
  4. ncbi request reprint Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
    J Mol Med (Berl) 85:1099-112. 2007
    ..These findings describe a new molecular pathway involved in the cytotoxic effects of UCB...
  5. pmc Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 9:1058-74. 2009
    ..Overall, our data show that APE1 acts as a hub in coordinating different and vital functions in mammalian cells, highlighting the molecular determinants of the multifunctional nature of APE1 protein...
  6. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
    ..Thus, the data open new perspectives in the comprehension of the many functions exerted by APE1 in controlling cell response to oxidative stress...
  7. ncbi request reprint Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Mol Cell Endocrinol 214:117-25. 2004
    ..These findings, together with other published data, suggest that a network of functional interactions between transcriptional regulators is present in TFC...
  8. ncbi request reprint Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006
    ..Accordingly, these two receptors resulted significantly upregulated in sample biopsies from different thyroid tumors...
  9. ncbi request reprint Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells
    Gianluca Tell
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocrinology 145:4660-6. 2004
    ..Thus, modification of the Egr-1-dependent mechanisms may play a role in the silencing of PTEN gene expression occurring during thyroid cell transformation...
  10. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009
    ..Strains carrying deletions in genes encoding potential drug targets show a variation of the intensity of their corresponding barcodes on the hybridization array over the time...
  11. doi request reprint Nucleophosmin delocalization in thyroid tumour cells
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocr Pathol 22:18-23. 2011
    ..Either presence of the histone deacetylase inhibitor trichostatin A or absence of thyroid-stimulating hormone induces NPM nuclear localization in non-tumorigenic thyroid cell lines...
  12. doi request reprint Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem J 452:545-57. 2013
    ..Although required, however, this region is not sufficient itself to stably interact with DNA or NPM1...
  13. ncbi request reprint Effects of histone acetylation on sodium iodide symporter promoter and expression of thyroid-specific transcription factors
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Policlinico Universitario di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocrinology 146:3967-74. 2005
    ..We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors...
  14. ncbi request reprint Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
    Endocrinology 145:1290-3. 2004
    ..However, restoring the PAX8-APE/Ref-1 expression in tumor cells may not be sufficient to obtain adequate levels of NIS gene expression...
  15. ncbi request reprint Galectin-3 expression in non-small cell lung carcinoma
    Fabio Puglisi
    Clinical Oncology, University of Udine, Italy
    Cancer Lett 212:233-9. 2004
    ..In the present study, concomitant expression of nuclear galectin-3 and TTF-1 was independently associated with a worse clinical outcome (HR 2.0; P = 0.01)...
  16. pmc Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
    Carlo Vascotto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Mol Biol Cell 22:3887-901. 2011
    ....
  17. doi request reprint A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 10:1645-57. 2010
    ..This study sheds light on the mechanisms of bilirubin-induced neurotoxicity and might help to design a strategy to prevent or ameliorate the neuronal damages leading to bilirubin encephalopathy...
  18. ncbi request reprint Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response
    Adalberto Costessi
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Bone 36:418-32. 2005
    ....
  19. pmc The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the pax protein family
    Luca Codutti
    Dipartimento di Scienze e Tecnologie Biomediche, Universita Degli Studi di Udine, P le Kolbe 4, 33100 Udine, Italy
    J Biol Chem 283:33321-8. 2008
    ..Finally, sequence conservation suggests that our findings could be a general feature of the Pax family transcription factors...
  20. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005
    ..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions...
  21. ncbi request reprint PTEN and Egr-1 expression in thyroid proliferative lesions
    Carla Di Loreto
    Anatomic Pathology, University of Udine, Udine, Italy
    Cancer Lett 224:105-9. 2005
    ..75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively)...
  22. doi request reprint Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers
    Mattia Poletto
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 424:34-9. 2012
    ..Our findings reveal a profound deregulation of APE1 acetylation status in TNBC, opening new perspectives for future improvements on treatment and prognosis of this molecular subtype of breast carcinomas...
  23. pmc Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 38:8239-56. 2010
    ....
  24. doi request reprint Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes
    Nicoletta Bivi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Proteomics 74:1113-22. 2011
    ..In conclusion, these findings unveil novel functions targeted by N-BPs in osteocytes and could be useful to design novel pharmaceutical compounds...
  25. doi request reprint Down-regulation of SM22/transgelin gene expression during H9c2 cells differentiation
    Elisa Bregant
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Mol Cell Biochem 327:145-52. 2009
    ..Moreover, a differential expression of this protein in different districts of the human heart embryo was detected. Therefore, these data suggest that SM22 expression is regulated during heart development...
  26. ncbi request reprint Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines
    Milena Romanello
    Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Bone 39:739-53. 2006
    ..These findings show that bisphosphonates, by inducing ATP release, may also act through nucleotide receptors signaling leading to ERKs activation and may exert their mitogenic role on osteoblasts through the involvement of Hsp90...
  27. ncbi request reprint Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Italy
    Curr Pharm Des 15:2908-14. 2009
    ..We then elucidate some of the molecular pathways that govern these effects...
  28. doi request reprint Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
    J Proteome Res 8:1131-42. 2009
    ..Data validated using gel imaging in combination with the GLaD post digestion isotopic labeling method provide the molecular basis for understanding the role of bisphosphonates as antiapoptotic drugs for osteocytes...
  29. pmc A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells
    Igor Paron
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Biochem J 378:929-37. 2004
    ..These results indicate that a combination of different approaches is required for a complete functional understanding of the biological events triggered by oxidative stress...
  30. ncbi request reprint Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Proteomics 6:3455-65. 2006
    ..Our data represent the first global approach in the study of I/R injury in liver...
  31. pmc The many functions of APE1/Ref-1: not only a DNA repair enzyme
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Antioxid Redox Signal 11:601-20. 2009
    ....
  32. ncbi request reprint Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress
    Marta Deganuto
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 212:223-35. 2007
    ..These data, suggesting that GD cells display an impairment in the cellular redox state and in the adaptive cellular response to oxidative stress, may open new perspectives in the comprehension of GD pathogenesis...
  33. ncbi request reprint Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers
    Barbara Dapas
    Department of Biomedical Sciences and Technologies, University of Udine, Italy
    Eur J Biochem 270:3251-62. 2003
    ..These results suggest the involvement of eEF1A, associated with the nuclear-enriched fraction, in the growth and maintenance of tumour cells, possibly modulated by post-translational processing of the polypeptide chain...
  34. doi request reprint Alterations in the redox state and liver damage: hints from the EASL Basic School of Hepatology
    Gianluca Tell
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Hepatol 58:365-74. 2013
    ..In parallel, understanding how alteration of the redox balance may be associated with liver damage may help define sensitive and ideally early biomarkers of the disorder...
  35. ncbi request reprint Oxidized transthyretin in amniotic fluid as an early marker of preeclampsia
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    J Proteome Res 6:160-70. 2007
    ....
  36. ncbi request reprint Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulation
    Igor Paron
    Dipartimento di Scienze e Tecnologie Biomediche, P le Kolbe 1, Universita Degli Studi di Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 302:545-53. 2003
    ....
  37. ncbi request reprint Functional analysis of a novel RUNX2 missense mutation found in a family with cleidocranial dysplasia
    Cinzia Puppin
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    J Hum Genet 50:679-83. 2005
    ..Computer modeling indicated that the G192R mutation perturbs not only loop 9, but also other parts of the runt domain, suggesting impairment of the interaction with CBFbeta...
  38. doi request reprint Thyroid tumors: novel insights from proteomic studies
    Giuseppe Damante
    Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 1, 33100 Udine, Italy
    Expert Rev Proteomics 6:363-76. 2009
    ..In this review, we describe the most relevant results that have been obtained for tumors derived from thyroid follicular cells using various proteomic approaches...
  39. ncbi request reprint Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas
    Fabio Puglisi
    Clinica Oncologica, Policlinico Universitario, Piazzale S M Misericordia I 33100 Udine, Italy
    Oncol Rep 9:11-7. 2002
    ..014) and Cox proportional hazard model analysis identified APE/Ref-1 as an independent prognostic factor. The results suggest that subcellular localisation of APE/Ref-1 may influence the aggressiveness of breast carcinomas...
  40. ncbi request reprint Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: a proteomics study
    Angela Risso
    Centro d Eccellenza MATI Microgravity, Ageing, Training, Immobility, Udine, Italy
    Proteomics 5:1827-37. 2005
    ..Seven proteins with modified expression values were identified; they are involved in nucleic acids processing, proteasome regulation and cytoskeleton structure...
  41. doi request reprint Emerging Roles of the Nucleolus in Regulating the DNA Damage Response: The Noncanonical DNA Repair Enzyme APE1/Ref-1 as a Paradigmatical Example
    Giulia Antoniali
    Department of Medical and Biological Sciences, University of Udine, Udine, Italy
    Antioxid Redox Signal 20:621-39. 2014
    ..Antioxid. Redox Signal. 20, 621-639. ..
  42. doi request reprint Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100, Udine, Italy
    Cell Mol Life Sci 67:3589-608. 2010
    ..This survey intends to give an overview of the multifunctional roles of APE1 and their regulation in the context of considering this protein a promising tool for anticancer therapy...
  43. ncbi request reprint Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissues
    Erika Codarin
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    J Proteome Res 8:2273-84. 2009
    ..These data may provide novel candidate biomarkers for HCC and useful insights for understanding the mechanisms of HCC pathogenesis and progression...
  44. pmc Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 30:366-71. 2010
    ..In this review, we introduce questions and speculations concerning the role of APE1 in RNA metabolism and discuss the implications of these findings in a broader evolutionary context...
  45. ncbi request reprint The importance of redox state in liver damage
    Laura Cesaratto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Ann Hepatol 3:86-92. 2004
    ....
  46. ncbi request reprint Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltration
    Gianluca Tell
    Department of Biomedical Sciences and Technologies, Molecular Biology Section, University of Udine, Udine, Italy
    Biotechnol Lett 29:65-72. 2007
    ....
  47. ncbi request reprint H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line
    Barbara Frossi
    Immunology Section, Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 193:180-6. 2002
    ..These findings indicate that the APE/Ref-1 translocates to mitochondria in response to oxidative stress and thereby it might exert a protective function...
  48. doi request reprint Combining RNAi and in vivo confocal microscopy analysis of the photoconvertible fluorescent protein Dendra2 to study a DNA repair protein
    Gianluca Tell
    Department of Medical and Biological Sciences, University of Udine, Udine, Italy
    Biotechniques 55:198-203. 2013
    ..In conclusion, we combined RNAi and in vivo confocal microscopy to study a DNA repair protein demonstrating the feasibility and the advantage of this approach for the study of the cellular dynamic of a DNA repair protein. ..
  49. ncbi request reprint Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors
    Angela V D'Elia
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, 33100 Udine, Italy
    J Clin Endocrinol Metab 87:1376-83. 2002
    ..These findings suggest that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis...
  50. ncbi request reprint Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop
    Alex Pines
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Free Radic Res 39:269-81. 2005
    ....
  51. ncbi request reprint Differential proteomic analysis of nuclear extracts from thyroid cell lines
    Anna Maria Salzano
    Proteomics and Mass Spectrometry Laboratory, I A B B A M, National Research Council, Via Argine 1085, 80147 Naples, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 833:41-50. 2006
    ..We show here that beta-actin directly interacted with APE1/Ref-1, as confirmed by co-immunoprecipitation assays and that this interaction was enhanced by oxidative stress on FRTL-5 cells...
  52. ncbi request reprint Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain
    Gianluca Tell
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Via Giorgieri 1, Universita degli Studi di Trieste, Trieste 34127, Italy
    J Biol Chem 277:14564-74. 2002
    ..Having previously demonstrated that Ref-1 is able to modulate the transcriptional activity of another thyroid-specific transcription factor (Pax-8), our data suggest that Ref-1 plays a central role in the regulation of thyroid cells...
  53. ncbi request reprint Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines
    Elisabetta Ferretti
    Department of Clinical Science, University of Rome, La Sapienza, Rome, Italy
    Endocrinology 146:4009-15. 2005
    ..These findings indicate that, in JAR cells, hCG activates a cAMP-dependent pathway that can up-regulate WT1 expression through PAX8...
  54. pmc Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line
    Alex Pines
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita degli Studi di Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Biochem J 373:815-24. 2003
    ..A target gene for Egr-1 that is fundamental in osteoblast physiology, COL1A2, is up-regulated by ATP stimulation of HOBIT cells in a timescale that is compatible with that of Egr-1 activation...
  55. ncbi request reprint Proteomic evaluation of core biopsy specimens from breast lesions
    Alessia Bisca
    Dipartimento di Scienze e Tecnologie Biomediche, Centro M A T I, Universita di Udine, Piazzale Kolbe 1, Udine 33100, Italy
    Cancer Lett 204:79-86. 2004
    ..Thus, our study provides a methodology to perform proteomic analysis on pre-operative samples of breast lesions...
  56. ncbi request reprint Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Via Celoria 26, I 20133, Milan, Italy
    Mass Spectrom Rev 24:55-99. 2005
    ..Indeed, identification and characterization of oxidatively/nitrosatively modified proteins in human diseases has just begun...
  57. ncbi request reprint Overoxidation of peroxiredoxins as an immediate and sensitive marker of oxidative stress in HepG2 cells and its application to the redox effects induced by ischemia/reperfusion in human liver
    Laura Cesaratto
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 34127 Trieste, Italy
    Free Radic Res 39:255-68. 2005
    ..Our present data could be of relevance in setting up more standardized procedures to preserve organs for transplantations...
  58. pmc The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells
    Alessio Iannetti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 105:14058-63. 2008
    ..Our data suggest that NF-kappaB contributes to thyroid tumor cell survival by controlling iron uptake via NGAL...
  59. ncbi request reprint RbAp48 is a target of nuclear factor-kappaB activity in thyroid cancer
    Francesco Pacifico
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Richerche, Naples, Italy
    J Clin Endocrinol Metab 92:1458-66. 2007
    ..The inhibition of NF-kappaB in the anaplastic thyroid carcinoma cell line (FRO) leads to increased susceptibility to apoptosis induced by chemotherapeutic drugs and to the block of oncogenic activity...
  60. pmc Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation
    Francesco Grassi
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15087-92. 2007
    ....
  61. pmc Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance
    Vittorio Di Maso
    Centro Studi Fegato, AREA Science Park and University of Trieste, Trieste, Italy
    Mol Med 13:89-96. 2007
    ....