S Taddei

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi Synergistic Effects of Calcium Antagonists and Statins on Endothelial Function : A New Lesson from the ASCOT Trial
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    High Blood Press Cardiovasc Prev 14:123-31. 2007
  2. ncbi Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
  3. ncbi Effects of antihypertensive drugs on endothelial dysfunction: clinical implications
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 62:265-84. 2002
  4. ncbi [Obesity and endothelial dysfunction]
    Stefano Taddei
    Prof Stefano Taddei Dipartimento di Medicina Interna, Universita degli Studi, Via Roma, 67 56100 Pisa
    G Ital Cardiol (Rome) 7:715-23. 2006
  5. ncbi Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
  6. ncbi Which endothelium-derived factors are really important in humans?
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    Biol Chem 387:151-7. 2006
  7. ncbi Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 9:2385-402. 2003
  8. ncbi Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
  9. ncbi Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Cardiovasc Pharmacol 41:579-85. 2003
  10. ncbi Endothelium, aging, and hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Hypertens Rep 8:84-9. 2006

Collaborators

Detail Information

Publications91

  1. ncbi Synergistic Effects of Calcium Antagonists and Statins on Endothelial Function : A New Lesson from the ASCOT Trial
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    High Blood Press Cardiovasc Prev 14:123-31. 2007
    ..Therefore, the possible mechanisms of interaction between statins and calcium antagonists on endothelial function will also be discussed...
  2. ncbi Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  3. ncbi Effects of antihypertensive drugs on endothelial dysfunction: clinical implications
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 62:265-84. 2002
    ..In the near future, large scale clinical trials are required to demonstrate that treatment of endothelial dysfunction can lead to better prognosis in patients with essential hypertension...
  4. ncbi [Obesity and endothelial dysfunction]
    Stefano Taddei
    Prof Stefano Taddei Dipartimento di Medicina Interna, Universita degli Studi, Via Roma, 67 56100 Pisa
    G Ital Cardiol (Rome) 7:715-23. 2006
    ..At present, whether an improvement of endothelial dysfunction secondary to weight loss is significantly associated with a better cardiovascular prognosis is still unknown. (G Ital Cardiol 2006; 7 (11): 715-723)..
  5. ncbi Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
    ..The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis...
  6. ncbi Which endothelium-derived factors are really important in humans?
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    Biol Chem 387:151-7. 2006
    ..Further studies are needed in the future to assess the specific impact of different endothelial responses on the clinical outcome in patients with cardiovascular risk factors and disease...
  7. ncbi Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 9:2385-402. 2003
    ..It is worth noting that most of non-pharmacological measures act by preventing or reducing oxidative stress...
  8. ncbi Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
    ....
  9. ncbi Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Cardiovasc Pharmacol 41:579-85. 2003
    ....
  10. ncbi Endothelium, aging, and hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Hypertens Rep 8:84-9. 2006
    ..Currently, dynamic physical activity represents the only effective intervention in preventing age-related impaired endothelium-dependent vasodilation in aged healthy individuals...
  11. ncbi Current treatment of patients with hypertension: therapeutic implications of INSIGHT
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 63:1435-44. 2003
    ..The clinical significance of this effect in the prevention of cardiovascular events still remains to be established...
  12. ncbi Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 101:2896-901. 2000
    ..Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction...
  13. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..These alterations are similar but anticipated in hypertensive patients compared with normotensive subjects...
  14. ncbi Effect of acute blood pressure reduction on endothelial function in the brachial artery of patients with essential hypertension
    L Ghiadoni
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 19:547-51. 2001
    ..To evaluate the effect of acute blood pressure reduction on endothelium-dependent vasodilation in the peripheral circulation of essential hypertensive patients...
  15. ncbi Mechanisms responsible for endothelial dysfunction induced by fasting hyperhomocystinemia in normotensive subjects and patients with essential hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 38:1106-15. 2001
    ..We sought to evaluate whether fasting hyperhomocystinemia reduces endothelial function by oxidative stress in normotensive subjects and hypertensive patients...
  16. ncbi Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Circulation 100:1400-5. 1999
    ..The present study was designed to identify the mechanism(s) responsible for NO-independent vasodilation to bradykinin in patients with essential hypertension...
  17. ncbi Effect of verapamil, trandolapril and their combination on vascular function and structure in essential hypertensive patients
    D Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Atherosclerosis 205:214-20. 2009
    ..The aim of the present study is to evaluate the effect of treatment with verapamil, trandolapril and their combination on peripheral microcirculation vasoreactivity...
  18. ncbi Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    J Hypertens 16:447-56. 1998
    ..Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation...
  19. ncbi Obesity in the childhood: a link to adult hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 15:1063-71. 2009
    ....
  20. ncbi Endothelial function in young subjects with vaso-vagal syncope
    F Galetta
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Biomed Pharmacother 60:448-52. 2006
    ..The aim of this study was to determine whether endothelial function and inappropriate peripheral vasomotion have a significant role in the pathogenesis of neurally mediated syncope...
  21. ncbi Endothelial dysfunction in hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Cardiovasc Pharmacol 38:S11-4. 2001
    ..This alteration in the NO pathway could be the main mechanism through which a dysfunctional endothelium could be a promoter of atherosclerosis and thrombosis and therefore lead to cardiovascular events in essential hypertensive patients...
  22. ncbi Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 19:1379-86. 2001
    ..Since calcium antagonists can improve endothelial function in hypertensive patients, we tested whether this beneficial effect could be related to restoration of NO availability by antioxidant activity...
  23. ncbi Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes
    R M Bruno
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 54:2430-9. 2011
    ....
  24. ncbi Exclusion of the ACE D/I gene polymorphism as a determinant of endothelial dysfunction
    G P Rossi
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Hypertension 37:293-300. 2001
    ....
  25. ncbi Role of endothelin in the control of peripheral vascular tone in human hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Heart Fail Rev 6:277-85. 2001
    ..Therefore endothelin-1 could potentially be involved in the pathogenesis of essential hypertension or of its complications, and blockade of this system is a fascinating new target for therapeutic intervention in this disease...
  26. ncbi Endothelial dysfunction and vascular disease in later life
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Maturitas 67:20-4. 2010
    ..Regular physical training is an important non-pharmacological intervention which protects the vascular endothelium from ageing-related alterations and ameliorates the cardiovascular risk profile among the elderly population...
  27. ncbi Endothelial function assessment in complicated hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 14:1761-70. 2008
    ....
  28. ncbi High serum levels of CXC (CXCL10) and CC (CCL2) chemokines in untreated essential hypertension
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    Int J Immunopathol Pharmacol 25:387-95. 2012
    ..In conclusion, this study demonstrates increased circulating levels of the prototype chemokines CXCL10 and CCL2 in patients with hypertension...
  29. ncbi Hypertension in the elderly: an evidence-based review
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 17:3020-31. 2011
    ..However the HYVET study suggests that a goal of 150/90 mmHg can be reasonable in patients aged 80 years or more. Drug treatment should be titrated with particular caution to adverse responses and excessive blood pressure lowering...
  30. ncbi Clinical and methodological aspects of endothelial function in patients with systemic autoimmune diseases
    L Ghiadoni
    Hypertension Unit, Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 26:680-7. 2008
    ..No single test currently available is specific for the vascular district tested or the risk factor/diseases considered, and a panel of several tests is therefore needed to characterize the multiple aspects of endothelial biology...
  31. ncbi Presence of cardiovascular structural changes in essential hypertensive patients with coronary microvascular disease and effects of long-term treatment
    A Virdis
    I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 9:361-9. 1996
    ..Our results also indicate that both cardiac and forearm vascular abnormalities can be reversed by antihypertensive treatment with an ACE inhibitor...
  32. ncbi C-reactive protein and hypertension: is there a causal relationship?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 13:1693-8. 2007
    ..Without such crucial information, at the present time the causal connection between inflammation and blood pressure, although regarded as an intriguing possibility, remains undiscovered...
  33. ncbi Soluble E-selectin in essential hypertension: a correlate of vascular structural changes
    R De Caterina
    CNR Institute of Clinical Physiology, University of Pisa, Italy
    Am J Hypertens 14:259-66. 2001
    ..We evaluated plasma soluble (s) E-selectin to assess its relationship with endothelium-dependent and endothelium-independent vasodilation in patients with hypertension...
  34. ncbi Ambulatory blood pressure monitoring and endothelium-dependent vasodilation in the elderly athletes
    F Galetta
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Biomed Pharmacother 60:443-7. 2006
    ..Aim of the present study was to evaluate in elderly athletes the effect of regular aerobic exercise on arterial blood pressure (BP) and on endothelium-dependent flow-mediated dilation (FMD) of the brachial artery...
  35. ncbi Endothelial dysfunction in hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Nephrol 13:205-10. 2000
    ..This alteration in the NO pathway could be the main mechanism through which a dysfunctional endothelium could be a promoter of atherosclerosis and thrombosis in essential hypertension...
  36. ncbi Cigarette smoking and hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 6756100 Pisa, Italy
    Curr Pharm Des 16:2518-25. 2010
    ..Hypertensive smokers are more likely to develop severe forms of hypertension, including malignant and renovascular hypertension, an effect likely due to an accelerated atherosclerosis...
  37. ncbi Is Hyperhomocyst(e)inemia a humoral predictor of coronary heart disease?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 11:2187-97. 2005
    ....
  38. ncbi Automatic evaluation of arterial diameter variation from vascular echographic images
    F Beux
    Scuola Normale Superiore di Pisa, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Ultrasound Med Biol 27:1621-9. 2001
    ..It thus represents a valuable tool for assessment of endothelium-dependent vasodilation, especially in large, multicentric clinical trials...
  39. ncbi The role of endothelium in human hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Opin Nephrol Hypertens 7:203-9. 1998
    ..Available evidence indicates that different classes of antihypertensive compounds have different effects on endothelial dysfunction...
  40. ncbi Type 2 diabetes mellitus worsens arterial stiffness in hypertensive patients through endothelial dysfunction
    R M Bruno
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy
    Diabetologia 55:1847-55. 2012
    ..The aim of the study was to investigate whether endothelial function could be a determinant of arterial stiffness in essential hypertensive patients, in relation with the concomitant presence of type 2 diabetes mellitus...
  41. ncbi Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study
    F Monzani
    Department of Internal Medicine and National Research Council Institute of Clinical Physiology, University of Pisa, Pisa 56126, Italy
    J Clin Endocrinol Metab 89:2099-106. 2004
    ....
  42. ncbi Dipyridamole decreases circulating renin-angiotensin system activity in hypertensive patients
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 5:29-31. 1992
    ..These data, showing that dipyridamole decreases PRA and aldosterone, confirm also in hypertensives that endogenous adenosine inhibits the circulating renin-angiotensin-aldosterone system...
  43. ncbi Endothelial aging and gender
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Maturitas 71:326-30. 2012
    ..Whether endogenous androgen may modulate endothelial function and the mechanisms involved are still unsolved issues, since data concerning the effect of testosterone on endothelium are scanty and contradictory...
  44. ncbi Persistence of sympathetic-mediated forearm vasoconstriction after alpha-blockade in hypertensive patients
    S Taddei
    Hypertension Unit, I Clinica Medica, University of Pisa, Italy
    Circulation 80:485-90. 1989
    ..abstract truncated at 250 words)..
  45. ncbi Blood pressure through aging and menopause
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Climacteric 12:36-40. 2009
    ....
  46. ncbi Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa Italy
    Hypertension 37:943-8. 2001
    ..These results indicate that nifedipine increases endothelium-dependent vasodilation by restoring NO availability, an effect probably determined by antioxidant activity...
  47. ncbi A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor
    M R Mazzoni
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Italy
    Mol Pharmacol 58:226-36. 2000
    ..Overall, our results point out the conformation requirement of Galpha(s) carboxyl-terminal peptides to modulate agonist binding to rat A(2A) adenosine receptors and disrupt signal transduction...
  48. ncbi Cardiovascular changes in patients with primary aldosteronism after surgical or medical treatment
    G Bernini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Endocrinol Invest 35:274-80. 2012
    ..Data on the cardiovascular middle-term follow-up of patients with primary aldosteronism (PA) are scanty...
  49. ncbi Further evidence for the existence of alpha 2-mediated adrenergic vasoconstriction in human vessels
    S Taddei
    Hypertension Unit I, University of Pisa, Italy
    Eur J Clin Pharmacol 34:407-10. 1988
    ..The data provide further evidence of the existence of alpha 2-mediated vasoconstriction in human forearm vessels...
  50. ncbi Treatment with low doses of cabergoline is not associated with increased prevalence of cardiac valve regurgitation in patients with hyperprolactinaemia
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Int J Clin Pract 62:1864-9. 2008
    ..The aim of the study was to evaluate whether HyperPRL patients treated with dopamine agonists had a higher prevalence of cardiac valves regurgitation than that of general population...
  51. ncbi Theophylline is an antagonist of adenosine in human forearm arterioles
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 4:256-9. 1991
    ..Our data show that theophylline acts as a specific antagonist of adenosine in humans, an effect which might be relevant for its pharmacological action...
  52. ncbi Role of cysteine residues of rat A2a adenosine receptors in agonist binding
    M R Mazzoni
    Istituto Policattedra di Discipline Biologiche, University of Pisa, Italy
    Biochim Biophys Acta 1324:159-70. 1997
    ....
  53. ncbi Endothelial dysfunction in essential hypertension: clinical implications
    Stefano Taddei
    J Hypertens 20:1671-4. 2002
  54. ncbi Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 51:440-5. 2008
    ..60, confidence limits: 1.01 to 12.78). In conclusion, in normotensive subjects at risk of developing diabetes mellitus, the presence of MS is associated with a selective alteration of central PWV...
  55. ncbi Long life to olive oil and wine! Long life with olive oil and wine?
    Daniele Versari
    J Hypertens 26:186-7. 2008
  56. ncbi Phosphodiesterase 5 inhibition in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 10:52-7. 2008
    ..Studies on safety during long-term administration, interactions with antihypertensive and nonantihypertensive drugs, and effect on target organ damage are needed...
  57. ncbi Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 20:392-7. 2007
    ..We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients...
  58. ncbi Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome
    Yvonne Plantinga
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 26:1216-22. 2008
    ..We evaluated whether metabolic syndrome is associated with early vascular alterations, such as increased peripheral wave reflections and endothelial dysfunction, in untreated essential hypertensive patients...
  59. ncbi Skin vasodilator effect of exogenous urotensin-II in hypertensives not exposed to antihypertensive medication
    Marco Rossi
    Department of Internal Medicine, University of Pisa, Italy
    Blood Press 17:18-25. 2008
    ....
  60. ncbi Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 52:314-21. 2008
    ..This impaired fibrinolytic activity might contribute to the increased cardiovascular risk associated with hypertension...
  61. ncbi Endothelial function in hypertension: role of gender
    Agostino Virdis
    Department of Internal Medicine, Hypertension Unit, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Hypertens Suppl 20:S11-6. 2002
    ..Finally, whether endogenous androgen can impair endothelial function is still an unsolved issue since data concerning the effect of testosterone on endothelial function are scanty and contradictory...
  62. ncbi Anthropometric and dietary determinants of blood pressure in over 7000 Mediterranean women: the European Prospective Investigation into Cancer and Nutrition-Florence cohort
    Giovanna Masala
    Molecular and Nutritional Epidemiology Unit, ISPO, Florence, Italy
    J Hypertens 26:2112-20. 2008
    ..Anthropometric characteristics and dietary habits are widely recognized to influence blood pressure. We evaluated their role in a large series of Mediterranean adult women...
  63. ncbi Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 21:2275-80. 2003
    ..We assessed whether third-generation oral contraceptive (OC) treatment (30 microg ethinylestradiol + 75 microg gestodene daily) could affect the endothelial function of healthy women...
  64. ncbi Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 18:510-6. 2005
    ..The aim of this study was to evaluate the relationship between long-term physical activity, plasma antioxidant status, and conduit artery endothelial function in young and older healthy men...
  65. ncbi Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 49:878-84. 2007
    ....
  66. ncbi Hyperhomocyst(e)inemia: is this a novel risk factor in hypertension?
    Agostino Virdis
    Department of Internal Medicine University of Pisa, Italy
    J Nephrol 15:414-21. 2002
    ....
  67. ncbi Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 25:361-6. 2007
    ..Plasma angiotensin II and oxidative stress markers were also assessed...
  68. ncbi Different effect of antihypertensive drugs on conduit artery endothelial function
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:1281-6. 2003
    ..In patients with essential hypertension, ACE inhibitors appear to be the only compounds able to improve conduit artery endothelium-dependent vasodilation...
  69. ncbi Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects
    Fabio Galetta
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126, Pisa, Italy
    Atherosclerosis 186:184-92. 2006
    ..56, p<0.0001). In conclusion, regular physical training can attenuate the age-related impairment of endothelium-dependent vasodilation, which is related to an attenuation of the age-induced remodeling of the carotid wall...
  70. ncbi Evolving the concept of regulation of vascular tone in humans
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Br J Pharmacol 146:165-6. 2005
    ..In that case, the anandamide system might represent a potential target for the treatment of important cardiovascular conditions, including severe shock...
  71. ncbi [Clinical significance of the assessment of endothelial function]
    Stefano Taddei
    Dipartimento di Medicina Interna, Universita degli Studi, Pisa
    Ital Heart J Suppl 5:357-65. 2004
    ....
  72. ncbi Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension
    Hanspeter Brunner
    Division of Cardiology, University Hospital, Basel, Switzerland
    J Hypertens 23:233-46. 2005
    ..This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments...
  73. ncbi Endothelium-dependent contractions in hypertension
    Paul M Vanhoutte
    Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Br J Pharmacol 144:449-58. 2005
    ....
  74. ncbi Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Pharmacol Exp Ther 312:945-53. 2005
    ..Oxidative stress is the main mechanism responsible for reduced NO availability, and COX-2 might act as a source of ROS...
  75. ncbi Endothelial dysfunction and oxidative stress in chronic renal failure
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 17:512-9. 2004
    ..HD patients showed a more marked alteration, which seems to be related, at least in part, to increased oxidative stress...
  76. ncbi The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:938-45. 2003
    ..We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release...
  77. ncbi Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:950-5. 2003
    ..These results indicate that in essential hypertension, lercanidipine increases endothelium-dependent vasodilation by restoring NO availability and preventing hyperpolarization, an effect probably determined by antioxidant activity...
  78. ncbi Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension
    Isabella Sudano
    Cardiovascular Center, Cardiology, University Hospital of Zurich, Zurich, Switzerland
    Hypertension 49:285-90. 2007
    ..Those vasculoprotective effects may importantly contribute to a reduction in major clinical events seen during treatment with these compounds...
  79. ncbi Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 49:679-86. 2007
    ....
  80. ncbi Soy protein diet improves endothelial dysfunction in renal transplant patients
    Adamasco Cupisti
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Nephrol Dial Transplant 22:229-34. 2007
    ....
  81. ncbi Myocardial ultrasonic backscatter in hypertension: relation to aldosterone and endothelin
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Italy
    Hypertension 41:230-6. 2003
    ..The data of this study suggest that in human hypertension, circulating aldosterone and immunoreactive endothelin may induce alterations in left ventricular myocardial texture, possibly related to increased myocardial collagen content...
  82. ncbi Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University of Padova, Padova, Italy
    J Hypertens 24:1955-63. 2006
    ....
  83. ncbi At the beginning of stiffening: endothelial dysfunction meets "pulsology"
    Paolo Verdecchia
    Hypertension 48:541-2. 2006
  84. ncbi Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy
    Giampaolo Bernini
    Department of Internal Medicine, Pisa University, Italy
    J Clin Endocrinol Metab 91:1691-7. 2006
    ..The contribution of endogenous testosterone (TS) in the functional integrity of peripheral circulation in men was studied...
  85. ncbi A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
    Francesco Cipollone
    G d Annunzio University of Chieti and G d Annunzio University Foundation, Chieti, Italy
    JAMA 291:2221-8. 2004
    ..Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear...
  86. ncbi Phosphodiesterase 5 inhibition to treat essential hypertension: is this the beginning of the story?
    Stefano Taddei
    Hypertension 48:546-8. 2006
  87. ncbi Angiotensin receptor blockers: therapeutic targets and cardiovascular protection
    Luis M Ruilope
    Hypertension Unit, Hospital 12 de Octobre, Madrid, Spain, and Division of Internal Medicine, Ospedali Civili, University of Brescia, Italy
    Blood Press 14:196-209. 2005
    ..Furthermore, evidence in favour of combining an ACE inhibitor and an ARB in certain circumstances is continuously growing...
  88. ncbi Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil
    Giorgio Pomara
    Department of Urology, Pisa University, Pisa, Italy
    J Androl 25:625-9. 2004
    ..quot; Moreover, it is necessary to pay particular attention to those patients in treatment with other drugs that could have a synergistic hypotensive effect as a result of vasodilation potentiation...
  89. ncbi Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension
    John Deanfield
    Vascular Physiology Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    J Hypertens 23:7-17. 2005
    ..Thus, the most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper...
  90. ncbi Angiotensin II as the link between nitric oxide and neuroadrenergic function
    Stefano Taddei
    J Hypertens 23:935-7. 2005
  91. ncbi Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma
    Angela Dardano
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 91:4175-8. 2006
    ..01). CONCLUSIONS: rhTSH administration acutely impaired endothelium-dependent vasodilation, possibly through the induction of low-grade inflammation and reduced nitric oxide availability by oxidative stress...