Research Topics
Genomes and Genes
| Gianluca TellSummaryAffiliation: University of Udine Country: Italy Publications
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Detail Information
Publications
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?Gianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
Antioxid Redox Signal 7:367-84. 2005..In the present review, we tried to put together a growing body of information concerning APE1/Ref-1's different functions, shedding new light on present and future directions to understand fully this unique molecule...
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control processCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
Mol Cell Biol 29:1834-54. 2009..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms...- Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathwayLaura Cesaratto
Department of Biomedical Sciences and Technologies, University of Udine, 33100, Udine, Italy
J Mol Med (Berl) 85:1099-112. 2007..These findings describe a new molecular pathway involved in the cytotoxic effects of UCB... 
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cellsCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Proteomics 9:1058-74. 2009..Overall, our data show that APE1 acts as a hub in coordinating different and vital functions in mammalian cells, highlighting the molecular determinants of the multifunctional nature of APE1 protein...- Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoterCinzia Puppin
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
Mol Cell Endocrinol 214:117-25. 2004..These findings, together with other published data, suggest that a network of functional interactions between transcriptional regulators is present in TFC... - APE1/Ref-1 regulates PTEN expression mediated by Egr-1Damiano Fantini
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Free Radic Res 42:20-9. 2008..Thus, the data open new perspectives in the comprehension of the many functions exerted by APE1 in controlling cell response to oxidative stress... - Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cellsGianluca Tell
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
Endocrinology 145:4660-6. 2004..Thus, modification of the Egr-1-dependent mechanisms may play a role in the silencing of PTEN gene expression occurring during thyroid cell transformation... - Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collectionNicoletta Bivi
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
Genome Biol 10:R93. 2009..Strains carrying deletions in genes encoding potential drug targets show a variation of the intensity of their corresponding barcodes on the hybridization array over the time... - Nucleophosmin delocalization in thyroid tumour cellsAnnalisa Pianta
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
Endocr Pathol 22:18-23. 2011..Either presence of the histone deacetylase inhibitor trichostatin A or absence of thyroid-stimulating hormone induces NPM nuclear localization in non-tumorigenic thyroid cell lines... - Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathwayAlex Pines
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
J Cell Physiol 209:44-55. 2006..Accordingly, these two receptors resulted significantly upregulated in sample biopsies from different thyroid tumors... - Galectin-3 expression in non-small cell lung carcinomaFabio Puglisi
Clinical Oncology, University of Udine, Italy
Cancer Lett 212:233-9. 2004..In the present study, concomitant expression of nuclear galectin-3 and TTF-1 was independently associated with a worse clinical outcome (HR 2.0; P = 0.01)... - Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1Cinzia Puppin
Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Italy
Endocrinology 145:1290-3. 2004..However, restoring the PAX8-APE/Ref-1 expression in tumor cells may not be sufficient to obtain adequate levels of NIS gene expression... - Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionCarlo Vascotto
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
Mol Biol Cell 22:3887-901. 2011.... - A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 proteinMarta Deganuto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Proteomics 10:1645-57. 2010..This study sheds light on the mechanisms of bilirubin-induced neurotoxicity and might help to design a strategy to prevent or ameliorate the neuronal damages leading to bilirubin encephalopathy... - Effects of histone acetylation on sodium iodide symporter promoter and expression of thyroid-specific transcription factorsCinzia Puppin
Dipartimento di Scienze e Tecnologie Biomediche, Policlinico Universitario di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
Endocrinology 146:3967-74. 2005..We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors... - The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the pax protein familyLuca Codutti
Dipartimento di Scienze e Tecnologie Biomediche, Universita Degli Studi di Udine, P le Kolbe 4, 33100 Udine, Italy
J Biol Chem 283:33321-8. 2008..Finally, sequence conservation suggests that our findings could be a general feature of the Pax family transcription factors... - PTEN and Egr-1 expression in thyroid proliferative lesionsCarla Di Loreto
Anatomic Pathology, University of Udine, Udine, Italy
Cancer Lett 224:105-9. 2005..75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively)... - Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATPAlex Pines
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
Nucleic Acids Res 33:4379-94. 2005..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions... - Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' responseAdalberto Costessi
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
Bone 36:418-32. 2005.... - Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancersMattia Poletto
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
Biochem Biophys Res Commun 424:34-9. 2012..Our findings reveal a profound deregulation of APE1 acetylation status in TNBC, opening new perspectives for future improvements on treatment and prognosis of this molecular subtype of breast carcinomas... - Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytesNicoletta Bivi
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
J Proteomics 74:1113-22. 2011..In conclusion, these findings unveil novel functions targeted by N-BPs in osteocytes and could be useful to design novel pharmaceutical compounds... - Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functionsDamiano Fantini
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
Nucleic Acids Res 38:8239-56. 2010.... - Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell linesMilena Romanello
Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P.le Kolbe 4, 33100 Udine, Italy
Bone 39:739-53. 2006..These findings show that bisphosphonates, by inducing ATP release, may also act through nucleotide receptors signaling leading to ERKs activation and may exert their mitogenic role on osteoblasts through the involvement of Hsp90... - Down-regulation of SM22/transgelin gene expression during H9c2 cells differentiationElisa Bregant
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
Mol Cell Biochem 327:145-52. 2009..Moreover, a differential expression of this protein in different districts of the human heart embryo was detected. Therefore, these data suggest that SM22 expression is regulated during heart development... - Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonatesNicoletta Bivi
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
J Proteome Res 8:1131-42. 2009..Data validated using gel imaging in combination with the GLaD post digestion isotopic labeling method provide the molecular basis for understanding the role of bisphosphonates as antiapoptotic drugs for osteocytes... - Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cellsGianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Italy
Curr Pharm Des 15:2908-14. 2009..We then elucidate some of the molecular pathways that govern these effects... - A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cellsIgor Paron
Department of Biomedical Sciences and Technologies, University of Udine, P. le Kolbe 4, 33100 Udine, Italy
Biochem J 378:929-37. 2004..These results indicate that a combination of different approaches is required for a complete functional understanding of the biological events triggered by oxidative stress... - Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stressMarta Deganuto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
J Cell Physiol 212:223-35. 2007..These data, suggesting that GD cells display an impairment in the cellular redox state and in the adaptive cellular response to oxidative stress, may open new perspectives in the comprehension of GD pathogenesis... - The many functions of APE1/Ref-1: not only a DNA repair enzymeGianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Antioxid Redox Signal 11:601-20. 2009.... - Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomersBarbara Dapas
Department of Biomedical Sciences and Technologies, University of Udine, Italy
Eur J Biochem 270:3251-62. 2003..These results suggest the involvement of eEF1A, associated with the nuclear-enriched fraction, in the growth and maintenance of tumour cells, possibly modulated by post-translational processing of the polypeptide chain... - Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantationCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Proteomics 6:3455-65. 2006..Our data represent the first global approach in the study of I/R injury in liver... - Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsLisa Lirussi
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
Mol Biol Cell 23:4079-96. 2012..They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo... - Oxidized transthyretin in amniotic fluid as an early marker of preeclampsiaCarlo Vascotto
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
J Proteome Res 6:160-70. 2007.... - Thyroid tumors: novel insights from proteomic studiesGiuseppe Damante
Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 1, 33100 Udine, Italy
Expert Rev Proteomics 6:363-76. 2009..In this review, we describe the most relevant results that have been obtained for tumors derived from thyroid follicular cells using various proteomic approaches... - Functional analysis of a novel RUNX2 missense mutation found in a family with cleidocranial dysplasiaCinzia Puppin
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
J Hum Genet 50:679-83. 2005..Computer modeling indicated that the G192R mutation perturbs not only loop 9, but also other parts of the runt domain, suggesting impairment of the interaction with CBFbeta... - Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomasFabio Puglisi
Clinica Oncologica, Policlinico Universitario, Piazzale S M Misericordia I 33100 Udine, Italy
Oncol Rep 9:11-7. 2002..014) and Cox proportional hazard model analysis identified APE/Ref-1 as an independent prognostic factor. The results suggest that subcellular localisation of APE/Ref-1 may influence the aggressiveness of breast carcinomas... - Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: a proteomics studyAngela Risso
Centro d Eccellenza MATI Microgravity, Ageing, Training, Immobility, Udine, Italy
Proteomics 5:1827-37. 2005..Seven proteins with modified expression values were identified; they are involved in nucleic acids processing, proteasome regulation and cytoskeleton structure... - Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Gianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100 Udine, Italy
Mol Cell Biol 30:366-71. 2010..In this review, we introduce questions and speculations concerning the role of APE1 in RNA metabolism and discuss the implications of these findings in a broader evolutionary context... - Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissuesErika Codarin
Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
J Proteome Res 8:2273-84. 2009..These data may provide novel candidate biomarkers for HCC and useful insights for understanding the mechanisms of HCC pathogenesis and progression... - Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatmentGianluca Tell
Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe 4, 33100, Udine, Italy
Cell Mol Life Sci 67:3589-608. 2010..This survey intends to give an overview of the multifunctional roles of APE1 and their regulation in the context of considering this protein a promising tool for anticancer therapy... - Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulationIgor Paron
Dipartimento di Scienze e Tecnologie Biomediche, P le Kolbe 1, Universita Degli Studi di Udine, 33100 Udine, Italy
Biochem Biophys Res Commun 302:545-53. 2003.... - H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell lineBarbara Frossi
Immunology Section, Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
J Cell Physiol 193:180-6. 2002..These findings indicate that the APE/Ref-1 translocates to mitochondria in response to oxidative stress and thereby it might exert a protective function... - Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltrationGianluca Tell
Department of Biomedical Sciences and Technologies, Molecular Biology Section, University of Udine, Udine, Italy
Biotechnol Lett 29:65-72. 2007.... - The importance of redox state in liver damageLaura Cesaratto
Department of Biomedical Sciences and Technologies, University of Udine, P.le Kolbe 4, 33100 Udine, Italy
Ann Hepatol 3:86-92. 2004.... - Expression and localization of the homeodomain-containing protein HEX in human thyroid tumorsAngela V D'Elia
Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, 33100 Udine, Italy
J Clin Endocrinol Metab 87:1376-83. 2002..These findings suggest that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis... - Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loopAlex Pines
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
Free Radic Res 39:269-81. 2005.... - Differential proteomic analysis of nuclear extracts from thyroid cell linesAnna Maria Salzano
Proteomics and Mass Spectrometry Laboratory, I.A.B.B.A.M, National Research Council, Via Argine 1085, 80147 Naples, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 833:41-50. 2006..We show here that beta-actin directly interacted with APE1/Ref-1, as confirmed by co-immunoprecipitation assays and that this interaction was enhanced by oxidative stress on FRTL-5 cells... - Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domainGianluca Tell
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Via Giorgieri 1, Universita degli Studi di Trieste, Trieste 34127, Italy
J Biol Chem 277:14564-74. 2002..Having previously demonstrated that Ref-1 is able to modulate the transcriptional activity of another thyroid-specific transcription factor (Pax-8), our data suggest that Ref-1 plays a central role in the regulation of thyroid cells... - Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell linesElisabetta Ferretti
Department of Clinical Science, University of Rome, La Sapienza, Rome, Italy
Endocrinology 146:4009-15. 2005..These findings indicate that, in JAR cells, hCG activates a cAMP-dependent pathway that can up-regulate WT1 expression through PAX8... - Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell lineAlex Pines
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita degli Studi di Trieste, Via Giorgieri 1, 34127 Trieste, Italy
Biochem J 373:815-24. 2003..A target gene for Egr-1 that is fundamental in osteoblast physiology, COL1A2, is up-regulated by ATP stimulation of HOBIT cells in a timescale that is compatible with that of Egr-1 activation... - Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activationFrancesco Grassi
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:15087-92. 2007.... - RbAp48 is a target of nuclear factor-kappaB activity in thyroid cancerFrancesco Pacifico
Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Richerche, Naples, Italy
J Clin Endocrinol Metab 92:1458-66. 2007..The inhibition of NF-kappaB in the anaplastic thyroid carcinoma cell line (FRO) leads to increased susceptibility to apoptosis induced by chemotherapeutic drugs and to the block of oncogenic activity... - Proteomic evaluation of core biopsy specimens from breast lesionsAlessia Bisca
Dipartimento di Scienze e Tecnologie Biomediche, Centro M.A.T.I, , Piazzale Kolbe 1, Udine 33100, Italy
Cancer Lett 204:79-86. 2004..Thus, our study provides a methodology to perform proteomic analysis on pre-operative samples of breast lesions... - Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significanceVittorio Di Maso
Centro Studi Fegato, AREA Science Park and University of Trieste, Trieste, Italy
Mol Med 13:89-96. 2007.... - The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cellsAlessio Iannetti
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
Proc Natl Acad Sci U S A 105:14058-63. 2008..Our data suggest that NF-kappaB contributes to thyroid tumor cell survival by controlling iron uptake via NGAL... - Overoxidation of peroxiredoxins as an immediate and sensitive marker of oxidative stress in HepG2 cells and its application to the redox effects induced by ischemia/reperfusion in human liverLaura Cesaratto
Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 34127 Trieste, Italy
Free Radic Res 39:255-68. 2005..Our present data could be of relevance in setting up more standardized procedures to preserve organs for transplantations... - Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomicsIsabella Dalle-Donne
Department of Biology, University of Milan, Via Celoria 26, I 20133, Milan, Italy
Mass Spectrom Rev 24:55-99. 2005..Indeed, identification and characterization of oxidatively/nitrosatively modified proteins in human diseases has just begun...