Sergio Siragusa

Summary

Affiliation: University of Palermo
Country: Italy

Publications

  1. doi request reprint Prevention of venous thromboembolism in patients with cancer: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)(1)
    Sergio Siragusa
    Cattedra ed UO di Ematologia con Trapianto, Dipartimento di Medicina Interna e Specialistica, Azienda Ospedaliera Universitaria Policlinico di Palermo, Via del Vespro 127, 90127 Palermo, Italy
    Thromb Res 129:e171-6. 2012
  2. doi request reprint How should we determine length of anticoagulation after proximal deep vein thrombosis of the lower limbs?
    Sergio Siragusa
    Cattedra ed U O di Ematologia con trapianto, Policlinico Universitario di Palermo P Giaccone, Palermo, Italy
    Br J Haematol 144:832-7. 2009
  3. ncbi request reprint Low molecular weight heparins as antineoplastic agents
    Sergio Siragusa
    Cattedra ed U O di Ematologia con trapianto, Azienda Ospedaliera Universitaria Policlinico P Giaccone, Via del Vespro 127, I 90127, Palermo, Italy
    Recent Pat Anticancer Drug Discov 3:159-61. 2008
  4. ncbi request reprint The risk of recurrent cardiovascular events in patients with increased plasma homocysteine levels is reduced by short but not long-term therapy with folate and B vitamins
    Sergio Siragusa
    Thrombosis Haemostasis and Haematology Unit, University Hospital of Palermo, Italy
    Thromb Res 121:51-3. 2007
  5. ncbi request reprint D-dimer testing: advantages and limitations in emergency medicine for managing acute venous thromboembolism
    Sergio Siragusa
    Thrombosis and Haemostasis Unit, Department of Oncology, University of Palermo, Palermo, Italy
    Intern Emerg Med 1:59-66. 2006
  6. doi request reprint Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature
    Sergio Siragusa
    Cattedra ed U O di Ematologia conTrapianto, Azienda Ospedaliera Universitaria Policlinico di Palermo, Via del Vespro 127, 90127, Palermo, Italy
    Ann Hematol 90:101-6. 2011
  7. ncbi request reprint Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients
    S Siragusa
    U O di Ematologia con trapianto, Azienda Ospedaliera Universitaria P Giaccone, Palermo, Italy
    Ann Oncol 16:iv136-139. 2005
  8. doi request reprint Residual vein thrombosis for assessing duration of anticoagulation after unprovoked deep vein thrombosis of the lower limbs: the extended DACUS study
    Sergio Siragusa
    Cattedra ed Unità di Ematologia con trapianto, Dipartimento di Medicina Interna e Specialistica, Universita degli Studi di Palermo, Italy
    Am J Hematol 86:914-7. 2011
  9. doi request reprint Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study
    Sergio Siragusa
    Cattedra ed Unità di Ematologia con trapianto, Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universita degli Studi di Palermo, Italy
    Blood 112:511-5. 2008
  10. doi request reprint Cancer patients requiring interruption of long-term warfarin because of surgery or chemotherapy induced thrombocytopenia: the use of fixed sub-therapeutic doses of low-molecular weight heparin
    Giorgia Saccullo
    Cattedra ed U O di Ematologia con trapianto, Dipartimento di Medicina Interna e Specialistica DIMIS, Azienda Ospedaliera Universitaria Policlinico P Giaccone, Universita di Palermo, Italy
    Am J Hematol 87:388-91. 2012

Collaborators

Detail Information

Publications25

  1. doi request reprint Prevention of venous thromboembolism in patients with cancer: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)(1)
    Sergio Siragusa
    Cattedra ed UO di Ematologia con Trapianto, Dipartimento di Medicina Interna e Specialistica, Azienda Ospedaliera Universitaria Policlinico di Palermo, Via del Vespro 127, 90127 Palermo, Italy
    Thromb Res 129:e171-6. 2012
    ..Prevention of venous thromboembolism (VTE) in cancer patients remains controversial in most clinical settings...
  2. doi request reprint How should we determine length of anticoagulation after proximal deep vein thrombosis of the lower limbs?
    Sergio Siragusa
    Cattedra ed U O di Ematologia con trapianto, Policlinico Universitario di Palermo P Giaccone, Palermo, Italy
    Br J Haematol 144:832-7. 2009
    ..This annotation discusses current practice and upcoming approaches regarding the length of VKA treatment after a first episode of DVT...
  3. ncbi request reprint Low molecular weight heparins as antineoplastic agents
    Sergio Siragusa
    Cattedra ed U O di Ematologia con trapianto, Azienda Ospedaliera Universitaria Policlinico P Giaccone, Via del Vespro 127, I 90127, Palermo, Italy
    Recent Pat Anticancer Drug Discov 3:159-61. 2008
    ..Recent reports are, at the same time, highlighting a potential role of LMWHs on patient survival due to their presumed antineoplastic action. This review will discuss the most recent reports and patents on these topics...
  4. ncbi request reprint The risk of recurrent cardiovascular events in patients with increased plasma homocysteine levels is reduced by short but not long-term therapy with folate and B vitamins
    Sergio Siragusa
    Thrombosis Haemostasis and Haematology Unit, University Hospital of Palermo, Italy
    Thromb Res 121:51-3. 2007
  5. ncbi request reprint D-dimer testing: advantages and limitations in emergency medicine for managing acute venous thromboembolism
    Sergio Siragusa
    Thrombosis and Haemostasis Unit, Department of Oncology, University of Palermo, Palermo, Italy
    Intern Emerg Med 1:59-66. 2006
    ..However, because of its heterogeneity related to the method used and setting implemented, it is preferable to assess D-dimer accuracy before its implementation in management strategies for VTE...
  6. doi request reprint Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature
    Sergio Siragusa
    Cattedra ed U O di Ematologia conTrapianto, Azienda Ospedaliera Universitaria Policlinico di Palermo, Via del Vespro 127, 90127, Palermo, Italy
    Ann Hematol 90:101-6. 2011
    ..Among the 142 other patients without amyloid deposition in their index bone marrow, one (0.7%, 95% CI -0.6 to 2.0) developed symptomatic AL after 119 months...
  7. ncbi request reprint Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients
    S Siragusa
    U O di Ematologia con trapianto, Azienda Ospedaliera Universitaria P Giaccone, Palermo, Italy
    Ann Oncol 16:iv136-139. 2005
    ..These results indicate that, regarding cancer patients with acute DVT and/or PE, there is no difference between hospitalised and home-treated patients in terms of major outcomes...
  8. doi request reprint Residual vein thrombosis for assessing duration of anticoagulation after unprovoked deep vein thrombosis of the lower limbs: the extended DACUS study
    Sergio Siragusa
    Cattedra ed Unità di Ematologia con trapianto, Dipartimento di Medicina Interna e Specialistica, Universita degli Studi di Palermo, Italy
    Am J Hematol 86:914-7. 2011
    ....
  9. doi request reprint Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study
    Sergio Siragusa
    Cattedra ed Unità di Ematologia con trapianto, Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universita degli Studi di Palermo, Italy
    Blood 112:511-5. 2008
    ..1% person-years) in those who continued OAT. Absence of RVT identifies a group of patients at very low risk for recurrent thrombosis who can safely stop OAT. This trial was registered at http://www.ClinicalTrials.gov as no. NCT00438230...
  10. doi request reprint Cancer patients requiring interruption of long-term warfarin because of surgery or chemotherapy induced thrombocytopenia: the use of fixed sub-therapeutic doses of low-molecular weight heparin
    Giorgia Saccullo
    Cattedra ed U O di Ematologia con trapianto, Dipartimento di Medicina Interna e Specialistica DIMIS, Azienda Ospedaliera Universitaria Policlinico P Giaccone, Universita di Palermo, Italy
    Am J Hematol 87:388-91. 2012
    ..In conclusion, LMWH given at fixed subtherapeutic is a feasible and relatively safe approach for bridging therapy in cancer patients on long-term VKA...
  11. ncbi request reprint Deferral of assessment of pulmonary embolism
    Sergio Siragusa
    U O di Ematologia con trapianto, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Universita di Palermo, Palermo, Italy sergio siragusa unipa it
    Haematologica 92:410-3. 2007
    ..upper 95% CI 0.9%]); only one event occurred in those at high-risk (1/125, 0.8% [upper 95% CI, 1.2]). Our study demonstrates that diagnostic imaging for PE can be safely deferred for up to 3 days...
  12. ncbi request reprint Managing cancer patients with acute venous thromboembolism: exploring safe alternatives to hospitalisation
    Sergio Siragusa
    Chair of Hematology, University of Palermo, Palermo, Italy
    Exp Oncol 26:192-5. 2004
    ....
  13. ncbi request reprint Residual vein thrombosis and D-dimer for optimizing duration of anticoagulation in idiopathic deep vein thrombosis
    Alessandra Malato
    Cattedra ed U O di Ematologia con trapianto Policlinico Universitario di Palermo, Via del Vespro 127, Palermo, Italy
    Curr Pharm Des 16:3483-6. 2010
    ..In the present review we will discuss advantages and potential limits of using these individual markers for the management of patients with a first episode of DVT of the lower limbs...
  14. doi request reprint Safety of plasma-derived protein C for treating disseminated intravascular coagulation in adult patients with active cancer
    Alessandra Malato
    Cattedra ed U O di Ematologia con trapianto, Dipartimento di Medicina Interna e Specialistica DIMIS, Universita degli Studi di Palermo, Italy
    Am J Hematol 87:230-2. 2012
    ..At 28-days follow-up, no bleeding or thrombosis was observed. This is the first study to investigate the use of pd- PC for treatment of cancer-related overt DIC...
  15. ncbi request reprint Deferment of objective assessment of deep vein thrombosis and pulmonary embolism without increased risk of thrombosis: a practical approach based on the pretest clinical model, D-dimer testing, and the use of low-molecular-weight heparins
    Sergio Siragusa
    Thrombosis and Hemostasis Unit, Division of Haematology, University of Palermo, Palermo, Italy
    Arch Intern Med 164:2477-82. 2004
    ....
  16. doi request reprint Relapsing or refractory idiopathic thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the role of rituximab
    Domenica Caramazza
    Cattedra ed U O di Ematologia con trapianto, U O di Immunoematologia e Servizio Trasfusionale, and U O di Neurologia, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone di Palermo, Palermo, Italy
    Transfusion 50:2753-60. 2010
    ..In conclusion, rituximab provides an effective, well-tolerated, and safe treatment option for patients with idiopathic TTP-HUS, thus giving an alternative approach to the current treatment based on PE...
  17. ncbi request reprint Drug-related cardiotoxicity for the treatment of haematological malignancies in elderly
    Alessandra Malato
    Cattedra ed U O di Ematologia con trapianto Azienda Ospedaliera Universitaria Policlinico di Palermo Via del Vespro 129, 90127 Palermo, Italy
    Curr Pharm Des 16:2872-9. 2010
    ....
  18. ncbi request reprint EGFR genomic alterations in cancer: prognostic and predictive values
    Giuseppe Bronte
    Department of Surgical and Oncological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
    Front Biosci (Elite Ed) 3:879-87. 2011
    ..This review summarizes both preclinical and clinical available data regarding EGFR genomic alterations as prognostic and predictive factors...
  19. doi request reprint Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms
    Domenica Caramazza
    Cattedra ed U O di Ematologia, Azienda Ospedaliera Universitaria Policlinico di Palermo, Via del Vespro 127, I 90127, Palermo, Italy
    Ann Hematol 88:967-71. 2009
    ..1, 95% CI 0.2 to 2.7). Finally, we could not identify the presence of JAK2 (V617F) as a risk factor for thrombosis. Properly designed prospective studies should corroborate such results...
  20. doi request reprint Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma
    Giuseppe Bronte
    Department of Surgical and Oncological Sciences, Section of Medical Oncology, University of Palermo, Via del Vespro 127, Palermo, Italy
    Cancer Treat Rev 36:S21-9. 2010
    ..We also provide a potential algorithm as a guide in the choice of the best treatment for patients with adenocarcinoma...
  21. doi request reprint Chromosome 1 abnormalities in myeloid malignancies: a literature survey and karyotype-phenotype associations
    Domenica Caramazza
    Cattedra ed U O di Ematologia, Policlinico Universitario di Palermo, Palermo, Italy
    Eur J Haematol 84:191-200. 2010
    ..These observations suggest that certain chromosome 1 regions, especially 1q21-1q32 and 1p11-13, might harbor oncogenes or tumor suppressor genes that are pathogenetically relevant to both chronic and advanced phases of MPN...
  22. doi request reprint Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial
    Enrico Bernardi
    Department of Emergency and Accident Medicine, Civic Hospital, Conegliano, Italy
    JAMA 300:1653-9. 2008
    ..No randomized comparisons are yet available evaluating the relative values of these 2 strategies...
  23. ncbi request reprint The incidence of heparin-induced thrombocytopenia in medical patients treated with low-molecular-weight heparin: a prospective cohort study
    Paolo Prandoni
    Scienze Mediche e Chirurgiche, Clinica Medica II, Universita di Padova, Italy
    Blood 106:3049-54. 2005
    ..The previous administration of heparin increases the rate of HIT...
  24. doi request reprint Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer
    Francesco Dentali
    Department of Clinical Medicine, Insubria University, Varese, Italy
    J Thorac Cardiovasc Surg 135:705-6. 2008
  25. ncbi request reprint Plasma D-dimer test accuracy can be affected by heparin administration
    Sergio Siragusa
    Arch Intern Med 163:246; author reply 247. 2003