Research Topics
| Alessandra StacchiottiSummaryAffiliation: University of Brescia Country: Italy Publications
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Detail Information
Publications
Stress proteins expression in rat kidney and liver chronically exposed to aluminium sulphateA Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Histol Histopathol 21:131-40. 2006..Their distribution in kidney and liver seems related to cumulative sublethal effects induced by metal and could be a sensitive index of Al susceptibility of these organs...- Tubular stress proteins and nitric oxide synthase expression in rat kidney exposed to mercuric chloride and melatoninAlessandra Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, I 25123 Brescia, Italy
J Histochem Cytochem 54:1149-57. 2006..These markers could represent sensitive recovery index against mercury damage... 
Effects of aluminium sulphate in the mouse liver: similarities to the aging processAlessandra Stacchiotti
Department of Biomedical Sciences and Biotechnologies, Brescia University, Brescia, Italy
Exp Gerontol 43:330-8. 2008..Pseudocapillarization and periportal laminin in senescent mice were similar to Al treated adult liver. In conclusion, prolonged Al sulphate intake accelerates features of senescence in the adult mice liver...- Bimoclomol ameliorates mercuric chloride nephrotoxicity through recruitment of stress proteinsAlessandra Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, I 25123 Brescia, Italy
Toxicol Lett 166:168-77. 2006..These novel findings suggest that BIM mitigates HgCl(2) nephrotoxicity in rats through the early recruitment of stress proteins in midcortical proximal tubules that are the main renal mercury-targets... - Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitroAlessandra Stacchiotti
Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Toxicology 286:48-57. 2011..This discrepancy might be partly attributable to Sch B influence on glomerular perfusion as corroborated by the recovery of vasoactive markers like macular and endothelial nitric oxide isoforms... - Stress proteins in experimental nephrotoxicity: a ten year experienceAlessandra Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia
Ital J Anat Embryol 115:153-8. 2010..In conclusion, experimental studies on the renal chaperones can greatly contribute to understand their role, and agents able to modulate the stress response might be considered promising therapeutic tools to reduce nephrotoxicity... - Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chlorideAlessandra Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, Viale Europa 11, 25123 Brescia, Italy
Food Chem Toxicol 47:2834-40. 2009..Taking together these data suggest that dietary Sch B counteracts HgCl2 hepatotoxicity in the rat by stimulating chaperones responsible for anabolic activity... - Mercuric chloride-induced alterations in stress protein distribution in rat kidneyA Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Histol Histopathol 19:1209-18. 2004..Stress proteins could represent sensitive biomarkers that strongly correlate with the degree of oxidative injury induced by HgCl2 in the rat proximal tubules... - Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liverRita Rezzani
Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, 25123 Brescia, Italy
Int Immunopharmacol 5:1397-405. 2005..Moreover, we show that Mel plays a protective action against CsA-induced oxidative stress, as supported by biochemical and immunohistochemical results... - Altered immunolocalization of heat-shock proteins in human peri-implant gingivaElisa Borsani
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Acta Histochem 109:221-7. 2007..In conclusion, we observed in peri-implantitis a clearly enhanced immunolabelling of two specific HSPs, HSP25 and HSP60, restricted to gingival epithelium and this could indicate a signal of local altered homeostasis... - Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and leadAlessandra Stacchiotti
Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
Toxicology 264:215-24. 2009..Indeed, different chaperones are involved in the specific nephrotoxic mechanism of these environmental pollutants and work together for cell survival... - Small heat shock proteins expression in rat kidneys treated with cyclosporine A alone and combined with melatoninAlessandra Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Histochem J 34:305-12. 2002..This could be a consequence of the cytoprotective effect of melatonin in this nephrotoxic model so that a beneficial sHSPs response is unnecessary... - Cyclosporine A induces vascular fibrosis and heat shock protein expression in ratRita Rezzani
Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, 25123 v.le Europa 11, Brescia, Italy
Int Immunopharmacol 5:169-76. 2005..These findings could suggest that these proteins are up-regulated after CsA treatment in order to play a defensive role in vascular damage... - ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatinFrancesca Rovetta
Unit of Biochemistry, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Exp Cell Res 318:238-50. 2012.... - Adverse effects of cyclosporine A on HSP25, alpha B-crystallin and myofibrillar cytoskeleton in rat heartAlessandra Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, V le Europa 11, I 2513 Brescia, Italy
Toxicology 262:192-8. 2009..In particular, the translocation of sHSPs to intercalated discs merits special consideration as a direct compensatory mechanism to limit CsA cardiotoxicity... - Histochemical and immunohistochemical evaluation of gingival collagen and metalloproteinases in peri-implantitisElisa Borsani
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa, 11, 25123 Italy
Acta Histochem 107:231-40. 2005..On the whole, these data suggest that in the extracellular matrix of peri-implantitis there are alterations of collagen V, tenascin and MMP-13 patterns... - Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brainL F Rodella
Unit of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Histol Histopathol 23:433-9. 2008..So, we hypothesise that chronic Al administration is responsible for oxidative cell damage that interferes with ER functions inducing Abeta accumulation and neurodegenerative damage... - Exposure to aluminium changes the NADPH-diaphorase/NPY pattern in the rat cerebral cortexL F Rodella
Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Arch Histol Cytol 69:13-21. 2006..In addition, the decrease in the NPY system found at 6 and 12 months may indicate that Al affected nitroxidergic and NPY systems at different times... - Supplementation with essential amino acids in middle age maintains the health of rat kidneyG Corsetti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Int J Immunopathol Pharmacol 23:523-33. 2010..Mitochondrial area and density after EAA intake did not differ from young groups. The results suggest that prolonged EAA intake could represent a strategy for maintaining the healthy status of the kidney in M-aged animals... - Morphological and biochemical studies on aging and autophagyRita Rezzani
Anatomy Section, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Ageing Res Rev 11:10-31. 2012..At the end, these data would summarize the autophagic link with aging process, as important tools in the future biogerontology scenario... - Cyclosporine A-induced kidney alterations are limited by melatonin in rats: an electron microscope studyA Stacchiotti
Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Ultrastruct Pathol 26:81-7. 2002..After CsA plus melatonin, these parameters were reduced in the proximal tubules and restored in the glomerulus. In conclusion, melatonin attenuated morpho-quantitative alterations induced by CsA in the rat kidney... - Dose-dependent mercuric chloride tubular injury in rat kidneyA Stacchiotti
Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Ultrastruct Pathol 27:253-9. 2003..These findings will be useful for better understanding of the pathogenesis of mercury nephrotoxicity and its genotoxic effect... - Distribution of heat shock proteins in kidneys of rats after immunosuppressive treatment with cyclosporine AA Stacchiotti
Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Acta Histochem 103:167-77. 2001..These findings suggest that these proteins are functionally involved in the defence against renal cellular damage caused by prolonged drug treatment in rat... - Cytoplasmic changes in satellite cells of spinal ganglia induced by cisplatin treatment in ratsG Corsetti
Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Ultrastruct Pathol 24:259-65. 2000..It appears that not only the DRG neurons but also and principally the SC were involved in the peripheral neuropathy mechanisms caused typically from therapeutic cis-DDP administration... - Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic ratsStephen J Peterson
Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
J Pharmacol Exp Ther 322:514-20. 2007....