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Species | Edoardo SpinaSummaryAffiliation: University of Messina Country: Italy Publications
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Clinically significant drug interactions with newer antidepressantsEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
CNS Drugs 26:39-67. 2012..Knowledge of the interaction potential of individual antidepressants is essential for safe prescribing and may help clinicians to predict and eventually avoid certain drug combinations...
Plasma risperidone concentrations during combined treatment with sertralineEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Ther Drug Monit 26:386-90. 2004..However, higher doses of sertraline may elevate plasma risperidone levels, presumably as a result of a dose-dependent inhibitory effect of sertraline on CYP2D6-mediated 9-hydroxylation of risperidone...- Metabolic drug interactions with newer antipsychotics: a comparative reviewEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and IRCCS Neurological Center Bonino Pulejo, Messina, Italy, and Eastern State Hospital, Lexington, KY, USA
Basic Clin Pharmacol Toxicol 100:4-22. 2007.... - Effect of adjunctive lamotrigine treatment on the plasma concentrations of clozapine, risperidone and olanzapine in patients with schizophrenia or bipolar disorderEdoardo Spina
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
Ther Drug Monit 28:599-602. 2006..The modest elevation in plasma olanzapine concentration, possibly due to inhibition of UGT1A4-mediated olanzapine glucuronidation, is unlikely to be of clinical significance... - The pharmacology and safety of paliperidone extended-release in the treatment of schizophreniaEdoardo Spina
Universiy of Messina, Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
Expert Opin Drug Saf 6:651-62. 2007..Safety data from elderly patients appear to be promising. Due to negligible hepatic biotransformation, paliperidone ER is unlikely to be involved in clinically significant metabolic drug-drug interactions... - Sertindole: pharmacological and clinical profile and role in the treatment of schizophreniaEdoardo Spina
University of Messina, Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
Expert Opin Drug Metab Toxicol 4:629-38. 2008..Sertindole is a second-generation antipsychotic recently reintroduced in the market for the treatment of schizophrenia after a reevaluation of its risks and benefits... - Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an updateEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Clin Ther 30:1206-27. 2008..Rather, concern about drug interactions with second-generation antidepressants is based on their in vitro potential to inhibit > or = 1 CYP isozyme... - Effect of valproate on olanzapine plasma concentrations in patients with bipolar or schizoaffective disorderEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
Ther Drug Monit 31:758-63. 2009..New studies are needed to confirm that valproate could have mild inductive effects... - Antiepileptic drugs: indications other than epilepsyEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Epileptic Disord 6:57-75. 2004..In addition, newer AEDs appear to have a more favourable tolerability and drug interaction profile as compared to older compounds, so thus improving compliance to treatment... - Metabolic drug interactions with new psychotropic agentsEdoardo Spina
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
Fundam Clin Pharmacol 17:517-38. 2003..This information is essential for rational prescribing and may guide selection of an appropriate compound which is less likely to interact with already taken medication(s)... - Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interactionEdoardo Spina
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy
J Clin Psychopharmacol 22:419-23. 2002..This interaction may lead to toxic plasma risperidone concentrations. In addition to careful clinical observation, monitoring plasma risperidone levels may be of value in patients given adjunctive therapy with fluoxetine... - Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetineMaria G Scordo
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
Basic Clin Pharmacol Toxicol 97:296-301. 2005..05). These results suggest that CYP2D6 and CYP2C9 polymorphisms contribute to the interindividual variability in fluoxetine pharmacokinetics at steady-state... - Use and tolerability of newer antipsychotics and antidepressants: a chart review in a paediatric settingMarianna Alacqua
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Pharm World Sci 30:44-50. 2008..To analyse the prescribing pattern and the safety profile of different atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) during the years 2002-2003 in paediatric setting... - Effect of aripiprazole augmentation of clozapine in schizophrenia: a double-blind, placebo-controlled studyMaria Rosaria A Muscatello
Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
Schizophr Res 127:93-9. 2011.... - Duloxetine as adjunctive treatment to clozapine in patients with schizophrenia: a randomized, placebo-controlled trialUmberto Mico'
Department of Neurosciences, Section of Psychiatry, Psychiatric and Anaesthesiological Sciences, Centro Neurolesi Bonino Pulejo, Messina, Italy
Int Clin Psychopharmacol 26:303-10. 2011..The findings provide evidence that duloxetine augmentation of clozapine treatment is safe and well tolerated and may be of benefit for patients who are partially responsive to clozapine monotherapy... - Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophreniaRocco Zoccali
Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy
Pharmacol Res 48:411-4. 2003.... - Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescentsGaetana Migliardi
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Prog Neuropsychopharmacol Biol Psychiatry 33:1496-501. 2009..Future prolactin studies in children and adolescents taking antipsychotics need to include larger samples with more frequent prolactin measures and long-term plasma concentrations... - Effect of fluvoxamine on plasma risperidone concentrations in patients with schizophreniaGaetana Migliardi
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario di Messina, Italy
Pharmacol Res 52:497-501. 2005..However, higher doses of fluvoxamine may elevate plasma risperidone levels, presumably as a result of a dose-dependent inhibitory effect of fluvoxamine on CYP2D6-and/or CYP3A4-mediated 9-hydroxylation of risperidone... - Plasma concentrations of risperidone and olanzapine during coadministration with oxcarbazepineMaria Rosaria Muscatello
Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Italy
Epilepsia 46:771-4. 2005..CONCLUSIONS: Our findings indicate that OXC does not affect the elimination of risperidone and olanzapine, thus confirming its weak inducing effect on hepatic drug-metabolizing enzymes... - The effect of mirtazapine augmentation of clozapine in the treatment of negative symptoms of schizophrenia: a double-blind, placebo-controlled studyRocco Zoccali
Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
Int Clin Psychopharmacol 19:71-6. 2004..These findings suggest a potential role for mirtazapine as an augmentation strategy in the treatment of negative symptoms of schizophrenia... 
Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: a population-based study during 2004-07Alessandro Oteri
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
Br J Clin Pharmacol 70:514-22. 2010....- Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005Gianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Parkinsonism Relat Disord 14:420-5. 2008..A high proportion of APD users (15-20%) received only one prescription during the study period... - Effect of topiramate on plasma concentrations of clozapine, olanzapine, risperidone, and quetiapine in patients with psychotic disordersGaetana Migliardi
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Clin Neuropharmacol 30:107-13. 2007..To investigate the effect of topiramate on the steady-state plasma concentrations of the second-generation antipsychotics--clozapine, olanzapine, risperidone, and quetiapine--in patients with schizophrenia or bipolar disorder... - Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in miceRosalia Crupi
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
BMC Complement Altern Med 11:7. 2011..The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration... - Melatonin's stimulatory effect on adult hippocampal neurogenesis in mice persists after ovariectomyRosalia Crupi
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
J Pineal Res 51:353-60. 2011.... - Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled studyAntonio Bruno
1Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
J Psychopharmacol 26:1456-62. 2012..004). The findings provide evidence that lamotrigine augmentation of SRI treatment is well tolerated and may be proposed as an effective therapeutic strategy to improve outcome in treatment-resistant OCD... - Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian populationMaria Gabriella Scordo
Department of Experimental and Clinical Medicine and Pharmacology, Section of Pharmacology, University of Messina, Torre Biologica, Policlinico Universitario, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Pharmacol Res 50:195-200. 2004..Conversely, the prevalence of CYP2D6 gene duplication among Italians resulted very high, confirming the higher frequency of CYP2D6 UM in the Mediterranean area compared to Northern Europe... - Interactions between antiepileptics and second-generation antipsychoticsJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Expert Opin Drug Metab Toxicol 8:311-34. 2012.... - Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004Gianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
Pharmacoepidemiol Drug Saf 16:552-9. 2007..To estimate 1-year prevalence, 1-year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003-2004... - Co-prescriptions with itraconazole and fluconazole as a signal for possible risk of drug-drug interactions: a four-year analysis from Italian general practiceLaura Galatti
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Torre Biologica Policlinico Universitario, Via Consolare Valeria Gazzi, Messina, Italy
Pharmacoepidemiol Drug Saf 16:422-8. 2007..To determine the prevalence of concomitant use of drugs potentially responsible for interactions among itraconazole and fluconazole users in general practice... - Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorderClemente Cedro
Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy
Prog Neuropsychopharmacol Biol Psychiatry 27:619-23. 2003..Our findings confirm the results of previous studies and indicate that the addition of olanzapine to ongoing treatment with serotonin reuptake inhibitors (SRI) may be beneficial in some patients unresponsive to SRI monotherapy... - Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implicationsAntonella Gagliano
University of Messina, Gazzi Messina, Italy
J Child Adolesc Psychopharmacol 14:39-47. 2004..In particular, risperidone appears to be effective in treating aggressiveness, hyperactivity, irritability, stereotypies, social withdrawal, and lack of interests... - Determination of olanzapine in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detectionGaetana Migliardi
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Ther Drug Monit 28:388-93. 2006..00% to 1.24%. Limit of detection and limit of quantification for olanzapine were 2 and 5 ng/mL, respectively. The method is suitable for pharmacokinetic studies and therapeutic drug monitoring... - Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002Gianluca Trifiro
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98100 Messina, Italy
Eur J Clin Pharmacol 61:47-53. 2005..To assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999-2002. To estimate the persistence with antipsychotic medications, and to measure their off-label use... - Restless Leg Syndrome in ADHD children: levetiracetam as a reasonable therapeutic optionAntonella Gagliano
Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Italy
Brain Dev 33:480-6. 2011..These children may represent a subgroup of ADHD patients in which the hyperactivity and attention difficulties might be aggravated by sleep disturbances and by IEDs. LEV could represent a therapeutic option for these comorbid conditions... - Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled studyMaria Rosaria A Muscatello
Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
J Clin Psychopharmacol 31:174-9. 2011..015). The findings provide evidence that aripiprazole augmentation of SRIs/clomipramine treatment is well tolerated and may be proposed as an effective therapeutic strategy to improve outcome in treatment-resistant OCD... - Short-term memory loss associated with rosuvastatinLaura Galatti
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy
Pharmacotherapy 26:1190-2. 2006..During the following year, the patient remained free from neuropsychiatric disturbances. Clinicians should be aware of possible adverse cognitive reactions during statin therapy, including rosuvastatin... - Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extractFilippo Caraci
Department of Pharmaceutical Sciences, University of Catania, Italy
Curr Drug Metab 12:570-7. 2011..Although these interactions are often predictable, the use of fluoxetine, paroxetine and Hypericum extract should be avoided in cancer patients... - Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosisLetterio Morgante
Department of Neuroscience, Psychiatry and Anesthesiology, University of Messina, Policlinico Universitario, Italy
Clin Neuropharmacol 27:153-6. 2004..05) in both groups. Side effects were mild, generally transient, and well tolerated. CONCLUSIONS: Quetiapine and clozapine appear equally efficacious for treatment of dopaminergic psychosis in patients with PD... - Cytochrome P450 polymorphisms and response to antipsychotic therapyMaria Gabriella Scordo
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, I 98125 Messina, Italy
Pharmacogenomics 3:201-18. 2002.... - Rabeprazole and psychiatric symptomsGiovanni Polimeni
Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino Pulejo, Messina, Italy
Ann Pharmacother 41:1315-7. 2007..To report the case of a patient who developed marked anxiety associated with episodes of panic attacks after starting rabeprazole therapy... - Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugsEdoardo Spina
Institute of Pharmacology, University of Messina, Messina, Italy
Epilepsia 43:37-44. 2002..Apart from careful clinical observation, serum level monitoring of AEDs and psychotropic drugs can be useful in determining the need for dosage adjustments, especially if there is any change in seizure control, or possible toxicity... - Venlafaxine-induced urinary incontinence resolved after switching to sertralineGiovanni Polimeni
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Clin Neuropharmacol 28:247-8. 2005..Further studies need to be carried out to clarify the pharmacologic differences between dual and selective 5-HT and norepinephrine reuptake inhibitors on lower urinary tract function... - Newer and older antiepileptic drug use in Southern Italy: a population-based study during the years 2003-2005Marianna Alacqua
IRCCS Centro Neurolesi Bonino Pulejo, Via Palermo C da Casazza, Messina 98124, Italy
Epilepsy Res 85:107-13. 2009..To analyse the prescribing pattern of newer and older antiepileptic drugs (AEDs) during the years 2003-2005... - Clinically relevant drug interactions in anxiety disordersMaria Rosaria Muscatello
Section of Psychiatry, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
Hum Psychopharmacol 27:239-53. 2012..There is a need for an updated comparative review of clinically relevant drug interactions in this area... - Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearanceMaria Gabriella Scordo
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Clin Pharmacol Ther 72:702-10. 2002..Our objective was to determine the influence of cytochrome P450 (CYP) 2C9 and CYP2C19 genetic polymorphisms on warfarin dose requirement and metabolic clearance... - Clinically significant drug interactions with antidepressants in the elderlyEdoardo Spina
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Policlinico Universitario, Messina, Italy
Drugs Aging 19:299-320. 2002..Among other newer antidepressants, nefazodone is a potent inhibitor of CYP3A4 and its combination with substrates of this isoform should be avoided... - Use of antipsychotics in elderly patients with dementia: do atypical and conventional agents have a similar safety profile?Gianluca Trifiro
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Pharmacol Res 59:1-12. 2009..More effective interventions are necessary to improve postmarket drug safety in vulnerable populations... - Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in ItalyLaura Galatti
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Torre Biologica Policlinico Universitario, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Pharmacol Res 51:211-6. 2005..In conclusion, the present study carried out in general practice underlines the importance of neuropsychiatric ADRs and reminds GPs to pay attention to this kind of toxicity when they prescribe pharmacological agents to their patients... - Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated miceRosalia Crupi
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
J Pineal Res 49:123-9. 2010..These findings suggest a strong correspondence between behavior and neurogenesis, strengthening the hypothesis that neurogenesis contributes to the effects of melatonin as an antidepressant... - Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patientsStefania Mondello
Department of Internal Medicine, Messina University Hospital, School of Medicine, University of Messina, Messina, Italy
Nutrition 26:677-81. 2010..We investigated the effect of total parenteral nutrition supplemented with glutamine on the immune system in anorectic patients... - Risk of stroke with typical and atypical anti-psychotics: a retrospective cohort study including unexposed subjectsEmilio Sacchetti
University Psychiatric Unit, Brescia University School of Medicine and Department of Mental Health, Brescia Spedali Civili, Italy
J Psychopharmacol 22:39-46. 2008..46 times for atypicals. Clinicians should be cautious in prescribing phenotiazines and butyrophenones in elderly patients, since the risk for stroke would seem comparable or even greater than with atypicals... - Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind studyJean Pierre Olie
Department of Mental Health and Therapy, Sainte Anne Hospital, Paris, France
Int Clin Psychopharmacol 21:143-51. 2006.... - Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical responseGiovanna Jannuzzi
Clinical Pharmacology Unit and University of Pavia, Italy
Ther Drug Monit 24:616-27. 2002..In addition, a considerable variability was found in the enantiomers' concentrations associated with a favorable therapeutic response... - Estimating the effects of co-medications on plasma olanzapine concentrations by using a mixed modelSheila Botts
College of Pharmacy, University of Kentucky, Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, United States
Prog Neuropsychopharmacol Biol Psychiatry 32:1453-8. 2008..Other limitations were the small sample size of some drug sub-samples and the lack of testing for plasma olanzapine metabolites... - No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian populationMaria Gabriella Scordo
Department of Medical Sciences, Clinical Pharmacology, University of Uppsala, Akademiska sjukhuset, Ing 61, 75185 Uppsala, Sweden
Pharmacol Res 53:162-5. 2006..Our results indicate that CYP2D6 polymorphism is unlikely to represent a major risk factor in susceptibility to Alzheimer's disease... - Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphismsCüneyt Güzey
Department of Clinical Pharmacology, St Olav University Hospital, Trondheim, Norway
Eur J Clin Pharmacol 63:233-41. 2007..Little is known about the influence of polymorphisms of the dopamine and serotonin system on the risk for extrapyramidal symptoms (EPS) during treatment with antipsychotic drugs... - Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatographyGiuliana Gatti
Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 784:375-83. 2003..Standard curves are linear for each enantiomer (r(2)>/=0.992) over the range of 10-1000 ng/ml with a limit of quantification of 10 ng/ml for each enantiomer. Within-day and between-day CV% are </=10% for each enantiomer... - Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patientsArzu Gunes
Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, SE 75185, Uppsala, Sweden
Eur J Clin Pharmacol 64:477-82. 2008..Serotonin 2C receptors (5-HT(2C)) have regulatory effects on dopaminergic pathways in brain regions involved with EPS. Polymorphisms in the 5-HT(2C) gene (HTR2C) have been suggested to be associated with the risk of developing EPS...