Giancarlo Solaini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Evaluating mitochondrial membrane potential in cells
    Giancarlo Solaini
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, Bologna, 40126, Italy
    Biosci Rep 27:11-21. 2007
  2. doi request reprint Oxidative phosphorylation in cancer cells
    Giancarlo Solaini
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1807:534-42. 2011
  3. doi request reprint Hypoxia and mitochondrial oxidative metabolism
    Giancarlo Solaini
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Biochim Biophys Acta 1797:1171-7. 2010
  4. doi request reprint The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics
    Giancarlo Solaini
    Dipartimento di Biochimica G Moruzzi, Via Irnerio, 48, Universita di Bologna, Italy
    Biochim Biophys Acta 1777:941-5. 2008
  5. ncbi request reprint Biochemical phenotypes associated with the mitochondrial ATP6 gene mutations at nt8993
    Alessandra Baracca
    Dipartimento di Biochimica G Moruzzi, Via Irnerio 48, Universita di Bologna, 40126 Bologna, and Fondazione Ospedale Maggiore IRCCS Centro Dino Ferrari, Milano, Italy
    Biochim Biophys Acta 1767:913-9. 2007
  6. doi request reprint Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy
    Gianluca Sgarbi
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Bologna, Italy
    Arch Neurol 66:951-7. 2009
  7. doi request reprint Mitochondrial respiratory chain super-complex I-III in physiology and pathology
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1797:633-40. 2010
  8. doi request reprint Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells
    Alessandra Baracca
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Biochim Biophys Acta 1797:314-23. 2010
  9. ncbi request reprint Bioenergetics of mitochondrial diseases associated with mtDNA mutations
    Giorgio Lenaz
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Via Irnerio 48, Bologna 40126, Italy
    Biochim Biophys Acta 1658:89-94. 2004
  10. ncbi request reprint Severe impairment of complex I-driven adenosine triphosphate synthesis in leber hereditary optic neuropathy cybrids
    Alessandra Baracca
    Dipartimento di Biochimica, University of Bologna, Italy
    Arch Neurol 62:730-6. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Evaluating mitochondrial membrane potential in cells
    Giancarlo Solaini
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, Bologna, 40126, Italy
    Biosci Rep 27:11-21. 2007
    ..Furthermore, we discuss the application and feasibility of various techniques and discuss their respective strength and weakness...
  2. doi request reprint Oxidative phosphorylation in cancer cells
    Giancarlo Solaini
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1807:534-42. 2011
    ..Here, we review the peculiarity of tumour mitochondrial bioenergetics and the mode it is linked to the cell metabolism, providing a short overview of the evidence accumulated so far, but highlighting the more recent advances...
  3. doi request reprint Hypoxia and mitochondrial oxidative metabolism
    Giancarlo Solaini
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Biochim Biophys Acta 1797:1171-7. 2010
    ..In addition, we address the involvement of HIF-1 and the inhibitor protein of F1F0 ATPase in the hypoxia-induced mitochondrial autophagy...
  4. doi request reprint The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics
    Giancarlo Solaini
    Dipartimento di Biochimica G Moruzzi, Via Irnerio, 48, Universita di Bologna, Italy
    Biochim Biophys Acta 1777:941-5. 2008
    ..We propose that the integrity of transmembrane helix III is essential for the mechanical function of ATPase 6 as a stator element in the ATP synthase, but that it is not relevant for oligomycin inhibition...
  5. ncbi request reprint Biochemical phenotypes associated with the mitochondrial ATP6 gene mutations at nt8993
    Alessandra Baracca
    Dipartimento di Biochimica G Moruzzi, Via Irnerio 48, Universita di Bologna, 40126 Bologna, and Fondazione Ospedale Maggiore IRCCS Centro Dino Ferrari, Milano, Italy
    Biochim Biophys Acta 1767:913-9. 2007
    ....
  6. doi request reprint Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy
    Gianluca Sgarbi
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Bologna, Italy
    Arch Neurol 66:951-7. 2009
    ....
  7. doi request reprint Mitochondrial respiratory chain super-complex I-III in physiology and pathology
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1797:633-40. 2010
    ..There is increasing evidence that disruption of the super-complex organization leads to functional derangements responsible for pathological changes, as we have found in K-ras-transformed fibroblasts...
  8. doi request reprint Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells
    Alessandra Baracca
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Biochim Biophys Acta 1797:314-23. 2010
    ..Taken together, our results provide the new insight that the reduction of respiration observed in K-ras transformed cells is specifically due to a Complex I activity decrease...
  9. ncbi request reprint Bioenergetics of mitochondrial diseases associated with mtDNA mutations
    Giorgio Lenaz
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Via Irnerio 48, Bologna 40126, Italy
    Biochim Biophys Acta 1658:89-94. 2004
    ....
  10. ncbi request reprint Severe impairment of complex I-driven adenosine triphosphate synthesis in leber hereditary optic neuropathy cybrids
    Alessandra Baracca
    Dipartimento di Biochimica, University of Bologna, Italy
    Arch Neurol 62:730-6. 2005
    ..Leber hereditary optic neuropathy (LHON) is a maternally inherited form of central vision loss associated with mitochondrial DNA point mutations that affect the ND subunits of complex I...
  11. doi request reprint Glucose plays a main role in human fibroblasts adaptation to hypoxia
    Alessandra Baracca
    Dipartimento di Scienze Biomediche e Neuromotorie, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Int J Biochem Cell Biol 45:1356-65. 2013
    ..Therefore, our data show for the first time that glucose availability significantly affects the hypoxia-induced HIF-1/BNIP3 response, and in particular glucose absence results in enhancing the OXPHOS rate...
  12. pmc Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA
    Gianluca Sgarbi
    Dipartimento di Biochimica G Moruzzi, Via Irnerio 48, Universita di Bologna, 40126 Bologna, Italy
    Biochem J 395:493-500. 2006
    ..We discuss our findings in view of the current knowledge regarding the rotary mechanism of catalysis of the enzyme...
  13. ncbi request reprint New insights into structure and function of mitochondria and their role in aging and disease
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Bologna, Italy
    Antioxid Redox Signal 8:417-37. 2006
    ..Evidence is presented favoring the mitochondrial theory, with primary mitochondrial alterations, although the problem is made more complex by changes in the cross-talk between nuclear and mitochondrial DNA...
  14. ncbi request reprint Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration
    Valerio Carelli
    Dipartimento di Scienze Neurologiche, Universita di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    Biochim Biophys Acta 1658:172-9. 2004
    ....
  15. ncbi request reprint Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis
    Alessandra Baracca
    Department of Biochemistry G Moruzzi Alma Mater Studiorum University of Bologna, Via Irnerio 48, I 40126, Bologna, Italy
    Biochim Biophys Acta 1606:137-46. 2003
    ....
  16. ncbi request reprint Mitochondrial Complex I: structure, function, and implications in neurodegeneration
    Giorgio Lenaz
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Italy
    Ital J Biochem 55:232-53. 2006
    ....
  17. pmc Fluorescence resonance energy transfer between coumarin-derived mitochondrial F(1)-ATPase gamma subunit and pyrenylmaleimide-labelled fragments of IF(1) and c subunit
    Alessandra Baracca
    Dipartimento di Biochimica G Moruzzi, Universita degli Studi di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochem J 362:165-71. 2002
    ....
  18. ncbi request reprint Biochemical-clinical correlation in patients with different loads of the mitochondrial DNA T8993G mutation
    Valerio Carelli
    Istituto di Clinica Neurologica, Universita di Bologna, Via U Foscolo 7, 40123 Bologna, Italy
    Arch Neurol 59:264-70. 2002
    ....
  19. doi request reprint Hyperoxia fully protects mitochondria of explanted livers
    G Sgarbi
    Department of Biochemistry, University of Bologna, Via Irnerio, 48, 40126, Bologna, Italy
    J Bioenerg Biomembr 43:673-82. 2011
    ..Remarkably, liver perfusion with hyperoxic solutions fully preserved mitochondrial morphology and function, suggesting that perfusion of the graft with hyperoxic solution should be considered in human transplantation...
  20. pmc Biochemical analysis of respiratory function in cybrid cell lines harbouring mitochondrial DNA mutations
    Francesco Pallotti
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Biochem J 384:287-93. 2004
    ..However, the distinct clinical features associated with some of these mutations still remain to be elucidated...
  21. ncbi request reprint Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease
    Michelangelo Mancuso
    Department of Neurosciences, Neurological Clinics, University of Pisa, Via Roma 67, 56126, Pisa, Italy
    Exp Neurol 182:421-6. 2003
    ..These results support the hypothesis of a systemic impairment of the mitochondrial function in AD and indicate that decreased COX activity could have functional consequences on metabolism...
  22. ncbi request reprint Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease
    Francesca Bosetti
    Scuola Superiore di Studi Universitari e di Perfezionamento S Anna, Via G Carducci 40, 56127 Pisa, Italy
    Neurobiol Aging 23:371-6. 2002
    ..A reduced COX activity may make the tissue vulnerable to excitotoxicity or reduced oxygen availability...
  23. ncbi request reprint Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation
    Ferdinando Squitieri
    Neurogenetics Unit, IRCCS Neuromed, Pozzilli, IS, Italy
    Mech Ageing Dev 127:217-20. 2006
    ..We argue that early mitochondrial impairment at basal level may affect the severity of HD progression in patients...
  24. ncbi request reprint Guanidine-induced dissociation of mitochondrial F1-ATPase
    Stavros Papageorgiou
    Scuola Superiore di Studi Universitari e di Perfezionamento S Anna, Piazza dei Martiri della Libertà, 33, 56127 Pisa, Italy
    Ital J Biochem 53:148-56. 2004
    ..Our results suggest that the delta and epsilon subunits are loosely bound to alpha3beta3gamma , and play an important role in determining structural stability to isolated mitochondrial F1-ATPase...
  25. ncbi request reprint Quenching of intracellular ROS generation as a mechanism for oleate-induced reduction of endothelial activation and early atherogenesis
    Marika Massaro
    Laboratory for Thrombosis and Vascular Research, C N R Institute of Clinical Physiology, Pisa, Italy
    Thromb Haemost 88:335-44. 2002
    ..These results indicate that oleate may exert direct vascular atheroprotective effects by inhibiting endothelial activation through a quenching of stimuli-induced increase in ROS...