Edoardo Spina

Summary

Affiliation: University of Messina
Country: Italy

Publications

  1. doi request reprint Clinically significant drug interactions with newer antidepressants
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    CNS Drugs 26:39-67. 2012
  2. pmc Pharmacogenetics of antidepressants
    Concetta Crisafulli
    Institute of Psychiatry, University of Bologna Bologna, Italy
    Front Pharmacol 2:6. 2011
  3. ncbi request reprint Clinically relevant interactions between newer antidepressants and second-generation antipsychotics
    Edoardo Spina
    University of Messina, Policlinico Universitario, Department of Clinical and Experimental Medicine, Via Consolare Valeria, 98125 Messina, Italy 39 090 2213647 39 090 2213300
    Expert Opin Drug Metab Toxicol 10:721-46. 2014
  4. ncbi request reprint Effect of adjunctive lamotrigine treatment on the plasma concentrations of clozapine, risperidone and olanzapine in patients with schizophrenia or bipolar disorder
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Ther Drug Monit 28:599-602. 2006
  5. ncbi request reprint Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia
    Edoardo Spina
    University of Messina, Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    Expert Opin Drug Metab Toxicol 4:629-38. 2008
  6. ncbi request reprint Antiepileptic drugs: indications other than epilepsy
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Epileptic Disord 6:57-75. 2004
  7. ncbi request reprint Plasma risperidone concentrations during combined treatment with sertraline
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Ther Drug Monit 26:386-90. 2004
  8. ncbi request reprint The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia
    Edoardo Spina
    Universiy of Messina, Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    Expert Opin Drug Saf 6:651-62. 2007
  9. ncbi request reprint Metabolic drug interactions with newer antipsychotics: a comparative review
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and IRCCS Neurological Center Bonino Pulejo, Messina, Italy, and Eastern State Hospital, Lexington, KY, USA
    Basic Clin Pharmacol Toxicol 100:4-22. 2007
  10. ncbi request reprint Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Clin Ther 30:1206-27. 2008

Collaborators

Detail Information

Publications71

  1. doi request reprint Clinically significant drug interactions with newer antidepressants
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    CNS Drugs 26:39-67. 2012
    ..Knowledge of the interaction potential of individual antidepressants is essential for safe prescribing and may help clinicians to predict and eventually avoid certain drug combinations...
  2. pmc Pharmacogenetics of antidepressants
    Concetta Crisafulli
    Institute of Psychiatry, University of Bologna Bologna, Italy
    Front Pharmacol 2:6. 2011
    ..In conclusion, gene variants seem to influence human behavior, liability to disorders and treatment response. Nonetheless, gene × environment interactions have been hypothesized to modulate several of these effects...
  3. ncbi request reprint Clinically relevant interactions between newer antidepressants and second-generation antipsychotics
    Edoardo Spina
    University of Messina, Policlinico Universitario, Department of Clinical and Experimental Medicine, Via Consolare Valeria, 98125 Messina, Italy 39 090 2213647 39 090 2213300
    Expert Opin Drug Metab Toxicol 10:721-46. 2014
    ..Pharmacokinetic drug interaction (PK DI) and poorly understood pharmacodynamic (PD) drug interaction (PD DI) can occur between them...
  4. ncbi request reprint Effect of adjunctive lamotrigine treatment on the plasma concentrations of clozapine, risperidone and olanzapine in patients with schizophrenia or bipolar disorder
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Ther Drug Monit 28:599-602. 2006
    ..The modest elevation in plasma olanzapine concentration, possibly due to inhibition of UGT1A4-mediated olanzapine glucuronidation, is unlikely to be of clinical significance...
  5. ncbi request reprint Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia
    Edoardo Spina
    University of Messina, Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    Expert Opin Drug Metab Toxicol 4:629-38. 2008
    ..Sertindole is a second-generation antipsychotic recently reintroduced in the market for the treatment of schizophrenia after a reevaluation of its risks and benefits...
  6. ncbi request reprint Antiepileptic drugs: indications other than epilepsy
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Epileptic Disord 6:57-75. 2004
    ..In addition, newer AEDs appear to have a more favourable tolerability and drug interaction profile as compared to older compounds, so thus improving compliance to treatment...
  7. ncbi request reprint Plasma risperidone concentrations during combined treatment with sertraline
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Ther Drug Monit 26:386-90. 2004
    ..However, higher doses of sertraline may elevate plasma risperidone levels, presumably as a result of a dose-dependent inhibitory effect of sertraline on CYP2D6-mediated 9-hydroxylation of risperidone...
  8. ncbi request reprint The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia
    Edoardo Spina
    Universiy of Messina, Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    Expert Opin Drug Saf 6:651-62. 2007
    ..Safety data from elderly patients appear to be promising. Due to negligible hepatic biotransformation, paliperidone ER is unlikely to be involved in clinically significant metabolic drug-drug interactions...
  9. ncbi request reprint Metabolic drug interactions with newer antipsychotics: a comparative review
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and IRCCS Neurological Center Bonino Pulejo, Messina, Italy, and Eastern State Hospital, Lexington, KY, USA
    Basic Clin Pharmacol Toxicol 100:4-22. 2007
    ....
  10. ncbi request reprint Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Clin Ther 30:1206-27. 2008
    ..Rather, concern about drug interactions with second-generation antidepressants is based on their in vitro potential to inhibit > or = 1 CYP isozyme...
  11. doi request reprint Effect of valproate on olanzapine plasma concentrations in patients with bipolar or schizoaffective disorder
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Ther Drug Monit 31:758-63. 2009
    ..New studies are needed to confirm that valproate could have mild inductive effects...
  12. ncbi request reprint Metabolic drug interactions with new psychotropic agents
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    Fundam Clin Pharmacol 17:517-38. 2003
    ..This information is essential for rational prescribing and may guide selection of an appropriate compound which is less likely to interact with already taken medication(s)...
  13. ncbi request reprint Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy
    J Clin Psychopharmacol 22:419-23. 2002
    ..This interaction may lead to toxic plasma risperidone concentrations. In addition to careful clinical observation, monitoring plasma risperidone levels may be of value in patients given adjunctive therapy with fluoxetine...
  14. ncbi request reprint Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine
    Maria G Scordo
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Basic Clin Pharmacol Toxicol 97:296-301. 2005
    ..05). These results suggest that CYP2D6 and CYP2C9 polymorphisms contribute to the interindividual variability in fluoxetine pharmacokinetics at steady-state...
  15. ncbi request reprint Use and tolerability of newer antipsychotics and antidepressants: a chart review in a paediatric setting
    Marianna Alacqua
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Pharm World Sci 30:44-50. 2008
    ..To analyse the prescribing pattern and the safety profile of different atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) during the years 2002-2003 in paediatric setting...
  16. ncbi request reprint Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophrenia
    Rocco Zoccali
    Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy
    Pharmacol Res 48:411-4. 2003
    ....
  17. doi request reprint Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study
    Antonio Bruno
    Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    J Psychopharmacol 26:1456-62. 2012
    ..004). The findings provide evidence that lamotrigine augmentation of SRI treatment is well tolerated and may be proposed as an effective therapeutic strategy to improve outcome in treatment-resistant OCD...
  18. doi request reprint Effect of aripiprazole augmentation of clozapine in schizophrenia: a double-blind, placebo-controlled study
    Maria Rosaria A Muscatello
    Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    Schizophr Res 127:93-9. 2011
    ....
  19. ncbi request reprint Plasma concentrations of risperidone and olanzapine during coadministration with oxcarbazepine
    Maria Rosaria Muscatello
    Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Italy
    Epilepsia 46:771-4. 2005
    ..The aim of this investigation was to evaluate the effect of a treatment with OXC on plasma concentrations of the new antipsychotics risperidone and olanzapine...
  20. ncbi request reprint Effect of fluvoxamine on plasma risperidone concentrations in patients with schizophrenia
    Concetta D'Arrigo
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario di Messina, Italy
    Pharmacol Res 52:497-501. 2005
    ..However, higher doses of fluvoxamine may elevate plasma risperidone levels, presumably as a result of a dose-dependent inhibitory effect of fluvoxamine on CYP2D6-and/or CYP3A4-mediated 9-hydroxylation of risperidone...
  21. doi request reprint Duloxetine as adjunctive treatment to clozapine in patients with schizophrenia: a randomized, placebo-controlled trial
    Umberto Mico'
    Department of Neurosciences, Section of Psychiatry, Psychiatric and Anaesthesiological Sciences, Centro Neurolesi Bonino Pulejo, Messina, Italy
    Int Clin Psychopharmacol 26:303-10. 2011
    ..The findings provide evidence that duloxetine augmentation of clozapine treatment is safe and well tolerated and may be of benefit for patients who are partially responsive to clozapine monotherapy...
  22. doi request reprint Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents
    Gaetana Migliardi
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 33:1496-501. 2009
    ..Future prolactin studies in children and adolescents taking antipsychotics need to include larger samples with more frequent prolactin measures and long-term plasma concentrations...
  23. ncbi request reprint The effect of mirtazapine augmentation of clozapine in the treatment of negative symptoms of schizophrenia: a double-blind, placebo-controlled study
    Rocco Zoccali
    Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    Int Clin Psychopharmacol 19:71-6. 2004
    ..These findings suggest a potential role for mirtazapine as an augmentation strategy in the treatment of negative symptoms of schizophrenia...
  24. pmc Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: a population-based study during 2004-07
    Alessandro Oteri
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
    Br J Clin Pharmacol 70:514-22. 2010
    ....
  25. ncbi request reprint Effect of topiramate on plasma concentrations of clozapine, olanzapine, risperidone, and quetiapine in patients with psychotic disorders
    Gaetana Migliardi
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Clin Neuropharmacol 30:107-13. 2007
    ..To investigate the effect of topiramate on the steady-state plasma concentrations of the second-generation antipsychotics--clozapine, olanzapine, risperidone, and quetiapine--in patients with schizophrenia or bipolar disorder...
  26. doi request reprint Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Parkinsonism Relat Disord 14:420-5. 2008
    ..A high proportion of APD users (15-20%) received only one prescription during the study period...
  27. pmc Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice
    Rosalia Crupi
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    BMC Complement Altern Med 11:7. 2011
    ..The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration...
  28. doi request reprint Melatonin's stimulatory effect on adult hippocampal neurogenesis in mice persists after ovariectomy
    Rosalia Crupi
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    J Pineal Res 51:353-60. 2011
    ....
  29. ncbi request reprint Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorder
    Giuseppina D'Amico
    Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 27:619-23. 2003
    ..Our findings confirm the results of previous studies and indicate that the addition of olanzapine to ongoing treatment with serotonin reuptake inhibitors (SRI) may be beneficial in some patients unresponsive to SRI monotherapy...
  30. doi request reprint A nationwide prospective study on prescribing pattern of antidepressant drugs in Italian primary care
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Eur J Clin Pharmacol 69:227-36. 2013
    ..Our purpose was to explore antidepressant drug (AD) prescribing patterns in Italian primary care...
  31. ncbi request reprint Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population
    Maria Gabriella Scordo
    Department of Experimental and Clinical Medicine and Pharmacology, Section of Pharmacology, University of Messina, Torre Biologica, Policlinico Universitario, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Pharmacol Res 50:195-200. 2004
    ..Conversely, the prevalence of CYP2D6 gene duplication among Italians resulted very high, confirming the higher frequency of CYP2D6 UM in the Mediterranean area compared to Northern Europe...
  32. doi request reprint Augmentation of clozapine with ziprasidone in refractory schizophrenia: a double-blind, placebo-controlled study
    Maria Rosaria A Muscatello
    From the Section of Psychiatry, Department of Neurosciences, University of Messina, Messina and Istituto Clinico Prof Dr R De Blasi, Reggio Calabria and Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    J Clin Psychopharmacol 34:129-33. 2014
    ..002). Ziprasidone added to clozapine was effective on negative and cognitive symptoms, although it may be proposed as a helpful treatment in schizophrenia, mainly for those patients who partially respond to clozapine monotherapy...
  33. ncbi request reprint Determination of olanzapine in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection
    Concetta D'Arrigo
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Ther Drug Monit 28:388-93. 2006
    ..00% to 1.24%. Limit of detection and limit of quantification for olanzapine were 2 and 5 ng/mL, respectively. The method is suitable for pharmacokinetic studies and therapeutic drug monitoring...
  34. doi request reprint Interactions between antiepileptics and second-generation antipsychotics
    Jose de Leon
    University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
    Expert Opin Drug Metab Toxicol 8:311-34. 2012
    ..Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder...
  35. ncbi request reprint Co-prescriptions with itraconazole and fluconazole as a signal for possible risk of drug-drug interactions: a four-year analysis from Italian general practice
    Laura Galatti
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Torre Biologica Policlinico Universitario, Via Consolare Valeria Gazzi, Messina, Italy
    Pharmacoepidemiol Drug Saf 16:422-8. 2007
    ..To determine the prevalence of concomitant use of drugs potentially responsible for interactions among itraconazole and fluconazole users in general practice...
  36. ncbi request reprint Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 16:552-9. 2007
    ..To estimate 1-year prevalence, 1-year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003-2004...
  37. doi request reprint Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism
    Stefano Porcelli
    University of Bologna, Institute of Psychiatry, Italy
    Expert Opin Drug Metab Toxicol 7:1101-15. 2011
    ..The authors aim to give an overview of the published studies analyzing the influence of CYP highly polymorphic loci on antidepressant treatment in order to translate the acquired knowledge to a clinical level...
  38. pmc Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies
    Jose de Leon
    University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky 40508, USA
    Ther Drug Monit 35:30-47. 2013
    ..Clobazam was recently approved for Lennox-Gastaut syndrome in the United States. There is no published review article focused on clobazam therapeutic drug monitoring (TDM) in English...
  39. ncbi request reprint Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98100 Messina, Italy
    Eur J Clin Pharmacol 61:47-53. 2005
    ..To assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999-2002. To estimate the persistence with antipsychotic medications, and to measure their off-label use...
  40. ncbi request reprint Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implications
    Antonella Gagliano
    University of Messina, Gazzi Messina, Italy
    J Child Adolesc Psychopharmacol 14:39-47. 2004
    ..In particular, risperidone appears to be effective in treating aggressiveness, hyperactivity, irritability, stereotypies, social withdrawal, and lack of interests...
  41. doi request reprint Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study
    Maria Rosaria A Muscatello
    Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    J Clin Psychopharmacol 31:174-9. 2011
    ..015). The findings provide evidence that aripiprazole augmentation of SRIs/clomipramine treatment is well tolerated and may be proposed as an effective therapeutic strategy to improve outcome in treatment-resistant OCD...
  42. ncbi request reprint Short-term memory loss associated with rosuvastatin
    Laura Galatti
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy
    Pharmacotherapy 26:1190-2. 2006
    ..During the following year, the patient remained free from neuropsychiatric disturbances. Clinicians should be aware of possible adverse cognitive reactions during statin therapy, including rosuvastatin...
  43. doi request reprint Restless Leg Syndrome in ADHD children: levetiracetam as a reasonable therapeutic option
    Antonella Gagliano
    Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Italy
    Brain Dev 33:480-6. 2011
    ..These children may represent a subgroup of ADHD patients in which the hyperactivity and attention difficulties might be aggravated by sleep disturbances and by IEDs. LEV could represent a therapeutic option for these comorbid conditions...
  44. ncbi request reprint Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract
    Filippo Caraci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Curr Drug Metab 12:570-7. 2011
    ..Although these interactions are often predictable, the use of fluoxetine, paroxetine and Hypericum extract should be avoided in cancer patients...
  45. doi request reprint Changes in the prescribing pattern of antidepressant drugs in elderly patients: an Italian, nationwide, population-based study
    Janet Sultana
    Department of Clinical and Experimental Medicine, Pharmacology Section, University of Messina, Via Consolare Valeria, 98125, Messina, Italy
    Eur J Clin Pharmacol 70:469-78. 2014
    ..The aim of this study was to analyze the trend in the use of ADs in the Italian elderly patients in the years 2003-2009, and specifically, to evaluate rates and predictors of AD treatment discontinuation in depressed older patients...
  46. ncbi request reprint Preclinical data supporting/refuting the use of Hypericum perforatum in the treatment of depression
    Rosalia Crupi
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    CNS Neurol Disord Drug Targets 12:474-86. 2013
    ....
  47. doi request reprint Acute cerebellar ataxia following meningococcal group C conjugate vaccination
    Paola Maria Cutroneo
    1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    J Child Neurol 29:128-30. 2014
    ..Progressive clinical improvement was obtained after corticosteroid treatment. This case increases the small number of postvaccinal ataxias and contributes to further clarifying the complex pathogenesis of this disorder. ..
  48. ncbi request reprint Cytochrome P450 polymorphisms and response to antipsychotic therapy
    Maria Gabriella Scordo
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, I 98125 Messina, Italy
    Pharmacogenomics 3:201-18. 2002
    ....
  49. ncbi request reprint Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis
    Letterio Morgante
    Department of Neuroscience, Psychiatry and Anesthesiology, University of Messina, Policlinico Universitario, Italy
    Clin Neuropharmacol 27:153-6. 2004
    ..This study aimed to compare the efficacy and safety of quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis in a randomized, open-label, blinded-rater, parallel group trial...
  50. ncbi request reprint Rabeprazole and psychiatric symptoms
    Giovanni Polimeni
    Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino Pulejo, Messina, Italy
    Ann Pharmacother 41:1315-7. 2007
    ..To report the case of a patient who developed marked anxiety associated with episodes of panic attacks after starting rabeprazole therapy...
  51. ncbi request reprint Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs
    Edoardo Spina
    Institute of Pharmacology, University of Messina, Messina, Italy
    Epilepsia 43:37-44. 2002
    ..Apart from careful clinical observation, serum level monitoring of AEDs and psychotropic drugs can be useful in determining the need for dosage adjustments, especially if there is any change in seizure control, or possible toxicity...
  52. ncbi request reprint Venlafaxine-induced urinary incontinence resolved after switching to sertraline
    Giovanni Polimeni
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Clin Neuropharmacol 28:247-8. 2005
    ..Further studies need to be carried out to clarify the pharmacologic differences between dual and selective 5-HT and norepinephrine reuptake inhibitors on lower urinary tract function...
  53. doi request reprint Newer and older antiepileptic drug use in Southern Italy: a population-based study during the years 2003-2005
    Marianna Alacqua
    IRCCS Centro Neurolesi Bonino Pulejo, Via Palermo C da Casazza, Messina 98124, Italy
    Epilepsy Res 85:107-13. 2009
    ..To analyse the prescribing pattern of newer and older antiepileptic drugs (AEDs) during the years 2003-2005...
  54. doi request reprint ECG parameters in children and adolescents treated with aripiprazole and risperidone
    Eva Germano
    Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 51:23-7. 2014
    ..Caution in prescribing these drugs, however, is necessary in patients with family history of a genetic predisposition to arrhythmias in order to warrant a reliable assessment of drug-induced QT prolongation...
  55. doi request reprint Clinically relevant drug interactions in anxiety disorders
    Maria Rosaria Muscatello
    Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    Hum Psychopharmacol 27:239-53. 2012
    ..There is a need for an updated comparative review of clinically relevant drug interactions in this area...
  56. ncbi request reprint Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance
    Maria Gabriella Scordo
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Clin Pharmacol Ther 72:702-10. 2002
    ..Our objective was to determine the influence of cytochrome P450 (CYP) 2C9 and CYP2C19 genetic polymorphisms on warfarin dose requirement and metabolic clearance...
  57. doi request reprint Use of antipsychotics in elderly patients with dementia: do atypical and conventional agents have a similar safety profile?
    Gianluca Trifiro
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Pharmacol Res 59:1-12. 2009
    ..More effective interventions are necessary to improve postmarket drug safety in vulnerable populations...
  58. ncbi request reprint Clinically significant drug interactions with antidepressants in the elderly
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario, Messina, Italy
    Drugs Aging 19:299-320. 2002
    ..Among other newer antidepressants, nefazodone is a potent inhibitor of CYP3A4 and its combination with substrates of this isoform should be avoided...
  59. doi request reprint Effects of L'Aquila earthquake on the prescribing pattern of antidepressant and antipsychotic drugs
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    Int J Clin Pharm 35:1053-62. 2013
    ..Moreover, it could be useful to both identify risk categories that require special assistance and assess possible drug abuse or misuse...
  60. ncbi request reprint Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in Italy
    Laura Galatti
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Torre Biologica Policlinico Universitario, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Pharmacol Res 51:211-6. 2005
    ..In conclusion, the present study carried out in general practice underlines the importance of neuropsychiatric ADRs and reminds GPs to pay attention to this kind of toxicity when they prescribe pharmacological agents to their patients...
  61. doi request reprint Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice
    Rosalia Crupi
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    J Pineal Res 49:123-9. 2010
    ..These findings suggest a strong correspondence between behavior and neurogenesis, strengthening the hypothesis that neurogenesis contributes to the effects of melatonin as an antidepressant...
  62. doi request reprint Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients
    Stefania Mondello
    Department of Internal Medicine, Messina University Hospital, School of Medicine, University of Messina, Messina, Italy
    Nutrition 26:677-81. 2010
    ..We investigated the effect of total parenteral nutrition supplemented with glutamine on the immune system in anorectic patients...
  63. ncbi request reprint Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response
    Giovanna Jannuzzi
    Clinical Pharmacology Unit and University of Pavia, Italy
    Ther Drug Monit 24:616-27. 2002
    ..In addition, a considerable variability was found in the enantiomers' concentrations associated with a favorable therapeutic response...
  64. ncbi request reprint Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind study
    Jean Pierre Olie
    Department of Mental Health and Therapy, Sainte Anne Hospital, Paris, France
    Int Clin Psychopharmacol 21:143-51. 2006
    ....
  65. doi request reprint Estimating the effects of co-medications on plasma olanzapine concentrations by using a mixed model
    Sheila Botts
    College of Pharmacy, University of Kentucky, Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, United States
    Prog Neuropsychopharmacol Biol Psychiatry 32:1453-8. 2008
    ..Other limitations were the small sample size of some drug sub-samples and the lack of testing for plasma olanzapine metabolites...
  66. doi request reprint Risk of stroke with typical and atypical anti-psychotics: a retrospective cohort study including unexposed subjects
    Emilio Sacchetti
    University Psychiatric Unit, Brescia University School of Medicine and Department of Mental Health, Brescia Spedali Civili, Italy
    J Psychopharmacol 22:39-46. 2008
    ..46 times for atypicals. Clinicians should be cautious in prescribing phenotiazines and butyrophenones in elderly patients, since the risk for stroke would seem comparable or even greater than with atypicals...
  67. doi request reprint Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients
    Arzu Gunes
    Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, SE 75185, Uppsala, Sweden
    Eur J Clin Pharmacol 64:477-82. 2008
    ..Serotonin 2C receptors (5-HT(2C)) have regulatory effects on dopaminergic pathways in brain regions involved with EPS. Polymorphisms in the 5-HT(2C) gene (HTR2C) have been suggested to be associated with the risk of developing EPS...
  68. ncbi request reprint Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms
    Cüneyt Güzey
    Department of Clinical Pharmacology, St Olav University Hospital, Trondheim, Norway
    Eur J Clin Pharmacol 63:233-41. 2007
    ..Little is known about the influence of polymorphisms of the dopamine and serotonin system on the risk for extrapyramidal symptoms (EPS) during treatment with antipsychotic drugs...
  69. ncbi request reprint No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population
    Maria Gabriella Scordo
    Department of Medical Sciences, Clinical Pharmacology, University of Uppsala, Akademiska sjukhuset, Ing 61, 75185 Uppsala, Sweden
    Pharmacol Res 53:162-5. 2006
    ..Our results indicate that CYP2D6 polymorphism is unlikely to represent a major risk factor in susceptibility to Alzheimer's disease...
  70. ncbi request reprint Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography
    Giuliana Gatti
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 784:375-83. 2003
    ..Standard curves are linear for each enantiomer (r(2)>/=0.992) over the range of 10-1000 ng/ml with a limit of quantification of 10 ng/ml for each enantiomer. Within-day and between-day CV% are </=10% for each enantiomer...