V Solfrizzi

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. doi request reprint Dietary fatty acids and predementia syndromes
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    ScientificWorldJournal 9:792-810. 2009
  2. doi request reprint Frailty syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Alzheimers Dement 9:113-22. 2013
  3. pmc Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Age (Dordr) 35:441-53. 2013
  4. pmc Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Memory Unit, Center for Aging Brain, Department of Geriatrics, University of Bari Policlinico, Italy
    Age (Dordr) 34:507-17. 2012
  5. ncbi request reprint Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit University of Bari, Bari, Italy
    J Nutr Health Aging 12:382-6. 2008
  6. ncbi request reprint Vascular risk factors, incidence of MCI, and rates of progression to dementia
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Neurology 63:1882-91. 2004
  7. ncbi request reprint Dietary fatty acids intake: possible role in cognitive decline and dementia
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11, Bari 70124, Italy
    Exp Gerontol 40:257-70. 2005
  8. ncbi request reprint Unsaturated fatty acids intake and all-causes mortality: a 8.5-year follow-up of the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari Policlinico, Piazza G Cesare, 11 70124 Bari, Italy
    Exp Gerontol 40:335-43. 2005
  9. ncbi request reprint Incident occurrence of depressive symptoms among patients with mild cognitive impairment - the Italian longitudinal study on aging
    Vincenzo Solfrizzi
    Memory Unit, Center for Aging Brain, Department of Geriatrics, University of Bari, Bari, Italy
    Dement Geriatr Cogn Disord 24:55-64. 2007
  10. ncbi request reprint Alcohol consumption, mild cognitive impairment, and progression to dementia
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
    Neurology 68:1790-9. 2007

Collaborators

Detail Information

Publications97

  1. doi request reprint Dietary fatty acids and predementia syndromes
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    ScientificWorldJournal 9:792-810. 2009
    ..Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible...
  2. doi request reprint Frailty syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Alzheimers Dement 9:113-22. 2013
    ..We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population...
  3. pmc Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Age (Dordr) 35:441-53. 2013
    ..However, within-class differences linked to different chemical structures and/or drug potencies may exist, with a possible effect of the enalapril and lisinopril sub-groups in reducing the risk of incident MCI...
  4. pmc Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Memory Unit, Center for Aging Brain, Department of Geriatrics, University of Bari Policlinico, Italy
    Age (Dordr) 34:507-17. 2012
    ..89, 95% CI 1.10-3.44), but not of disability. Frailty syndrome was a short-term predictor of disability in nondemented older subjects and short- and long-term predictor of all-cause mortality in nondemented and demented patients...
  5. ncbi request reprint Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit University of Bari, Bari, Italy
    J Nutr Health Aging 12:382-6. 2008
    ....
  6. ncbi request reprint Vascular risk factors, incidence of MCI, and rates of progression to dementia
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Neurology 63:1882-91. 2004
    ..To estimate prevalence, incidence, and rate of progression of mild cognitive impairment (MCI) to dementia and correlated vascular risk factors with incident MCI and its progression to dementia...
  7. ncbi request reprint Dietary fatty acids intake: possible role in cognitive decline and dementia
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11, Bari 70124, Italy
    Exp Gerontol 40:257-70. 2005
    ..Appropriate dietary measures or supplementation with specific micro- and macronutrients might open new ways for the prevention and management of cognitive decline and dementia...
  8. ncbi request reprint Unsaturated fatty acids intake and all-causes mortality: a 8.5-year follow-up of the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari Policlinico, Piazza G Cesare, 11 70124 Bari, Italy
    Exp Gerontol 40:335-43. 2005
    ..In conclusion, in this prospective study on older nondemented subjects with a typical Mediterranean diet, a higher MUFA intake increased survival, while a higher UFA/SFA ratio increased total mortality, but only marginally...
  9. ncbi request reprint Incident occurrence of depressive symptoms among patients with mild cognitive impairment - the Italian longitudinal study on aging
    Vincenzo Solfrizzi
    Memory Unit, Center for Aging Brain, Department of Geriatrics, University of Bari, Bari, Italy
    Dement Geriatr Cogn Disord 24:55-64. 2007
    ..We estimated the prevalence and incidence rates of depressive symptoms and the role of vascular risk factors and sociodemographic variables on the occurrence of depressive symptoms in mild cognitive impairment (MCI)...
  10. ncbi request reprint Alcohol consumption, mild cognitive impairment, and progression to dementia
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
    Neurology 68:1790-9. 2007
    ..To estimate the impact of alcohol consumption on the incidence of mild cognitive impairment and its progression to dementia...
  11. ncbi request reprint Lifestyle-related factors in predementia and dementia syndromes
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Expert Rev Neurother 8:133-58. 2008
    ....
  12. ncbi request reprint Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 27:1694-704. 2006
    ..5-year follow-up. In this prospective population-based study on older nondemented subjects with a typical Mediterranean diet, high MUFA and PUFA intakes appeared to be protective against ARCD...
  13. ncbi request reprint Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Exp Gerontol 41:619-27. 2006
    ..34-1.13, p=0.12). In our population, dietary fatty acids intakes were not associated with incident MCI in older age, only high PUFA intake evidenced a borderline nonsignificant trend for a protective effect against the development of MCI...
  14. doi request reprint All-cause mortality and competing risks of fatal and nonfatal vascular events in the Italian longitudinal study on aging: impact of lipoprotein(a)
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari, Bari, Italy
    Rejuvenation Res 12:395-402. 2009
    ..Finally competing risk, conditioning the timing and occurrence of vascular events in our study population, could be a correct approach for evaluating the role of Lp(a) lipoprotein in vascular disease among elderly people...
  15. doi request reprint Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Ageing Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 81:433-40. 2010
    ..The authors investigated the relationship of metabolic syndrome (MetS) and its individual components with incident dementia in a prospective population-based study with a 3.5-year follow-up...
  16. ncbi request reprint Vascular risk factors, alcohol intake, and cognitive decline
    F Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
    J Nutr Health Aging 12:376-81. 2008
    ..At present, vascular risk factor management, lifestyle changes, and drugs could be employed together to delay the onset of dementia syndromes...
  17. doi request reprint Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 32:1932-41. 2011
    ..In our population, among MCI patients the presence of MetS independently predicted an increased risk of progression to dementia over 3.5 years of follow-up...
  18. ncbi request reprint Mediterranean diet and cognitive decline
    F Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Public Health Nutr 7:959-63. 2004
    ..To investigate the possible role of diet in age-related cognitive decline (ARCD) and cognitive impairment of both degenerative (Alzheimer's disease, AD) and vascular (vascular dementia, VaD) origin...
  19. doi request reprint Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Dement Geriatr Cogn Disord 25:336-46. 2008
    ..We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI...
  20. ncbi request reprint Interleukin 6 variable number of tandem repeats (VNTR) gene polymorphism in centenarians
    C Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, Foggia, Italy
    Ann Hum Genet 71:843-8. 2007
    ..Our findings suggested that the presence of the IL6 VNTR allele B could be detrimental for reaching extreme longevity...
  21. doi request reprint Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:177-82. 2010
    ..Furthermore, the C allele of the IL-6 variable number of tandem repeats (VNTR) polymorphism was associated with a delayed onset and a decreased risk of AD...
  22. ncbi request reprint Towards disease-modifying treatment of Alzheimer's disease: drugs targeting beta-amyloid
    V Frisardi
    Department of Geriatrics, Center for Aging Brain, University of Bari Policlinico, Piazza Giulio Cesare, 11 70124 Bari Italy
    Curr Alzheimer Res 7:40-55. 2010
    ..With all these anti-Abeta approaches in clinical testing, we will know in few years if the Abeta hypothesis of AD is correct...
  23. ncbi request reprint F175S change and a novel polymorphism in presenilin-1 gene in late-onset familial Alzheimer's disease
    A M Colacicco
    Department of Geriatrics, Center for Aging Brain Memory Unit, University of Bari, Italy
    Eur Neurol 47:209-13. 2002
    ..This study provides evidence that a PS-1 gene missense change does not necessarily associate with early-onset disease, and can occur in single cases affected by late-onset disease...
  24. doi request reprint Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Neurosci Lett 432:237-42. 2008
    ..Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD...
  25. ncbi request reprint The role of diet in cognitive decline
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
    J Neural Transm 110:95-110. 2003
    ..Dietary anti-oxidants and supplements and specific macronutrients of the diet may act synergistically with other protective factors opening new possibilities of intervention for cognitive decline...
  26. ncbi request reprint Vascular risk and genetics of sporadic late-onset Alzheimer's disease
    F Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Neural Transm 111:69-89. 2004
    ..This review will focus on the current knowledge on genetic and nongenetic vascular factors likely to be involved in LOAD, with special emphasis placed on the APOE and ACE1 genes...
  27. ncbi request reprint Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease
    Alessia D'Introno
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    J Gerontol A Biol Sci Med Sci 60:280-4. 2005
    ..In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic Alzheimer's disease...
  28. ncbi request reprint The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Foggia, Italy
    J Gerontol A Biol Sci Med Sci 60:991-6. 2005
    ..The regional differences in CTSD allele frequencies could be related to the different patterns of association between this polymorphism and AD in various European studies...
  29. ncbi request reprint Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water
    A Capurso
    Department of Geriatrics, University of Bari, Italy
    Aging (Milano) 11:273-6. 1999
    ..We suggest that salt-rich spring water treatment reduces serum and LDL-cholesterol levels in subjects with mild hypercholesterolemia through a mechanism of increased excretion of fecal bile acid sterols...
  30. doi request reprint Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease
    Anna Maria Colacicco
    Department of Geriatrics, Center for Aging Brain, University of Bari, Italy
    Neurobiol Aging 30:1518-20. 2009
    ....
  31. ncbi request reprint Selective attention skills in differentiating between Alzheimer's disease and normal aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, University of Bari Policlinico, Italy
    J Geriatr Psychiatry Neurol 15:99-109. 2002
    ..62 and 0.91, respectively. The SCT is a valid and reliable test to assess selective attention in elderly subjects, in whom dementing illness must be diagnosed and clinically distinct from age-related cognitive decline...
  32. pmc Lipoprotein(a), apolipoprotein E genotype, and risk of Alzheimer's disease
    V Solfrizzi
    Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 72:732-6. 2002
    ..To explore the possible role of serum lipoprotein(a) (Lp(a)), apolipoprotein E polymorphism, and total cholesterol (TC) serum concentrations in Alzheimer's disease (AD)...
  33. doi request reprint Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Ageing Res Rev 9:399-417. 2010
    ....
  34. ncbi request reprint Cerebrovascular disease in the elderly: lipoprotein metabolism and cognitive decline
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    Aging Clin Exp Res 18:144-8. 2006
    ..In conclusion, in our population, among MCI patients who progressed to dementia, 60% progressed to AD and 33% to VaD. Vascular risk factors and CVD may influence the development of MCI and the rate of progression to dementia...
  35. doi request reprint Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Ageing Res Rev 9:184-99. 2010
    ....
  36. ncbi request reprint Mediterranean diet in predementia and dementia syndromes
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Curr Alzheimer Res 8:520-42. 2011
    ....
  37. ncbi request reprint Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti Viale L Pinto, 71100 Foggia, Italy
    Exp Gerontol 39:1567-73. 2004
    ..We suggest that regional European differences in genotype and allele frequencies of the IL-6-174 G/C promoter polymorphism may explain in part controversial findings on this polymorphism in AD in various European studies...
  38. ncbi request reprint Relation of lipoprotein(a) as coronary risk factor to type 2 diabetes mellitus and low-density lipoprotein cholesterol in patients > or =65 years of age (The Italian Longitudinal Study on Aging)
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari, Bari, Italy
    Am J Cardiol 89:825-9. 2002
    ..40 to 1.25). In the elderly, elevated Lp(a) levels appear not to be an independent predictor of CAD, but this lipoprotein is a risk factor only in subjects with type 2 diabetes mellitus and elevated LDL cholesterol...
  39. doi request reprint Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 17:7-31. 2009
    ..At present, there is no indication that light to moderate alcohol drinking would be harmful to cognition and dementia, and it is not possible to define a specific beneficial level of alcohol intake...
  40. doi request reprint Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Drugs Aging 26:537-55. 2009
    ..All these therapeutic approaches increase the hope of slowing the rate of decline in patients with AD and modifying the natural history of this devastating disease within the next 5 years...
  41. ncbi request reprint Current epidemiology of mild cognitive impairment and other predementia syndromes
    Francesco Panza
    Dept of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Am J Geriatr Psychiatry 13:633-44. 2005
    ..To clarify the sources of discrepant findings in the literature, this review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia...
  42. ncbi request reprint Cognitive frailty: Predementia syndrome and vascular risk factors
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 27:933-40. 2006
    ..This review will focus on the possible role of vascular risk factors in modulating the risk of age-related cognitive decline, and the progression of predementia syndrome such as MCI to dementia...
  43. doi request reprint Temporal relationship between depressive symptoms and cognitive impairment: the Italian Longitudinal Study on Aging
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 17:899-911. 2009
    ..Global cognitive function and episodic memory at baseline were not associated with the course of depressive symptoms during the follow-up...
  44. doi request reprint Polyunsaturated fatty acid and S-adenosylmethionine supplementation in predementia syndromes and Alzheimer's disease: a review
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    ScientificWorldJournal 9:373-89. 2009
    ..g., 3-5 years of follow-up)...
  45. doi request reprint Possible role of S-adenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 16:467-70. 2009
    ....
  46. ncbi request reprint Lipoproteins, vascular-related genetic factors, and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Lipoprotein Metabolism and Atherosclerosis, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Rejuvenation Res 10:441-58. 2007
    ..While further studies are needed to confirm the possible role of apolipoprotein E concentration as putative longevity factor this paper provides an overview of many of the investigated vascular factors with respect to longevity...
  47. ncbi request reprint Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Am J Med Genet B Neuropsychiatr Genet 126:69-73. 2004
    ..We suggest that these regional variations in LRP1 genotype and allele frequencies in AD could be related to the different patterns of association between this polymorphism and the disease in various European studies...
  48. doi request reprint Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Int J Geriatr Psychiatry 23:726-34. 2008
    ..5-year follow-up; and the interaction between depressive symptoms and vascular risk factors for conversion to dementia...
  49. ncbi request reprint Vascular genetic factors and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Mech Ageing Dev 125:169-78. 2004
    ..While further studies are needed to confirm the possible role of APOE concentration as putative longevity factor, this paper provides an overview of genetic vascular factors potentially involved in human longevity...
  50. ncbi request reprint Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe
    Francesco Panza
    Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, Bari 70124, Italy
    Exp Gerontol 38:1015-20. 2003
    ..Such genetic differences in conjunction with differing environmental factors may explain in part previous results suggesting a role of this polymorphism in longevity...
  51. ncbi request reprint Heterogeneity of mild cognitive impairment and other predementia syndromes in progression to dementia
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Neurobiol Aging 28:1631-2; discussion 1633-4. 2007
    ....
  52. ncbi request reprint Lipid metabolism in cognitive decline and dementia
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    Brain Res Rev 51:275-92. 2006
    ..Thus, more studies with long-term follow-up and serial assessments of TC are needed to further clarify the causal relationship between cholesterol and dementia...
  53. ncbi request reprint Candidate genes for late-onset Alzheimer's disease: focus on chromosome 12
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Mech Ageing Dev 127:36-47. 2006
    ..In this article, we focused on the current knowledge of the genetics of familial late-onset and sporadic AD linked to the chromosome 12, and the future search for other candidate genes...
  54. doi request reprint Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer's disease
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Immunotherapy 2:767-82. 2010
    ..The results of four ongoing large Phase III trials on bapineuzumab will provide answers regarding whether passive anti-Aβ immunization is able to alter the course of this devastating disease...
  55. doi request reprint REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current state
    Francesco Panza
    IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    CNS Neurosci Ther 16:272-84. 2010
    ..This article briefly reviews the profile of γ-secretase inhibitors, compounds that inhibit γ-secretase, the pivotal enzyme that generates Aβ, and that have reached the clinic...
  56. ncbi request reprint Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, 70124, Bari, Italy
    Aging Clin Exp Res 21:386-406. 2009
    ..With all these approaches on their way, the hope for disease-modifying therapy in this devastating disease may become a reality in the next 5 years...
  57. doi request reprint Late-life depression, mild cognitive impairment, and dementia: possible continuum?
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Am J Geriatr Psychiatry 18:98-116. 2010
    ..In this scenario, at least in certain subsets of elderly patients, late-life depression, MCI, and dementia could represent a possible clinical continuum...
  58. ncbi request reprint Macronutrients, aluminium from drinking water and foods, and other metals in cognitive decline and dementia
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 10:303-30. 2006
    ....
  59. ncbi request reprint S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Neurobiol Aging 29:478-80. 2008
    ....
  60. ncbi request reprint [Genetics of late-onset Alzheimer's disease: vascular risk and beta-amyloid metabolism]
    Francesco Panza
    Cattedra di Geriatria, Centro Universitario per lo Studio dell Invecchiamento Cerebrale, Unità di Ricerca per la Memoria, Universita, Bari
    Recenti Prog Med 93:489-97. 2002
    ....
  61. ncbi request reprint Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians
    Francesco Panza
    Department of Geriatrics, Center for Agin Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, Bari, Italy
    Neuroreport 14:605-8. 2003
    ..In these highly selected populations, APOE genotype distribution strongly influences serum APOE concentration, not suggesting, at present, a possible role as a biochemical marker for AD, but only as a putative longevity factor...
  62. ncbi request reprint Circulating biomarkers of cognitive decline and dementia
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Clin Chim Acta 364:91-112. 2006
    ....
  63. doi request reprint Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy
    J Alzheimers Dis 20:17-30. 2010
    ....
  64. ncbi request reprint Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease
    Alessia D'Introno
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Neurobiol Aging 27:1537-53. 2006
    ..This paper reviews studies that have provided evidence of linkage for AD on chromosome 12 and in turn discusses the work conducted to date on candidate genes that have been identified and map to the chromosome 12 regions of interest...
  65. ncbi request reprint Molecular determinants of human longevity
    Francesco Panza
    Department of Geriatrics, Center for the Aging Brain, Memory Unit, University of Bari, 11 70124, Bari, Italy
    Adv Clin Chem 39:185-210. 2005
  66. ncbi request reprint Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Atherosclerosis 188:455-61. 2006
    ..Our results strongly suggest that l-carnitine may have a role among lipid-lowering strategies...
  67. doi request reprint Is insulin resistant brain state a central feature of the metabolic-cognitive syndrome?
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 21:57-63. 2010
    ....
  68. ncbi request reprint Apolipoprotein E genotypes in mild cognitive impairment subtypes
    Giuseppe Orsitto
    J Am Geriatr Soc 54:1965-6. 2006
  69. ncbi request reprint Possible role of unsaturated fatty acids in a 14-day healthy longevity lifestyle program
    Francesco Panza
    Am J Geriatr Psychiatry 15:266; author reply 267. 2007
  70. ncbi request reprint Diet, cholesterol metabolism, and Alzheimer's disease: Apolipoprotein E as a possible link?
    Francesco Panza
    J Am Geriatr Soc 54:1963-5. 2006
  71. ncbi request reprint Whole-diet approach and risk of chronic disease: Limits and advantages
    Vincenzo Solfrizzi
    J Am Geriatr Soc 54:1800-2. 2006
  72. ncbi request reprint Cardiovascular factors and cognitive impairment: a role for unsaturated fatty acids and Mediterranean diet?
    Francesco Panza
    Am J Cardiol 98:1120-1. 2006
  73. ncbi request reprint [Predementia syndromes and mild cognitive impairment: diagnosis and progression to dementia]
    Francesco Panza
    Recenti Prog Med 98:281-9. 2007
    ..Furthermore, recent findings suggest that in population-based studies the MCI classification is unstable, in contrast with clinic-based studies where progression is more uniform...
  74. doi request reprint Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 25:287-92. 2008
    ..Glutamate transmits signals via the N-methyl-D-aspartate receptors (NMDARs). Aims: The potential involvement of polymorphisms in the GRIN2B gene, encoding subunit 2B of the NMDA receptor, in the risk for AD was evaluated...
  75. ncbi request reprint Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different ages
    Francesco Panza
    Atherosclerosis 193:455-7. 2007
  76. ncbi request reprint Prevalence rates of mild cognitive impairment subtypes and progression to dementia
    Francesco Panza
    J Am Geriatr Soc 54:1474-5. 2006
  77. ncbi request reprint Adherence to a Mediterranean dietary pattern and risk of Alzheimer's disease
    Vincenzo Solfrizzi
    Ann Neurol 60:620; author reply 621. 2006
  78. ncbi request reprint Low incidence for predementia and dementia syndromes in a brain imaging study
    Francesco Panza
    Ann Neurol 60:619; author reply 619-20. 2006
  79. ncbi request reprint Serum total cholesterol as a biomarker for Alzheimer's disease: mid-life or late-life determinations?
    Francesco Panza
    Exp Gerontol 41:805-6. 2006
  80. ncbi request reprint Nutritional factors, cognitive decline, and dementia
    Angelo Del Parigi
    National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Obesity and Diabetes Clinical Research Section, 4212N 16 Street, Phoenix, AZ 85016, USA
    Brain Res Bull 69:1-19. 2006
    ..We point out that well designed intervention studies are warranted in order to establish specific levels of micro- and macronutrient deficiencies and to set general recommendations for the population...
  81. ncbi request reprint Total cholesterol levels and the risk of mild cognitive impairment and Alzheimer's disease
    Francesco Panza
    J Am Geriatr Soc 55:133-5. 2007
  82. ncbi request reprint [Depression in old age: a diagnostic and therapeutic challenge]
    Antonio Capurso
    Cattedra di Geriatria, Centro per lo Studio dell Invecchiamento Cerebrale, Memory Unit, Universita di Bari
    Recenti Prog Med 98:43-52. 2007
    ..Therefore, it should be considered the opportunity of a depression prophylaxis, particularly in those circumstances in which the risk of depression is noteworthy increased, such as stroke, cancer, institutionalization, etc...
  83. ncbi request reprint Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia
    Giuseppe Orsitto
    Geriatric Unit, Medical Sciences Department, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 23:327-33. 2007
    ..However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects...
  84. ncbi request reprint The Caregiver Burden Inventory in evaluating the burden of caregivers of elderly demented patients: results from a multicenter study
    Martina Marvardi
    Dept of Gerontology and Geriatrics, University of Perugia
    Aging Clin Exp Res 17:46-53. 2005
    ....
  85. doi request reprint Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Neurosci Lett 438:335-9. 2008
    ..No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD...
  86. ncbi request reprint Italian Project on Epidemiology of Alzheimer's disease (I.PR.E.A.): study design and methodology of cross-sectional survey
    Emanuele Scafato
    National Center on Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità ISS, Roma, Italy
    Aging Clin Exp Res 17:29-34. 2005
    ....
  87. doi request reprint Alcohol use, thiamine deficiency, and cognitive impairment
    Francesco Panza
    JAMA 299:2853-4; author reply 2854-5. 2008
  88. ncbi request reprint The RELN locus in Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo dalla Sofferenza, San Giovanni Rotondo FG, I 71013, Italy
    J Alzheimers Dis 14:335-44. 2008
    ..These findings suggest that RELN gene variants may play a role in the pathogenesis of AD, particularly in females...
  89. doi request reprint Hypertension and mild cognitive impairment subtypes
    Francesco Panza
    Arch Neurol 65:992-3; author reply 994-5. 2008
  90. ncbi request reprint Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy
    Davide Seripa
    Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy
    J Gerontol A Biol Sci Med Sci 61:918-23. 2006
    ..636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity...
  91. ncbi request reprint Mild cognitive impairment: dementia risk factor or high-risk state for progression to dementia?
    Francesco Panza
    J Am Geriatr Soc 56:1367-9. 2008
  92. ncbi request reprint Lifestyle-related factors, alcohol consumption, and mild cognitive impairment
    Vincenzo Solfrizzi
    J Am Geriatr Soc 55:1679-81. 2007
  93. ncbi request reprint Change of diagnoses in probable and possible mild cognitive impairment: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    J Am Geriatr Soc 55:1480-2. 2007
  94. ncbi request reprint Progression to dementia in probable and possible mild cognitive impairment
    Francesco Panza
    Arch Neurol 64:1209-10; author reply 1210-1. 2007
  95. ncbi request reprint Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles
    Cristiano Capurso
    Department of Geriatrics University of Foggia, Italy
    Exp Gerontol 39:1109-14. 2004
    ..Regional genetic differences in conjunction with differing environmental factors may explain in part previous results suggesting a role of this polymorphism in longevity...
  96. ncbi request reprint Whole-diet approach, Mediterranean diet, and Alzheimer disease
    Vincenzo Solfrizzi
    Arch Neurol 64:606; author reply 607. 2007
  97. doi request reprint Beyond coronary artery disease: rosuvastatin in older patients with ischemic systolic heart failure
    Cristiano Capurso
    J Am Geriatr Soc 56:1366-7. 2008