Alessandra Stacchiotti

Summary

Affiliation: University of Brescia
Country: Italy

Publications

  1. ncbi request reprint Stress proteins expression in rat kidney and liver chronically exposed to aluminium sulphate
    A Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Histol Histopathol 21:131-40. 2006
  2. pmc Tubular stress proteins and nitric oxide synthase expression in rat kidney exposed to mercuric chloride and melatonin
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, I 25123 Brescia, Italy
    J Histochem Cytochem 54:1149-57. 2006
  3. doi request reprint Effects of aluminium sulphate in the mouse liver: similarities to the aging process
    Alessandra Stacchiotti
    Department of Biomedical Sciences and Biotechnologies, Brescia University, Brescia, Italy
    Exp Gerontol 43:330-8. 2008
  4. ncbi request reprint Bimoclomol ameliorates mercuric chloride nephrotoxicity through recruitment of stress proteins
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, I 25123 Brescia, Italy
    Toxicol Lett 166:168-77. 2006
  5. doi request reprint Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro
    Alessandra Stacchiotti
    Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Toxicology 286:48-57. 2011
  6. ncbi request reprint Stress proteins in experimental nephrotoxicity: a ten year experience
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia
    Ital J Anat Embryol 115:153-8. 2010
  7. ncbi request reprint Mercuric chloride-induced alterations in stress protein distribution in rat kidney
    A Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Histol Histopathol 19:1209-18. 2004
  8. doi request reprint Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, Viale Europa 11, 25123 Brescia, Italy
    Food Chem Toxicol 47:2834-40. 2009
  9. ncbi request reprint Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver
    Rita Rezzani
    Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, 25123 Brescia, Italy
    Int Immunopharmacol 5:1397-405. 2005
  10. ncbi request reprint Altered immunolocalization of heat-shock proteins in human peri-implant gingiva
    Elisa Borsani
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Acta Histochem 109:221-7. 2007

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Stress proteins expression in rat kidney and liver chronically exposed to aluminium sulphate
    A Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Histol Histopathol 21:131-40. 2006
    ..Their distribution in kidney and liver seems related to cumulative sublethal effects induced by metal and could be a sensitive index of Al susceptibility of these organs...
  2. pmc Tubular stress proteins and nitric oxide synthase expression in rat kidney exposed to mercuric chloride and melatonin
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, I 25123 Brescia, Italy
    J Histochem Cytochem 54:1149-57. 2006
    ..These markers could represent sensitive recovery index against mercury damage...
  3. doi request reprint Effects of aluminium sulphate in the mouse liver: similarities to the aging process
    Alessandra Stacchiotti
    Department of Biomedical Sciences and Biotechnologies, Brescia University, Brescia, Italy
    Exp Gerontol 43:330-8. 2008
    ..Pseudocapillarization and periportal laminin in senescent mice were similar to Al treated adult liver. In conclusion, prolonged Al sulphate intake accelerates features of senescence in the adult mice liver...
  4. ncbi request reprint Bimoclomol ameliorates mercuric chloride nephrotoxicity through recruitment of stress proteins
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, I 25123 Brescia, Italy
    Toxicol Lett 166:168-77. 2006
    ..These novel findings suggest that BIM mitigates HgCl(2) nephrotoxicity in rats through the early recruitment of stress proteins in midcortical proximal tubules that are the main renal mercury-targets...
  5. doi request reprint Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro
    Alessandra Stacchiotti
    Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Toxicology 286:48-57. 2011
    ..This discrepancy might be partly attributable to Sch B influence on glomerular perfusion as corroborated by the recovery of vasoactive markers like macular and endothelial nitric oxide isoforms...
  6. ncbi request reprint Stress proteins in experimental nephrotoxicity: a ten year experience
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia
    Ital J Anat Embryol 115:153-8. 2010
    ..In conclusion, experimental studies on the renal chaperones can greatly contribute to understand their role, and agents able to modulate the stress response might be considered promising therapeutic tools to reduce nephrotoxicity...
  7. ncbi request reprint Mercuric chloride-induced alterations in stress protein distribution in rat kidney
    A Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Histol Histopathol 19:1209-18. 2004
    ..Stress proteins could represent sensitive biomarkers that strongly correlate with the degree of oxidative injury induced by HgCl2 in the rat proximal tubules...
  8. doi request reprint Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, Viale Europa 11, 25123 Brescia, Italy
    Food Chem Toxicol 47:2834-40. 2009
    ..Taking together these data suggest that dietary Sch B counteracts HgCl2 hepatotoxicity in the rat by stimulating chaperones responsible for anabolic activity...
  9. ncbi request reprint Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver
    Rita Rezzani
    Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, 25123 Brescia, Italy
    Int Immunopharmacol 5:1397-405. 2005
    ..Moreover, we show that Mel plays a protective action against CsA-induced oxidative stress, as supported by biochemical and immunohistochemical results...
  10. ncbi request reprint Altered immunolocalization of heat-shock proteins in human peri-implant gingiva
    Elisa Borsani
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Acta Histochem 109:221-7. 2007
    ..In conclusion, we observed in peri-implantitis a clearly enhanced immunolabelling of two specific HSPs, HSP25 and HSP60, restricted to gingival epithelium and this could indicate a signal of local altered homeostasis...
  11. doi request reprint Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead
    Alessandra Stacchiotti
    Human Anatomy Unit, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
    Toxicology 264:215-24. 2009
    ..Indeed, different chaperones are involved in the specific nephrotoxic mechanism of these environmental pollutants and work together for cell survival...
  12. ncbi request reprint Cyclosporine A induces vascular fibrosis and heat shock protein expression in rat
    Rita Rezzani
    Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, 25123 v le Europa 11, Brescia, Italy
    Int Immunopharmacol 5:169-76. 2005
    ..These findings could suggest that these proteins are up-regulated after CsA treatment in order to play a defensive role in vascular damage...
  13. ncbi request reprint Small heat shock proteins expression in rat kidneys treated with cyclosporine A alone and combined with melatonin
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Histochem J 34:305-12. 2002
    ..This could be a consequence of the cytoprotective effect of melatonin in this nephrotoxic model so that a beneficial sHSPs response is unnecessary...
  14. doi request reprint ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin
    Francesca Rovetta
    Unit of Biochemistry, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Exp Cell Res 318:238-50. 2012
    ....
  15. ncbi request reprint Adverse effects of cyclosporine A on HSP25, alpha B-crystallin and myofibrillar cytoskeleton in rat heart
    Alessandra Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, V le Europa 11, I 2513 Brescia, Italy
    Toxicology 262:192-8. 2009
    ..In particular, the translocation of sHSPs to intercalated discs merits special consideration as a direct compensatory mechanism to limit CsA cardiotoxicity...
  16. doi request reprint Endothelial and vascular smooth muscle cell dysfunction mediated by cyclophylin A and the atheroprotective effects of melatonin
    Rita Rezzani
    Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Life Sci 92:875-82. 2013
    ..This study evaluated the role of cyclophilin A (CyPA) in early phase of atherosclerosis and also examined the atheroprotective effects of melatonin due to its antioxidant properties...
  17. pmc Taurine rescues Cisplatin-induced muscle atrophy in vitro: a morphological study
    Alessandra Stacchiotti
    Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, Brescia University, Viale Europa 11, 25123 Brescia, Italy
    Oxid Med Cell Longev 2014:840951. 2014
    ..Such a promising taurine action in preventing atrophy needs further molecular and biochemical studies to best define its impact on muscle homeostasis and the maintenance of an adequate skeletal mass in vivo. ..
  18. ncbi request reprint Histochemical and immunohistochemical evaluation of gingival collagen and metalloproteinases in peri-implantitis
    Elisa Borsani
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa, 11, 25123 Italy
    Acta Histochem 107:231-40. 2005
    ..On the whole, these data suggest that in the extracellular matrix of peri-implantitis there are alterations of collagen V, tenascin and MMP-13 patterns...
  19. doi request reprint Cobalt triggers necrotic cell death and atrophy in skeletal C2C12 myotubes
    Francesca Rovetta
    Unit of Biotechnologies, Department of Molecular and Translational Medicine, University of Brescia, Brescia I 25123, Italy Interuniversity Institute of Myology IIM, Italy
    Toxicol Appl Pharmacol 271:196-205. 2013
    ..Overall, these results suggested that cobalt may impact skeletal muscle homeostasis as an inducer of cell necrosis and myofiber atrophy. ..
  20. ncbi request reprint Supplementation with essential amino acids in middle age maintains the health of rat kidney
    G Corsetti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Int J Immunopathol Pharmacol 23:523-33. 2010
    ..Mitochondrial area and density after EAA intake did not differ from young groups. The results suggest that prolonged EAA intake could represent a strategy for maintaining the healthy status of the kidney in M-aged animals...
  21. ncbi request reprint Exposure to aluminium changes the NADPH-diaphorase/NPY pattern in the rat cerebral cortex
    L F Rodella
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Arch Histol Cytol 69:13-21. 2006
    ..In addition, the decrease in the NPY system found at 6 and 12 months may indicate that Al affected nitroxidergic and NPY systems at different times...
  22. ncbi request reprint Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain
    L F Rodella
    Unit of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Histol Histopathol 23:433-9. 2008
    ..So, we hypothesise that chronic Al administration is responsible for oxidative cell damage that interferes with ER functions inducing Abeta accumulation and neurodegenerative damage...
  23. doi request reprint Morphological and biochemical studies on aging and autophagy
    Rita Rezzani
    Anatomy Section, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Ageing Res Rev 11:10-31. 2012
    ..At the end, these data would summarize the autophagic link with aging process, as important tools in the future biogerontology scenario...
  24. ncbi request reprint Dose-dependent mercuric chloride tubular injury in rat kidney
    A Stacchiotti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Ultrastruct Pathol 27:253-9. 2003
    ..These findings will be useful for better understanding of the pathogenesis of mercury nephrotoxicity and its genotoxic effect...
  25. ncbi request reprint Cyclosporine A-induced kidney alterations are limited by melatonin in rats: an electron microscope study
    A Stacchiotti
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Ultrastruct Pathol 26:81-7. 2002
    ..After CsA plus melatonin, these parameters were reduced in the proximal tubules and restored in the glomerulus. In conclusion, melatonin attenuated morpho-quantitative alterations induced by CsA in the rat kidney...
  26. ncbi request reprint Distribution of heat shock proteins in kidneys of rats after immunosuppressive treatment with cyclosporine A
    A Stacchiotti
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Acta Histochem 103:167-77. 2001
    ..These findings suggest that these proteins are functionally involved in the defence against renal cellular damage caused by prolonged drug treatment in rat...
  27. ncbi request reprint Cytoplasmic changes in satellite cells of spinal ganglia induced by cisplatin treatment in rats
    G Corsetti
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Ultrastruct Pathol 24:259-65. 2000
    ..It appears that not only the DRG neurons but also and principally the SC were involved in the peripheral neuropathy mechanisms caused typically from therapeutic cis-DDP administration...
  28. ncbi request reprint Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats
    Stephen J Peterson
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 322:514-20. 2007
    ....