G Targher

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. doi request reprint Nonalcoholic fatty liver disease and reduced serum vitamin D(3) levels
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Metab Syndr Relat Disord 11:217-28. 2013
  2. doi request reprint Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Clin Sci (Lond) 125:301-9. 2013
  3. pmc Non-alcoholic fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    PLoS ONE 8:e57183. 2013
  4. doi request reprint Diagnosis and management of nonalcoholic fatty liver disease and its hemostatic/thrombotic and vascular complications
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Semin Thromb Hemost 39:214-28. 2013
  5. doi request reprint Clinical Review: Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications
    Giovanni Targher
    Division of Endocrinology and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata, Piazzale Stefani, 1, 37126 Verona, Italy
    J Clin Endocrinol Metab 98:483-95. 2013
  6. pmc Comparison of two creatinine-based estimating equations in predicting all-cause and cardiovascular mortality in patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Diabetes Care 35:2347-53. 2012
  7. pmc Increased pulse pressure independently predicts incident atrial fibrillation in patients with type 2 diabetes
    Filippo Valbusa
    Division of Internal Medicine, Sacro Cuore Hospital of Negrar, Verona, Italy
    Diabetes Care 35:2337-9. 2012
  8. ncbi request reprint Pancreatic fat accumulation and its relationship with liver fat content and other fat depots in obese individuals
    G Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    J Endocrinol Invest 35:748-53. 2012
  9. doi request reprint Increased prevalence of cardiovascular disease in Type 1 diabetic patients with non-alcoholic fatty liver disease
    G Targher
    Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    J Endocrinol Invest 35:535-40. 2012
  10. doi request reprint Vitamin D, thrombosis, and hemostasis: more than skin deep
    Giovanni Targher
    Section of Endocrinology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Semin Thromb Hemost 38:114-24. 2012

Detail Information

Publications139 found, 100 shown here

  1. doi request reprint Nonalcoholic fatty liver disease and reduced serum vitamin D(3) levels
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Metab Syndr Relat Disord 11:217-28. 2013
    ..Large placebo-controlled randomized clinical trials are urgently needed to determine whether vitamin D3 supplementation could have any potential benefit in reducing the development and progression of NAFLD...
  2. doi request reprint Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Clin Sci (Lond) 125:301-9. 2013
    ..The potential impact of NAFLD on AF deserves particular attention, especially with respect to the implications for screening and surveillance strategies in the growing number of patients with NAFLD...
  3. pmc Non-alcoholic fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    PLoS ONE 8:e57183. 2013
    ..The relationship between non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) in type 2 diabetes is currently unknown. We examined the relationship between NAFLD and risk of incident AF in people with type 2 diabetes...
  4. doi request reprint Diagnosis and management of nonalcoholic fatty liver disease and its hemostatic/thrombotic and vascular complications
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Semin Thromb Hemost 39:214-28. 2013
    ....
  5. doi request reprint Clinical Review: Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications
    Giovanni Targher
    Division of Endocrinology and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata, Piazzale Stefani, 1, 37126 Verona, Italy
    J Clin Endocrinol Metab 98:483-95. 2013
    ....
  6. pmc Comparison of two creatinine-based estimating equations in predicting all-cause and cardiovascular mortality in patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Diabetes Care 35:2347-53. 2012
    ..To compare the performance of two glomerular filtration rate (GFR)-estimating equations in predicting the risk of all-cause and cardiovascular mortality in type 2 diabetic patients...
  7. pmc Increased pulse pressure independently predicts incident atrial fibrillation in patients with type 2 diabetes
    Filippo Valbusa
    Division of Internal Medicine, Sacro Cuore Hospital of Negrar, Verona, Italy
    Diabetes Care 35:2337-9. 2012
    ..To examine whether baseline pulse pressure (PP), a marker of arterial stiffness, is associated with subsequent development of atrial fibrillation (AF) in type 2 diabetes...
  8. ncbi request reprint Pancreatic fat accumulation and its relationship with liver fat content and other fat depots in obese individuals
    G Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    J Endocrinol Invest 35:748-53. 2012
    ..We assessed the associations between pancreatic fat accumulation and other fat compartments, including liver fat and visceral adipose tissue as well as insulin resistance and other metabolic abnormalities in obese individuals...
  9. doi request reprint Increased prevalence of cardiovascular disease in Type 1 diabetic patients with non-alcoholic fatty liver disease
    G Targher
    Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    J Endocrinol Invest 35:535-40. 2012
    ..We sought to examine whether NAFLD is associated with prevalent CVD in patients with Type 1 diabetes...
  10. doi request reprint Vitamin D, thrombosis, and hemostasis: more than skin deep
    Giovanni Targher
    Section of Endocrinology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Semin Thromb Hemost 38:114-24. 2012
    ..Large placebo-controlled randomized clinical trials are urgently needed to determine whether vitamin D supplementation could have any potential benefit in reducing future CVD events and mortality risk...
  11. doi request reprint Predictors of estimated GFR decline in patients with type 2 diabetes and preserved kidney function
    Giacomo Zoppini
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Italy
    Clin J Am Soc Nephrol 7:401-8. 2012
    ..This study examined predictors of the annual decline in estimated GFR (eGFR) in patients with type 2 diabetes and preserved kidney function...
  12. doi request reprint Increased prevalence of chronic kidney disease in patients with Type 1 diabetes and non-alcoholic fatty liver
    G Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Diabet Med 29:220-6. 2012
    ..We determined whether non-alcoholic fatty liver is associated with an increased prevalence of chronic kidney disease in Type 1 diabetes...
  13. pmc Relationship between kidney function and liver histology in subjects with nonalcoholic steatohepatitis
    Giovanni Targher
    Division of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Clin J Am Soc Nephrol 5:2166-71. 2010
    ..We assessed whether nonalcoholic steatohepatitis (NASH) diagnosed by liver biopsy is associated with decreased kidney function and whether such association is independent of insulin resistance and features of the metabolic syndrome...
  14. doi request reprint Hemostatic and fibrinolytic abnormalities in endocrine diseases: a narrative review
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Semin Thromb Hemost 35:605-12. 2009
    ..Nevertheless, the prompt recognition of potentially severe disorders of blood coagulation is mandatory for the correct management of these patients...
  15. doi request reprint Glomerular filtration rate, albuminuria and risk of cardiovascular and all-cause mortality in type 2 diabetic individuals
    G Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1 37126 Verona, Italy
    Nutr Metab Cardiovasc Dis 21:294-301. 2011
    ..To assess all-cause and cardiovascular mortality in type 2 diabetic individuals according to estimated glomerular filtration rate (eGFR) and albuminuria...
  16. doi request reprint Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients
    G Targher
    Section of Endocrinology and Metabolism, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126, Verona, Italy
    Diabetologia 53:1341-8. 2010
    ..Information on this issue is lacking for type 1 diabetes. We evaluated whether NAFLD is associated with increased prevalence of retinopathy and CKD in type 1 diabetic patients...
  17. doi request reprint Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    J Hepatol 53:713-8. 2010
    ..To estimate the prevalence of non-alcoholic fatty liver disease (NAFLD) in type 1 diabetic individuals, and to evaluate whether NAFLD is associated with increased prevalence of cardiovascular disease (CVD)...
  18. doi request reprint Disorders of coagulation and hemostasis in abdominal obesity: emerging role of fatty liver
    Giovanni Targher
    Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Semin Thromb Hemost 36:41-8. 2010
    ..e., nonalcoholic fatty liver disease, a very frequent pathological condition in subjects with abdominal obesity) in the pathogenesis of the obesity-induced disorders of coagulation and fibrinolysis...
  19. doi request reprint Elevated serum gamma-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer - a narrative review
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Clin Chem Lab Med 48:147-57. 2010
    ..e., cardiovascular morbidity and mortality) and non-vascular outcomes (i.e., incident type 2 diabetes, chronic kidney disease and cancer), independent of alcohol consumption and other prognostic factors...
  20. ncbi request reprint Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients
    Giovanni Targher
    Unit of Internal Medicine and Diabetes, Sacro Cuore Hospital of Negrar, Negrar, Italy
    Diabetes Care 30:2119-21. 2007
  21. doi request reprint Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Clin Chem Lab Med 47:1367-71. 2009
    ..The prevalence of thyroid autoimmunity and subclinical primary hypothyroidism in persons with chronic kidney disease (CKD) not requiring chronic dialysis is not well defined...
  22. ncbi request reprint Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients
    G Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Diabetologia 51:444-50. 2008
    ..We assessed the associations between NAFLD and both chronic kidney disease (CKD) and retinopathy in a large cohort of type 2 diabetic individuals using a cross-sectional design...
  23. doi request reprint Diabetic retinopathy is associated with an increased incidence of cardiovascular events in Type 2 diabetic patients
    G Targher
    Division of Internal Medicine, Sacro Cuore Hospital of Negrar VR, Verona, Italy
    Diabet Med 25:45-50. 2008
    ..We investigated the association of diabetic retinopathy with the risk of incident cardiovascular disease (CVD) events in a large cohort of Type 2 diabetic adults...
  24. ncbi request reprint Association between serum TSH, free T4 and serum liver enzyme activities in a large cohort of unselected outpatients
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Clin Endocrinol (Oxf) 68:481-4. 2008
    ..We assessed the relationship between serum liver enzyme activity and thyroid function tests in a cohort of adult individuals...
  25. doi request reprint NASH predicts plasma inflammatory biomarkers independently of visceral fat in men
    Giovanni Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Obesity (Silver Spring) 16:1394-9. 2008
    ..In conclusion, our results suggest that NASH can predict a more atherogenic risk profile in a manner that is partly independent from the contribution of visceral adiposity in adult men...
  26. pmc Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37126 Verona, Italy
    J Am Soc Nephrol 19:1564-70. 2008
    ..1 to 2.2; P < 0.01). In conclusion, our findings suggest that nonalcoholic fatty liver disease is associated with an increased incidence of CKD in individuals with type 2 diabetes, independent of numerous baseline confounding factors...
  27. doi request reprint Relationship between soluble CD40 ligand and gamma-glutamyltransferase concentrations in non-drinking, young Type 1 diabetic individuals
    G Zoppini
    Department of Biomedical and Surgical Sciences, Section of Clinical Chemistry, Section of Endocrinology, University of Verona, Verona, Italy
    Diabet Med 25:1283-8. 2008
    ..To assess the association between circulating levels of soluble CD40 ligand (sCD40L), an emerging cardiovascular risk factor, and gamma-glutamyltransferase (GGT) activity concentrations in Type 1 diabetic subjects...
  28. doi request reprint Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome
    Giovanni Targher
    Department of Biomedical and Surgical Sciences, University of Verona, Italy
    Semin Thromb Hemost 35:277-87. 2009
    ..The clinical impact of NAFLD on the proinflammatory/prothrombotic risk profile deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD...
  29. doi request reprint Abnormal serum alanine aminotransferase levels are associated with impaired insulin sensitivity in young women with polycystic ovary syndrome
    G Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, 37126 Verona, Italy
    J Endocrinol Invest 32:695-700. 2009
    ..We assessed whether NAFLD is associated with impaired insulin sensitivity in PCOS women independently of age and total adiposity...
  30. doi request reprint Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Clin Chem Lab Med 47:1055-62. 2009
    ..The association of serum bilirubin concentrations with kidney function and albuminuria has not been established in the US general population...
  31. doi request reprint Relationship between serum gamma-glutamyltransferase and chronic kidney disease in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006
    G Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Nutr Metab Cardiovasc Dis 20:583-90. 2010
    ..Currently, the association of serum GGT concentrations with chronic kidney disease has not been established in the U.S. general population...
  32. doi request reprint Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?
    Giovanni Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University Hospital, Verona, Italy
    J Hepatol 54:1020-9. 2011
    ....
  33. doi request reprint Hemostatic disorders in type 1 diabetes mellitus
    Giovanni Targher
    Section of Endocrinology, Department of Medicine, University of Verona, Verona, Italy
    Semin Thromb Hemost 37:58-65. 2011
    ....
  34. doi request reprint Risk of cardiovascular disease and chronic kidney disease in diabetic patients with non-alcoholic fatty liver disease: just a coincidence?
    G Targher
    Section of Endocrinology and Metabolism, Department of Medicine, University Hospital, 37126 Verona, Italy
    J Endocrinol Invest 34:544-51. 2011
    ....
  35. pmc Nonalcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes
    Stefano Bonapace
    Division of Cardiology, Sacro Cuore Hospital, Negrar, Italy
    Diabetes Care 35:389-95. 2012
    ..Data on cardiac function in patients with nonalcoholic fatty liver disease (NAFLD) are limited and conflicting. We assessed whether NAFLD is associated with abnormalities in cardiac function in patients with type 2 diabetes...
  36. pmc Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function
    Giacomo Zoppini
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Diabetes Care 35:99-104. 2012
    ..We determined whether baseline serum uric acid levels predict the subsequent development of CKD in patients with type 2 diabetes...
  37. doi request reprint Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?
    G Targher
    Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Verona, Italy
    Diabetologia 51:1947-53. 2008
    ..The clinical impact of NAFLD on CVD risk deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD...
  38. ncbi request reprint Non-alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in non-diabetic men. Role of visceral adipose tissue
    G Targher
    Department of Internal Medicine, Sacro Cuore Hospital of Negrar VR, Verona, Italy
    Diabet Med 22:1354-8. 2005
    ....
  39. ncbi request reprint Increased prevalence of cardiovascular disease in Type 2 diabetic patients with non-alcoholic fatty liver disease
    G Targher
    Division of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Diabet Med 23:403-9. 2006
    ..To estimate the prevalence of cardiovascular disease (CVD) in Type 2 diabetic patients with and without non-alcoholic fatty liver disease (NAFLD), and to assess whether NAFLD is independently related to prevalent CVD...
  40. doi request reprint Higher HDL cholesterol levels are associated with a lower incidence of chronic kidney disease in patients with type 2 diabetes
    G Zoppini
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37126 Verona, Italy
    Nutr Metab Cardiovasc Dis 19:580-6. 2009
    ..We have prospectively assessed the effects of plasma HDL-C levels on the incidence of CKD in a large cohort of type 2 diabetic patients...
  41. ncbi request reprint Elevated plasma levels of soluble receptors of TNF-alpha and their association with smoking and microvascular complications in young adults with type 1 diabetes
    G Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    J Clin Endocrinol Metab 86:3805-8. 2001
    ....
  42. ncbi request reprint The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabet Med 21:52-8. 2004
    ..To evaluate the cardiovascular risk associated with the presence of the Metabolic Syndrome in Type 2 diabetic subjects...
  43. ncbi request reprint Non-alcoholic fatty liver disease is associated with carotid artery wall thickness in diet-controlled type 2 diabetic patients
    G Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    J Endocrinol Invest 29:55-60. 2006
    ..In conclusion, these results suggest that among diet-controlled Type 2 diabetic individuals the significant increase of carotid IMT in the presence of NAFLD is largely explained by HOMA-estimated insulin resistance...
  44. ncbi request reprint HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study
    Enzo Bonora
    Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes Care 25:1135-41. 2002
    ..To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes...
  45. ncbi request reprint Increased plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in Type 1 diabetic patients without clinically manifest macroangiopathy
    G Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar, Italy
    Diabet Med 22:999-1004. 2005
    ....
  46. ncbi request reprint Relation between soluble adhesion molecules and insulin sensitivity in type 2 diabetic individuals: role of adipose tissue
    G Targher
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes Care 24:1961-6. 2001
    ..These findings support the possibility that adipose tissue releases one or more factors that may adversely affect endothelial function on one hand and insulin sensitivity on the other...
  47. ncbi request reprint Intracellular partition of plasma glucose disposal in hypertensive and normotensive subjects with type 2 diabetes mellitus
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    J Clin Endocrinol Metab 86:2073-9. 2001
    ..These results indicate that hypertension markedly aggravates insulin resistance featuring type 2 diabetes mellitus. The molecular defects underlying this phenomenon involve primarily GS...
  48. ncbi request reprint Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease
    Giovanni Targher
    Division of Internal Medicine, Sacro Cuore Hospital, Negrar, VR, Italy
    Clin Endocrinol (Oxf) 64:337-41. 2006
    ..To assess associations between the activity of hypothalamo-pituitary-adrenal (HPA) axis and liver histology in patients with nonalcoholic fatty liver disease (NAFLD)...
  49. doi request reprint Relationship of serum gamma-glutamyltransferase to atherogenic dyslipidemia and glycemic control in type 2 diabetes
    Giacomo Zoppini
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Obesity (Silver Spring) 17:370-4. 2009
    ..These findings suggest that obesity itself may not be a sufficient risk factor for atherogenic dyslipidemia or poor glycemic control in people with type 2 diabetes...
  50. ncbi request reprint Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled Type 2 diabetic patients
    G Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar, Italy
    Diabet Med 22:1146-50. 2005
    ..To examine the association of non-alcoholic hepatic steatosis (HS) with the activity of the hypothalamo-pituitary-adrenal (HPA) axis in Type 2 diabetic individuals...
  51. doi request reprint Epidemiological association between uric acid concentration in plasma, lipoprotein(a), and the traditional lipid profile
    Giuseppe Lippi
    Section of Clinical Chemistry, University of Verona Medical School, Verona, Italy
    Clin Cardiol 33:E76-80. 2010
    ..It is unclear whether they are independent risk factors or simply markers, reflecting association with other traditional risk factors...
  52. ncbi request reprint Biochemical correlates of lipoprotein(a) in a general adult population. Possible implications for cardiovascular risk assessment
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro 10, 37134, Verona, Italy
    J Thromb Thrombolysis 27:44-7. 2009
    ....
  53. ncbi request reprint Effect of moderate aerobic exercise on sympatho-vagal balance in Type 2 diabetic patients
    G Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona and National Research Council, Institute of Bioengineery, Padua, Italy
    Diabet Med 24:370-6. 2007
    ..The purpose of the study was to determine long-term cardiovascular autonomic adaptation to moderate endurance aerobic exercise in people with Type 2 diabetes in order to test the hypothesis of an enhanced vagal drive...
  54. ncbi request reprint The role of serum uric acid in cardiovascular disease in type 2 diabetic and non-diabetic subjects: a narrative review
    G Zoppini
    Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    J Endocrinol Invest 34:881-6. 2011
    ..At this time, the treatment of asymptomatic hyperuricemia for the primary prevention of CVD is not recommended...
  55. ncbi request reprint Non-alcoholic fatty liver disease and increased risk of cardiovascular disease
    Giovanni Targher
    Division of Internal Medicine, Sacro Cuore Hospital of Negrar VR, Negrar, Italy
    Atherosclerosis 191:235-40. 2007
    ..Overall, the current body of evidence strongly suggests that NAFLD is likely to be associated with increased CVD risk, and raises the possibility that NAFLD may be not only a marker but also an early mediator of atherosclerosis...
  56. ncbi request reprint Measurement of microvolt T-wave alternans, a new arrhythmic risk stratification test, in Type 2 diabetic patients without clinical cardiovascular disease
    G Molon
    Division of Cardiology, Sacro Cuore Hospital, Negrar VR, Italy
    Diabet Med 23:207-10. 2006
    ..Although Type 2 diabetes is associated with an increased risk of these events, there is a dearth of available data on measurements of TWA in people with Type 2 diabetes...
  57. ncbi request reprint Non-alcoholic fatty liver disease is independently associated with left ventricular hypertrophy in hypertensive Type 2 diabetic individuals
    A Mantovani
    Division of Endocrinology and Metabolism, Department of Medicine, University of Verona Medical School, Italy
    J Endocrinol Invest 35:215-8. 2012
    ..The aim of this study is to evaluate whether there is an association between NAFLD and echocardiographically detected LVH in Type 2 diabetes...
  58. ncbi request reprint Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease
    Giovanni Targher
    Division of Internal Medicine and Diabetes Unit, Sacro Cuore don G Calabria Hospital, Negrar, Italy
    Nutr Metab Cardiovasc Dis 17:517-24. 2007
    ..To explore associations between serum 25-hydroxyvitamin D(3) [25(OH)D] concentrations and liver histology in patients with non-alcoholic fatty liver disease (NAFLD)...
  59. doi request reprint Anaemia, independent of chronic kidney disease, predicts all-cause and cardiovascular mortality in type 2 diabetic patients
    Giacomo Zoppini
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37126 Verona, Italy
    Atherosclerosis 210:575-80. 2010
    ..We assessed the predictive role of lower hemoglobin concentrations on all-cause and cardiovascular mortality in a cohort of type 2 diabetic individuals...
  60. ncbi request reprint Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients
    Giovanni Targher
    Division of Internal Medicine and Diabetes Unit, Sacro Cuore Hospital of Negrar, Verona, Negrar, Italy
    Diabetes 54:3541-6. 2005
    ..This relationship is independent of classical risk factors and is only partly explained by occurrence of metabolic syndrome...
  61. ncbi request reprint Effect of chronic treatment with lacidipine or lisinopril on intracellular partitioning of glucose metabolism in type 2 diabetes mellitus
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    J Clin Endocrinol Metab 84:1544-50. 1999
    ..These results suggest that treatment of subjects with type 2 diabetes with either lacidipine or lisinopril has no adverse effect on glucose metabolism. Conversely, both drugs seem to improve insulin sensitivity...
  62. ncbi request reprint Chronic cigarette smoking is associated with increased plasma circulating intercellular adhesion molecule 1 levels in young type 1 diabetic patients
    G Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 22:1871-4. 1999
    ....
  63. ncbi request reprint Inherited platelet disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Italy
    Clin Chim Acta 387:1-8. 2008
    ..This review briefly discusses the inherited platelet disorders with respect to molecular defects, diagnostic evaluation and treatment strategies...
  64. doi request reprint Antithrombotic prophylaxis in patients with von Willebrand disease undergoing major surgery: when is it necessary?
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Thromb Thrombolysis 28:215-9. 2009
    ..Thus, in absence of a widely accepted consensus and adequate prospective studies, we advise that the need for thromboprophylaxis in such patients should be evaluated individually, after a careful risk/benefit analysis...
  65. ncbi request reprint Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease
    Giovanni Targher
    Division of Internal Medicine, Sacro Cuore Hospital, Negrar, Italy
    Clin Endocrinol (Oxf) 64:679-83. 2006
    ..To explore associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease (NAFLD)...
  66. doi request reprint Variability of body weight, pulse pressure and glycaemia strongly predict total mortality in elderly type 2 diabetic patients. The Verona Diabetes Study
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Diabetes Metab Res Rev 24:624-8. 2008
    ....
  67. doi request reprint Relationship between serum phosphate and cardiovascular risk factors in a large cohort of adult outpatients
    Giuseppe Lippi
    Sezione di Chimica e Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Italy
    Diabetes Res Clin Pract 84:e3-5. 2009
    ....
  68. doi request reprint Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Arch Pathol Lab Med 133:628-32. 2009
    ..A strong independent association has been recently observed between elevated red blood cell distribution width (RDW) and increased incidence of cardiovascular events...
  69. pmc Elevated serum uric acid concentrations independently predict cardiovascular mortality in type 2 diabetic patients
    Giacomo Zoppini
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Diabetes Care 32:1716-20. 2009
    ..We assessed the predictive role of serum uric acid levels on all-cause and cardiovascular mortality in a large cohort of type 2 diabetic individuals...
  70. doi request reprint Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis
    Paolo Gisondi
    Section of Dermatology, Department of Biomedical and Surgical Science, University of Verona, Piazzale A Stefani 1, 37126 Verona, Italy
    J Hepatol 51:758-64. 2009
    ..We assessed the frequency and characteristics of NAFLD in patients with chronic plaque psoriasis...
  71. pmc The effect of iron depletion on chronic hepatitis C virus infection
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, Verona, 37134, Italy
    Hepatol Int 2:335-40. 2008
    ..Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy...
  72. doi request reprint Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox"
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 36:59-70. 2010
    ....
  73. pmc High-normal HbA1c is a strong predictor of type 2 diabetes in the general population
    Enzo Bonora
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Diabetes Care 34:1038-40. 2011
    ..In this study we evaluated how high-normal HbA(1c) levels predict type 2 diabetes...
  74. ncbi request reprint Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients
    Giovanni Targher
    Division of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Clin Endocrinol (Oxf) 65:593-7. 2006
    ..To estimate the prevalence of hypovitaminosis D among type 2 diabetic adults and to assess the relationship between hypovitaminosis D and intimal medial thickening (IMT) of the common carotid artery, a marker of preclinical atherosclerosis...
  75. ncbi request reprint Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Nutr Metab Cardiovasc Dis 16:543-9. 2006
    ..We have therefore assessed the effects of a twice-weekly moderate, aerobic exercise programme, without a concomitant weight loss diet, on plasma inflammatory and endothelial dysfunction biomarkers in older type 2 diabetic patients...
  76. ncbi request reprint Pathogenesis, clinical and laboratory aspects of thrombosis in cancer
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azinda ospedaliera de Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134, Verona, Italy
    J Thromb Thrombolysis 24:29-38. 2007
    ..In this review article, we briefly analyze the pathogenesis, laboratory, clinical and therapeutic features of cancer and thrombosis...
  77. doi request reprint Prevention and treatment of nonalcoholic fatty liver disease
    Giovanni Targher
    Sezione di Endocrinologia, Dipartimento di Scienze Biomediche e Chirurgiche, Universita di Verona, Verona, Italy
    Dig Liver Dis 42:331-40. 2010
    ..It remains to be determined whether these treatments are able to modify the natural history of nonalcoholic fatty liver disease in the long term...
  78. doi request reprint Usefulness of the triglyceride to high-density lipoprotein cholesterol ratio for predicting mortality risk in type 2 diabetes: role of kidney dysfunction
    Giacomo Zoppini
    Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Atherosclerosis 212:287-91. 2010
    ....
  79. doi request reprint Eosinophilia and first-line coagulation testing
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Ospedale Policlinico G B Rossi, Verona, Italy
    J Thromb Thrombolysis 28:90-3. 2009
    ....
  80. doi request reprint The paradoxical relationship between serum uric acid and cardiovascular disease
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Italy
    Clin Chim Acta 392:1-7. 2008
    ..The aim of this article is to review uric acid metabolism and physiology, highlighting its association with cardiovascular disease...
  81. doi request reprint Inherited and acquired risk factors for arterial ischemic stroke in childhood
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, 37134 Verona, Italy
    J Thromb Thrombolysis 27:239-48. 2009
    ....
  82. ncbi request reprint Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation
    Giovanni Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar, Italy
    Diabetes Care 27:2498-500. 2004
  83. pmc Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Thromb J 5:14. 2007
    ..In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed...
  84. doi request reprint Acquired factor VIII inhibitors in oncohematology: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, and Dipartimento di Scienze Biomediche e Chirurgiche, Universita di Verona, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Crit Rev Oncol Hematol 66:194-9. 2008
    ..Based on electronic and hand searches of the published literature, this systematic review examines the current knowledge on factor VIII autoantibodies associated with oncohematological disorders...
  85. ncbi request reprint The metabolic syndrome and the risk of arterial and venous thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Thromb Res 122:727-35. 2008
    ..In this review, we will summarize the current knowledge on the relationship between the metabolic syndrome and arterial and venous thrombosis from a pathogenic and clinical point of view...
  86. ncbi request reprint Plasma gamma-glutamyl transferase activity predicts homocysteine concentration in a large cohort of unselected outpatients
    Giuseppe Lippi
    Division of Clinical Chemistry, University of Verona Medical School, Verona, Italy
    Intern Med 47:705-7. 2008
    ..To evaluate the association between gamma-glutamyl transferase (GGT) and homocysteine in plasma...
  87. doi request reprint Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications
    Giuseppe Lippi
    Section of Clinical Chemistry, University Hospital of Verona, Verona, Italy
    Clin Chem Lab Med 47:1183-94. 2009
    ....
  88. pmc Iron and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 87:167-73. 2008
    ..The results of the literature on the effect of iron deficiency and overload on vascular health are critically reviewed in this study from a pathogenic and clinical point of view...
  89. doi request reprint Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Semin Thromb Hemost 33:787-97. 2007
    ..This latter issue will be critically addressed in this review article. In addition, the published literature evaluating plasma ADAMTS-13 levels in other pathologic conditions different from TMA will also be discussed...
  90. ncbi request reprint Relationship of nonalcoholic hepatic steatosis to overnight low-dose dexamethasone suppression test in obese individuals
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Clin Endocrinol (Oxf) 61:711-5. 2004
    ..To examine the association between nonalcoholic hepatic steatosis (HS) and the activity of the hypothalamo-pituitary-adrenal (HPA) axis, as evaluated by a low-dose dexamethasone suppression test, in obese subjects...
  91. doi request reprint Effect of hemodialysis on traditional and innovative cardiac markers
    Martina Montagnana
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G B Rossi, Verona, Italy
    J Clin Lab Anal 22:59-65. 2008
    ..Moreover, IMA might be reliably applied to stratify the long-term risk of these patients, but not for diagnosing an ACS during or immediately post-HD...
  92. doi request reprint Increased mean platelet volume in patients with acute coronary syndromes
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G B Rossi, Verona, Italy
    Arch Pathol Lab Med 133:1441-3. 2009
    ..Despite remarkable progress, the diagnosis of acute coronary syndromes (ACS) is still challenging...
  93. doi request reprint No correlation between lipoprotein(a) and biochemical markers of renal function in the general population
    Giuseppe Lippi
    Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Verona, Italy
    Arch Pathol Lab Med 132:1436-8. 2008
    ..Results of studies on Lp(a) in patients with impaired renal function are contradictory, and no information is available on the association between Lp(a) and estimated glomerular filtration rate and cystatin C...
  94. ncbi request reprint Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals
    Giovanni Targher
    Department of Internal Medicine, Sacro Cuore Hospital, 37024 Negrar Vr, Italy
    Clin Endocrinol (Oxf) 61:700-3. 2004
    ....
  95. ncbi request reprint Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens
    G Targher
    Division of Internal Medicine and Diabetes Unit, Sacro Cuore Hospital of Negrar, Italy
    Diabet Med 24:1-6. 2007
    ..Moreover, these novel findings suggest a more complex picture and raise the possibility that NAFLD, as a component of the MetS, might not only be a marker but also an early mediator of CVD...
  96. doi request reprint Hyperthyroidism is associated with shortened APTT and increased fibrinogen values in a general population of unselected outpatients
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico GB Rossi, Piazzale Scuro, Verona, Italy
    J Thromb Thrombolysis 28:362-5. 2009
    ..Should these findings be confirmed, consideration should be given to prevent thrombotic complications in patients with hyperthyroidism...
  97. doi request reprint Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients
    Giuseppe Lippi
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Clinica, Universita degli Studi di Verona, Verona, Italy
    Scand J Clin Lab Invest 68:745-8. 2008
    ..However, the mechanism(s) underlying this association remains unclear. Since impaired kidney function is a well-known risk factor for cardiovascular disease, we assessed whether RDW is associated with decreased kidney function...
  98. doi request reprint Optimal therapy for reduction of lipoprotein(a)
    G Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Clin Pharm Ther 37:1-3. 2012
    ..We comment on novel strategies for reducing Lp(a) levels...
  99. ncbi request reprint Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin?
    Gian Luca Salvagno
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Clin Chem Lab Med 45:1065-7. 2007
    ..Regardless of the available recommendations to perform glycated haemoglobin testing at a 2- to 3-month frequency, there is increasing evidence of an inappropriate laboratory use of this test in clinical practice...
  100. ncbi request reprint Prophylaxis in von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 86:699-704. 2007
    ....
  101. ncbi request reprint Glucose challenge test does not predict gestational diabetes mellitus
    Martina Montagnana
    Clinical Chemistry Section, Department of Morphological Biomedical Sciences, University Hospital of Verona, Verona, Italy
    Intern Med 47:1171-4. 2008
    ..However, the utility of the glucose challenge test (GCT) remains controversial regarding the diagnostic approach and decision making...