T Simoncini

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. pmc Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    PLoS ONE 3:e2790. 2008
  2. pmc Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion
    Maria Silvia Giretti
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    PLoS ONE 3:e2238. 2008
  3. pmc Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    BMC Cancer 8:166. 2008
  4. ncbi request reprint In vitro effects of progesterone and progestins on vascular cells
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Steroids 68:831-6. 2003
  5. ncbi request reprint Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors
    T Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 57, Pisa 56100, Italy
    Hum Reprod 22:2325-34. 2007
  6. ncbi request reprint Rapid estrogen actions in the cardiovascular system
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, 56100 Pisa, Italy
    Ann N Y Acad Sci 1089:424-30. 2006
  7. ncbi request reprint Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Obstet Gynecol 108:969-78. 2006
  8. ncbi request reprint Dehydroepiandrosterone, the endothelium, and cardiovascular protection
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    Endocrinology 148:3065-7. 2007
  9. ncbi request reprint Effects of dydrogesterone and of its stable metabolite, 20-alpha-dihydrodydrogesterone, on nitric oxide synthesis in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Fertil Steril 86:1235-42. 2006
  10. ncbi request reprint Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Mol Endocrinol 20:1756-71. 2006

Collaborators

Detail Information

Publications56

  1. pmc Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    PLoS ONE 3:e2790. 2008
    ..These results provide original mechanistic explanations for the effects of progestins on breast cancer progression and highlight potential targets to treat endocrine-sensitive breast cancers...
  2. pmc Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion
    Maria Silvia Giretti
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    PLoS ONE 3:e2238. 2008
    ..We studied the effect of estrogen receptor recruitment on actin cytoskeleton remodeling and breast cancer cell movement and invasion. Moreover, we characterized the signaling steps through which these actions are enacted...
  3. pmc Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    BMC Cancer 8:166. 2008
    ..Cell migration and invasion are central for these processes, and require dynamic cytoskeletal and cell membrane rearrangements for cell motility to be enacted...
  4. ncbi request reprint In vitro effects of progesterone and progestins on vascular cells
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Steroids 68:831-6. 2003
    ..The understanding of the molecular basis of progesterone receptor signaling in vascular tissue is therefore of paramount importance for the development of hormonal agents with an optimal cardiovascular profile...
  5. ncbi request reprint Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors
    T Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 57, Pisa 56100, Italy
    Hum Reprod 22:2325-34. 2007
    ..Drospirenone (DRSP) is a progestin that uniquely interferes with the signaling of the mineralocorticoid receptor (MR). Hormone therapy containing DRSP results in blood pressure reduction in hypertensive post-menopausal women...
  6. ncbi request reprint Rapid estrogen actions in the cardiovascular system
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, 56100 Pisa, Italy
    Ann N Y Acad Sci 1089:424-30. 2006
    ....
  7. ncbi request reprint Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Obstet Gynecol 108:969-78. 2006
    ..The aim of this study was to establish whether nomegestrol acetate induces signaling events in human endothelial cells that differ from those of other progestins, such as natural progesterone or medroxyprogesterone acetate...
  8. ncbi request reprint Dehydroepiandrosterone, the endothelium, and cardiovascular protection
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    Endocrinology 148:3065-7. 2007
  9. ncbi request reprint Effects of dydrogesterone and of its stable metabolite, 20-alpha-dihydrodydrogesterone, on nitric oxide synthesis in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Fertil Steril 86:1235-42. 2006
    ..The Women's Health Initiative trial reports an excess of heart disease in postmenopausal women receiving MPA...
  10. ncbi request reprint Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Mol Endocrinol 20:1756-71. 2006
    ..Furthermore, exposure of this estrogen receptor-dependent, nongenomic action of estrogen on human vascular endothelial cells is especially relevant to the present interest in the role of estrogen in cardiovascular protection...
  11. doi request reprint Effects of phytoestrogens derived from red clover on atherogenic adhesion molecules in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Menopause 15:542-50. 2008
    ..Recent evidence suggests that these compounds may act neutrally or even beneficially on surrogate cardiovascular risk markers in postmenopausal women. However, little is known of the effects of phytoestrogens on vascular cells...
  12. ncbi request reprint Activation of nitric oxide synthesis in human endothelial cells by red clover extracts
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100, Pisa, Italy
    Menopause 12:69-77. 2005
    ..This is particularly important for estrogen-like compounds such as phytoestrogens, whose mechanisms of action may significantly differ from those of other estrogenic compounds...
  13. ncbi request reprint Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Endocrinology 145:5745-56. 2004
    ..Our findings show significant differences in the signal transduction pathways recruited by P and MPA in endothelial cells, which may have relevant clinical implications...
  14. ncbi request reprint Tibolone activates nitric oxide synthesis in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    J Clin Endocrinol Metab 89:4594-600. 2004
    ..These results help to understand the mechanisms of action of tibolone on the cardiovascular system and have relevant clinical implications...
  15. ncbi request reprint Genomic and non-genomic effects of estrogens on endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Steroids 69:537-42. 2004
    ....
  16. ncbi request reprint [Cardiovascular effects of selective estrogen receptor modulators. Current perspectives]
    Tommaso Simoncini
    Laboratorio di Endocrinologia Ginecologica Cellulare e Molecolare, Divisione di Ostetricia e Ginecologia, Dipartimento di Medicina della Riproduzione e dell Età Evolutiva, Universita di Pisa
    Recenti Prog Med 94:51-6. 2003
    ....
  17. ncbi request reprint Non-genomic actions of sex steroid hormones
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, Italy
    Eur J Endocrinol 148:281-92. 2003
    ..The understanding of the molecular basis of the rapid effects of steroids is therefore important, and may in the future turn out to be of relevance for clinical purposes...
  18. ncbi request reprint Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells
    Tommaso Simoncini
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Mass, USA
    Arterioscler Thromb Vasc Biol 23:198-203. 2003
    ..Because PI3K is mainly a cytoplasmic complex, we studied the cellular site of interaction between this enzyme and ERalpha, and we dissected the molecular mechanisms that mediate this interaction...
  19. ncbi request reprint Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase
    Tommaso Simoncini
    Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Steroids 67:935-9. 2002
    ..This original non-transcriptional mechanism for ER signaling may play an important role in the generation of some of the rapid 'non-genomic' effects of estrogen...
  20. ncbi request reprint Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, 56100 Pisa, Italy
    Endocrinology 143:2052-61. 2002
    ..The present data show that EM-652 (acolbifene) has estrogen-like activity on the vascular wall, directly increasing NO production through genomic and nongenomic mechanisms in vitro and in vivo...
  21. ncbi request reprint Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase
    T Simoncini
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    J Clin Endocrinol Metab 85:2966-9. 2000
    ..In conclusion, raloxifene activates eNOS in human endothelial cells, exerting a potentially important direct vasculo-protective effect stimulating endothelial NO production...
  22. doi request reprint Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells
    M I Flamini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    Mol Hum Reprod 15:675-85. 2009
    ....
  23. ncbi request reprint Mechanisms of action of estrogen receptors in vascular cells: relevance for menopause and aging
    T Simoncini
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Climacteric 12:6-11. 2009
    ....
  24. ncbi request reprint Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Italy
    Circulation 105:1368-73. 2002
    ..The selective estrogen receptor modulator (SERM) raloxifene is effective for the treatment of postmenopausal osteoporosis, but its ability to activate eNOS via PI3K is unknown...
  25. doi request reprint A review of the cardiovascular and breast actions of drospirenone in preclinical studies
    T Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 13:22-33. 2010
    ..This literature-based review explores differences in the preclinical and clinical profiles of the progestins used in hormone therapy, focusing on their effects on the cardiovascular system and breast...
  26. doi request reprint Progestogens regulate endothelial actin cytoskeleton and cell movement via the actin-binding protein moesin
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    Mol Hum Reprod 14:225-34. 2008
    ..These findings provide new information on the biological actions of progestins on human endothelial cells that are relevant for vascular function...
  27. doi request reprint Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo
    L Goglia
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, University of Pisa, Pisa, Italy
    Mol Hum Reprod 16:761-9. 2010
    ..Physiological, but not higher amounts are associated with enhanced NO synthesis and an increased t-PA/PAI-1 ratio. These findings are useful to understand the impact of androgens in ageing individuals...
  28. ncbi request reprint Non-genomic sex steroid actions in the vascular system
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Semin Reprod Med 25:178-86. 2007
    ..The understanding of the molecular basis of the non-genomic actions of sex steroids on the vascular system is important, and may become relevant for clinical purposes in the future...
  29. pmc Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
    T Simoncini
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 407:538-41. 2000
    ..Our findings define a physiologically important non-nuclear oestrogen-signalling pathway involving the direct interaction of ER alpha with PI(3)K...
  30. ncbi request reprint Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells
    T Simoncini
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    J Clin Endocrinol Metab 84:815-8. 1999
    ..Therefore, only some SERMs have potential anti-atherogenic actions exerted directly at the vascular level through the regulation of endothelial cell adhesion molecules expression and of endothelial-leukocyte interactions...
  31. pmc Rapid signaling of estrogen to WAVE1 and moesin controls neuronal spine formation via the actin cytoskeleton
    Angel Matias Sanchez
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, 56100 Pisa, Italy
    Mol Endocrinol 23:1193-202. 2009
    ....
  32. pmc Rapid nongenomic actions of thyroid hormone
    Yukio Hiroi
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:14104-9. 2006
    ....
  33. ncbi request reprint Comparative effects of dydrogesterone and medroxyprogesterone acetate in critical areas: the brain and the vessels
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 23:9-16. 2007
    ..The aim of the present paper is to review the comparative effects of dydrogesterone and other progestins at these sites, supporting the idea that the progestin has to be clinically selected...
  34. pmc Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
    Florian P Limbourg
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 110:1729-38. 2002
    ..These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF...
  35. ncbi request reprint Selective steroid receptor modulators in reproductive medicine
    A Giannini
    Division of Obstetrics and Gynecology, Department of Experimental and Clinical Medicine, University of Pisa, Pisa, Italy
    Minerva Ginecol 67:431-55. 2015
    ..Based on the future advancements on the understanding of the mechanisms of action of these compounds, it is to be expected that future SRMs will emerge for newer indications. ..
  36. ncbi request reprint Drospirenone and its antialdosterone properties
    A R Genazzani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 10:11-8. 2007
    ..The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins...
  37. ncbi request reprint Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Endocrinology 144:3449-55. 2003
    ..Our present data suggest that DHEA may have direct genomic and nongenomic effects on the vascular wall that are not mediated by other steroid hormone receptors, leading to eNOS activation and induction...
  38. doi request reprint Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions
    Alessandro Fasciani
    Ospedali Galliera, Genova, Italy
    J Clin Endocrinol Metab 95:5315-9. 2010
    ..Five subtypes of somatostatin receptors have been identified, and the therapeutic use of somatostatin receptor-selective agonists has been reported in several diseases...
  39. doi request reprint Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase
    Xiao Dong Fu
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Endocr Relat Cancer 17:431-43. 2010
    ..These results provide novel mechanistic views on the effects of progesterone on breast cancer progression, and may in the future be helpful to develop new strategies for the treatment of endocrine-sensitive breast cancers...
  40. doi request reprint Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons depending on prior hormonal exposure via the induction of neural nitric oxide synthase
    Paolo Mannella
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, 56100, Italy
    Steroids 74:650-6. 2009
    ..Furthermore, these data supports the hypothesis that prolonged and continued exposure to oestrogen and progesterone, leading to changes in gene expression, is necessary to obtain neuroprotection induced by sex steroids...
  41. ncbi request reprint "Controversial issues in climacteric medicine" series 3rd Pisa workshop "HRT in climacteric and aging brain". Pisa, Italy, 15-18 March 2003
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Maturitas 46:7-26. 2003
  42. ncbi request reprint Differential estrogen signaling in endothelial cells upon pulsed or continuous administration
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Maturitas 50:247-58. 2005
    ..We therefore, tested whether a different kinetics of exposure of endothelial cells to estrogens may alter the balance between transcriptional and non-transcriptional signaling...
  43. doi request reprint Actin cytoskeleton remodelling by sex steroids in neurones
    A M Sanchez
    Institute of Medicine and Experimental Biology of Cuyo, CCT CONICET Mendoza, National University of Cuyo, Parque General San Martin S N, Mendoza, Argentina
    J Neuroendocrinol 24:195-201. 2012
    ....
  44. ncbi request reprint Menopause and aging, quality of life and sexuality
    A R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Climacteric 10:88-96. 2007
  45. doi request reprint Presence of a putative steroidal allosteric site on glycoprotein hormone receptors
    Mario Rossi
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Eur J Pharmacol 623:155-9. 2009
    ..These data suggest the presence of a steroidal-like allosteric binding site on glycoprotein hormone receptors...
  46. ncbi request reprint Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses
    Giuseppina Basta
    CNR Institute of Clinical Physiology, Pisa, Italy
    Circulation 105:816-22. 2002
    ..A principal means by which AGEs alter cellular properties is through interaction with their signal-transduction receptor RAGE. We tested the hypothesis that interaction of AGEs with RAGE on endothelial cells enhances vascular activation...
  47. doi request reprint Extra-nuclear signaling of ERalpha to the actin cytoskeleton in the central nervous system
    Angel Matias Sanchez
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    Steroids 75:528-32. 2010
    ....
  48. doi request reprint Extra-nuclear signaling of estrogen receptors
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    IUBMB Life 60:502-10. 2008
    ....
  49. doi request reprint Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton
    Marina Ines Flamini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    J Cell Mol Med 13:2396-407. 2009
    ..These results highlight a novel mechanism of action of the SERM raloxifene that might be important for the interference of breast cancer progression or metastasis induced by oestrogens in postmenopausal women...
  50. ncbi request reprint Cytoarchitecture modifications of the human uterine endocervical mucosa in long-term three-dimensional organotypic culture
    Monica Michelini
    Immunobiology and Cell Differentiation Unit, Institute of Biomedical Technologies, CNR, Via G Moruzzi 1, 56100 Pisa, Italy
    Pathol Res Pract 201:679-89. 2005
    ..The addition of Es and Pg further improved the histology and physiology of the fragments: in DMEM(pr-)(Es+Pg), epithelial cells retained a columnar shape, secreted mucins, and formed areas of squamous hyperplasia...
  51. doi request reprint Rapid regulatory actions of sex steroids on cell movement through the actin cytoskeleton
    Maria Silvia Giretti
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Steroids 73:895-900. 2008
    ....
  52. ncbi request reprint A three-dimensional organotypic culture of the human uterine exocervix for studying mucosal epithelial differentiation and migrating leukocytes
    Monica Michelini
    Institute of Biomedical Technologies, Immunobiology and Cell Differentiation Unit, CNR, Via G Moruzzi 1, 56100 Pisa, Italy
    Differentiation 72:138-49. 2004
    ....
  53. doi request reprint Effects in postmenopausal women of estradiol and medroxyprogesterone alone and combined on resistance artery function and endothelial morphology and movement
    Karolina Kublickiene
    Department of Clinical Science, Intervention and Technology, Section for Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    J Clin Endocrinol Metab 93:1874-83. 2008
    ..Endothelial dysfunction in resistance arteries after menopause is important for the development of high blood pressure and cardiovascular disease...
  54. pmc Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
    Ali Hafezi-Moghadam
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:473-9. 2002
    ..The rapid activation of eNOS by the non-nuclear actions of GR, therefore, represents an important cardiovascular protective effect of acute high-dose corticosteroid therapy...
  55. ncbi request reprint The latest elaboration of the Women's Health Initiative data on hormone replacement therapy and cardiovascular disease in postmenopausal women
    Andrea R Genazzani
    Gynecol Endocrinol 23:183-5. 2007
  56. ncbi request reprint Timing is everything
    Andrea Riccardo Genazzani
    Gynecol Endocrinol 23:1-4. 2007