Stefano Taddei

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. pmc Adipocytokine levels mark endothelial function in normotensive individuals
    Anna Solini
    Department of Internal Medicine University of Pisa, Via Roma 67, Pisa I 56100, Italy
    Cardiovasc Diabetol 11:103. 2012
  2. doi request reprint Fixed-dose combination therapy in hypertension: pros
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    High Blood Press Cardiovasc Prev 19:55-7. 2012
  3. ncbi request reprint Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
  4. ncbi request reprint Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
  5. ncbi request reprint Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 49:878-84. 2007
  6. ncbi request reprint Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:392-7. 2007
  7. doi request reprint Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Circulation 119:1625-33. 2009
  8. doi request reprint Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrinology 150:1033-42. 2009
  9. doi request reprint Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation
    Agostino Virdis
    Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Hypertension 62:337-44. 2013
  10. ncbi request reprint Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects
    Fabio Galetta
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126, Pisa, Italy
    Atherosclerosis 186:184-92. 2006

Detail Information

Publications75

  1. pmc Adipocytokine levels mark endothelial function in normotensive individuals
    Anna Solini
    Department of Internal Medicine University of Pisa, Via Roma 67, Pisa I 56100, Italy
    Cardiovasc Diabetol 11:103. 2012
    ..Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction. This study addressed the relationship of adipocytokines with endothelial function and blood pressure...
  2. doi request reprint Fixed-dose combination therapy in hypertension: pros
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    High Blood Press Cardiovasc Prev 19:55-7. 2012
    ....
  3. ncbi request reprint Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
    ....
  4. ncbi request reprint Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
    ..The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis...
  5. ncbi request reprint Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 49:878-84. 2007
    ....
  6. ncbi request reprint Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:392-7. 2007
    ..We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients...
  7. doi request reprint Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Circulation 119:1625-33. 2009
    ..We aimed to assess the effect of sulfaphenazole, a specific CYP 2C9 inhibitor, on tPA release in normotensive subjects and patients with essential hypertension...
  8. doi request reprint Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrinology 150:1033-42. 2009
    ..It is suggested that in this animal model, characterized by TSH elevation and low-grade inflammation, an increased expression and function of iNOS, resulting in superoxide generation, accounts for an impaired NO availability...
  9. doi request reprint Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation
    Agostino Virdis
    Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Hypertension 62:337-44. 2013
    ..COX-2 represents a major source of oxidative stress generation, whereas nicotinamide adenine dinucleotide phosphate oxidase plays a minor, but significant, role in promoting superoxide generation. ..
  10. ncbi request reprint Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects
    Fabio Galetta
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126, Pisa, Italy
    Atherosclerosis 186:184-92. 2006
    ..56, p<0.0001). In conclusion, regular physical training can attenuate the age-related impairment of endothelium-dependent vasodilation, which is related to an attenuation of the age-induced remodeling of the carotid wall...
  11. ncbi request reprint Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy
    Giampaolo Bernini
    Department of Internal Medicine, Pisa University, Italy
    J Clin Endocrinol Metab 91:1691-7. 2006
    ..The contribution of endogenous testosterone (TS) in the functional integrity of peripheral circulation in men was studied...
  12. ncbi request reprint Vascular reactivity in patients with undifferentiated connective tissue diseases
    Marta Mosca
    Rheumatology Unit, Department of Internal Medicine, University of Pisa, Italy
    Atherosclerosis 203:185-91. 2009
    ..We investigated endothelial function in the peripheral circulation of patients with undifferentiated connective tissue diseases (UCTDs), in comparison to healthy controls...
  13. ncbi request reprint Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 21:2275-80. 2003
    ..We assessed whether third-generation oral contraceptive (OC) treatment (30 microg ethinylestradiol + 75 microg gestodene daily) could affect the endothelial function of healthy women...
  14. doi request reprint Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 53:1008-16. 2009
    ....
  15. ncbi request reprint Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 51:440-5. 2008
    ..60, confidence limits: 1.01 to 12.78). In conclusion, in normotensive subjects at risk of developing diabetes mellitus, the presence of MS is associated with a selective alteration of central PWV...
  16. doi request reprint Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 26:1216-22. 2008
    ..We evaluated whether metabolic syndrome is associated with early vascular alterations, such as increased peripheral wave reflections and endothelial dysfunction, in untreated essential hypertensive patients...
  17. doi request reprint Vascular generation of tumor necrosis factor-α reduces nitric oxide availability in small arteries from visceral fat of obese patients
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 58:238-47. 2011
    ....
  18. ncbi request reprint Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Eur Heart J 33:2225-34. 2012
    ....
  19. doi request reprint Effect of aliskiren treatment on endothelium-dependent vasodilation and aortic stiffness in essential hypertensive patients
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Eur Heart J 33:1530-8. 2012
    ..We assessed whether aliskiren may improve peripheral endothelial function and arterial stiffness in essential hypertensive patients (EH), when compared with the angiotensin-converting enzyme-inhibitor ramipril...
  20. doi request reprint Effect of acute administration of vitamin C on muscle sympathetic activity, cardiac sympathovagal balance, and baroreflex sensitivity in hypertensive patients
    Rosa M Bruno
    Department of Internal Medicine, University Hospital of Pisa, Italy
    Am J Clin Nutr 96:302-8. 2012
    ..Essential hypertension is characterized by both increased oxidative stress and sympathetic traffic. Experimental studies have shown that reactive oxygen species can modulate autonomic activity...
  21. ncbi request reprint Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 25:361-6. 2007
    ..Plasma angiotensin II and oxidative stress markers were also assessed...
  22. doi request reprint Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 52:314-21. 2008
    ..This impaired fibrinolytic activity might contribute to the increased cardiovascular risk associated with hypertension...
  23. doi request reprint Human endothelial dysfunction: EDCFs
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Pflugers Arch 459:1015-23. 2010
    ..The mechanisms that regulate the balance between NO and EDCFs and the processes transforming the endothelium from a protective organ to a source of vasoconstrictor, proaggregatory and promitogenic mediators, remain to be determined...
  24. doi request reprint The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
    ..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx...
  25. ncbi request reprint Endothelial dysfunction and oxidative stress in chronic renal failure
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 17:512-9. 2004
    ..HD patients showed a more marked alteration, which seems to be related, at least in part, to increased oxidative stress...
  26. ncbi request reprint Phosphodiesterase 5 inhibition in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 10:52-7. 2008
    ..Studies on safety during long-term administration, interactions with antihypertensive and nonantihypertensive drugs, and effect on target organ damage are needed...
  27. ncbi request reprint Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma
    Angela Dardano
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 91:4175-8. 2006
    ..We evaluated endothelial-dependent vasodilation after administration of recombinant human TSH (rhTSH) in patients monitored for differentiated thyroid carcinoma. The role of inflammation and oxidative stress was also assessed...
  28. ncbi request reprint Different effect of antihypertensive drugs on conduit artery endothelial function
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:1281-6. 2003
    ..In patients with essential hypertension, ACE inhibitors appear to be the only compounds able to improve conduit artery endothelium-dependent vasodilation...
  29. ncbi request reprint Endothelium, aging, and hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Hypertens Rep 8:84-9. 2006
    ..Currently, dynamic physical activity represents the only effective intervention in preventing age-related impaired endothelium-dependent vasodilation in aged healthy individuals...
  30. doi request reprint Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:506-12. 2009
    ..625 mg, daily) and atenolol (50 mg, daily), was evaluated in 62 untreated essential hypertensive patients according a double-blind, parallel group, randomized study...
  31. ncbi request reprint Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 49:679-86. 2007
    ....
  32. pmc Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1
    Rocchina Colucci
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Pharmacol 169:554-66. 2013
    ..We investigated the effect of rosuvastatin on endothelial dysfunction, vascular remodelling, changes in extracellular matrix components and mechanical properties of small mesenteric arteries from angiotensin II-infused rats...
  33. ncbi request reprint Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Pharmacol Exp Ther 312:945-53. 2005
    ..Oxidative stress is the main mechanism responsible for reduced NO availability, and COX-2 might act as a source of ROS...
  34. ncbi request reprint Skin vasodilator effect of exogenous urotensin-II in hypertensives not exposed to antihypertensive medication
    Marco Rossi
    Department of Internal Medicine, University of Pisa, Italy
    Blood Press 17:18-25. 2008
    ....
  35. doi request reprint Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Atherosclerosis 223:372-7. 2012
    ..RF-based echotracking device...
  36. pmc Endothelium-dependent contractions and endothelial dysfunction in human hypertension
    Daniele Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Pharmacol 157:527-36. 2009
    ..The mechanisms that regulate the balance between NO and EDCF, and the processes transforming the endothelium from a protective organ to a source of vasoconstrictor, proaggregatory and promitogenic mediators remain to be determined...
  37. doi request reprint Cholecalciferol administration blunts the systemic renin-angiotensin system in essential hypertensives with hypovitaminosis D
    Davide Carrara
    Department of Internal Medicine, University of Pisa, Italy
    J Renin Angiotensin Aldosterone Syst 15:82-7. 2014
    ..Renin-angiotensin system (RAS) suppression may be one of the mechanisms involved. However, there are no interventional prospective studies demonstrating a reduction in circulating RAS components after vitamin D treatment...
  38. ncbi request reprint Relationship between wave reflection and renal damage in hypertensive patients: a retrospective analysis
    Francesco Stea
    aInstitute of Clinical Physiology, National Research Council bDepartment of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:2418-24. 2013
    ..The aim of this study was, therefore, to explore the relationship between wave reflection and small vessel damage in the kidney...
  39. pmc Vascular dysfunction in a mouse model of Rett syndrome and effects of curcumin treatment
    Anna Panighini
    Institute of Neuroscience, Italian National Research Council CNR, Pisa, Italy
    PLoS ONE 8:e64863. 2013
    ..In conclusion our findings highlight alterations in the vascular/endothelial system in the absence of a correct function of MeCP2, and uncover related cellular/molecular mechanisms that are rescued by an anti-oxidant treatment...
  40. ncbi request reprint Functional and structural alterations of large arteries: methodological issues
    Elisabetta Bianchini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Curr Pharm Des 19:2390-400. 2013
    ....
  41. ncbi request reprint Non-invasive diagnostic tools for investigating endothelial dysfunction
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Curr Pharm Des 14:3715-22. 2008
    ....
  42. doi request reprint Investigation of skin vasoreactivity and blood flow oscillations in hypertensive patients: effect of short-term antihypertensive treatment
    Marco Rossi
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 29:1569-76. 2011
    ..To evaluate whether antihypertensive treatment affects skin microcirculation, the same measurements were repeated in 22 of the recruited hypertensive patients after 8 ± 2 weeks of antihypertensive treatment...
  43. ncbi request reprint Current treatment of patients with hypertension: therapeutic implications of INSIGHT
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 63:1435-44. 2003
    ..The clinical significance of this effect in the prevention of cardiovascular events still remains to be established...
  44. ncbi request reprint Central blood pressure, arterial stiffness, and wave reflection: new targets of treatment in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 11:190-6. 2009
    ..Thus, whether these measurements should be routinely performed as a diagnostic or therapeutic indicator remains debatable...
  45. ncbi request reprint Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  46. doi request reprint Interactions between sympathetic nervous system and endogenous endothelin in patients with essential hypertension
    Rosa Maria Bruno
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 57:79-84. 2011
    ..Moreover, essential hypertension shows an increased susceptibility to the sympathoexcitatory effect of endogenous endothelin 1...
  47. ncbi request reprint Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 18:510-6. 2005
    ..The aim of this study was to evaluate the relationship between long-term physical activity, plasma antioxidant status, and conduit artery endothelial function in young and older healthy men...
  48. ncbi request reprint The ageing endothelium, cardiovascular risk and disease in man
    Daniele Versari
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Exp Physiol 94:317-21. 2009
    ..Therefore, it is conceivable that endothelial dysfunction plays a major role in predisposing to age-related increased cardiovascular risk in the elderly...
  49. ncbi request reprint Poor sleep quality and resistant hypertension
    Rosa Maria Bruno
    Institute of Clinical Physiology CNR, Pisa, Italy Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Sleep Med 14:1157-63. 2013
    ..We aimed to determine the relationship between sleep quality and treatment-resistant hypertension (RH)...
  50. ncbi request reprint Device-based therapies for resistant hypertension
    Rosa Maria Bruno
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Curr Pharm Des 19:2401-8. 2013
    ..Present limitations and future perspectives were also considered...
  51. ncbi request reprint Hypertension and endothelial dysfunction: therapeutic approach
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Vasc Pharmacol 10:42-60. 2012
    ..Some beneficial effects were also exerted by nebivolol and statins. Future studies are needed to confirm whether the improvement in endothelial dysfunction is associated to better cardiovascular prognosis in hypertension...
  52. pmc Osteopontin is associated with increased arterial stiffness in rheumatoid arthritis
    Laura Bazzichi
    Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
    Mol Med 15:402-6. 2009
    ....
  53. ncbi request reprint Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:950-5. 2003
    ..These results indicate that in essential hypertension, lercanidipine increases endothelium-dependent vasodilation by restoring NO availability and preventing hyperpolarization, an effect probably determined by antioxidant activity...
  54. ncbi request reprint Hypertension, left ventricular hypertrophy and chronic kidney disease
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Heart Fail Rev 16:615-20. 2011
    ....
  55. ncbi request reprint Soy protein diet improves endothelial dysfunction in renal transplant patients
    Adamasco Cupisti
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Nephrol Dial Transplant 22:229-34. 2007
    ....
  56. ncbi request reprint Renal vasodilating capacity and endothelial function are impaired in patients with obstructive sleep apnea syndrome and no traditional cardiovascular risk factors
    Rosa M Bruno
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:1456-64; discussion 1464. 2013
    ..Aim of the study was to investigate whether vascular dysfunction is a feature of obstructive sleep apnea syndrome per se or instead related to the presence of traditional cardiovascular risk factors...
  57. ncbi request reprint P2X7 receptor polymorphisms do not influence endothelial function and vascular tone in neo-diagnosed, treatment-naive essential hypertensive patients
    Lorenzo Ghiadoni
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:2362-9. 2013
    ..This study evaluated the effects of P2X7R gene polymorphisms (single nucleotide polymorphisms, SNPs) on a detailed vascular hypertensive phenotype...
  58. doi request reprint Role of 18F-DOPA PET/CT in diagnosis and follow-up of adrenal and extra-adrenal paragangliomas
    Alessandra Bacca
    From the Department of Clinical and Experimental Medicine and Regional Center of Nuclear Medicine, University of Pisa Department of Radiodiagnostic, Vascular, and Interventional Radiology and Nuclear Medicine and Medical Genetics Laboratory, Department of Medical Laboratories, University Hospital of Pisa and Department of Surgical, Molecular, Clinical Pathology and of Critical Care, University of Pisa, Pisa, Italy
    Clin Nucl Med 39:14-20. 2014
    ..The objective of this study was to establish the clinical value of F-DOPA PET/CT in patients with adrenal and extra-adrenal paragangliomas (PGLs)...
  59. ncbi request reprint Microvascular endothelial dysfunction in obesity and hypertension
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Pharm Des 19:2382-9. 2013
    ....
  60. doi request reprint Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure
    Simona Buralli
    Internal Medicine Department, University of Pisa, Pisa, Italy
    Am J Cardiol 105:853-6. 2010
    ..9 ng/mL (p <0.0001). In conclusion, the assessment of circulating MMP levels and tissue Doppler measures of LV diastolic dysfunction may improve the prognostic stratification of patients with systolic HF...
  61. ncbi request reprint Endothelial function in hypertension: role of gender
    Agostino Virdis
    Department of Internal Medicine, Hypertension Unit, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Hypertens Suppl 20:S11-6. 2002
    ..Finally, whether endogenous androgen can impair endothelial function is still an unsolved issue since data concerning the effect of testosterone on endothelial function are scanty and contradictory...
  62. doi request reprint How to evaluate microvascular organ damage in hypertension: assessment of endothelial function
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    High Blood Press Cardiovasc Prev 18:163-7. 2011
    ....
  63. ncbi request reprint Which endothelium-derived factors are really important in humans?
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    Biol Chem 387:151-7. 2006
    ..Further studies are needed in the future to assess the specific impact of different endothelial responses on the clinical outcome in patients with cardiovascular risk factors and disease...
  64. ncbi request reprint Blood pressure and vascular alterations with growth in childhood
    Stefano Masi
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 17:3045-61. 2011
    ..We also summarise current non-invasive approaches to investigate the precursors and early development of CV disease, emphasising their potential applications in childhood...
  65. pmc Lack of pharmacokinetic bioequivalence between generic and branded amoxicillin formulations. A post-marketing clinical study on healthy volunteers
    Mario Del Tacca
    Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, Pisa, Italy
    Br J Clin Pharmacol 68:34-42. 2009
    ..The aim was to establish whether two generic formulations of amoxicillin, available on the Italian market, fulfil the criteria for clinical pharmacokinetic bioequivalence vs. the branded drug...
  66. doi request reprint Effects of antihypertensive treatment on endothelial function
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 13:276-81. 2011
    ..Large-scale clinical trials are required to definitively demonstrate that treatment of endothelial dysfunction can improve the prognosis of patients with essential hypertension...
  67. doi request reprint The correct administration of antihypertensive drugs according to the principles of clinical pharmacology
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Cardiovasc Drugs 11:13-20. 2011
    ....
  68. ncbi request reprint Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil
    Giorgio Pomara
    Department of Urology, Pisa University, Pisa, Italy
    J Androl 25:625-9. 2004
    ..Moreover, it is necessary to pay particular attention to those patients in treatment with other drugs that could have a synergistic hypotensive effect as a result of vasodilation potentiation...
  69. ncbi request reprint Myocardial ultrasonic backscatter in hypertension: relation to aldosterone and endothelin
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Italy
    Hypertension 41:230-6. 2003
    ..The data of this study suggest that in human hypertension, circulating aldosterone and immunoreactive endothelin may induce alterations in left ventricular myocardial texture, possibly related to increased myocardial collagen content...
  70. doi request reprint Coronary flow reserve in idiopathic dilated cardiomyopathy: relation with left ventricular wall stress, natriuretic peptides, and endothelial dysfunction
    Frank Lloyd Dini
    Unità Malattie Cardiovascolari 2, Santa Chiara Hospital, Pisa, Italy
    J Am Soc Echocardiogr 22:354-60. 2009
    ....
  71. ncbi request reprint Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Cardiovasc Pharmacol 41:579-85. 2003
    ....
  72. doi request reprint Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study
    Lorenzo Ghiadoni
    Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 30:1399-405. 2012
    ..The aim of this study was to evaluate impact of methodological standardization among different investigation sites on brachial artery FMD reproducibility...
  73. doi request reprint Hypertension in special populations: athletes
    Rosa Maria Bruno
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56123 Pisa, Italy
    Future Cardiol 7:571-84. 2011
    ....
  74. doi request reprint Hydrogen sulphide: novel opportunity for drug discovery
    Alma Martelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Pisa, Italy
    Med Res Rev 32:1093-130. 2012
    ....
  75. pmc Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    Int J Hypertens 2011:916310. 2011
    ..Recent development of signalling pathways whereby angiotensin II-driven vascular ROS induce and accelerate functional and structural vascular injury will be also considered...