Stefano Sotgiu

Summary

Affiliation: University of Sassari
Country: Italy

Publications

  1. pmc Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population
    Maria Giovanna Marrosu
    Centro Sclerosi Multipla, Dipartimento di Scienze Neurologiche e Cardiovascolari, University of Cagliari, Italy
    BMC Genet 8:25. 2007
  2. ncbi request reprint Multiple sclerosis-associated retrovirus and optic neuritis
    S Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy
    Mult Scler 12:357-9. 2006
  3. ncbi request reprint Inflammatory biomarkers in blood of patients with acute brain ischemia
    S Sotgiu
    Institute of Clinical Neurology, University of Sassari, Sassari, Italy
    Eur J Neurol 13:505-13. 2006
  4. ncbi request reprint Seasonal fluctuation of multiple sclerosis births in Sardinia
    Stefano Sotgiu
    Istituto di Clinica Neurologica, Universita di Sassari, Viale San Pietro, 10, 07100, Sassari, Italy
    J Neurol 253:38-44. 2006
  5. ncbi request reprint Genes, environment, and susceptibility to multiple sclerosis
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, 07100 Sassari, Italy
    Neurobiol Dis 17:131-43. 2004
  6. ncbi request reprint Intrathecal chitotriosidase and the outcome of multiple sclerosis
    S Sotgiu
    Institute of Clinical Neurology, University of Sassari, Sassari, Italy
    Mult Scler 12:551-7. 2006
  7. doi request reprint Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains
    Stefano Sotgiu
    Dipartimento di Neuroscienze e Scienze Materno Infantili, University of Sassari, Italy
    J Neuroimmunol 197:70-3. 2008
  8. ncbi request reprint Chitotriosidase in patients with acute ischemic stroke
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Italy
    Eur Neurol 54:149-53. 2005
  9. ncbi request reprint Evidence of early childhood as the susceptibility period in multiple sclerosis: space-time cluster analysis in a Sardinian population
    Maura Pugliatti
    Institute of Clinical Neurology, Faculty of Medicine, University of Sassari, Sassari, Italy
    Am J Epidemiol 164:326-33. 2006
  10. ncbi request reprint Multiple sclerosis and anti-Plasmodium falciparum innate immune response
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro, 10 I 07100, Italy
    J Neuroimmunol 185:201-7. 2007

Collaborators

Detail Information

Publications35

  1. pmc Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population
    Maria Giovanna Marrosu
    Centro Sclerosi Multipla, Dipartimento di Scienze Neurologiche e Cardiovascolari, University of Cagliari, Italy
    BMC Genet 8:25. 2007
    ..Here we have assessed the association of MOG variation with MS in the Sardinian population to see if it represents an independent contributor to MS predisposition...
  2. ncbi request reprint Multiple sclerosis-associated retrovirus and optic neuritis
    S Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy
    Mult Scler 12:357-9. 2006
    ..3%). This intriguing finding is discussed in the light of the abundant discrepancies observed in the MSRV literature. Multiple Sclerosis 2006; 12: 357-359. www.multiplesclerosisjournal.com..
  3. ncbi request reprint Inflammatory biomarkers in blood of patients with acute brain ischemia
    S Sotgiu
    Institute of Clinical Neurology, University of Sassari, Sassari, Italy
    Eur J Neurol 13:505-13. 2006
    ..001). This novel finding allows us suggesting that IL-6, in the context of a complex pro-inflammatory network occurring during stroke, is associated with neuroprotection rather than neurotoxicity in patients with ischemic brain injury...
  4. ncbi request reprint Seasonal fluctuation of multiple sclerosis births in Sardinia
    Stefano Sotgiu
    Istituto di Clinica Neurologica, Universita di Sassari, Viale San Pietro, 10, 07100, Sassari, Italy
    J Neurol 253:38-44. 2006
    ....
  5. ncbi request reprint Genes, environment, and susceptibility to multiple sclerosis
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, 07100 Sassari, Italy
    Neurobiol Dis 17:131-43. 2004
    ..This renders MS etiopathogenesis more complex than formerly thought even in this selected and genetically stable population...
  6. ncbi request reprint Intrathecal chitotriosidase and the outcome of multiple sclerosis
    S Sotgiu
    Institute of Clinical Neurology, University of Sassari, Sassari, Italy
    Mult Scler 12:551-7. 2006
    ..001). These findings confirm that innate immunity, here represented by Chit, is clinically relevant in MS and allows, if confirmed, reconsidering novel MS therapeutic strategies specifically aimed at this branch of the immune response...
  7. doi request reprint Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains
    Stefano Sotgiu
    Dipartimento di Neuroscienze e Scienze Materno Infantili, University of Sassari, Italy
    J Neuroimmunol 197:70-3. 2008
    ..Microglia-derived Chit activity in MS may counterbalance the naturally occurring glucosamine aggregation, protecting the brain from the chitin-like substance deposition...
  8. ncbi request reprint Chitotriosidase in patients with acute ischemic stroke
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Italy
    Eur Neurol 54:149-53. 2005
    ..A relationship exists between the extent of brain damage and the plasma level of monocyte products, including chitotriosidase, though usually strictly related to preexisting infectious-inflammatory diseases...
  9. ncbi request reprint Evidence of early childhood as the susceptibility period in multiple sclerosis: space-time cluster analysis in a Sardinian population
    Maura Pugliatti
    Institute of Clinical Neurology, Faculty of Medicine, University of Sassari, Sassari, Italy
    Am J Epidemiol 164:326-33. 2006
    ..Early childhood seemed to be a period of increased susceptibility to MS. This evidence and the increasing incidence of MS in northern Sardinia are compatible with a change in environmental exposure...
  10. ncbi request reprint Multiple sclerosis and anti-Plasmodium falciparum innate immune response
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro, 10 I 07100, Italy
    J Neuroimmunol 185:201-7. 2007
    ..In conclusion, we have found evidences that some genetic traits formerly selected to confer a protective responses to P. falciparum now partially contribute to the elevated MS susceptibility amongst Sardinians...
  11. doi request reprint Clustering of multiple sclerosis, age of onset and gender in Sardinia
    Maura Pugliatti
    Dept Neurosciences, University of Sassari, Viale San Pietro 10, I 07100 Sassari, Italy
    J Neurol Sci 286:6-13. 2009
    ..Such factors are unlikely agents with fixed latency incubation period, but they could rather be the result of recent lifestyle changes and/or of their interplay with a highly susceptible genetic background...
  12. pmc Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis
    Giuseppe Mameli
    Department of Biomedical Sciences and Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari, Italy
    PLoS ONE 7:e44991. 2012
    ....
  13. ncbi request reprint Hygiene hypothesis: innate immunity, malaria and multiple sclerosis
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro, 10, 07100 Sassari, Italy
    Med Hypotheses 70:819-25. 2008
    ..This hypothesis may have an influence in re-directing clinicians toward a innate immunity-based rather than an antigen specific-based new MS therapies...
  14. ncbi request reprint Chitotriosidase and Alzheimer's disease
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Italy
    Curr Alzheimer Res 4:295-6. 2007
  15. ncbi request reprint Does the "hygiene hypothesis" provide an explanation for the high prevalence of multiple sclerosis in Sardinia?
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro, 10 I 07100 Sassari, Italy
    Autoimmunity 36:257-60. 2003
    ..On this basis we believe that, beside hygiene-related factors, genetics could represent a more relevant determinant of Sardinian high susceptibility to MS...
  16. ncbi request reprint Increasing incidence of multiple sclerosis in the province of Sassari, northern Sardinia
    Maura Pugliatti
    Institute of Clinical Neurology, University of Sassari, Italy
    Neuroepidemiology 25:129-34. 2005
    ....
  17. doi request reprint Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis
    Giuseppe Mameli
    Section of Microbiology, Department of Biomedical Sciences, Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Viale San Pietro 43b, Sassari, Italy
    J Virol Methods 161:98-106. 2009
    ..Beyond MSRVenv DNA copy numbers were more abundant in MS patients than in healthy humans, while syncytin-1 were unchanged. These findings reinforce the link between MSRV and MS...
  18. ncbi request reprint Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6
    Giuseppe Mameli
    Section of Microbiology, Department of Biomedical Sciences, Center of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari, Italy
    J Gen Virol 88:264-74. 2007
    ....
  19. doi request reprint Self-perceived physical functioning and health status among fully ambulatory multiple sclerosis patients
    Maura Pugliatti
    Istituto di Clinica Neurologica, University of Sassari, Viale San Pietro 10, Sassari, Italy
    J Neurol 255:157-62. 2008
    ..These findings should encourage the implementation of specific strategies aimed at improving the quality of the self-perceived health status already in the early disease stage...
  20. ncbi request reprint In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis
    Caterina Serra
    Section of Microbiology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    J Neurovirol 9:637-43. 2003
    ..Interferon beta, used in MS therapy, inhibits MSRV release. A parallel between the effects of these cytokines on MSRV production in vitro and on MS disease in vivo is observed, which deserves further elucidations...
  21. ncbi request reprint Multiple sclerosis in Northern Sardinia, Italy: a methodological approach for genetic epidemiological studies
    Maura Pugliatti
    Institute of Clinical Neurology, University of Sassari, Sassari, Italy
    Neuroepidemiology 22:362-5. 2003
    ..Statistical analyses of the familial risk for MS will depend on the completeness of MS 'age at onset' data for affected individuals and age at the time family history is obtained (or age at death) for unaffected family members...
  22. doi request reprint Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis
    Roberto Madeddu
    Dipartimento di Scienze Biomediche, Universita di Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Neurol Sci 34:181-6. 2013
    ..Overall, our results might indicate β-Tub II as a potential candidate for diagnostic and β-Tub III as a possible prognostic biomarker of MS. Therefore, further analyses are legitimated and desirable...
  23. ncbi request reprint The worldwide prevalence of multiple sclerosis
    Maura Pugliatti
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy
    Clin Neurol Neurosurg 104:182-91. 2002
  24. pmc Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report
    Stefano Sotgiu
    Department of Neuroscience, Section of Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy
    BMC Neurol 10:84. 2010
    ..In addition, vascular alterations and increased leukocyte accumulation into the brain were recently documented in patients with refractory epilepsy independently on the disease etiology...
  25. ncbi request reprint NRAMP1 polymorphism and viral factors in Sardinian multiple sclerosis patients
    Maria Gazouli
    Department of Neurology, School of Medicine, University of Athens, Athens, Greece
    Can J Neurol Sci 35:491-4. 2008
    ..In the present study we aimed to evaluate the contribution of the allelic variation in the NRAMPI promoter to MS susceptibility and to study the role of viral infection in relation to specific NRAMP1 genotypes, in a Sardinian cohort...
  26. ncbi request reprint Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosis
    Stephan Schmidt
    Dept of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurol 250:607-11. 2003
    ..Taken together, a disease-modifying effect of IL-6 C allele could not be demonstrated in MS patients of German Caucasian descent...
  27. ncbi request reprint Plasma chitotriosidase in health and pathology
    Rita Barone
    Institute of Chemistry and Technology of Polymers, National Research Council CNR, Catania, Italy
    Clin Lab 53:321-33. 2007
    ..The increased activity of Chit, wherever it is documented, represents one ancestral response of innate immunity which may have a wide range of clinical applications...
  28. ncbi request reprint High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia
    Sebastian A Wirz
    The Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR307, La Jolla, CA 92037, USA
    Cytokine 26:149-54. 2004
    ....
  29. ncbi request reprint Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden
    Yu Min Huang
    Neurotec Department, Karolinska Institute, Stockholm, Sweden
    Mult Scler 11:16-23. 2005
    ..The changes of pro-inflammatory and other immune response-related variables differ however between the two MS populations. This may be attributed to the genetic and/or environmental background...
  30. ncbi request reprint Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden
    Xuan Liu
    Neurotec Department, Division of Neuroimmunology, Karolinska Institute, 141 86 Stockholm, Sweden
    Neurobiol Dis 20:961-8. 2005
    ..Higher levels of AR mRNA are present in HC from Sassari. The findings indicate that the expression levels of anti-inflammatory nuclear receptor superfamily genes in MS appear to reflect both ethnic and environmental influences...
  31. ncbi request reprint Multiple sclerosis in twins from continental Italy and Sardinia: a nationwide study
    Giovanni Ristori
    Neurology and Center for Experimental Neurological Therapy, S Andrea Hospital, University of Rome La Sapienza, Via di Grottarossa 1035 1039, 00189 Rome, Italy
    Ann Neurol 59:27-34. 2006
    ..They highlight the relevance of nonheritable variables in Mediterranean areas. The apparent underrepresentation of MS among Italian twins draws attention to protective factors, shared by twins, that may influence susceptibility...
  32. doi request reprint Safety and tolerability in relapsing-remitting multiple sclerosis patients treated with high-dose subcutaneous interferon-beta by Rebiject autoinjection over a 1-year period: the CoSa study
    Alessandra Lugaresi
    Department of Oncology and Neuroscience, University G D Annunzio, Chieti, Italy
    Clin Neuropharmacol 31:167-72. 2008
    ..This study investigated the satisfaction of patients with relapsing-remitting MS treated with IFN-beta-1a (Rebif) by the autoinjection system, Rebiject...
  33. ncbi request reprint Oligosaccharides in colostrum of Italian and Burkinabe women
    Maria Musumeci
    Department of Biomedical Sciences, University of Catania, Catania, East Sicily, Italy
    J Pediatr Gastroenterol Nutr 43:372-8. 2006
    ..2-Fucosyllactose in milk should be biologically significant for Burkinabe infants because of the high levels found in their mothers' colostrum after the second day of lactation...
  34. ncbi request reprint A family based linkage analysis of HLA and 5-HTTLPR gene polymorphisms in Sardinian children with autism spectrum disorder
    Franca R Guerini
    Laboratory of Molecular Medicine and Biotechnologies, Don C Gnocchi Foundation IRCCS, S Maria Nascente, Milan, Italy
    Hum Immunol 67:108-17. 2006
    ....
  35. ncbi request reprint The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis
    Francesco Lolli
    Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Firenze, Viale Morgagni 85, I 50134 Firenze, Italy
    J Neuroimmunol 167:131-7. 2005
    ..The study of antibodies to CSF114(Glc) is a new, potential immunological marker of MS...