P Simioni

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua, Via Ospedale 105, 35100, Padua, Italy
    Thromb Res 101:219-30. 2001
  2. ncbi Clinical and laboratory expression of associated thrombophilic conditions (homozygous/heterozygous factor V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian family
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Blood Coagul Fibrinolysis 11:379-84. 2000
  3. ncbi The incidence of venous thromboembolism in carriers of antithrombin, protein C or protein S deficiency associated with the HR2 haplotype of factor V: a family cohort study
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 3:1414-20. 2005
  4. ncbi Abnormal propeptide processing resulting in the presence of two abnormal species of protein C in plasma: characterization of the dysfunctional protein C Padua3 (protein C(R-1L/propeptide))
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Thromb Haemost 86:1017-22. 2001
  5. ncbi Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile 105, 35128 Padua, Italy
    Haematologica 86:1305-9. 2001
  6. ncbi Long-term use of oral contraceptive therapy in women with the prothrombin 20210 G-A polymorphism without thrombotic complications: a study of 13 women (12 heterozygotes and 1 homozygote)
    A Girolami
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua Medical School, Padua, Italy
    Thromb Res 102:205-10. 2001
  7. ncbi The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study
    D Tormene
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 5:2193-6. 2007
  8. ncbi Prothrombin and the prothrombin 20210 G to A polymorphism: their relationship with hypercoagulability and thrombosis
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Italy
    Blood Rev 13:205-10. 1999
  9. ncbi Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein S
    F Bilora
    University of Padua Medical School, Department of Medical and Surgery Sciences, Italy
    Clin Appl Thromb Hemost 8:231-7. 2002
  10. ncbi Increased anticoagulant response to low-molecular-weight heparin in plasma from patients with advanced cirrhosis
    M Senzolo
    Multivisceral Transplant Unit, Department of Surgical and Gastroenterological Sciences Padua University Hospital, Padua, Italy
    J Thromb Haemost 10:1823-9. 2012

Collaborators

Detail Information

Publications30

  1. ncbi A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua, Via Ospedale 105, 35100, Padua, Italy
    Thromb Res 101:219-30. 2001
    ..X Lys(408)-->Asn substitution. This is the first characterisation of a naturally occurring F.X variant with a mutation at the COOH-terminal end of the molecule...
  2. ncbi Clinical and laboratory expression of associated thrombophilic conditions (homozygous/heterozygous factor V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian family
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Blood Coagul Fibrinolysis 11:379-84. 2000
    ..It is likely that acquired triggering conditions play a major role in determining VTE in carriers of a mild genetic predisposition. This has to be taken into account when recommendation for thromboprophylaxis is given...
  3. ncbi The incidence of venous thromboembolism in carriers of antithrombin, protein C or protein S deficiency associated with the HR2 haplotype of factor V: a family cohort study
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 3:1414-20. 2005
    ..0%) and none in 147 non-carriers. In family members of patients with AT, PC or PS defects the coinheritance of HR2 haplotype does not seem to increase the thromboembolic risk...
  4. ncbi Abnormal propeptide processing resulting in the presence of two abnormal species of protein C in plasma: characterization of the dysfunctional protein C Padua3 (protein C(R-1L/propeptide))
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Thromb Haemost 86:1017-22. 2001
    ..Impaired interaction of elongated APC molecules with a membrane-surface and/or factor Va which is the physiological substrate for APC, is manifested in vivo by thrombophilia...
  5. ncbi Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile 105, 35128 Padua, Italy
    Haematologica 86:1305-9. 2001
    ....
  6. ncbi Long-term use of oral contraceptive therapy in women with the prothrombin 20210 G-A polymorphism without thrombotic complications: a study of 13 women (12 heterozygotes and 1 homozygote)
    A Girolami
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua Medical School, Padua, Italy
    Thromb Res 102:205-10. 2001
    ..Occasional reports suggesting a link between this polymorphism and oral contraception-related venous thrombosis should be carefully evaluated in order to avoid premature and incorrect conclusions...
  7. ncbi The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study
    D Tormene
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 5:2193-6. 2007
    ..However, because of the different design and sample sizes of these studies the estimated risks have varied...
  8. ncbi Prothrombin and the prothrombin 20210 G to A polymorphism: their relationship with hypercoagulability and thrombosis
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Italy
    Blood Rev 13:205-10. 1999
    ....
  9. ncbi Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein S
    F Bilora
    University of Padua Medical School, Department of Medical and Surgery Sciences, Italy
    Clin Appl Thromb Hemost 8:231-7. 2002
    ..There was also a significant falling circaseptanal rhythm on Fridays. These observations may optimize an adequate and precise anticoagulant therapy in patients with protein C or protein S deficits...
  10. ncbi Increased anticoagulant response to low-molecular-weight heparin in plasma from patients with advanced cirrhosis
    M Senzolo
    Multivisceral Transplant Unit, Department of Surgical and Gastroenterological Sciences Padua University Hospital, Padua, Italy
    J Thromb Haemost 10:1823-9. 2012
    ..Cirrhotic patients may present thrombotic complications that warrant anticoagulant therapy. However, the efficacy of low-molecular-weight heparin (LMWH) in this clinical setting is still unclear...
  11. ncbi Factor VIIa-antithrombin complexes in patients with non-neoplastic portal vein thrombosis with and without cirrhosis
    V Rossetto
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Int J Lab Hematol 35:101-5. 2013
    ..In this case-control study, we evaluated the use of the Factor VIIa-antithrombin complex (FVIIa-AT) complex assay as a hypercoagulability marker in patients with PVT...
  12. ncbi Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 96:3329-33. 2000
    ..2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications...
  13. ncbi Postthrombotic syndrome: incidence, prevention, and management
    E Bernardi
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Semin Vasc Med 1:71-80. 2001
    ..Clinical presentation has a prognostic value, as patients with initially severe symptoms enjoy a more favorable outcome than those who progressively deteriorate over time...
  14. ncbi Risk of recurrent venous thromboembolism and thrombophilia: does discrepancy make complexity or vice versa?
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 1:16-8. 2003
  15. ncbi Whole blood rotation thromboelastometry (ROTEM(®)) in nine severe factor V deficient patients and evaluation of the role of intraplatelets factor V
    L Spiezia
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Haemophilia 18:463-8. 2012
    ..Residual intraplatelets FV in parahaemophilia contributes significantly to thrombin generation as shown in artificially reconstituted PRP models...
  16. ncbi Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial
    Paolo Prandoni
    Department of Cardiothoracic and Vascular Sciences, Clinica Medica II, Thromboembolism Unit, University of Padua, Padua, Italy
    Ann Intern Med 150:577-85. 2009
    ..The optimal duration of oral anticoagulant therapy in patients with deep venous thrombosis (DVT) of the lower extremities remains uncertain...
  17. ncbi Severe arterial cerebral thrombosis in a patient with protein S deficiency (moderately reduced total and markedly reduced free protein S): a family study
    A Girolami
    Institute of Medical Semeiotics, University of Padua Medical School, Italy
    Thromb Haemost 61:144-7. 1989
    ..No other risk factors for thrombotic episodes were present in the family members. The patient reported was treated with ASA and dipyridamole and so far there were no relapses...
  18. ncbi Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN
    C Van 't Veer
    Department of Biochemistry, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Biol Chem 272:20721-9. 1997
    ..Altogether the data predict that TFPI levels in the lower range of normal values are a risk factor for thrombosis when combined with the Arg506 --> Gln mutation in factor VLEIDEN...
  19. ncbi A highly polymorphic microsatellite in the factor V gene is an informative tool for the study of factor V-related disorders
    E Castoldi
    Department of Biochemistry and Molecular Biology, University of Ferrara, Via L. Borsari 46, I-44100 Ferrara, Italy
    Br J Haematol 114:868-70. 2001
    ..An example of the use of the microsatellite marker in family studies of thrombophilia and FV deficiency is also provided...
  20. ncbi Factor V Leiden and prothrombin gene mutation in inflammatory bowel disease in a Mediterranean area
    D Turri
    University of Palermo, Italy
    Dig Liver Dis 33:559-62. 2001
    ..CONCLUSIONS: Data emerging from the present study do not support any role of factor V Leiden and prothrombin gene mutation as the cause of thromboembolism in inflammatory bowel disease...
  21. ncbi Procoagulant activity in children with community acquired pneumonia, pleural effusion and empyema
    E Michelin
    Paediatric Pulmonology Unit, Department of Pediatrics, Padova, Italy
    Pediatr Pulmonol 43:472-5. 2008
    ..To contribute to the knowledge of underlying mechanisms, we have studied the fibrinolytic activity in children with CAP and parapneumonic effusions...
  22. ncbi A matrix-assisted laser desorption/ionization time-of-flight based method for screening the 1691G --> A mutation in the factor V gene
    K Hung
    Department of Chemistry, Cleveland State University, Ohio 44115, USA
    Blood Coagul Fibrinolysis 13:117-22. 2002
    ..The genotypes of all samples were correctly identified. This method is accurate, fast, and potentially allows for simultaneous multiplex genotyping of a number of mutation sites associated with thrombophilia and clot formation...
  23. ncbi Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation
    J M Brugge
    Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM, Maastricht University, Maastricht, Netherlands
    J Thromb Haemost 3:2695-702. 2005
    ..These findings provide an explanation for the higher thrombotic risk of FV Leiden pseudo-homozygotes when compared with heterozygotes...
  24. ncbi Activated protein C resistance in normal and pre-eclamptic pregnancies
    D M Paternoster
    Department of Obstetrics and Gynecology, Padova University, Padova, Italy
    Gynecol Obstet Invest 54:145-9. 2002
    ..Finally, this prospective study was performed to investigate the prevalence of APC-R among pregnant women and to elucidate its obstetric consequences...
  25. ncbi The G20210A prothrombin gene mutation: is there room for screening families?
    D Tormene
    J Thromb Haemost 2:1487-8. 2004
  26. ncbi [Therapeutic indications for acute venous thromboembolism. Current status and future perspectives]
    P Prandoni
    Clinica Medica II, , Padova, Italy
    Minerva Cardioangiol 51:361-71. 2003
    ..The efficacy and safety of emerging drugs (pentasaccharide, ximelagatran) in the treatment and secondary prevention of venous thromboembolic disorders is currently under investigation...
  27. ncbi Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia
    E Castoldi
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 5:971-9. 2007
    ..Differently, in prothrombin G20210A carriers only prothrombin levels are elevated...
  28. ncbi Factor V Leiden is associated with more distal location of deep vein thrombosis of the leg
    M V Huisman
    J Thromb Haemost 6:544-5. 2008
  29. ncbi Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor
    W R Gould
    Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Thromb Haemost 3:450-6. 2005
    ..This process results in the sequestration of active FVa within the platelet compartment, poised for immediate action subsequent to release from platelets at a site of injury...
  30. ncbi Screening for thrombophilia in children: a puzzling decision with unclear implications
    D Tormene
    J Thromb Haemost 2:1193-4. 2004