I L Simone

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. pmc Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
    Francesca Luisa Conforti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    J Negat Results Biomed 5:7. 2006
  2. ncbi request reprint Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study
    I L Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare, 70124, Bari, Italy
    J Neurol Sci 182:143-50. 2001
  3. ncbi request reprint Course and prognosis in early-onset MS: comparison with adult-onset forms
    I L Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurology 59:1922-8. 2002
  4. doi request reprint Serum N-acetylaspartate level in amyotrophic lateral sclerosis
    Isabella L Simone
    Department of Neurological and Psychiatric Sciences, Policlinico, University of Bari, Italy
    Arch Neurol 68:1308-12. 2011
  5. doi request reprint Laser evoked potentials in amyotrophic lateral sclerosis
    Isabella Laura Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    J Neurol Sci 288:106-11. 2010
  6. pmc Influence of Interferon beta treatment on quality of life in multiple sclerosis patients
    Isabella Laura Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Health Qual Life Outcomes 4:96. 2006
  7. doi request reprint Post-marketing of disease modifying drugs in multiple sclerosis: an exploratory analysis of gender effect in interferon beta treatment
    M Trojano
    Department of Neurological and Psychiatric Sciences University of Bari, Bari, Italy
    J Neurol Sci 286:109-13. 2009
  8. ncbi request reprint Analysis of survival and prognostic factors in amyotrophic lateral sclerosis: a population based study
    S Zoccolella
    Department of Neurological Sciences, University of Bari, Italy
    J Neurol Neurosurg Psychiatry 79:33-7. 2008
  9. pmc Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV
    I L Simone
    Institute of Neurology, University of Bari, Italy
    J Neurol Neurosurg Psychiatry 64:516-23. 1998
  10. ncbi request reprint Proton MR spectroscopy in idiopathic spasmodic torticollis
    F Federico
    Department of Neurology and Psychiatry, Bari, Italy
    Neuroradiology 43:532-6. 2001

Collaborators

Detail Information

Publications18

  1. pmc Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
    Francesca Luisa Conforti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    J Negat Results Biomed 5:7. 2006
    ..The frequency of the detected exon variation in the VAPB gene was not significantly different between patients and controls. In conclusion, our study suggests that VAPB mutations are not a common cause of adult-onset SALS...
  2. ncbi request reprint Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study
    I L Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare, 70124, Bari, Italy
    J Neurol Sci 182:143-50. 2001
    ..Nevertheless, the lack of statistical differences in NAA/Cr between plaque subgroups suggests that axonal impairment might occur even in the early stages...
  3. ncbi request reprint Course and prognosis in early-onset MS: comparison with adult-onset forms
    I L Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurology 59:1922-8. 2002
    ..To establish the prognostic role of clinical and demographic factors in a hospital-based cohort of MS patients categorized by age at clinical onset and clinical course...
  4. doi request reprint Serum N-acetylaspartate level in amyotrophic lateral sclerosis
    Isabella L Simone
    Department of Neurological and Psychiatric Sciences, Policlinico, University of Bari, Italy
    Arch Neurol 68:1308-12. 2011
    ..In vivo multisection proton ((1)H)-magnetic resonance spectroscopy studies indicate that NAA level decreases in specific cortical brain areas of patients with amyotrophic lateral sclerosis (ALS)...
  5. doi request reprint Laser evoked potentials in amyotrophic lateral sclerosis
    Isabella Laura Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    J Neurol Sci 288:106-11. 2010
    ..On the other hand, an increase of pain processing at the cortical level may derive from a potential sensory compensation to motor cortex dysfunction...
  6. pmc Influence of Interferon beta treatment on quality of life in multiple sclerosis patients
    Isabella Laura Simone
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Health Qual Life Outcomes 4:96. 2006
    ..The objective of this study was to evaluate the influence of IFN-beta on QoL in MS patients...
  7. doi request reprint Post-marketing of disease modifying drugs in multiple sclerosis: an exploratory analysis of gender effect in interferon beta treatment
    M Trojano
    Department of Neurological and Psychiatric Sciences University of Bari, Bari, Italy
    J Neurol Sci 286:109-13. 2009
    ..Observational studies may be especially valuable for answering effectiveness questions in subgroups not studied in RCTs...
  8. ncbi request reprint Analysis of survival and prognostic factors in amyotrophic lateral sclerosis: a population based study
    S Zoccolella
    Department of Neurological Sciences, University of Bari, Italy
    J Neurol Neurosurg Psychiatry 79:33-7. 2008
    ..To measure survivorship and predictors of prognosis of amyotrophic lateral sclerosis (ALS)...
  9. pmc Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV
    I L Simone
    Institute of Neurology, University of Bari, Italy
    J Neurol Neurosurg Psychiatry 64:516-23. 1998
    ..To evaluate the role of proton MR spectroscopy (1H-MRS) in detecting metabolic changes in diffuse or focal lesions in the brain of patients infected with HIV...
  10. ncbi request reprint Proton MR spectroscopy in idiopathic spasmodic torticollis
    F Federico
    Department of Neurology and Psychiatry, Bari, Italy
    Neuroradiology 43:532-6. 2001
    ..0304 and 0.0431, respectively). These results indicate a reduction in NAA, and suggest striatal involvement in the pathogenesis IST...
  11. doi request reprint Real-life impact of early interferon beta therapy in relapsing multiple sclerosis
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Ann Neurol 66:513-20. 2009
    ..We aimed to evaluate the effectiveness of early IFNbeta treatment in definite relapsing-remitting MS (RRMS) and to assess the optimal time to initiate IFNbeta treatment with regard to the greatest benefits on disability progression...
  12. ncbi request reprint Riluzole and amyotrophic lateral sclerosis survival: a population-based study in southern Italy
    S Zoccolella
    Department of Neurological Sciences, University of Bari, Italy
    Eur J Neurol 14:262-8. 2007
    ..Our observations support the use of riluzole at an early stage of ALS in bulbar and elderly patients. However, the appropriate duration of riluzole treatment remains to be established...
  13. doi request reprint Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression
    R Tortelli
    Department of Neurosciences and Sense Organs, University of Bari, Policlinico, Bari, Italy
    Eur J Neurol 19:1561-7. 2012
    ..The aim of our study is to assess the neurofilament light chain (NFL) in cerebrospinal fluid (CSF) samples as a measure of disease activity and progression in ALS...
  14. ncbi request reprint Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis
    D M Mezzapesa
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    AJNR Am J Neuroradiol 28:255-9. 2007
    ..Our purpose was to obtain measures of global and regional atrophy in nondemented patients with ALS to assess subtle structural brain changes...
  15. ncbi request reprint ALS multidisciplinary clinic and survival. Results from a population-based study in Southern Italy
    Stefano Zoccolella
    Department of Neurological Sciences, University of Bari, Operative Unit of Neurology, L Bonomo Hospital, Andria BA, Italy
    J Neurol 254:1107-12. 2007
    ..Because of the multifactorial nature of impairment and disablity in ALS, multidisciplinary clinics (MDC) have been recently introduced in the management of ALS patients; their effects on survival remain, however, largely debated...
  16. ncbi request reprint Predictors of long survival in amyotrophic lateral sclerosis: a population-based study
    Stefano Zoccolella
    Department of Neurological Sciences, University of Bari, Italy
    J Neurol Sci 268:28-32. 2008
    ..Although amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder, some ALS cases can survive beyond 10 years. However, the predictors of long survival in ALS patients remain uncertain...
  17. ncbi request reprint Age-related gadolinium-enhancement of MRI brain lesions in multiple sclerosis
    Carla Tortorella
    Neurophysiopathology Unit, San Paolo Hospital, Bari, Italy
    J Neurol Sci 239:95-9. 2005
    ..0001) and current age (p=0.0003) were the best predictors of the number of enhancing lesions. This information can be used to increase the statistical power of clinical trials using Gd-enhancing lesions as an outcome measure...
  18. ncbi request reprint Could mitochondrial haplogroups play a role in sporadic amyotrophic lateral sclerosis?
    Michelangelo Mancuso
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 371:158-62. 2004
    ..Further it may help elucidate the mechanism of the mitochondrial dysfunction detectable in ALS, and may be of relevance in development of strategies for the treatment of this disease...