Maria Pia Sormani

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. doi request reprint Magnetic resonance imaging as a potential surrogate for relapses in multiple sclerosis: a meta-analytic approach
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Ann Neurol 65:268-75. 2009
  2. ncbi request reprint Statistical issues related to the use of MRI data in multiple sclerosis
    Maria Pia Sormani
    Unit of Biostatistics, Department of Health Sciences, University of Genoa, Genoa, Italy
    J Neuroimaging 17:56S-59S. 2007
  3. pmc Clinical baseline factors predict response to natalizumab: their usefulness in patient selection
    Alice Laroni
    Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Largo Daneo 3, 16132 Genova, Italy
    BMC Neurol 14:103. 2014
  4. pmc Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures
    Alberto Lerario
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Centro Dino Ferrari, IRCCS Istituto Auxologico Italiano, Universita di Milano, Fondazione, Ospedale Maggiore Policlinico di Milano, Italy
    BMC Neurol 12:91. 2012
  5. doi request reprint MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Lancet Neurol 12:669-76. 2013
  6. doi request reprint Scoring treatment response in patients with relapsing multiple sclerosis
    M P Sormani
    Department of Health Sciences, University of Genoa, Italy
    Mult Scler 19:605-12. 2013
  7. doi request reprint Time to first relapse as an endpoint in multiple sclerosis clinical trials
    M P Sormani
    Department of Health Sciences DISSAL, University of Genova, Via Pastore 1, Genova, 16132, Italy
    Mult Scler 19:466-74. 2013
  8. doi request reprint Modelling the distribution of cortical lesions in multiple sclerosis
    Mariapia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Italy
    Mult Scler 18:229-31. 2012
  9. pmc Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    PLoS ONE 6:e26712. 2011
  10. doi request reprint Surrogate endpoints for EDSS worsening in multiple sclerosis. A meta-analytic approach
    M P Sormani
    Department of Health Sciences, Via Pastore 1, Genoa, Italy
    Neurology 75:302-9. 2010

Detail Information

Publications46

  1. doi request reprint Magnetic resonance imaging as a potential surrogate for relapses in multiple sclerosis: a meta-analytic approach
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Ann Neurol 65:268-75. 2009
    ..The aim of this work was to evaluate whether the treatment effects on magnetic resonance imaging (MRI) markers at the trial level were able to predict the treatment effects on relapse rate in relapsing-remitting multiple sclerosis...
  2. ncbi request reprint Statistical issues related to the use of MRI data in multiple sclerosis
    Maria Pia Sormani
    Unit of Biostatistics, Department of Health Sciences, University of Genoa, Genoa, Italy
    J Neuroimaging 17:56S-59S. 2007
    ....
  3. pmc Clinical baseline factors predict response to natalizumab: their usefulness in patient selection
    Alice Laroni
    Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Largo Daneo 3, 16132 Genova, Italy
    BMC Neurol 14:103. 2014
    ..Optimal patient selection would improve the risk-benefit ratio of natalizumab treatment for relapsing-remitting multiple sclerosis (RR MS). Clinical features of subjects responding to natalizumab have not been univocally recognized...
  4. pmc Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures
    Alberto Lerario
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Centro Dino Ferrari, IRCCS Istituto Auxologico Italiano, Universita di Milano, Fondazione, Ospedale Maggiore Policlinico di Milano, Italy
    BMC Neurol 12:91. 2012
    ..This study is to date the most thorough long-term evaluation of QMT in a cohort of DMD patients correlated with other measures, such as the North Star Ambulatory Assessment (NSAA) or three 6-min walk test (6MWT)...
  5. doi request reprint MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Lancet Neurol 12:669-76. 2013
    ..We aimed to validate that relation using data from a large and independent set of clinical trials in multiple sclerosis...
  6. doi request reprint Scoring treatment response in patients with relapsing multiple sclerosis
    M P Sormani
    Department of Health Sciences, University of Genoa, Italy
    Mult Scler 19:605-12. 2013
    ..We employed clinical and magnetic resonance imaging (MRI) measures in combination, to assess patient responses to interferon in multiple sclerosis...
  7. doi request reprint Time to first relapse as an endpoint in multiple sclerosis clinical trials
    M P Sormani
    Department of Health Sciences DISSAL, University of Genova, Via Pastore 1, Genova, 16132, Italy
    Mult Scler 19:466-74. 2013
    ..The increasing number of effective therapies to treat multiple sclerosis (MS) raises ethical concerns for the use of placebo in clinical trials, suggesting that new clinical trial design strategies are needed...
  8. doi request reprint Modelling the distribution of cortical lesions in multiple sclerosis
    Mariapia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Italy
    Mult Scler 18:229-31. 2012
    ..This observation has important implications for the statistical analysis of CLs in MS studies...
  9. pmc Modeling the distribution of new MRI cortical lesions in multiple sclerosis longitudinal studies
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    PLoS ONE 6:e26712. 2011
    ..Aim of this study is to define the statistical model better describing the distribution of new CLs developed over 12 and 24 months in patients with relapsing-remitting (RR) MS...
  10. doi request reprint Surrogate endpoints for EDSS worsening in multiple sclerosis. A meta-analytic approach
    M P Sormani
    Department of Health Sciences, Via Pastore 1, Genoa, Italy
    Neurology 75:302-9. 2010
    ....
  11. doi request reprint Magnetic resonance active lesions as individual-level surrogate for relapses in multiple sclerosis
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Mult Scler 17:541-9. 2011
    ..Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical outcomes in multiple sclerosis (MS) trials is controversial...
  12. doi request reprint Magnetic resonance imaging as surrogate for clinical endpoints in multiple sclerosis: data on novel oral drugs
    M P Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Italy
    Mult Scler 17:630-3. 2011
    ..The 92% of observed effects of oral drugs on clinical outcomes resulted close to those predicted by MRI active lesions. This further validates MRI surrogacy in MS, with important implications for future trials planning...
  13. doi request reprint The Will Rogers phenomenon: the effect of different diagnostic criteria
    Maria Pia Sormani
    Biostatistics Unit, University of Genoa, Genova, Italy
    J Neurol Sci 287:S46-9. 2009
    ..In this context, the use of different diagnostic criteria may generate spurious improvements in the medium-term prognosis of multiple sclerosis, which may be wrongly interpreted as treatment effects...
  14. doi request reprint Combined MRI lesions and relapses as a surrogate for disability in multiple sclerosis
    M P Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Neurology 77:1684-90. 2011
    ..We sought to validate, at the individual patient level, MRI lesions and relapses as surrogates for disability progression over the course of MS trials...
  15. doi request reprint A reassessment of the plateauing relationship between T2 lesion load and disability in MS
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Milan, Italy
    Neurology 73:1538-42. 2009
    ....
  16. pmc Clinical and MRI activity as determinants of sample size for pediatric multiple sclerosis trials
    Leonard H Verhey
    From the Pediatric Demyelinating Disease Program L H V, Program in Neuroscience and Mental Health, The Hospital for Sick Children, University of Toronto, Canada Biostatistics Unit A S, M P S, Department of Health Sciences, University of Genova, Italy Department of Neurology and Neurosurgery D L A, A B O, Montreal Neurological Institute and Hospital, McGill University, Montreal Department of Neurology and Division of Medical Genetics A D S, University of British Columbia, Vancouver Departments of Internal Medicine and Community Health Sciences R A M, Winnipeg Health Sciences Centre, University of Manitoba, Winnipeg, Canada and Division of Neurology B B, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania
    Neurology 81:1215-21. 2013
    ..To estimate sample sizes for pediatric multiple sclerosis (MS) trials using new T2 lesion count, annualized relapse rate (ARR), and time to first relapse (TTFR) endpoints...
  17. doi request reprint Will Rogers phenomenon in multiple sclerosis
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences DISSAL, University of Genoa, Italy
    Ann Neurol 64:428-33. 2008
    ..We assessed whether the Will Rogers phenomenon may affect multiple sclerosis (MS) prognosis when applying different diagnostic criteria...
  18. doi request reprint Clinical epidemiology of ALS in Liguria, Italy
    Monica Bandettini di Poggio
    Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 14:52-7. 2013
    ..The observed crude incidence was higher compared to other Italian studies, due in part to a very careful case ascertainment and in part to a high percentage of the elderly in Liguria...
  19. doi request reprint Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis
    Maria Pia Sormani
    Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
    Ann Neurol 75:43-9. 2014
    ..To evaluate the extent to which treatment effect on brain atrophy is able to mediate, at the trial level, the treatment effect on disability progression in relapsing-remitting multiple sclerosis (RRMS)...
  20. doi request reprint The quality of reports of randomized trials in multiple sclerosis: a review
    Alessio Signori
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mult Scler 18:776-81. 2012
    ..A complete and transparent reporting of trial methodology is becoming even more important in an era when new design strategies are required for the feasibility of future trials in MS...
  21. ncbi request reprint Evaluation of insulin resistance in a cohort of HIV-infected youth
    Raffaella Rosso
    Department of Infectious Diseases, San Martino Hospital, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Eur J Endocrinol 157:655-9. 2007
    ..Metabolic abnormalities, including impairment of glucose homeostasis, have been well characterized in HIV-infected patients. In contrast to adults, insulin resistance and diabetes mellitus appear to be relatively uncommon finding in youth...
  22. pmc Quantitative assessment of finger motor impairment in multiple sclerosis
    Laura Bonzano
    Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy
    PLoS ONE 8:e65225. 2013
    ....
  23. ncbi request reprint MRI metrics as surrogate markers for clinical relapse rate in relapsing-remitting MS patients
    Maria Pia Sormani
    Unit of Clinical Epidemiology and Trials, National Institute for Cancer Research, Genoa, Italy
    Neurology 58:417-21. 2002
    ..To formally validate metrics derived from conventional MRI as surrogate endpoints for relapse rate in MS...
  24. doi request reprint Pharmacokinetics of lopinavir determined with an ELISA test in youths with perinatally acquired HIV
    Roberta Prinapori
    Infectious Diseases Clinic, San Martino Hospital, University of Genoa, Genoa, Italy
    Indian J Pediatr 81:856-60. 2014
    ..To investigate the plasma levels of lopinavir by enzyme-linked immunosorbent assay (ELISA) in a cohort of patients who were vertically infected with human immunodeficiency virus 1 (HIV)...
  25. doi request reprint Defining and scoring response to IFN-β in multiple sclerosis
    Maria Pia Sormani
    Department of Health Sciences DISSAL, University of Genoa, Via Pastore 1, Genoa 16132, Italy mariapia sormani unige it
    Nat Rev Neurol 9:504-12. 2013
    ..We also highlight advantages and limitations of the existing scoring systems in light of future expansion of these models to biological markers and to other classes of emerging therapies for MS. ..
  26. doi request reprint Putative predictive parameters for the outcome of laparoscopic splenectomy: a multicenter analysis performed on the Italian Registry of Laparoscopic Surgery of the Spleen
    Marco Casaccia
    Department of General Surgery and Transplant, San Martino University Hospital, University of Genoa, Genoa, Italy
    Ann Surg 251:287-91. 2010
    ..To identify predictive risk factors for conversion to open splenectomy and postoperative complications in patients undergoing elective laparoscopic splenectomy...
  27. ncbi request reprint An unconventional cancer treatment lacking clinical efficacy remains available to Italian cancer patients
    Domenico Franco Merlo
    Epidemiology and Biostatistics and Clinical Trials and Bioethics, National Cancer Research Institute, Genoa, Italy
    Tumori 94:830-2. 2008
    ..Access to the multitherapy was investigated three years later within the post-bereavement Italian Survey of the Dying of Cancer (ISDOC), whose broader aim was to investigate the end-of-life care experiences of terminal cancer patients...
  28. doi request reprint Breast cancer incidence after hormonal treatments for infertility: systematic review and meta-analysis of population-based studies
    Alessandra Gennari
    S C Oncologia Medica, E O Ospedali Galliera, Via Volta 6, 16128, Genoa, Italy
    Breast Cancer Res Treat 150:405-13. 2015
    ..The long-term administration of clomiphene outside the current indications should be discouraged because of a possible increase in BC risk. ..
  29. pmc Breast density assessment using a 3T MRI system: comparison among different sequences
    Alberto Tagliafico
    Institute of Anatomy, Department of Experimental Medicine, University of Genova, Genova, Italy
    PLoS ONE 9:e99027. 2014
    ..To compare MRI sequences for breast density measurements on a 3T MRI system using IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least squares estimation) as possible physiology-like reference...
  30. ncbi request reprint Thirteen years of follow-up in patients with adjustable silicone gastric banding for obesity: weight loss and constant rate of late specific complications
    Giovanni Camerini
    Department of Surgery, School of Medicine, University of Genoa, Italy
    Obes Surg 14:1343-8. 2004
    ..The aim of this study is to evaluate the long-term results of this operation in our patient population...
  31. ncbi request reprint Assessment of disease activity in acromegaly by means of a single blood sample: comparison of the 120th minute postglucose value with spontaneous GH secretion and with the IGF system
    Francesco Minuto
    Department of Endocrinology and Metabolism, University of Genova, Genova, Italy
    Clin Endocrinol (Oxf) 61:138-44. 2004
    ..With the aim of simplifying the follow-up protocol in these patients we also tested if one single sample taken after glucose load could replace the nadir value...
  32. doi request reprint Effects of hepatitis C virus infection on the pharmacokinetics of ritonavir-boosted atazanavir in HIV-1-infected patients
    Antonio Di Biagio
    Department of Infectious Diseases, San Martino Hospital Genoa, University of Genoa, Largo Rosanna Benzi, 10, 16132, Genoa, Italy
    J Infect Chemother 18:587-90. 2012
    ..In our patients with mild impairment of hepatic function caused by HCV infection, atazanavir C (trough) was comparable in HIV-infected and HIV/HCV-co-infected patients...
  33. doi request reprint Atlas-based versus individual-based fiber tracking of the corpus callosum in patients with multiple sclerosis: reliability and clinical correlations
    Maria Marcella Laganà
    Department of Biomedical Engineering, Politecnico di Milano, Milan, Italy
    J Neuroimaging 22:355-64. 2012
    ..We compared the performance of an individual-based method for corpus callosum (CC) fiber tracking in MS with those of two atlas-based methods...
  34. doi request reprint Sexual behaviour in Ligurian (Northern Italy) adolescents and young people: suggestions for HPV vaccination policies
    Donatella Panatto
    Department of Health Sciences of Genoa University, Via Pastore 1, 16132 Genoa, Italy
    Vaccine 27:A6-10. 2009
    ..Our findings suggest that current HPV vaccination should be implemented by introducing new cohorts, especially young girls (14-16 years)...
  35. ncbi request reprint Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation
    Andrea Bacigalupo
    Dipartimento di Emato Oncologia, Ospedale San Martino, Genoa, Italy
    Haematologica 89:1238-47. 2004
    ..The aims of this study were to determine whether these relationships still hold and whether the outcome of transplants is continuing to improve...
  36. ncbi request reprint Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter Phase III study
    Giuseppe Sanguineti
    Department of Radiation Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Int J Radiat Oncol Biol Phys 61:762-71. 2005
    ....
  37. doi request reprint Differentiating PFAPA syndrome from monogenic periodic fevers
    Marco Gattorno
    UO Pediatria II, G Gaslini Institute, Largo G Gaslini 5, 16146, Genova, Italy
    Pediatrics 124:e721-8. 2009
    ....
  38. ncbi request reprint Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study
    Celia Oreja-Guevara
    Neuroimaging Unit and Department of Neurology, Scientific Institute and University H San Raffaele, Milan, Italy
    Arch Neurol 62:578-84. 2005
    ..In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues...
  39. ncbi request reprint Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
    IEEE Trans Med Imaging 26:1670-80. 2007
    ..The operator interaction time required to evaluate one subject was reduced from an average of 111 min with contouring to 16 min with the FC method...
  40. ncbi request reprint The distribution of magnetic resonance imaging response to interferonbeta-1b in multiple sclerosis
    Maria Pia Sormani
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 252:1455-8. 2005
    ..This study might be regarded as a first step toward the definition of markers potentially useful to identify IFNbeta treatment responders and non-responders with regard to T2 lesion activity...
  41. ncbi request reprint Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis
    Federica Agosta
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Brain 129:2620-7. 2006
    ..This study also suggests that GM damage is one of the key factors associated with disability accumulation in this 'white matter' condition...
  42. ncbi request reprint European study on intravenous immunoglobulin in multiple sclerosis: results of magnetization transfer magnetic resonance imaging analysis
    Massimo Filippi
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 61:1409-12. 2004
    ..Magnetization transfer magnetic resonance imaging (MT MRI) can provide in vivo markers reflecting the severity of multiple sclerosis-related brain damage occurring within and outside T2-visible lesions...
  43. ncbi request reprint Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
    Annalisa Pulizzi
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Arch Neurol 64:1163-8. 2007
    ....
  44. ncbi request reprint Irreversible disability and tissue loss in multiple sclerosis: a conventional and magnetization transfer magnetic resonance imaging study of the optic nerves
    Matilde Inglese
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Arch Neurol 59:250-5. 2002
    ....
  45. ncbi request reprint Changes in markers of bone turnover and inflammatory variables during alendronate therapy in pediatric patients with rheumatic diseases
    Rolando Cimaz
    Clinica Pediatrica, ICP, Milano, Italy
    J Rheumatol 29:1786-92. 2002
    ..In this study, we evaluated the changes in bone metabolism and disease activity markers in 45 patients ages 5 to 18 years (31 female, 14 male) with rheumatic diseases treated with alendronate for 12 months...
  46. ncbi request reprint A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis
    Antonio Gallo
    Neuroimaging Research Unit, Dept of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 254:78-83. 2007
    ..001). This study shows that MT MRI-detectable damage to NAWM and NAGM may not be an important feature of all patients at presentation with a CIS highly suggestive of MS and that such a damage may develop with subsequent disease evolution...