Michele Simonato

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi request reprint Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures
    Gianni Bregola
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    J Neurosci 22:10030-8. 2002
  2. doi request reprint Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development
    Terence J O'Brien
    Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 54:70-4. 2013
  3. pmc Issues for new antiepilepsy drug development
    Michele Simonato
    Section of Pharmacology, Department of Medical Sciences, Neuroscience Center, University of Ferrara, Via Fossato di Mortara 17 19, Ferrara, Italy
    Curr Opin Neurol 26:195-200. 2013
  4. doi request reprint Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design
    Michele Simonato
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Ferrara, and National Institute of Neuroscience, Via Fossato di Mortara 17 19, Ferrara, Italy
    Epilepsia 53:1860-7. 2012
  5. ncbi request reprint Angels and demons: neurotrophic factors and epilepsy
    Michele Simonato
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Ferrara 44100, Italy
    Trends Pharmacol Sci 27:631-8. 2006
  6. doi request reprint Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?
    Michele Simonato
    Section of Pharmacology, Department of Clinical and Experimental Medicine, Neuroscience Center, University of Ferrara, and National Institute of Neuroscience, Ferrara, Italy
    Epilepsia 51:48-51. 2010
  7. doi request reprint Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus
    Beatrice Paradiso
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Epilepsia 52:572-8. 2011
  8. pmc Mechanisms of action of CHF3381 in the forebrain
    Mario Barbieri
    Department of Clinical and Experimental Medicine Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Br J Pharmacol 139:1333-41. 2003
  9. pmc Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss
    Silvia Zucchini
    Section of Pharmacology, Department of Clinical Experimental Medicine, Section of Pathology, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, 44100 Ferrara, Italy
    J Neurosci 28:13112-24. 2008
  10. pmc Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures
    Roberta Bovolenta
    Section of Pharmacology, Department of Clinical and Experimental Medicine, and Neuroscience Center, University of Ferrara, Italy
    J Neuroinflammation 7:81. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures
    Gianni Bregola
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    J Neurosci 22:10030-8. 2002
    ....
  2. doi request reprint Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development
    Terence J O'Brien
    Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 54:70-4. 2013
    ..This should reduce the risk for expensive clinical studies in epilepsy and therefore increase the appeal for funders (industry and government) to invest in their clinical development. ..
  3. pmc Issues for new antiepilepsy drug development
    Michele Simonato
    Section of Pharmacology, Department of Medical Sciences, Neuroscience Center, University of Ferrara, Via Fossato di Mortara 17 19, Ferrara, Italy
    Curr Opin Neurol 26:195-200. 2013
    ..New preclinical and clinical drug development strategies are needed to identify drugs that target these unmet medical needs...
  4. doi request reprint Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design
    Michele Simonato
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Ferrara, and National Institute of Neuroscience, Via Fossato di Mortara 17 19, Ferrara, Italy
    Epilepsia 53:1860-7. 2012
    ..In this review, we overview some of the issues related to these topics and provide examples of new approaches that we hope will be more successful than those used in the past...
  5. ncbi request reprint Angels and demons: neurotrophic factors and epilepsy
    Michele Simonato
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Ferrara 44100, Italy
    Trends Pharmacol Sci 27:631-8. 2006
    ..Here, we critically evaluate new information emerging in this area and discuss its implications for clinical treatment...
  6. doi request reprint Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?
    Michele Simonato
    Section of Pharmacology, Department of Clinical and Experimental Medicine, Neuroscience Center, University of Ferrara, and National Institute of Neuroscience, Ferrara, Italy
    Epilepsia 51:48-51. 2010
    ..These findings are discussed with consideration of the hurdles that will have to be overcome before clinical application...
  7. doi request reprint Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus
    Beatrice Paradiso
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Epilepsia 52:572-8. 2011
    ..To test if this treatment can also prevent hippocampal circuit reorganization, we examined here its effect on mossy fiber sprouting, the best studied form of axonal plasticity in epilepsy...
  8. pmc Mechanisms of action of CHF3381 in the forebrain
    Mario Barbieri
    Department of Clinical and Experimental Medicine Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Br J Pharmacol 139:1333-41. 2003
    ..On this basis, this compound may have a potential use in other diseases caused by or associated with a pathologically high level of NMDA receptor activation...
  9. pmc Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss
    Silvia Zucchini
    Section of Pharmacology, Department of Clinical Experimental Medicine, Section of Pathology, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, 44100 Ferrara, Italy
    J Neurosci 28:13112-24. 2008
    ..These data suggest that FGF-2 may be implicated in seizure susceptibility and in seizure-induced plasticity, exerting different, and apparently contrasting effects: favoring ictogenesis but reducing seizure-induced cell death...
  10. pmc Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures
    Roberta Bovolenta
    Section of Pharmacology, Department of Clinical and Experimental Medicine, and Neuroscience Center, University of Ferrara, Italy
    J Neuroinflammation 7:81. 2010
    ..Nonetheless, the concept that neurotrophic factors affect neuroinflammation in vivo may be highly relevant for the understanding of the epileptogenic process...
  11. ncbi request reprint Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study
    Liliana Carmona Aparicio
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Ferrara, Italy
    J Neurochem 91:30-7. 2004
    ..The present data indicate that acute limbic seizures are associated with increased N/OFQ release, which may prime the molecular changes described above, i.e. cause down-regulation of NOP receptors and activation of N/OFQ biosynthesis...
  12. ncbi request reprint Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice
    Anna Binaschi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Neuroreport 14:825-7. 2003
    ..These data indicate that N/OFQ is involved in the development of kindling and that it may play a pro-epileptogenic role...
  13. pmc Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model
    Beatrice Paradiso
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Proc Natl Acad Sci U S A 106:7191-6. 2009
    ..It is concluded that reduction of damage reduces epileptogenesis and that supplementing specific NTFs in lesion areas represents a new approach to the therapy of neuronal damage and of its consequences...
  14. doi request reprint Bystander effect on brain tissue of mesoangioblasts producing neurotrophins
    Tao Su
    Department of Clinical and Experimental Medicine, Section of Pharmacology, Neuroscience Center, University of Ferrara, Ferrara, Italy
    Cell Transplant 21:1613-27. 2012
    ..Since MABs may be capable of homing into damaged brain areas, they represent a conceptually novel, promising therapeutic approach to treat neurodegenerative diseases...
  15. ncbi request reprint On the role of somatostatin in seizure control: clues from the hippocampus
    Anna Binaschi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Ferrara, Italy
    Rev Neurosci 14:285-301. 2003
    ..Taken together, the data presented suggest that the hippocampal SRIF system plays a role in the control of partial complex seizures and, therefore, that it may be proposed as a therapeutic target for TLE...
  16. ncbi request reprint Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis
    Donata Rodi
    Department of Clinical and Experimental Medicine, Pharmacology Section, and Neuroscience Centre, University of Ferrara, 44100 Ferrara, Italy
    Psychopharmacology (Berl) 196:523-31. 2008
    ..The bed nucleus of the stria terminalis (BST) is highly sensitive to the inhibitory effect of N/OFQ on CRF-induced anorexia...
  17. ncbi request reprint Alterations in seizure susceptibility and in seizure-induced plasticity after pharmacologic and genetic manipulation of the fibroblast growth factor-2 system
    Silvia Zucchini
    Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Ferrara, Italy
    Epilepsia 46:52-8. 2005
    ..The aim of this minireview is to summarize and discuss the data supporting the idea that FGF-2 may be involved in seizure generation and in their sequelae...
  18. ncbi request reprint Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease
    Matteo Marti
    Department of Experimental and Clinical Medicine, Neuroscience Center, University of Ferrara, 44100 Ferrara, Italy
    J Neurosci 25:9591-601. 2005
    ..Based on these data, we propose that NOP receptor antagonists may represent a novel approach for combined (symptomatic and neuroprotective) therapy of Parkinson's disease...
  19. doi request reprint Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease
    Matteo Marti
    Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Ferrara, Italy
    Mov Disord 25:1723-32. 2010
    ..They strengthen the pathogenic role of N/OFQ in the modulation of parkinsonism across species and provide a rationale for developing N/OFQ receptor antagonists as antiparkinsonian drugs...
  20. ncbi request reprint Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy
    Marie Soukupova
    Department of Medical Sciences, Section of Pharmacology, Neuroscience Center, University of Ferrara, Italy National Institute of Neuroscience, Italy Electronic address
    Exp Neurol 257:39-49. 2014
    ....
  21. ncbi request reprint Pro-nociceptin/orphanin FQ and NOP receptor mRNA levels in the forebrain of food deprived rats
    Donata Rodi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Ferrara, Italy
    Brain Res 957:354-61. 2002
    ..Consistently, in the present study N/OFQ stimulated food intake in freely feeding rats, but did not further increase feeding in food deprived rats...
  22. ncbi request reprint Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist
    Silvia Zucchini
    Department of Clinical and Experimental Medicine, Section of Pharmacology Neuroscience Center, University of Ferrara, Via Fossato di Mortara, 17 19, 44100 Ferrara, Italy
    Neuroreport 13:2071-4. 2002
    ..In contrast, MK-801 and CHF3381 completely prevented cell damage. These data indicate that CHF3381 may be successfully utilized in neurological disorders characterized by or associated with neurodegenerative excitotoxicity...
  23. pmc Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy
    Manuela Mazzuferi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, 44100 Ferrara, Italy
    Proc Natl Acad Sci U S A 107:3180-5. 2010
    ..These observations disclose research opportunities in the field of epileptogenesis that may lead to a better understanding of the mechanism whereby a previously normal tissue becomes epileptic...
  24. ncbi request reprint Changes in NPY-mediated modulation of hippocampal [3H]D-aspartate outflow in the kindling model of epilepsy
    Donata Rodi
    Department of Clinical and Experimental Medicine Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Synapse 49:116-24. 2003
    ....
  25. doi request reprint Increased excitability in tat-transgenic mice: role of tat in HIV-related neurological disorders
    Silvia Zucchini
    Department of Medical Sciences, Neuroscience Center, University of Ferrara, National Institute of Neuroscience, Italy
    Neurobiol Dis 55:110-9. 2013
    ..These events may play a key role in the development of HAND...
  26. doi request reprint Loss of cortical GABA terminals in Unverricht-Lundborg disease
    Andrea Buzzi
    Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Neurobiol Dis 47:216-24. 2012
    ..These findings contribute to the understanding of the pathogenic mechanism of ULD and of the neurobiological basis of the effect of currently employed drugs...
  27. doi request reprint The biocompatibility of materials used in printed circuit board technologies with respect to primary neuronal and K562 cells
    Manuela Mazzuferi
    Department of Clinical and Experimental Medicine, Section of Pharmacology and Neuroscience Center, University of Ferrara, Ferrara 44100, Italy
    Biomaterials 31:1045-54. 2010
    ....
  28. ncbi request reprint Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy
    Brice Ongali
    Department of Physiology, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 461:506-19. 2003
    ..An altered balance between B(1) and B(2) receptor populations may play a pivotal role in the onset and/or maintenance of epilepsy...
  29. ncbi request reprint Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain
    Gino Villetti
    Research and Development Department, Chiesi Farmaceutici SpA, Parma, Italy
    J Pharmacol Exp Ther 306:804-14. 2003
    ..o.). Memantine (15 mg/kg i.p.) produced an antinociceptive effect, whereas gabapentin (100 mg/kg p.o.) had no significant effect. Thus, CHF3381 may be useful for the therapy of peripheral painful neuropathies...
  30. ncbi request reprint Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis
    Enrico Tongiorgi
    BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, 34127 Trieste, Italy
    J Neurosci 24:6842-52. 2004
    ..Together, these results suggest that dendritic accumulation of BDNF mRNA and protein plays a critical role in the cellular changes leading to epilepsy...
  31. ncbi request reprint What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development
    Enrico Tongiorgi
    BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Trieste, Italy
    Mol Neurobiol 33:17-32. 2006
    ....
  32. ncbi request reprint Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives
    Eleonora Ghidini
    R and D Department, Chiesi Farmaceutici s p a, Via Palermo 26 A, 43100 Parma, Italy
    Bioorg Med Chem 14:3263-74. 2006
    ..Some of the most potent compounds appear worthy of a further investigation aimed at assessing their anticonvulsant activity in other models and at elucidating the underlying mechanism of action...
  33. ncbi request reprint Third conference on epileptogenesis. S Servolo Island, Venice, Italy, July 27-30, 2005
    Marco de Curtis
    Istituto Nazionale Neurologico Carlo Besta, Milano, Itlay
    Epilepsia 47:1243-6. 2006
  34. ncbi request reprint A pathogenetic hypothesis of Unverricht-Lundborg disease onset and progression
    Silvana Franceschetti
    Division of Neurophysiology and Epileptology, Neurological Institute C Besta via Caloria 11, 20133 Milan, Milan, Italy
    Neurobiol Dis 25:675-85. 2007
    ..Furthermore, a greater degree of neuronal damage was observed in CSTB-deficient than in WT mice after seizures of identical grade, indicating increased susceptibility to seizure-induced cell death...
  35. pmc Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors
    Cristina Roseti
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 105:15118-23. 2008
    ..Our findings strongly suggest that cortical A2-A3 receptors alter the stability of GABA(A) receptors, which could offer therapeutic opportunities...
  36. doi request reprint Fourth conference on epileptogenesis, May 23-26, 2007, Pisa, Italy
    Yuri Bozzi
    Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Epilepsia 49:929-34. 2008