Alessandro Stefani

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Strength and weaknesses of cerebrospinal fluid biomarkers in Alzheimer's disease and possible detection of overlaps with frailty process
    Alessandro Stefani
    Department of Neuroscience, UOSD Parkinson, University of Rome Tor Vergata, Viale Oxford 81, Rome, Italy
    CNS Neurol Disord Drug Targets 12:538-46. 2013
  2. doi request reprint Successful subthalamic stimulation, but levodopa-induced dystonia, in a genetic Parkinson's disease
    Alessandro Stefani
    IRCCS Fondazione S Lucia, Rome, Italy
    Neurol Sci 34:383-6. 2013
  3. doi request reprint CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD
    Alessandro Stefani
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neural Transm 119:861-75. 2012
  4. ncbi request reprint The modulation of calcium current by GABA metabotropic receptors in a sub-population of pallidal neurons
    A Stefani
    1RCCS Ospedale S Lucia Via Ardeatina 306, 00179 Rome, Italy
    Eur J Neurosci 11:3995-4005. 1999
  5. ncbi request reprint CSF markers in Alzheimer disease patients are not related to the different degree of cognitive impairment
    Alessandro Stefani
    IRCCS Fondazione S Lucia, Rome, Italy
    J Neurol Sci 251:124-8. 2006
  6. ncbi request reprint Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
    Alessandro Stefani
    1IRCCS Fondazione St Lucia, 2Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Brain 130:1596-607. 2007
  7. ncbi request reprint AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis
    Alessandro Stefani
    CERC IRCCS Fondazione Santa Lucia, Rome, Italy
    J Neurol Sci 237:83-8. 2005
  8. ncbi request reprint Spontaneous sleep modulates the firing pattern of parkinsonian subthalamic nucleus
    Alessandro Stefani
    CERC IRCCS Fondazione S Lucia, Via Ardeatina 306, Roma, Italy
    Exp Brain Res 168:277-80. 2006
  9. ncbi request reprint D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation
    Alessandro Stefani
    IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Roma, Italy
    Eur J Neurosci 15:815-25. 2002
  10. doi request reprint CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer's and mixed dementia
    Alessandro Stefani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neurol Sci 283:109-15. 2009

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Strength and weaknesses of cerebrospinal fluid biomarkers in Alzheimer's disease and possible detection of overlaps with frailty process
    Alessandro Stefani
    Department of Neuroscience, UOSD Parkinson, University of Rome Tor Vergata, Viale Oxford 81, Rome, Italy
    CNS Neurol Disord Drug Targets 12:538-46. 2013
    ..A crucial test for these hypotheses would be to apply this sort of interventional, and not merely pharmacological, therapy to homogeneous patient cohorts...
  2. doi request reprint Successful subthalamic stimulation, but levodopa-induced dystonia, in a genetic Parkinson's disease
    Alessandro Stefani
    IRCCS Fondazione S Lucia, Rome, Italy
    Neurol Sci 34:383-6. 2013
    ....
  3. doi request reprint CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD
    Alessandro Stefani
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neural Transm 119:861-75. 2012
    ..However, more complete data, possibly collected in fieri during the progressive derangement of cognitive abilities, are needed to improve our ability to decipher and treat these entities...
  4. ncbi request reprint The modulation of calcium current by GABA metabotropic receptors in a sub-population of pallidal neurons
    A Stefani
    1RCCS Ospedale S Lucia Via Ardeatina 306, 00179 Rome, Italy
    Eur J Neurosci 11:3995-4005. 1999
    ....
  5. ncbi request reprint CSF markers in Alzheimer disease patients are not related to the different degree of cognitive impairment
    Alessandro Stefani
    IRCCS Fondazione S Lucia, Rome, Italy
    J Neurol Sci 251:124-8. 2006
    ..Conversely, t-tau concentration correlates with the transition towards marked cognitive impairment...
  6. ncbi request reprint Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
    Alessandro Stefani
    1IRCCS Fondazione St Lucia, 2Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Brain 130:1596-607. 2007
    ..This combination of targets may also prove useful in extra-pyramidal disorders, such as progressive supranuclear palsy, for which treatments are currently elusive...
  7. ncbi request reprint AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis
    Alessandro Stefani
    CERC IRCCS Fondazione Santa Lucia, Rome, Italy
    J Neurol Sci 237:83-8. 2005
    ..VD. In conclusion, Abeta1-42 proved to be a valuable tool to discriminate AD vs. VD patients and possibly to improve diagnostic accuracy in clinical forms, improperly classified as "mixed dementia" based on radiological vascular lesions...
  8. ncbi request reprint Spontaneous sleep modulates the firing pattern of parkinsonian subthalamic nucleus
    Alessandro Stefani
    CERC IRCCS Fondazione S Lucia, Via Ardeatina 306, Roma, Italy
    Exp Brain Res 168:277-80. 2006
    ..Further, it is suggested that specific STN electrophysiological features are potential targets for future therapeutic interventions...
  9. ncbi request reprint D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation
    Alessandro Stefani
    IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Roma, Italy
    Eur J Neurosci 15:815-25. 2002
    ..A direct D2 modulation of calcium conductance in GP may alter GP firing properties and GABA release onto pallidofugal targets...
  10. doi request reprint CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer's and mixed dementia
    Alessandro Stefani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neurol Sci 283:109-15. 2009
    ....
  11. doi request reprint Non-motor functions in parkinsonian patients implanted in the pedunculopontine nucleus: focus on sleep and cognitive domains
    Stefani Alessandro
    IRCCS Fondazione S Lucia, Rome, Italy
    J Neurol Sci 289:44-8. 2010
    ....
  12. ncbi request reprint The activation of mu opioid receptors promotes a small modulation of calcium currents in rat pallidal neurons
    A Stefani
    IRCCS Fondazione, S Lucia, Italy
    Brain Res 897:207-12. 2001
    ..In degenerative conditions as Parkinsonism, an excessive stimulation of mu binding sites might induce a pathological inhibition of calcium signals, thus contributing to modify the GP firing pattern and transmitter release...
  13. ncbi request reprint The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons
    A Stefani
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Ospedale Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy
    Epilepsy Res 43:239-48. 2001
    ..These unconventional effects might underlie its efficacy in a variety of diseases which involve periodic discharge patterns as neuropathic pain or essential tremor...
  14. ncbi request reprint Group I mGluRs modulate calcium currents in rat GP: functional implications
    A Stefani
    IRCCS Ospedale S Lucia, Italy
    Synapse 30:424-32. 1998
    ..Nevertheless, the putative mGluR-induced reduction of intrinsic excitability might turn out to decrease the transmitter release from pallidal axon terminals, leading to further disinhibition of the output stations of the basal ganglia...
  15. doi request reprint Multi-target strategy for Parkinsonian patients: the role of deep brain stimulation in the centromedian-parafascicularis complex
    Alessandro Stefani
    IRCCS Fondazione S Lucia, Roma, Italy
    Brain Res Bull 78:113-8. 2009
    ....
  16. ncbi request reprint Neurotensin effects on N-type calcium currents among rat pallidal neurons: an electrophysiological and immunohistochemical study
    Alessandro Martorana
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Synapse 60:371-83. 2006
    ..This hypothesis might have implications on both sensori-motor and associative functions of the GP and should be tested in DA-denervated disease models...
  17. doi request reprint In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway
    Salvatore Galati
    Division of Neurology, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Synapse 62:409-20. 2008
    ..In addition, these findings suggest a functional cross-talk between NO, spontaneously active interneurons, and projection neurons that becomes critical in the parkinsonian state...
  18. ncbi request reprint Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response
    Francesca Spadoni
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Synapse 51:194-205. 2004
    ..The suppression of the kappa response only in striatum reinforces the notion of an imbalance of endogenous opiates as relevant in extrapyramidal motor dysfunctions...
  19. ncbi request reprint Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease
    Salvatore Galati
    I R C C S Fondazione S, Via Ardeatina 306 00133, Rome, Italy
    Eur J Neurosci 23:2923-8. 2006
    ..Our findings suggest that, during STN-DBS, a critical change towards a high-frequency oscillatory discharge occurs...
  20. ncbi request reprint Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    ....
  21. pmc The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway
    Salvatore Galati
    Department of Neuroscience, University of Rome Tor Vergata, Roma, Italy
    J Physiol 587:4405-23. 2009
    ....
  22. doi request reprint Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: a challenge for the 6-OHDA model?
    Salvatore Galati
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Exp Neurol 225:294-301. 2010
    ..Hence, our data support the proposition that LFO, is tightly correlated to cortex, and represent a critical hallmark of a basal ganglia (BG) failure from the early stages of dopamine denervation...
  23. doi request reprint Effects of deep brain stimulation of the peduncolopontine area on working memory tasks in patients with Parkinson's disease
    Alberto Costa
    Laboratorio di Neurologia Clinica e Comportamentale, I R C C S Fondazione Santa Lucia, Rome, Italy
    Parkinsonism Relat Disord 16:64-7. 2010
    ..The present findings, although preliminary, suggest that PPN area stimulation facilitates the speed processing of information in the content of WM, possibly through the modulation of the attentional resources...
  24. ncbi request reprint Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients
    Alessandro Stefani
    Instituto di Ricovero e Cura a Carrattere Scientificio IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    Ann Neurol 57:448-52. 2005
    ..This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi...
  25. doi request reprint Hedonic tone and its mood and cognitive correlates in Parkinson's disease
    Gianfranco Spalletta
    I R C C S Santa Lucia Foundation, Via Ardeatina 306, Rome, Italy
    Depress Anxiety 30:85-91. 2013
    ..Here, we investigated whether hedonic tone depends on depression and clarified its relationship with the cognitive performance of PD patients with different mood disorders...
  26. doi request reprint Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients
    Mariangela Pierantozzi
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    J Neural Transm 115:731-5. 2008
    ....
  27. doi request reprint L-dopa modulates motor cortex excitability in Alzheimer's disease patients
    Alessandro Martorana
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma, Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    J Neural Transm 115:1313-9. 2008
    ..In addition, considering that L-dopa showed a pharmacological profile similar to the one of cholinomimetics, L-dopa might represent a reliable tool to study new therapeutic perspective and strategies for AD...
  28. ncbi request reprint Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons
    Francesca Spadoni
    IRCCS Fondazione Santa Lucia, Roma, Italy
    Neuroreport 13:1167-70. 2002
    ..Given the damaging role of a sustained influx of sodium in both pharmaco-resistant seizures or excitotoxic insults, we suggest the utilization of drugs that suppress the persistent conductance...
  29. pmc Deep brain stimulation of pedunculopontine tegmental nucleus: role in sleep modulation in advanced Parkinson disease patients: one-year follow-up
    Antonella Peppe
    I R C C S Fondazione Santa Lucia, Rome, Italy
    Sleep 35:1637-42. 2012
    ....
  30. ncbi request reprint Actions of the sodium channel inhibitor 202W92 on rat midbrain dopaminergic neurons
    Luigi Caputi
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Synapse 48:123-30. 2003
    ..202W92 did not affect postsynaptic responses to locally applied glutamate and GABA, nor spontaneously occurring mini-IPSCs. These actions of 202W92 are compatible with sodium channel inhibition and depression of transmitter release...
  31. doi request reprint Sad and happy facial emotion recognition impairment in progressive supranuclear palsy in comparison with Parkinson's disease
    Francesco E Pontieri
    I R C C S Santa Lucia Foundation, Rome, Italy
    Parkinsonism Relat Disord 18:871-5. 2012
    ....
  32. doi request reprint Deep brain stimulation promotes excitation and inhibition in subthalamic nucleus in Parkinson's disease
    Salvatore Galati
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    Neuroreport 19:661-6. 2008
    ..As a result, the implantation of pedunculopontine [corrected] nucleus alone may be hazardous while the association of subthalamic nucleus plus pedunculopontine [corrected] nucleus seems to be reasonable...
  33. ncbi request reprint Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92
    L Caputi
    Fondazione IRCCS Santa Lucia, 00179 Rome, Italy
    Brain Res 919:259-68. 2001
    ..In conclusion, 202W92 is an effective neuroprotective agent when administered post-ischaemia and a potent sodium channel inhibitor in vitro...
  34. ncbi request reprint Gabapentin inhibits calcium currents in isolated rat brain neurons
    A Stefani
    IRCCS Ospedale S Lucia, Rome, Italy
    Neuropharmacology 37:83-91. 1998
    ....
  35. pmc Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease
    Valerio Pisani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neuroinflammation 9:188. 2012
    ..Alterations in blood-brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson's disease progression. However, few studies have addressed this issue in patients at different stages of disease...
  36. pmc Depressive symptoms in Parkinson's disease and in non-neurological medical illnesses
    Francesca Assogna
    I R C C S Santa Lucia Foundation, Rome, Italy
    Neuropsychiatr Dis Treat 9:389-96. 2013
    ..We compared the profile of depressive symptoms in Parkinson's disease (PD) patients with that of control subjects (CS) suffering from non-neurological medical illnesses...
  37. pmc Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus
    Alessandro Stefani
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione S Lucia, Roma, Italy
    Front Syst Neurosci 5:17. 2011
    ..Finally, given the demonstration of a key role of VA in inducing clinical relief, locally administration of drugs modulating GABA transmission in thalamic nuclei could become an innovative therapeutic strategy...
  38. ncbi request reprint Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms
    Antonio Orlacchio
    Laboratorio di Neurogenetica, IRCCS Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy
    Neurosci Lett 333:115-8. 2002
    ..But considering its biological effects, the result can not exclude the NCSTN as candidate for genetic factor in AD. Further genetic study of the NCSTN would be necessary to evaluate the potential genetic involvement in AD...
  39. ncbi request reprint Clinical and genetic study of a large SPG4 Italian family
    Antonio Orlacchio
    Laboratorio di Neurogenetica, IRCCS Santa Lucia, Rome, Italy
    Mov Disord 20:1055-9. 2005
    ....
  40. doi request reprint Intensity-dependent facial emotion recognition and cognitive functions in Parkinson's disease
    Francesca Assogna
    I R C C S Santa Lucia Foundation, Rome, Italy
    J Int Neuropsychol Soc 16:867-76. 2010
    ..Therefore, it is likely that structural or functional derangement of the discrete neural pathways involved in these cognitive functions in patients with PD makes it difficult for them to recognize emotions expressed by others...
  41. pmc Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007
    ..We report clinical, biochemical, and genetic features in four patients from four unrelated families with NA in order to explain the cause of morphological abnormalities and the relationship with neurodegenerative processes...
  42. pmc Blood dendritic cell frequency declines in idiopathic Parkinson's disease and is associated with motor symptom severity
    Antonio Ciaramella
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Rome, Italy
    PLoS ONE 8:e65352. 2013
    ....
  43. doi request reprint Cardiac sympathetic denervation is not related to nigrostriatal degeneration in Parkinson's disease
    Agostino Chiaravalloti
    Department of Biopathology and Diagnostic Imaging, University Hospital Tor Vergata, Viale Oxford 81, 00173 Rome, Italy
    Ann Nucl Med 27:444-51. 2013
    ....
  44. ncbi request reprint The impact of rotigotine on cardiovascular autonomic function in early Parkinson's disease
    Camilla Rocchi
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Eur Neurol 68:187-92. 2012
    ..Our study demonstrates that rotigotine does not influence cardiovascular autonomic responses in early de novo PD patients. Consequently, it may represent a well-tolerated and efficacious therapeutic option in newly diagnosed PD subjects...
  45. doi request reprint Alexithymia is a non-motor symptom of Parkinson disease
    Francesca Assogna
    IRCCS Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 20:133-41. 2012
    ..To investigate whether alexithymia is linked to the disease process or to psychopathology, particularly depression, in Parkinson disease (PD) patients...
  46. pmc The serendipity case of the pedunculopontine nucleus low-frequency brain stimulation: chasing a gait response, finding sleep, and cognition improvement
    Alessandro Stefani
    Department of Neuroscience, Tor Vergata University, Rome, Italy IRCCS, Fondazione Santa Lucia, Rome, Italy
    Front Neurol 4:68. 2013
    ..This review explores our angle of vision, by which PPTg-LFS activates cholinergic and glutamatergic ascending fibers, influencing non-motor behaviors...
  47. doi request reprint Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature
    Patrice Peran
    Department of Radiology, I R C C S Foundation Santa Lucia, Via Ardeatina 306, 00179 Rome
    Brain 133:3423-33. 2010
    ..These findings demonstrate that multimodal magnetic resonance imaging of subcortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortical pathologies...
  48. ncbi request reprint Group III metabotropic glutamate receptor agonists modulate high voltage-activated Ca2+ currents in pyramidal neurons of the adult rat
    A Stefani
    Clinica Neurologica, Dip Sanità Pubblica, Universita di Roma Tor Vergata, Italy
    Exp Brain Res 119:237-44. 1998
    ....
  49. ncbi request reprint Electrophysiology of sipatrigine: a lamotrigine derivative exhibiting neuroprotective effects
    P Calabresi
    Clinica Neurologica, Universita Tor Vergata, Rome, 00133, Italy
    Exp Neurol 162:171-9. 2000
    ....
  50. doi request reprint Acute nigro-striatal blockade alters cortico-striatal encoding: an in vivo electrophysiological study
    Chiara Prosperetti
    Experimental Laboratory, Neurocenter of Southern Switzerland, Lugano, Switzerland
    Exp Neurol 247:730-6. 2013
    ..These acute changes might contribute to the diffusion of cortical activity to BG and the pathophysiology of Parkinson's disease (PD). ..
  51. ncbi request reprint Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease
    Antonio Orlacchio
    Laboratorio di Neurogenetica, I R C C S Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy
    Neurosci Lett 325:13-6. 2002
    ..Our result suggests that the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD...
  52. ncbi request reprint Deep brain stimulation of both subthalamic nucleus and internal globus pallidus restores intracortical inhibition in Parkinson's disease paralleling apomorphine effects: a paired magnetic stimulation study
    M Pierantozzi
    Servizio di Neurofisiopatologia, Policlinico di Tor Vergata, Rome, Italy
    Clin Neurophysiol 113:108-13. 2002
    ..We investigated the effect of bilateral subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) on intracortical inhibition (ICI) in patients with advanced Parkinson's disease (PD)...
  53. ncbi request reprint Different TMS patterns of intracortical inhibition in early onset Alzheimer dementia and frontotemporal dementia
    M Pierantozzi
    IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00173 Rome, Italy
    Clin Neurophysiol 115:2410-8. 2004
    ....
  54. ncbi request reprint Bilateral GPi DBS is useful to reduce abnormal involuntary movements in advanced Parkinson's disease patients, but its action is related to modality and site of stimulation
    A Peppe
    I R C C S Fondazione Santa Lucia, Via Ardeatina 306, Roma, Italia
    Eur J Neurol 8:579-86. 2001
    ..On the contrary, the UP ON, most probably located in the external globus pallidus (GPe), does not modify the AIM occurrence...
  55. ncbi request reprint Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease
    Paolo Mazzone
    Functional and Stereotactic Neurosurgery, CTO, ASL RMC, Italy
    Neuroreport 16:1877-81. 2005
    ..These findings demonstrate that the stereotactic approach of peduncolopontine nucleus is safe. The target may reliably be identified by microrecordings. Low-frequency stimulation may produce acute improvements in motor function...
  56. ncbi request reprint High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat
    Tiziana Florio
    Department of Sciences and Biomedical Technologies, University of L Aquila, L Aquila, Italy
    Eur J Neurosci 25:1174-86. 2007
    ..In the absence of inhibitory EP fibres, the direct excitatory influence exerted by the STN on the PPN appears to predominate...
  57. ncbi request reprint Whole-cell patch clamp recording of voltage-sensitive Ca2+ channel currents heterologous expression systems and dissociated brain neurons
    Atticus H Hainsworth
    Pharmacology Research Group, Leicester School of Pharmacy, De Montfort University, UK
    Methods Mol Biol 312:161-79. 2006
  58. ncbi request reprint Peripeduncular and pedunculopontine nuclei: a dispute on a clinically relevant target
    Paolo Mazzone
    Neuroreport 18:1407-8. 2007
  59. ncbi request reprint Differential post-translational modifications of transthyretin in Alzheimer's disease: a study of the cerebral spinal fluid
    Antonino Biroccio
    Laboratori di Ricerca, Ospedale Pediatrico del Bambino Gesu IRCCS, Roma, Citta del Vaticano
    Proteomics 6:2305-13. 2006
    ..This manuscript is the first report describing the presence of differential post-translational oxidations of TTR in the CSF of AD patients...
  60. doi request reprint Surgical treatment of bronchiectasis: early and long-term results
    Riccardo Giovannetti
    Departement of Thoracic Surgery, Hotel Dieu University Hospital, Paris V University, Paris, France
    Interact Cardiovasc Thorac Surg 7:609-12. 2008
    ..Surgical treatment of bronchiectasis obtains satisfactory long-term results, with acceptable morbidity rates...