Genomes and Genes
Affiliation: University of Turin
- Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebratesL Tamagnone
Institute for Cancer Research and Treatment, University of Torino, Candiolo, Italy
Cell 99:71-80. 1999..We conclude that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion...
- Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growthA Bardelli
Institute for Cancer Research and Treatment, University of Torino, School of Medicine 10060, Candiolo, Italy
Proc Natl Acad Sci U S A 95:14379-83. 1998....
- Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growthP M Comoglio
Institute for Cancer Research and Treatment, University of Turin School of Medicine, Candiolo, 10060, Italy
Exp Cell Res 253:88-99. 1999..Deregulated activation of PRGF or semaphorin ligands or receptors, by mutation or overexpression, confers to cancer cells invasive and metastatic properties...
- Induction of epithelial tubules by growth factor HGF depends on the STAT pathwayC Boccaccio
Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
Nature 391:285-8. 1998..Activation of signal transducers that directly control transcription is therefore required for morphogenesis...
- Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factorL Naldini
Department of Biomedical Sciences and Oncology, University of Torino, Italy
EMBO J 11:4825-33. 1992..These data show that urokinase acts as a pro-HGF/SF convertase, and suggest that some of the growth and invasive cellular responses mediated by this enzyme may involve activation of HGF/SF...
- A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptorE Maestrini
Institute of Genetics Biochemistry and Evolution, Consiglio Nazionale delle Ricerche, Pavia, Italy
Proc Natl Acad Sci U S A 93:674-8. 1996..These data define a gene family (SEX family) involved in the development of neural and epithelial tissues, which encodes putative receptors with unexpected enzymatic or binding properties...
- Plexin A is a neuronal semaphorin receptor that controls axon guidanceM L Winberg
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
Cell 95:903-16. 1998..Plexins, which themselves contain complete Semaphorin domains, may be both the ancestors of classical Semaphorins and binding partners for Semaphorins...
- The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidanceM L Winberg
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 519 LSA, University of California, Berkeley, CA 94720, USA
Neuron 32:53-62. 2001..The otk gene displays strong genetic interactions with Sema1a and PlexA, suggesting that OTK and Plexin A function downstream of Sema 1a...
- The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domainL Tamagnone
Department of Pathology, University of Helsinki, Finland
Oncogene 8:2009-14. 1993..The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined...
- BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2L Tamagnone
Department of Genetics, University of Helsinki, Finland
Oncogene 9:3683-8. 1994..The BMX gene thus encodes a novel nonreceptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells...