Alessandro Stefani


Affiliation: University of Rome Tor Vergata
Country: Italy


  1. Stefani A, Grandi L, Galati S. Deep brain stimulation of the pedunculopontine nucleus modulates subthalamic pathological oscillations. Neurobiol Dis. 2018;: pubmed publisher
    ..Our observation might turn out to be helpful in new protocols designed with adaptive DBS supporting the addition of PPN implantation in PD patients experiencing declining efficacy of STN-DBS. ..
  2. Olivola E, Brusa L, Rocchi C, Schillaci O, Liguori C, Cerroni R, et al. Does fatigue in Parkinson's disease correlate with autonomic nervous system dysfunction?. Neurol Sci. 2018;: pubmed publisher
    ..Our data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue. ..
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    Stefani A, Spadoni F, Martorana A, Lavaroni F, Martella G, Sancesario G, et al. D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation. Eur J Neurosci. 2002;15:815-25 pubmed
    ..A direct D2 modulation of calcium conductance in GP may alter GP firing properties and GABA release onto pallidofugal targets. ..
  4. Mazzone P, Stefani A, Viselli F, Scarnati E. Frameless Stereotaxis for Subthalamic Nucleus Deep Brain Stimulation: An Innovative Method for the Direct Visualization of Electrode Implantation by Intraoperative X-ray Control. Brain Sci. 2018;8: pubmed publisher
  5. Orfei M, Assogna F, Pellicano C, Pontieri F, Caltagirone C, Pierantozzi M, et al. Anosognosia for cognitive and behavioral symptoms in Parkinson's disease with mild dementia and mild cognitive impairment: Frequency and neuropsychological/neuropsychiatric correlates. Parkinsonism Relat Disord. 2018;: pubmed publisher
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    Stefani A, Spadoni F, Giacomini P, Lavaroni F, Bernardi G. The activation of mu opioid receptors promotes a small modulation of calcium currents in rat pallidal neurons. Brain Res. 2001;897:207-12 pubmed
    ..In degenerative conditions as Parkinsonism, an excessive stimulation of mu binding sites might induce a pathological inhibition of calcium signals, thus contributing to modify the GP firing pattern and transmitter release. ..
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    Stefani A, Spadoni F, Giacomini P, Lavaroni F, Bernardi G. The modulation of calcium current by GABA metabotropic receptors in a sub-population of pallidal neurons. Eur J Neurosci. 1999;11:3995-4005 pubmed
  8. Stefani A, Peppe A, Pierantozzi M, Galati S, Moschella V, Stanzione P, et al. Multi-target strategy for Parkinsonian patients: the role of deep brain stimulation in the centromedian-parafascicularis complex. Brain Res Bull. 2009;78:113-8 pubmed publisher
  9. Alessandro S, Ceravolo R, Brusa L, Pierantozzi M, Costa A, Galati S, et al. Non-motor functions in parkinsonian patients implanted in the pedunculopontine nucleus: focus on sleep and cognitive domains. J Neurol Sci. 2010;289:44-8 pubmed publisher

More Information


  1. Stefani A, Brusa L, Olivola E, Pierantozzi M, Martorana A. CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD. J Neural Transm (Vienna). 2012;119:861-75 pubmed publisher
    ..However, more complete data, possibly collected in fieri during the progressive derangement of cognitive abilities, are needed to improve our ability to decipher and treat these entities...
  2. Stefani A, Pierantozzi M, Olivola E, Galati S, Cerroni R, D Angelo V, et al. Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment. Neurochem Int. 2017;105:58-63 pubmed publisher
    ..Therefore, we suggest the potential use of measuring the CSF HVA level as a possible biomarker of PD stage changes in order to monitor the effectiveness of PD-modifying pharmacological therapies. ..