V Stanghellini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi [Some practical questions on chronic stipsis treatment with prucalopride]
    L Bellacosa
    Dipartimento di Scienze Mediche e Chirurgiche Università di Bologna, Bologna, Italia
    Minerva Gastroenterol Dietol 60:85-99. 2014
  2. doi Perspectives on irritable bowel syndrome: where have we been? Where are we now?
    Vincenzo Stanghellini
    Department of Digestive Diseases and Internal Medicine, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Expert Rev Gastroenterol Hepatol 7:3-7. 2013
  3. ncbi Fiber and macrogol in the therapy of chronic constipation
    V Stanghellini
    Department of Medical and Surgical Sciences DIMEC, University of Bologna, Bologna, Italy
    Minerva Gastroenterol Dietol 59:217-30. 2013
  4. pmc Seasonal pattern of peptic ulcer hospitalizations: analysis of the hospital discharge data of the Emilia-Romagna region of Italy
    Roberto Manfredini
    Department of Internal Medicine, Hospital of the Delta, Lagosanto, Azienda Unita Sanitaria Locale, Ferrara, Italy
    BMC Gastroenterol 10:37. 2010
  5. ncbi Determination of ReQuest-based symptom thresholds to define symptom relief in GERD clinical studies
    Vincenzo Stanghellini
    S Orsola Malpighi University Hospital, Bologna, Italy
    Digestion 75:55-61. 2007
  6. ncbi Natural history of chronic idiopathic intestinal pseudo-obstruction in adults: a single center study
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Clin Gastroenterol Hepatol 3:449-58. 2005
  7. ncbi Determination of ReQuest-based symptom thresholds to define symptom relief in GERD clinical studies
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, S Orsola Malpighi University Hospital, Via Massarento 9, IT 40138 Bologna, Italy
    Digestion 71:145-51. 2005
  8. doi How relevant is symptom evaluation in NERD?
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Digestion 78:11-6. 2008
  9. ncbi Overlapping functional syndromes: a way forward for medical therapy?
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Eur Rev Med Pharmacol Sci 12:138. 2008
  10. doi Natural history of intestinal failure induced by chronic idiopathic intestinal pseudo-obstruction
    V Stanghellini
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Transplant Proc 42:15-8. 2010

Collaborators

Detail Information

Publications86

  1. ncbi [Some practical questions on chronic stipsis treatment with prucalopride]
    L Bellacosa
    Dipartimento di Scienze Mediche e Chirurgiche Università di Bologna, Bologna, Italia
    Minerva Gastroenterol Dietol 60:85-99. 2014
    ....
  2. doi Perspectives on irritable bowel syndrome: where have we been? Where are we now?
    Vincenzo Stanghellini
    Department of Digestive Diseases and Internal Medicine, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Expert Rev Gastroenterol Hepatol 7:3-7. 2013
    ..Irritable bowel syndrome is characterized by long-lasting abdominal pain or discomfort, abnormal bowel habits and typically inadequate response to many of the available therapies. ..
  3. ncbi Fiber and macrogol in the therapy of chronic constipation
    V Stanghellini
    Department of Medical and Surgical Sciences DIMEC, University of Bologna, Bologna, Italy
    Minerva Gastroenterol Dietol 59:217-30. 2013
    ..The combination of psyllium and PEG could combine the advantages of fiber and isotonic solutions and represent an important therapeutic option for patients suffering from chronic constipation. ..
  4. pmc Seasonal pattern of peptic ulcer hospitalizations: analysis of the hospital discharge data of the Emilia-Romagna region of Italy
    Roberto Manfredini
    Department of Internal Medicine, Hospital of the Delta, Lagosanto, Azienda Unita Sanitaria Locale, Ferrara, Italy
    BMC Gastroenterol 10:37. 2010
    ..Previous studies have reported seasonal variation in peptic ulcer disease (PUD), but few large-scale, population-based studies have been conducted...
  5. ncbi Determination of ReQuest-based symptom thresholds to define symptom relief in GERD clinical studies
    Vincenzo Stanghellini
    S Orsola Malpighi University Hospital, Bologna, Italy
    Digestion 75:55-61. 2007
    ....
  6. ncbi Natural history of chronic idiopathic intestinal pseudo-obstruction in adults: a single center study
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Clin Gastroenterol Hepatol 3:449-58. 2005
    ..Intestinal motor abnormalities have long been identified in CIIP patients. Little is known of the natural history of the disease in adults. This study evaluated the clinical course of CIIP over time...
  7. ncbi Determination of ReQuest-based symptom thresholds to define symptom relief in GERD clinical studies
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, S Orsola Malpighi University Hospital, Via Massarento 9, IT 40138 Bologna, Italy
    Digestion 71:145-51. 2005
    ....
  8. doi How relevant is symptom evaluation in NERD?
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Digestion 78:11-6. 2008
    ..Through instruments like this, our understanding of NERD and its management will certainly further improve in the years to come...
  9. ncbi Overlapping functional syndromes: a way forward for medical therapy?
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Eur Rev Med Pharmacol Sci 12:138. 2008
  10. doi Natural history of intestinal failure induced by chronic idiopathic intestinal pseudo-obstruction
    V Stanghellini
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Transplant Proc 42:15-8. 2010
    ..A substantial percentage of patients requires parenteral nutrition. Failure of this nutritional support represents an indication for small bowel transplantation...
  11. ncbi Chronic intestinal pseudo-obstruction: manifestations, natural history and management
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 19:440-52. 2007
    ..This article focuses on the main clinical features, the management and long-term outcome of patients affected by CIPO, with particular emphasis on those aspects which remain a matter of debate...
  12. doi Gut microbiota and related diseases: clinical features
    Vincenzo Stanghellini
    Department of Clinical Medicine, St Orsola Malpighi Hospital, University of Bologna, Building No 5, Via Massarenti, 9, 40138, Bologna, Italy
    Intern Emerg Med 5:S57-63. 2010
    ....
  13. ncbi Relationship between upper gastrointestinal symptoms and lifestyle, psychosocial factors and comorbidity in the general population: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST)
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Scand J Gastroenterol Suppl 231:29-37. 1999
    ....
  14. doi Patient-reported outcomes and gut dysmotility in functional gastrointestinal disorders
    R F Cogliandro
    Department of Clinical Medicine, S Orsola Malpighi University Hospital, Bologna, Italy
    Neurogastroenterol Motil 23:1084-91. 2011
    ..The present study compared clinical features, small bowel motility, and quality of life (QoL) in patients with CIIP or severe functional gastrointestinal disorders (SFGID), compared to irritable bowel syndrome (IBS)...
  15. ncbi Review article: Helicobacter pylori, mucosal inflammation and symptom perception--new insights into an old hypothesis
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, St Orsola Hospital, University of Bologna, Via Massarenti 9, I 40138 Bologna, Italy
    Aliment Pharmacol Ther 15:28-32. 2001
    ..The identification of these mechanisms may provide a better understanding of the pathophysiology of H. pylori-related dyspepsia and prompt innovative therapeutic approaches...
  16. ncbi Use of macrogol 4000 in chronic constipation
    R De Giorgio
    Department of Clinical Medicine, School of Medicine, Alma Mater Studiorum University, Bologna, Italy
    Eur Rev Med Pharmacol Sci 15:960-6. 2011
    ..Lifestyle changes do not usually meet with complete patient satisfaction. Other treatments include different types of laxatives. Of these, osmotic laxatives appear one of the most effective and are, therefore, frequently prescribed...
  17. ncbi Unsolved problems in the management of patients with gastro-oesophageal reflux disease
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola Malpighi, Via Massarenti, 9 Bologna 1 40138, Italy
    Dig Liver Dis 35:843-8. 2003
    ..The high prevalence of gastro-oesophageal reflux disease in the general population and the relatively high management costs should prompt any doctor to seek the best possible therapeutic approach...
  18. ncbi Diagnosis and therapy of irritable bowel syndrome
    R De Giorgio
    Departments of Internal Medicine and Gastroenterology and Pharmacology, University of Bologna, Italy
    Aliment Pharmacol Ther 20:10-22. 2004
    ..A wide array of potentially useful drugs are currently under consideration in pre-clinical trials. A better understanding of the pathogenetic mechanisms underlying IBS may help to develop more effective drugs for this disease...
  19. ncbi Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study
    R Corinaldesi
    Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 30:245-52. 2009
    ..Intestinal immune infiltration contributes to symptoms in patients with irritable bowel syndrome (IBS)...
  20. ncbi Systematic review: do we need a new gastro-oesophageal reflux disease questionnaire?
    V Stanghellini
    S Orsola Malpighi Hospital, Bologna, Italy
    Digestion 75:3-16. 2007
    ..Self-assessed symptom questionnaires are now key instruments in clinical trials...
  21. ncbi Predictors of gastroparesis in out-patients with secondary and idiopathic upper gastrointestinal symptoms
    V Stanghellini
    Department of Internal Medicine, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Dig Liver Dis 35:389-96. 2003
    ..Delayed gastric emptying occurs frequently in patients with upper gastrointestinal symptoms associated with functional or organic diseases...
  22. ncbi Gastro-oesophageal reflux and interstitial lung disease
    B Salvioli
    Department of Internal Medicine and Gastroenterology, S Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Dig Liver Dis 38:879-84. 2006
    ..Gastro-oesophageal reflux appears to be more prevalent in idiopathic pulmonary fibrosis than in controls and in patients with secondary pulmonary fibrosis, but its contribution to interstitial lung disease remains unsettled...
  23. ncbi Standards for non-invasive methods for gastrointestinal motility: scintigraphy. A position statement from the Gruppo Italiano di Studio Motilità Apparato Digerente (GISMAD)
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Dig Liver Dis 32:447-52. 2000
    ....
  24. ncbi New insights into human enteric neuropathies
    R De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 16:143-7. 2004
    ..The study of the ENS abnormalities in gut dysmotility provides a framework to better understand the mechanisms involved in degeneration and neuronal loss and fosters the development of targeted therapeutic options...
  25. doi Chronic intestinal pseudo-obstruction related to viral infections
    R De Giorgio
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Transplant Proc 42:9-14. 2010
    ..The review thus provides some new perspectives in the pathophysiology and perhaps targeted treatment of CIIPO...
  26. ncbi Role of antibiotic therapy on long-term germ excretion in faeces and digestive symptoms after Salmonella infection
    G Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 14:1127-31. 2000
    ..Acute Salmonella gastroenteritis induces long-lasting digestive symptoms in up to one-third of subjects. The role of antimicrobial therapy on persistent post-infectious symptoms is unknown...
  27. pmc Neurogenic chronic intestinal pseudo-obstruction: antineuronal antibody-mediated activation of autophagy via Fas
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, Centro Unificato di Ricerca BioMedica Applicata, University of Bologna, Bologna, Italy
    Gastroenterology 135:601-9. 2008
    ..In this study we tested the hypothesis that sera from a subpopulation of patients with CIP contain autoantibodies that activate autophagy via a Fas-dependent pathway in cultured human neuroblastoma SH-Sy5Y cells...
  28. ncbi New pathophysiological mechanisms in irritable bowel syndrome
    G Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Aliment Pharmacol Ther 20:1-9. 2004
    ..These novel mechanisms may aid a better understanding of the complex pathophysiology of IBS and to develop new therapies...
  29. ncbi Functional gastrointestinal disorders and mast cells: implications for therapy
    G Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 18:6-17. 2006
    ..g., second generation antihistamines, proteinase-activated receptor antagonists) may be useful pharmacological tools for these common disorders...
  30. pmc A role for inflammation in irritable bowel syndrome?
    G Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Gut 51:i41-4. 2002
    ..A brief review of the human and animal studies that have focused on the putative role of intestinal inflammation and infections in the pathogenesis of IBS is given...
  31. ncbi Abnormalities of somatic peptide-containing nerves supplying the pelvic floor of women with genitourinary prolapse and stress urinary incontinence
    P Busacchi
    Department of Obstetrics and Gynecology, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Urology 63:591-5. 2004
    ....
  32. ncbi Dyspepsia and dyspepsia subgroups. Not all roads lead to Rome
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna S Orsola Malpighi Hospital, Italy
    Dig Liver Dis 34:316-8. 2002
  33. pmc Intestinal inflammation and activation of sensory nerve pathways: a functional and morphological study in the nematode infected rat
    R De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Gut 49:822-7. 2001
    ..As the pseudoaffective response is capsaicin sensitive, the rightward shift of the response is likely the consequence of the decrease in NK-1 receptors in the sensory pathways...
  34. ncbi Review article: the pharmacological treatment of acute colonic pseudo-obstruction
    R De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 15:1717-27. 2001
    ..Among these agents, the potential of 5-hydroxytryptamine-4 receptor agonists and motilin receptor agonists is discussed...
  35. ncbi Anti-ganglioside antibodies in coeliac disease with neurological disorders
    U Volta
    Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Building 11, St Orsola Malpighi Hospital, Via Massarenti, 9, 40138 Bologna, Italy
    Dig Liver Dis 38:183-7. 2006
    ..Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia...
  36. ncbi Interactions between commensal bacteria and gut sensorimotor function in health and disease
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, Univeristy of Bologna, Bologna, Italy
    Am J Gastroenterol 100:2560-8. 2005
    ..The potential benefit of antibiotic and probiotic therapy is currently under investigation and opens new perspectives in irritable bowel syndrome treatment...
  37. pmc Chronic intestinal pseudo-obstruction
    Alexandra Antonucci
    Department of Internal Medicine and Gastroenterology, St Orsola Malpighi Hospital, Via Massarenti 9, Bologna I 40138, Italy
    World J Gastroenterol 14:2953-61. 2008
    ..Treatment of intestinal pseudo-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases...
  38. ncbi Upper gastrointestinal bleeding due to duodenal metastasis from primary lung carcinoma
    C Cremon
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Dig Liver Dis 34:141-3. 2002
    ..Herein, we report a case of duodenal metastatic involvement leading to severe upper gastrointestinal bleeding in the absence of symptoms referable to the primary tumour...
  39. ncbi Idiopathic achalasia is not allelic to alacrima achalasia adrenal insufficiency syndrome at the ALADIN locus
    G Di Nardo
    Department of Internal Medicine and Gastroenterology, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti, 9, I 40138 Bologna, Italy
    Dig Liver Dis 37:312-5. 2005
    ..e. alacrima, achalasia and adrenocorticotropin-resistant adrenal insufficiency with neurological impairment) have mutations of the alacrima achalasia adrenal insufficiency syndrome (AAAS) gene...
  40. ncbi Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST)
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Scand J Gastroenterol Suppl 231:20-8. 1999
    ....
  41. pmc Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction
    R De Giorgio
    Department of Internal Medicine and Gastroenterology, St Orsola Malpighi Hospital, Via Massarenti, 9, I 40138 Bologna, Italy
    Gut 53:1549-52. 2004
    ..Combined clinical and histopathological studies are needed to highlight new perspectives in the understanding and management of chronic intestinal pseudo-obstruction...
  42. ncbi [Gastroesophageal reflux disease: clinical and pathophysiological features (part I)]
    R Corinaldesi
    Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Italia
    Clin Ter 158:77-83. 2007
    ..Moreover, barium swallow X-ray, 24-h esophageal pH monitoring and gastro-esophageal manometry can be useful to support diagnosis in some unusual cases or in cases partially or unresponsive to standard pharmacologic treatment...
  43. ncbi [Gastroesophageal reflux disease: therapeutic features (Part II)]
    R Corinaldesi
    Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Italia
    Clin Ter 158:165-72. 2007
    ..Surgery, based on anti-reflux procedures, and endoscopic approaches may have a role in the management of patients with GERD...
  44. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    ..We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients...
  45. ncbi New developments in the treatment of functional dyspepsia
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Drugs 63:869-92. 2003
    ..e., P2X2/3 receptors), NMDA receptors (NR2B subtype), protease-activated receptor-2, the vanilloid receptor-1, tachykinin receptors (NK(1)/NK(2)) and cholecystokinin (CCK)(1) receptors...
  46. ncbi Probiotics and irritable bowel syndrome: rationale and clinical evidence for their use
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    J Clin Gastroenterol 42:S214-7. 2008
    ..However, these results, although encouraging, should be confirmed in larger well-designed, placebo-controlled studies. A number of open questions remain to be addressed, including the dose, type, and time of administration of probiotics...
  47. doi Aminosalicylates and other anti-inflammatory compounds for irritable bowel syndrome
    Giovanni Barbara
    Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy
    Dig Dis 27:115-21. 2009
    ....
  48. ncbi Almost all irritable bowel syndromes are post-infectious and respond to probiotics: controversial issues
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Dig Dis 25:245-8. 2007
    ..Probiotics have been claimed to be of some benefit in IBS, but the majority of studies have been performed in non-specific IBS rather than in PI-IBS and a number of issues still remain to be elucidated...
  49. ncbi Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Gastroenterology 125:70-9. 2003
    ....
  50. doi Postinfectious irritable bowel syndrome
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology and CRBA, University of Bologna, Bologna, Italy
    J Pediatr Gastroenterol Nutr 48:S95-7. 2009
    ..There is little evidence about a specific treatment for PI-IBS. Although probiotics and antibiotics may be promising in the prevention of PI-IBS, the efficacy of these treatments should be assessed in an ad hoc designed study...
  51. ncbi Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Am J Gastroenterol 97:2454-9. 2002
    ..The immunosuppressive approach deserves further investigation in patients with severe gut motor abnormalities attributable to idiopathic myenteric ganglionitis...
  52. ncbi Prokinetics in the treatment of acute intestinal pseudo-obstruction
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna I 40138, Italy
    IDrugs 7:160-5. 2004
    ..New colokinetic agents, including 5-HT(4) receptor agonists and motilides, may represent other useful therapeutic options for Ogilvie's syndrome...
  53. ncbi Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, and CRBA, University of Bologna, St Orsola Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 132:26-37. 2007
    ..However, the underlying mechanisms remain unknown. We assessed the effect of mast cell mediators released from the colonic mucosa of IBS patients on the activation of rat sensory neurons in vitro...
  54. ncbi ReQuest-- the challenge of quantifying both esophageal and extra-esophageal manifestations of GERD
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Best Pract Res Clin Gastroenterol 18:27-30. 2004
    ....
  55. ncbi Inflammatory neuropathies of the enteric nervous system
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 126:1872-83. 2004
    ....
  56. doi Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons
    B Balestra
    Department of Forensic Medicine, Pharmacology and Toxicology, University of Pavia, Pavia, Italy
    Neurogastroenterol Motil 24:1118-e570. 2012
    ..Mediators released in the mucosal milieu have been suggested to be involved in visceral hypersensitivity and abdominal pain in patients with irritable bowel syndrome (IBS). However, their impact on myenteric neurons remains unsettled...
  57. ncbi Systematic review: do we need a new gastro-oesophageal reflux disease questionnaire?
    V Stanghellini
    S Orsola Malpighi Hospital, Bologna, Italy
    Aliment Pharmacol Ther 19:463-79. 2004
    ..Self-assessed symptom questionnaires are now key instruments in clinical trials...
  58. ncbi Best cut-off values for [14C]-urea breath tests for Helicobacter pylori detection
    L Gatta
    Dept of Internal Medicine and Gastroenterology, University of Bologna, S Orsola Hospital, Bologna, Italy
    Scand J Gastroenterol 38:1144-8. 2003
    ....
  59. ncbi Helicobacter pylori infection and gastric function in patients with fundic atrophic gastritis
    A Tucci
    Department of Internal Medicine and Gastroenterology, Hospital S. Orsola-Malpighi, University of Bologna, Italy
    Dig Dis Sci 46:1573-83. 2001
    ..Our data suggest that fundic atrophic gastritis represents a possible end stage of H. pylori infection, characterized by a progressive disappearance of the bacterium and a progressive deterioration of gastric functions...
  60. doi Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients
    S Buhner
    Human Biology, Technische Universitat Munchen, Germany
    Neurogastroenterol Motil 24:1134-e572. 2012
    ..Based on the concept that mucosa-nerve signaling is altered in IBS, we tested in this study whether the nerve sensitizing effect of IBS mucosal biopsy supernatants is more prominent in the submucous than myenteric plexus...
  61. doi Slow gallbladder emptying reverts to normal but small intestinal transit of a physiological meal remains slow in celiac patients during gluten-free diet
    F Benini
    Gastroenterology Unit and Histopathology Unit, University and Spedali Civili of Brescia, Brescia, Italy
    Neurogastroenterol Motil 24:100-7, e79-80. 2012
    ..Our aims were to quantitate non-invasively small intestinal transit time and GB emptying during administration of a physiological and palatable solid meal, and to assess the effect of gluten-free diet (GFD)...
  62. ncbi Review Article: pain versus discomfort--is differentiation clinically useful?
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 15:145-9. 2001
    ..It is likely that precise symptom definitions and history-taking will be of pivotal importance in management strategies for functional dyspepsia...
  63. doi Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms
    Cesare Cremon
    Department of Internal Medicine and Gastroenterology, St Orsola Hospital, Center for Applied Biomedical Research, Bologna, Italy
    Am J Gastroenterol 104:392-400. 2009
    ..However, the relative magnitude of this immune component and its correlation with gender and gastrointestinal complaints in IBS patients remains poorly elucidated...
  64. ncbi Management of gastroesophageal reflux disease
    V Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Drugs Today (Barc) 39:15-20. 2003
    ..Pantoprazole is the only PPI found not to interact with the metabolism of other drugs and is therefore the treatment of choice especially for patients with co-morbidities and co-medication...
  65. ncbi A novel locus for syndromic chronic idiopathic intestinal pseudo-obstruction maps to chromosome 8q23-q24
    Alessia Deglincerti
    Laboratory of Medical Genetics, Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Bologna, Italy
    Eur J Hum Genet 15:889-97. 2007
    ..01). Our data strongly support the presence of a new genetic locus associated with CIIP, long-segment Barrett esophagus, and cardiac involvement on chromosome 8...
  66. ncbi Chronic intestinal pseudo-obstruction
    Rosanna F Cogliandro
    Department of Internal Medicine and Gastroenterology, University of Bologna, and St Orsola Malpighi Hospital, Bologna, Italy
    Best Pract Res Clin Gastroenterol 21:657-69. 2007
    ..The main pathogenetic and clinical features of the syndrome, together with current management recommendations are reviewed in this chapter...
  67. ncbi Enteric neuroplasticity evoked by inflammation
    Valentina Vasina
    Department of Pharmacology, University of Bologna, St Orsola Malpighi Hospital, Italy
    Auton Neurosci 126:264-72. 2006
    ..A better comprehension of ENS plasticity during inflammation could be instrumental to develop new therapeutic options for patients with IBD and inflammatory enteric neuropathies...
  68. ncbi ReQuest: new dimensions in the assessment and management of GERD
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Drugs Today (Barc) 41:7-11. 2005
    ..Furthermore, ReQuest(TM) fulfills the criteria set by the regulatory authorities for a validated symptom-based system for use as the primary outcome measure in clinical trials of GERD therapy...
  69. ncbi Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome
    Vincenzo Stanghellini
    Department of Internal Medicine, S Orsola Malpighi University Hospital, Bologna, Italy
    Am J Gastroenterol 97:2738-43. 2002
    ..Whether overlapping dyspepsia correlates with gastric emptying abnormalities in IBS patients has not been clarified. This study aimed to evaluate gastric emptying of solids and its relationship with dyspeptic symptoms in IBS patients...
  70. ncbi HOX11L1: a promoter study to evaluate possible expression defects in intestinal motility disorders
    Monica Fava
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Int J Mol Med 10:101-6. 2002
    ....
  71. ncbi Intestinal transplantation for chronic intestinal pseudo-obstruction in adult patients
    Michele Masetti
    University of Modena and Reggio Emilia, Liver and Multivisceral Transplant Center, Modena, Italy
    Am J Transplant 4:826-9. 2004
    ..3% and 66.6%. Although our series is limited by the number of patients, our experience suggests that ITx transplantation should be considered in adult patients suffering from CIPO and PN life-threatening complication...
  72. ncbi The construction of a new evaluative GERD questionnaire--methods and state of the art
    David Armstrong
    McMaster University, Hamilton, Ont, Canada
    Digestion 75:17-24. 2007
    ....
  73. ncbi Enteric neuropathology of congenital intestinal obstruction: A case report
    Giovanni Di Nardo
    Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy
    World J Gastroenterol 12:5229-33. 2006
    ..Such ENS changes mimic neuronal abnormalities observed in intestinal pseudo-obstruction...
  74. ncbi Cross-cultural development and validation of a patient self-administered questionnaire to assess quality of life in upper gastrointestinal disorders: the PAGI-QOL
    Christine de la Loge
    Mapi Values, Lyon, France
    Qual Life Res 13:1751-62. 2004
    ....
  75. doi A case of paraneoplastic inflammatory neuropathy of the gastrointestinal tract related to an underlying neuroblastoma: successful management with immunosuppressive therapy
    Alessandra Martin
    Department of Pediatric Surgery, Meyer Children s Hospital, University of Florence, Italy
    J Pediatr Gastroenterol Nutr 46:457-60. 2008
  76. ncbi Responsiveness and interpretation of a symptom severity index specific to upper gastrointestinal disorders
    Dennis A Revicki
    Center for Health Outcome Research, MEDTAP International, Bethesda, MD 20814, USA
    Clin Gastroenterol Hepatol 2:769-77. 2004
    ..This study evaluates responsiveness of the Patient Assessment of Gastrointestinal Disorders-Symptom Severity Index (PAGI-SYM) in gastroesophageal reflux disease (GERD) and dyspepsia...
  77. ncbi Responsiveness and interpretation of a quality of life questionnaire specific to upper gastrointestinal disorders
    Christine de la Loge
    Mapi Values, Lyon, France
    Clin Gastroenterol Hepatol 2:778-86. 2004
    ..The aim of this work was to assess responsiveness of the PAGI-QOL to clinical changes and provide guidance for the interpretation of score changes...
  78. ncbi Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms
    Dennis A Revicki
    Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, MD 20814, USA
    Qual Life Res 13:833-44. 2004
    ..Patient-rated symptom assessments are needed for evaluating the effectiveness of medical treatments and for monitoring outcomes in gastroparesis...
  79. ncbi GERD 2003 -- a consensus on the way ahead
    Steven F Moss
    Brown University, Providence, R I, USA
    Digestion 67:111-7. 2003
    ..Intestinal metaplasia in the lower esophagus is probably very common. Whether and how to, first, screen for, and then, perform surveillance in Barrett's esophagus remains highly problematic and contentious...
  80. ncbi Sympathetic hyperactivity in patients with ulcerative colitis
    Simona Maule
    Autonomic Unit, S Vito Hospital, University of Turin, Turin, Italy
    Clin Auton Res 17:217-20. 2007
    ..At rest, LF/HF ratios were significantly (P < 0.05) higher in chronic UC patients (2.4 +/- 1.6) compared to controls (1.2 +/- 1.0). Our results suggest a higher sympathetic tone at rest in patients with chronic UC...
  81. ncbi Functional gastroduodenal disorders
    Jan Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Gastroenterology 130:1466-79. 2006
    ..The proposed classification requires further research and careful validation but the criteria should be of value for clinical practice; for epidemiological, pathophysiological, and clinical management studies; and for drug development...
  82. ncbi The construction of a new evaluative GERD questionnaire - methods and state of the art
    David Armstrong
    HSC 4W8, Division of Gastroenterology, McMaster University, 1200 Mian Street West, Hamilton, Ontario L8N 3Z5, Canada
    Digestion 70:71-8. 2004
    ....
  83. ncbi 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Gastroenterology 129:1557-66. 2005
    ..In this study, we evaluated the expression of 5-HT7 receptors in the guinea pig ileum and their role in peristalsis and accommodation of the circular muscle...
  84. ncbi Neurology and neuropathology of the pancreatic innervation
    Beatrice Salvioli
    JOP 3:26-33. 2002
  85. ncbi Dyspeptic symptoms in primary care. An observational study in general practice
    Giovanni Maconi
    Gastrointestinal Unit, L Sacco University Hospital, Via G B Grassi 74, 20157 Milan, Italy
    Eur J Gastroenterol Hepatol 14:985-90. 2002
    ..This study describes features of dyspepsia and its relationship with demographic, clinical and socio-economic factors in patients seen by general practitioners in Italy...
  86. ncbi Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes
    Silvia Borghini
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Eur J Hum Genet 15:848-55. 2007
    ....