C R Sirtori

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Assessment of individual lung cancer risk by the proteomic analysis of exhaled breath condensate
    I Eberini
    University of Milano, Department of Pharmacological Sciences, via Balzaretti 9 I 20133, Milano, Italy 39 02 5031 8311 39 02 5031 8284
    Expert Opin Med Diagn 2:1309-15. 2008
  2. doi request reprint Clinical response to statins: mechanism(s) of variable activity and adverse effects
    Cesare R Sirtori
    Dyslipidemia Center, Niguarda Hospital, Milan, Italy
    Ann Med 44:419-32. 2012
  3. ncbi request reprint Aescin: pharmacology, pharmacokinetics and therapeutic profile
    C R Sirtori
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 44:183-93. 2001
  4. doi request reprint Investigational CETP antagonists for hyperlipidemia and atherosclerosis prevention
    Cesare R Sirtori
    University of Milano, Department of Pharmacological Sciences, Milano, Italy
    Expert Opin Investig Drugs 20:1543-54. 2011
  5. ncbi request reprint Soy milk with a high glycitein content does not reduce low-density lipoprotein cholesterolemia in type II hypercholesterolemic patients
    Cesare R Sirtori
    E Grossi Paoletti Center, Niguarda Hospital, Milan, Italy
    Ann Nutr Metab 46:88-92. 2002
  6. doi request reprint Functional foods for dyslipidaemia and cardiovascular risk prevention
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, Italy
    Nutr Res Rev 22:244-61. 2009
  7. ncbi request reprint Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, I 20100 Milano, Italy
    Atherosclerosis 203:8-17. 2009
  8. ncbi request reprint N-3 fatty acids and diabetes
    C R Sirtori
    Department of Pharmacological Sciences, University of Milano, Milan, Italy
    Biomed Pharmacother 56:397-406. 2002
  9. ncbi request reprint Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, 20133 Milan, Italy
    J Nutr 134:18-23. 2004
  10. doi request reprint Viability of developing CETP inhibitors
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Cardiovasc Ther 26:135-46. 2008

Detail Information

Publications88

  1. doi request reprint Assessment of individual lung cancer risk by the proteomic analysis of exhaled breath condensate
    I Eberini
    University of Milano, Department of Pharmacological Sciences, via Balzaretti 9 I 20133, Milano, Italy 39 02 5031 8311 39 02 5031 8284
    Expert Opin Med Diagn 2:1309-15. 2008
    ..Accessibility of an early marker of lung cancer will be a great advantage for potentially early treatment by surgical procedures with limited tissue removal, possibly preceding metastasis development...
  2. doi request reprint Clinical response to statins: mechanism(s) of variable activity and adverse effects
    Cesare R Sirtori
    Dyslipidemia Center, Niguarda Hospital, Milan, Italy
    Ann Med 44:419-32. 2012
    ..A better understanding of the mechanisms of statin handling will help to minimize adverse effects and interactions, as well as to improve their lipid-lowering efficiency...
  3. ncbi request reprint Aescin: pharmacology, pharmacokinetics and therapeutic profile
    C R Sirtori
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 44:183-93. 2001
    ..The excellent tolerability of aescin in the clinic indicates this treatment is of definite clinical benefit in patients with clinical conditions resulting in CVI, haemorrhoids or peripheral oedema formation...
  4. doi request reprint Investigational CETP antagonists for hyperlipidemia and atherosclerosis prevention
    Cesare R Sirtori
    University of Milano, Department of Pharmacological Sciences, Milano, Italy
    Expert Opin Investig Drugs 20:1543-54. 2011
    ..Inhibition of CETP may provide a useful strategy to raise HDL, the protective lipoprotein fraction in plasma...
  5. ncbi request reprint Soy milk with a high glycitein content does not reduce low-density lipoprotein cholesterolemia in type II hypercholesterolemic patients
    Cesare R Sirtori
    E Grossi Paoletti Center, Niguarda Hospital, Milan, Italy
    Ann Nutr Metab 46:88-92. 2002
    ....
  6. doi request reprint Functional foods for dyslipidaemia and cardiovascular risk prevention
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, Italy
    Nutr Res Rev 22:244-61. 2009
    ..Finally, consensus opinions about tea and coffee have not emerged yet, and the benefits of vitamin E, garlic, fenugreek and policosanols in the management of dyslipidaemia and prevention of arterial disease are still controversial...
  7. ncbi request reprint Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, I 20100 Milano, Italy
    Atherosclerosis 203:8-17. 2009
    ..Active peptides have been identified for the latter indication, whereas works is in progress in attempting to identify specific cholesterol lowering peptides...
  8. ncbi request reprint N-3 fatty acids and diabetes
    C R Sirtori
    Department of Pharmacological Sciences, University of Milano, Milan, Italy
    Biomed Pharmacother 56:397-406. 2002
    ....
  9. ncbi request reprint Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, 20133 Milan, Italy
    J Nutr 134:18-23. 2004
    ..Further, the cholesterol reduction appears to be associated with stimulation of LDL receptors by a well-defined protein component of the lupin seeds as demonstrated by in vitro studies...
  10. doi request reprint Viability of developing CETP inhibitors
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Cardiovasc Ther 26:135-46. 2008
    ..Potentially CETP stimulation, for example by probucol or derivatives may provide instead a more satisfactory approach to cardiovascular prevention...
  11. ncbi request reprint Effect of statins on LDL particle size in patients with familial combined hyperlipidemia: a comparison between atorvastatin and pravastatin
    Cesare R Sirtori
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Nutr Metab Cardiovasc Dis 15:47-55. 2005
    ..There are, at present, inconsistent data on the effects of different treatments on size and density of LDL particles in FCHL patients...
  12. ncbi request reprint Hypocholesterolaemic effects of soya proteins: results of recent studies are predictable from the anderson meta-analysis data
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, Italy
    Br J Nutr 97:816-22. 2007
    ..The re-evaluation thus shows that the thirty-three studies published in the past 10 years are in agreement with the Anderson meta-analysis and confirm its validity...
  13. ncbi request reprint Japan: are statins still good for everybody?
    Cesare R Sirtori
    University Centre for Dyslipidaemias, Niguarda Hospital, Milan 20133, Italy
    Lancet 368:1135-6. 2006
  14. ncbi request reprint Phytoestrogens: end of a tale?
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, Milano, Italy
    Ann Med 37:423-38. 2005
    ..There is now growing interest in the use of soy products containing low levels of phytoestrogens and in research on other phytoestrogen free legumes such as lupin...
  15. ncbi request reprint LDL-cholesterol lowering or HDL-cholesterol raising for cardiovascular prevention. A lesson from cholesterol turnover studies and others
    Cesare R Sirtori
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti, 20133 Milano, Italy
    Atherosclerosis 186:1-11. 2006
    ..Evaluation of these, at times, historical data provides, however, an important clue to the understanding of current results with different medications for the management of lipoprotein disorders...
  16. ncbi request reprint Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis
    C R Sirtori
    Institute of Pharmacological Sciences, University of Milan, Italy
    Drug Saf 24:665-82. 2001
    ..Available data do not appear to unequivocally support beneficial effects of soy isoflavones, and warn against their wide use, in the absence of satisfactory clinical findings...
  17. ncbi request reprint Soy proteins and cardiovascular disease
    C R Sirtori
    Center E Grossi Paoletti and Institute of Pharmacological Sciences, University of Milano, Via Balzaretti 9, Milano 20133, Italy
    Curr Atheroscler Rep 3:47-53. 2001
    ....
  18. ncbi request reprint Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study
    C R Sirtori
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Milan, Italy
    Circulation 103:1949-54. 2001
    ..The objective of this study was to establish whether this high-risk lipid/lipoprotein profile is associated with structural changes in the carotid arteries and heart, indicative of preclinical atherosclerosis...
  19. ncbi request reprint Double-blind study of the addition of high-protein soya milk v. cows' milk to the diet of patients with severe hypercholesterolaemia and resistance to or intolerance of statins
    C R Sirtori
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milan, Italy
    Br J Nutr 82:91-6. 1999
    ..05). These first data from a double-blind study confirm a significant cholesterol-lowering effect of soyabean protein, even when only partly replacing animal protein in the diet, in individuals with extreme plasma cholesterol elevations...
  20. ncbi request reprint Cardiovascular risk changes after lipid lowering medications: are they predictable?
    C R Sirtori
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Atherosclerosis 152:1-8. 2000
    ....
  21. ncbi request reprint Development of a lipid-rich, soft plaque in rabbits, monitored by histology and intravascular ultrasound
    G Chiesa
    Institute of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133, Milano, Italy
    Atherosclerosis 156:277-87. 2001
    ..The easy accessibility of the arterial lesion allows serial IVUS investigations and the direct evaluation of a number of locally or generally delivered therapeutic agents...
  22. ncbi request reprint Increased cholesterol efflux potential of sera from ApoA-IMilano carriers and transgenic mice
    G Franceschini
    Center E Grossi Paoletti and Institute of Pharmacological Sciences, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 19:1257-62. 1999
    ..The high efficiency of A-IM-containing HDL for cell cholesterol uptake would result in an improved reverse cholesterol transport in the A-IM carriers, possibly explaining the low susceptibility to atherosclerosis development...
  23. ncbi request reprint Development of a model based on body composition to predict drug kinetics; II. Application of the model to the use of digoxin in elderlies
    S Ferrara
    Department of Pharmacological Sciences, Grossi Paoletti Center, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 50:105-8. 2004
    ..These findings indicate that digoxin levels, calculated based on a BIA evaluation, may be sufficiently reliable, in the majority of patients, to allow direct determination of the more appropriate doses of digoxin...
  24. ncbi request reprint Soy proteins reduce progression of a focal lesion and lipoprotein oxidiability in rabbits fed a cholesterol-rich diet
    Silvia Castiglioni
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133, Milan, Italy
    Atherosclerosis 171:163-70. 2003
    ..05). These data, while confirming the well-known lipid lowering properties of soy proteins, indicate, in this animal model, a remarkable activity on a focal atheromatous lesion, possibly also linked to a powerful antioxidant activity...
  25. ncbi request reprint Statins enhance arachidonic acid synthesis in hypercholesterolemic patients
    P Rise
    Department of Pharmacological Sciences, Niguarda Hospital, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Nutr Metab Cardiovasc Dis 11:88-94. 2001
    ..The aim of this study was to investigate the possible effects of statins on the desaturating steps of arachidonic acid biosynthesis in patients...
  26. doi request reprint The metabolic syndrome predicts carotid intima-media thickness no better than the sum of individual risk factors in a lipid clinic population
    D Baldassarre
    Dept of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Atherosclerosis 210:214-9. 2010
    ..To assess whether the diagnosis 'metabolic syndrome' (MS) predicts the degree of subclinical atherosclerosis better than its component parts or the total number of vascular risk factors (VRFs) in patients attending a lipid clinic...
  27. ncbi request reprint Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors
    D Baldassarre
    E Grossi Paoletti Center, Institute of Pharmacological Sciences, University of Milan, Italy
    Stroke 31:2426-30. 2000
    ....
  28. ncbi request reprint Plasma triglycerides and lipoprotein(a): inverse relationship in a hyperlipidemic Italian population
    J P Werba
    Center E Grossi Paoletti, University of Milan, Italy
    Atherosclerosis 101:203-11. 1993
    ..In HC patients, the presence of tendon xanthomas was associated with twofold higher Lp(a) levels. These findings argue for a regulatory role of triglycerides on plasma Lp(a) levels in hyperlipidemic patients...
  29. doi request reprint Hypolipidemic effect of dietary pea proteins: Impact on genes regulating hepatic lipid metabolism
    Elena Rigamonti
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Mol Nutr Food Res 54:S24-30. 2010
    ..Moreover, pea proteins appear to affect cellular lipid homeostasis by upregulating genes involved in hepatic cholesterol uptake and by downregulating fatty acid synthesis genes...
  30. ncbi request reprint Apolipoprotein AIMilano. Partial lecithin:cholesterol acyltransferase deficiency due to low levels of a functional enzyme
    G Franceschini
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milan, Italy
    Biochim Biophys Acta 1043:1-6. 1990
    ....
  31. doi request reprint Effects of smoking regular or light cigarettes on brachial artery flow-mediated dilation
    M Amato
    Centro Cardiologico Monzino, IRCCS, Milan, Italy
    Atherosclerosis 228:153-60. 2013
    ....
  32. ncbi request reprint N-3 fatty acids do not lead to an increased diabetic risk in patients with hyperlipidemia and abnormal glucose tolerance. Italian Fish Oil Multicenter Study
    C R Sirtori
    University of Milano, Center E Grossi Paoletti, Institute of Pharmacological Science, Italy
    Am J Clin Nutr 65:1874-81. 1997
    ....
  33. ncbi request reprint Time course of forearm arterial compliance changes during reactive hyperemia
    D Baldassarre
    E. Grossi Paoletti Center, Department of Pharmacological Sciences, University of Milan, Milan 20133, Italy
    Am J Physiol Heart Circ Physiol 281:H1093-103. 2001
    ..The proposed technique is highly sensitive and well comparable with the generally accepted echotracking system. It may thus be considered as an alternative tool to detect and monitor compliance changes induced by arterial occlusion...
  34. ncbi request reprint Triglycerides are major determinants of cholesterol esterification/transfer and HDL remodeling in human plasma
    T Murakami
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 15:1819-28. 1995
    ....
  35. ncbi request reprint Management of lipoprotein-X accumulation in severe cholestasis by semi-selective LDL-apheresis
    G Franceschini
    Center E Grossi Paoletti, University of Milano, Italy
    Am J Med 90:633-8. 1991
    ..The reduction of plasma cholesterol levels was associated with a complete regression of the xanthomas, supporting DF apheresis as a first-choice treatment for patients with massive LP-X accumulation due to cholestasis...
  36. ncbi request reprint Lupin (Lupinus albus) protein isolate (L-ISO) has adequate nutritional value and reduces large intestinal weight in rats after restricted and ad libitum feeding
    Silvia Caligari
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Ann Nutr Metab 50:528-37. 2006
    ..A protein isolate from white lupin (Lupinus albus; L-ISO) has potential as a novel human food ingredient, but its nutritional effects are unknown...
  37. doi request reprint Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: in vivo assessment by intravascular ultrasound and magnetic resonance im
    Cinzia Parolini
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Am Coll Cardiol 51:1098-103. 2008
    ....
  38. doi request reprint Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study
    Damiano Baldassarre
    Department of Pharmacological Sciences, University of Milan, Italy
    Eur Heart J 31:614-22. 2010
    ..This paper reports the results of the baseline analyses aimed at identifying the major determinants of increased carotid IMT (C-IMT)...
  39. ncbi request reprint Limited proteolysis of a disulfide-linked apoA-I dimer in reconstituted HDL
    L Calabresi
    Center E. Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, 20133 Milano, Italy
    J Lipid Res 42:935-42. 2001
    ..This suggests the presence of a novel carboxy-terminal domain in A-I(M)/A-I(M), not organized in a compact structure and not shared by wild-type apoA-I, which may account for the unique functional properties of A-I(M)/A-I(M)...
  40. ncbi request reprint Interactions between carbonic anhydrase and its inhibitors revealed by gel electrophoresis and circular dichroism
    E Gianazza
    Istituto di Scienze Farmacologiche, Universita di Milano, Italy
    Electrophoresis 21:1435-45. 2000
    ..These observations point out peculiar properties of each CA inhibitor, of potential value in the definition of their biological activities and also in the potential development of novel antagonist molecules...
  41. ncbi request reprint Denaturation and self-association of apolipoprotein A-I investigated by electrophoretic techniques
    E Gianazza
    Istituto di Scienze Farmacologiche and Centro Enrica Grossi Paoletti, Facolta di Farmacia, Universita di Milano, Italy
    Biochemistry 36:7898-905. 1997
    ..At acidic pH, apoA-I does not form aggregates and has little secondary structure; unfolding is then a progressive rather than a cooperative process...
  42. ncbi request reprint Therapeutic use of the high-density lipoprotein protein and peptides
    Marta Marchesi
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Expert Opin Investig Drugs 15:227-41. 2006
    ..Other therapeutic options of HDL therapy have recently became available...
  43. ncbi request reprint Apolipoprotein A-IMilano/POPC complex attenuates post-ischemic ventricular dysfunction in the isolated rabbit heart
    Marta Marchesi
    Department of Pharmacological Sciences, University of Milan, Italy
    Atherosclerosis 197:572-8. 2008
    ..The apoA-I(M)/POPC complex thus appears to reduce reperfusion injury under global ischemic conditions, and may therefore have therapeutic application in the reduction of myocardial ischemia...
  44. ncbi request reprint Targeted replacement of mouse apolipoprotein A-I with human ApoA-I or the mutant ApoA-IMilano. Evidence of APOA-IM impaired hepatic secretion
    Cinzia Parolini
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 278:4740-6. 2003
    ..These results provide the first evidence that the hypoalphalipoproteinemia in apoA-I(M) human carriers may be partially explained by impaired apoA-I(M) secretion...
  45. doi request reprint Reduced mammary tumor progression in a transgenic mouse model fed an isoflavone-poor soy protein concentrate
    Giulia Chiesa
    Department of Pharmacological Sciences, University of Milano, Milan, Italy
    Mol Nutr Food Res 52:1121-9. 2008
    ..These results indicate that a diet containing an isoflavone-poor soy protein concentrate may inhibit breast tumor progression and metastasis development...
  46. ncbi request reprint A new noninvasive method for the accurate and precise assessment of varicose vein diameters
    Damiano Baldassarre
    E Grossi Paoletti Center, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Angiology 54:541-9. 2003
    ..The method offers an innovative approach to obtain a quantitative assessment of varicose vein progression and of treatment effects, thus providing a basis for epidemiologic surveys...
  47. doi request reprint Effects of timing and extent of smoking, type of cigarettes, and concomitant risk factors on the association between smoking and subclinical atherosclerosis
    Damiano Baldassarre
    E Grossi Paoletti Center, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Stroke 40:1991-8. 2009
    ....
  48. ncbi request reprint Carotid intima-media thickness and markers of inflammation, endothelial damage and hemostasis
    Damiano Baldassarre
    E Grossi Paoletti Center, Department of Pharmacological Sciences, University of Milan, Italy
    Ann Med 40:21-44. 2008
    ..Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provide contrasting results...
  49. ncbi request reprint Effect of n-3 fatty acids on carotid atherosclerosis and haemostasis in patients with combined hyperlipoproteinemia: a double-blind pilot study in primary prevention
    Damiano Baldassarre
    E Grossi Paoletti Center, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Ann Med 38:367-75. 2006
    ..Intake of n-3 polyunsaturated fatty acids (n-3 PUFA) either from natural sources or dietary supplementation is inversely associated with atherothrombosis...
  50. doi request reprint A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy
    Atherosclerosis 205:506-11. 2009
    ..To analyze the cholesteryl ester transfer protein (CETP) gene and the plasma HDL phenotype in a Caucasian subject with extremely elevated plasma high density lipoprotein-cholesterol (HDL-C)...
  51. ncbi request reprint Effects of fenofibrate and simvastatin on HDL-related biomarkers in low-HDL patients
    Guido Franceschini
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy
    Atherosclerosis 195:385-91. 2007
    ..The distinct and complementary effects of fenofibrate and simvastatin on lipid parameters and HDL-related biomarkers suggest that a combination therapy with the two drugs in dyslipidemic patients with low HDL would be fully justified...
  52. ncbi request reprint Serum from hypercholesterolemic patients treated with atorvastatin or simvastatin inhibits cultured human smooth muscle cell proliferation
    Lorenzo Arnaboldi
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
    Pharmacol Res 56:503-8. 2007
    ....
  53. ncbi request reprint Measurement of carotid artery intima-media thickness in dyslipidemic patients increases the power of traditional risk factors to predict cardiovascular events
    Damiano Baldassarre
    University Centre for Dyslipidemia Niguarda Hospital, Department of Pharmacological Sciences, University of Milan, Italy
    Atherosclerosis 191:403-8. 2007
    ....
  54. ncbi request reprint An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Milan, Italy
    Metabolism 53:153-8. 2004
    ..The plasma concentration of the HDL-bound antioxidant enzyme paraoxonase increased by 10% after Omacor. Omacor may be helpful in correcting multiple lipoprotein abnormalities and reducing cardiovascular risk in FCHL patients...
  55. ncbi request reprint Apolipoprotein A-I(Milano): current perspectives
    Giulia Chiesa
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133, Milano, Italy
    Curr Opin Lipidol 14:159-63. 2003
    ..This review is aimed at providing an update on the experimental studies in which apolipoprotein A-I(Milano), produced as a recombinant protein, has displayed important effects in the treatment of vascular diseases...
  56. ncbi request reprint Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease
    Barbara Villa
    Department of Pharmacological Sciences, Centre E Grossi Paoletti, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 45:475. 2002
    ....
  57. ncbi request reprint Use of recombinant apolipoproteins in vascular diseases: the case of apoA-I
    Giulia Chiesa
    Department of Pharmacological Sciences, University of Milan, Italy
    Curr Opin Investig Drugs 3:420-6. 2002
    ....
  58. ncbi request reprint Correlation of parents' longevity with carotid intima-media thickness in patients attending a Lipid Clinic
    Damiano Baldassarre
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy Center Cardiologico Monzino, IRCCS, Milan, Italy
    Atherosclerosis 179:111-7. 2005
    ..01 and 0.05 for Avg-IMT and Max-IMT, respectively). These data highlight a significant relationship between carotid artery IMT and a familial predisposition to be long-lived that is independent of the individual's vascular risk profile...
  59. ncbi request reprint Recombinant apolipoprotein A-I(Milano) infusion into rabbit carotid artery rapidly removes lipid from fatty streaks
    Giulia Chiesa
    Department of Pharmacological Sciences, University of Milano, Italy
    Circ Res 90:974-80. 2002
    ..These results suggest AIM-PL complexes enhanced lipid removal from arteries is the mechanism responsible for the observed plaque changes...
  60. pmc Size is a major determinant of dissociation and denaturation behaviour of reconstituted high-density lipoproteins
    Elisabetta Gianazza
    Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, via G Balzaretti 9, I 20133 Milano, Italy
    Biochem J 366:245-53. 2002
    ..5/12.7 nm rHDL is likely connected to the higher number of protein-lipid and lipid-lipid interactions in larger as compared with smaller rHDL...
  61. ncbi request reprint Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia
    Damiano Baldassarre
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 22:317-22. 2002
    ....
  62. ncbi request reprint Recombinant apolipoprotein A-IMilano for the treatment of cardiovascular diseases
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, 20133 Milano, Italy
    Curr Atheroscler Rep 8:163-7. 2006
    ..Although at early stages of drug development, A-I(M)/A-I(M) sHDL holds vast promise for the treatment of a variety of cardiovascular diseases in humans...
  63. ncbi request reprint Evaluation of a soft atherosclerotic lesion in the rabbit aorta by an invasive IVUS method versus a non-invasive MRI technology
    G Chiesa
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Atherosclerosis 174:25-33. 2004
    ....
  64. ncbi request reprint Human apolipoproteins A-I and A-II in cell cholesterol efflux: studies with transgenic mice
    G Chiesa
    Center E Grossi Paoletti and Institute of Pharmacological Sciences, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 18:1417-23. 1998
    ....
  65. ncbi request reprint Development of a model based on body composition to predict drug kinetics-1 evaluation in healthy volunteers
    F Pazzucconi
    Department of Pharmacological Sciences, Grossi Paoletti Center, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 50:99-104. 2004
    ..89 to 0.85) and amlodipine (R(2) between 0.81 and 0.91), less satisfactory (with a wide range of R(2), from 0.65 to 0.94), in the case of tobramycin...
  66. pmc A model structure for the heterodimer apoA-IMilano-apoA-II supports its peculiar susceptibility to proteolysis
    Alessandro Guerini Rocco
    Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Centro E Grossi Paoletti, Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Milan, Italy
    Biophys J 91:3043-9. 2006
    ..Circular dichroism on synthetic HDL containing apoA-I(M)-apoA-II was consistent with the alpha-helix content computed on the proposed model...
  67. ncbi request reprint Recombinant apolipoprotein A-I(Milano): a novel agent for the induction of regression of atherosclerotic plaques
    Giulia Chiesa
    Department of Pharmacological Sciences, University of Milano, Italy
    Ann Med 35:267-73. 2003
    ..Ongoing clinical studies will provide final indication as to the potential of this new therapeutic approach...
  68. ncbi request reprint A proteomic investigation of isolated soy proteins with variable effects in experimental and clinical studies
    Elisabetta Gianazza
    Department of Pharmacological Sciences, University of Milano, Italy
    J Nutr 133:9-14. 2003
    ..These findings indicate differences in the protein composition of soy products used in clinical studies. We suggest that standardization should be improved before products are assessed for clinical outcome studies...
  69. doi request reprint Paradoxical decrease in high-density lipoprotein cholesterol with fenofibrate: a quite rare phenomenon indeed
    Giuliana Mombelli
    University Center for Dyslipidemias, Niguarda Hospital, Milano, Italy
    Cardiovasc Ther 28:153-60. 2010
    ..Also based on our very long experience with this drug, it appears that fenofibrate raises HDL-C levels in the vast majority of treated patients, with a particularly dramatic effect in individuals with low HDL-C and hypertriglyceridemia...
  70. doi request reprint Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, Universita degli Studi di Milano, 20133 Milano, Italy
    Circulation 120:628-35. 2009
    ..Theoretically, hypoalphalipoproteinemia cases with LCAT deficiency should be at increased cardiovascular risk because of high-density lipoprotein deficiency and defective reverse cholesterol transport...
  71. doi request reprint Structural features and dynamics properties of human apolipoprotein A-I in a model of synthetic HDL
    Alessandro Guerini Rocco
    Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, 20133 Milano, Italy
    J Mol Graph Model 28:305-12. 2009
    ..Our findings help in defining a molecular model for apoA-I contained in HDL and suggest a possible mechanism through which apoA-I can vary its diameter and accommodate different numbers of phospholipids during the metabolism of HDL...
  72. ncbi request reprint Synthetic high-density lipoproteins exert cardioprotective effects in myocardial ischemia/reperfusion injury
    Giuseppe Rossoni
    Department of Pharmacological Sciences, University of Milano, Italy
    J Pharmacol Exp Ther 308:79-84. 2004
    ....
  73. doi request reprint Acute effects of high-density lipoproteins: biochemical basis and clinical findings
    Giulia Chiesa
    Department of Pharmacological Sciences, University of Milano, Milan, Italy
    Curr Opin Cardiol 23:379-85. 2008
    ..This review aims to provide an overview and an update of all therapeutic applications of synthetic high-density lipoproteins tested in animal models or in clinical trials...
  74. doi request reprint Waist-to-height ratio is a highly sensitive index for the metabolic syndrome in a Mediterranean population
    Giuliana Mombelli
    University Center for Dyslipidemias, Niguarda Hospital, Milano, Italy
    Metab Syndr Relat Disord 7:477-84. 2009
    ..Performance of the WHtR versus body mass index (BMI) and enlarged waist circumference (WC) in the assessment of the metabolic syndrome was tested in nonobese males and females in a high-risk Italian population...
  75. ncbi request reprint Normal vascular function despite low levels of high-density lipoprotein cholesterol in carriers of the apolipoprotein A-I(Milano) mutant
    Monica Gomaraschi
    Center Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy
    Circulation 116:2165-72. 2007
    ..Whether the low HDL level of apoA-I(M) carriers is associated with impaired vascular function is presently unknown...
  76. ncbi request reprint Recognition of patients with cardiovascular disease by artificial neural networks
    Damiano Baldassarre
    E Grossi Paoletti Center, Department of Pharmacological Sciences and Niguarda Hospital, University of Milan, Milan, Italy
    Ann Med 36:630-40. 2004
    ..When exposed to complex data sets, ANNs can learn the mechanisms that correlate different variables and perform complex classification tasks...
  77. ncbi request reprint High-density lipoproteins attenuate interleukin-6 production in endothelial cells exposed to pro-inflammatory stimuli
    Monica Gomaraschi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milano, Italy
    Biochim Biophys Acta 1736:136-43. 2005
    ..38, P<0.001). By inhibiting IL-6 production and lowering plasma IL-6 concentration, HDL may limit the pro-atherogenic effects of both acute and chronic inflammatory states, of which IL-6 is a key orchestrator...
  78. ncbi request reprint Apolipoprotein A-I breakdown is induced by thrombolysis in coronary patients
    Ivano Eberini
    Proteomics and Protein Structure Study Group, University of Milan, Milan, Italy
    Ann Med 39:306-11. 2007
    ..There have never been reports of the detection of apolipoprotein breakdown products in the circulation...
  79. ncbi request reprint Increased keratin content detected by proteomic analysis of exhaled breath condensate from healthy persons who smoke
    Elisabetta Gianazza
    Dipartimento di Scienze Farmacologiche, Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Universita degli Studi di Milano, Milan, Italy
    Am J Med 117:51-4. 2004
  80. ncbi request reprint The FIELD study
    Cesare R Sirtori
    Lancet 367:1141-2; author reply 1142-3. 2006
  81. pmc Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini
    Ivano Eberini
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, via G Balzaretti, 9, I 20133 Milan, Italy
    Biochem J 362:627-34. 2002
    ..Proteolytic fragments produced by metalloproteinase action were shown by gel filtration and electrophoresis to be neither associated with lipids nor self-associated...
  82. ncbi request reprint Analysis of Lupinus albus storage proteins by two-dimensional electrophoresis and mass spectrometry
    Robin Wait
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Agric Food Chem 53:4599-606. 2005
    ....
  83. ncbi request reprint A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding Cassette A1-mediated cell cholesterol efflux
    Elda Favari
    Department of Pharmacological and Biological Sciences, and Applied Chemistries, University of Parma, Viale delle Scienze 27A, 43100 Parma, Italy
    J Biol Chem 282:5125-32. 2007
    ....
  84. ncbi request reprint Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin
    Piergiorgio Zuccaro
    Department of Drug Research and Evaluation, Italian National Institute of Health, Rome, Italy
    Pharmacol Res 55:310-7. 2007
    ..On the other hand, CYP2D6 PM status is associated to an increased efficacy of statins metabolized by this system...
  85. ncbi request reprint Isoflavones and postmenopausal women
    Cesare R Sirtori
    JAMA 292:2336-7; author reply 2337. 2004
  86. ncbi request reprint Comments on the MRC/BHF Heart Protection Study
    Cesare R Sirtori
    Lancet 362:744; author reply 744-5. 2003
  87. ncbi request reprint CETP levels rather than polymorphisms as markers of coronary risk: healthy athlete with high HDL-C and coronary disease--effectiveness of probucol
    Cesare R Sirtori
    Atherosclerosis 186:225-7. 2006
  88. ncbi request reprint ApoA-1 Milano and regression of atherosclerosis
    Cesare R Sirtori
    JAMA 291:1319; author reply 1320. 2004