P Simioni

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Factor IX-Padua enhances the fibrinolytic resistance of plasma clots
    Concetta T Ammollo
    Paolo Simioni, MD, PhD, Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Giustiniani 2 35100 Padua, Italy, Tel Fax 39 049 8212667, E mail
    Thromb Haemost 111:226-32. 2014
  2. ncbi request reprint Circulating microparticles in carriers of factor V Leiden with and without a history of venous thrombosis
    Elena Campello
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Thromb Haemost 108:633-9. 2012
  3. ncbi request reprint Risk of recurrent venous thromboembolism and thrombophilia: does discrepancy make complexity or vice versa?
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 1:16-8. 2003
  4. doi request reprint Effects of long-term administration of recombinant human protein C in xenografted primates
    Paolo Simioni
    Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua, Padua, Italy
    Transplantation 91:161-8. 2011
  5. ncbi request reprint Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants
    Paolo Simioni
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Thromb Res 117:523-8. 2006
  6. ncbi request reprint An underestimated combination of opposites resulting in enhanced thrombotic tendency
    Paolo Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Blood 106:2363-5. 2005
  7. doi request reprint X-linked thrombophilia with a mutant factor IX (factor IX Padua)
    Paolo Simioni
    Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
    N Engl J Med 361:1671-5. 2009
  8. ncbi request reprint Who should be tested for thrombophilia?
    Paolo Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Curr Opin Hematol 13:337-43. 2006
  9. ncbi request reprint Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort study
    Paolo Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Via Ospedale, 105 35128 Padua, Italy
    Blood 99:1938-42. 2002
  10. ncbi request reprint Inherited thrombophilia and venous thromboembolism
    Paolo Simioni
    Department of Medical and Surgical Sciences, University of Padua, Medical School, Padua, Italy
    Semin Thromb Hemost 32:700-8. 2006

Detail Information

Publications62

  1. doi request reprint Factor IX-Padua enhances the fibrinolytic resistance of plasma clots
    Concetta T Ammollo
    Paolo Simioni, MD, PhD, Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Giustiniani 2 35100 Padua, Italy, Tel Fax 39 049 8212667, E mail
    Thromb Haemost 111:226-32. 2014
    ..This thrombin-mediated, TAFI-dependent down-regulation of fibrinolysis provides new clues for explaining the heightened thrombotic risk in subjects carrying the FIX-Padua mutation...
  2. ncbi request reprint Circulating microparticles in carriers of factor V Leiden with and without a history of venous thrombosis
    Elena Campello
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Thromb Haemost 108:633-9. 2012
    ..005). Our study results suggest that circulating MP may contribute to the development of thrombosis in carriers of FVL mutation...
  3. ncbi request reprint Risk of recurrent venous thromboembolism and thrombophilia: does discrepancy make complexity or vice versa?
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 1:16-8. 2003
  4. doi request reprint Effects of long-term administration of recombinant human protein C in xenografted primates
    Paolo Simioni
    Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua, Padua, Italy
    Transplantation 91:161-8. 2011
    ....
  5. ncbi request reprint Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants
    Paolo Simioni
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Thromb Res 117:523-8. 2006
    ..Whether high plasma levels of sEPCR and/or the presence of the A3 haplotype increase the risk of thrombosis in carriers of other PC defects or thrombophilic conditions remains to be clarified...
  6. ncbi request reprint An underestimated combination of opposites resulting in enhanced thrombotic tendency
    Paolo Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Blood 106:2363-5. 2005
    ..Thus, failure to recognize FV deficiency in FV Leiden heterozygotes may result in an underestimate of the thrombosis risk and inadequate management of affected patients...
  7. doi request reprint X-linked thrombophilia with a mutant factor IX (factor IX Padua)
    Paolo Simioni
    Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
    N Engl J Med 361:1671-5. 2009
    ..The R338 substitution causes a gain-of-function mutation, resulting in factor IX that is hyperfunctional...
  8. ncbi request reprint Who should be tested for thrombophilia?
    Paolo Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Curr Opin Hematol 13:337-43. 2006
    ..The purpose of this review is to identify on the basis of available data and expert opinions who would benefit most from screening for thrombophilia...
  9. ncbi request reprint Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort study
    Paolo Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Via Ospedale, 105 35128 Padua, Italy
    Blood 99:1938-42. 2002
    ..Screening families of symptomatic probands with the factor V Leiden mutation has the potential to identify those asymptomatic carriers who might benefit from thromboprophylaxis during risk periods...
  10. ncbi request reprint Inherited thrombophilia and venous thromboembolism
    Paolo Simioni
    Department of Medical and Surgical Sciences, University of Padua, Medical School, Padua, Italy
    Semin Thromb Hemost 32:700-8. 2006
    ....
  11. ncbi request reprint Abnormal propeptide processing resulting in the presence of two abnormal species of protein C in plasma: characterization of the dysfunctional protein C Padua3 (protein C(R-1L/propeptide))
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Thromb Haemost 86:1017-22. 2001
    ..Impaired interaction of elongated APC molecules with a membrane-surface and/or factor Va which is the physiological substrate for APC, is manifested in vivo by thrombophilia...
  12. ncbi request reprint The incidence of venous thromboembolism in carriers of antithrombin, protein C or protein S deficiency associated with the HR2 haplotype of factor V: a family cohort study
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 3:1414-20. 2005
    ..0%) and none in 147 non-carriers. In family members of patients with AT, PC or PS defects the coinheritance of HR2 haplotype does not seem to increase the thromboembolic risk...
  13. ncbi request reprint Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women
    D Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile 105, 35128 Padua, Italy
    Haematologica 86:1305-9. 2001
    ....
  14. ncbi request reprint A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua, Via Ospedale 105, 35100, Padua, Italy
    Thromb Res 101:219-30. 2001
    ..X Lys(408)-->Asn substitution. This is the first characterisation of a naturally occurring F.X variant with a mutation at the COOH-terminal end of the molecule...
  15. ncbi request reprint Clinical and laboratory expression of associated thrombophilic conditions (homozygous/heterozygous factor V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian family
    P Simioni
    Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Blood Coagul Fibrinolysis 11:379-84. 2000
    ..It is likely that acquired triggering conditions play a major role in determining VTE in carriers of a mild genetic predisposition. This has to be taken into account when recommendation for thromboprophylaxis is given...
  16. doi request reprint Factor VIIa-antithrombin complexes in patients with non-neoplastic portal vein thrombosis with and without cirrhosis
    V Rossetto
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Int J Lab Hematol 35:101-5. 2013
    ..In this case-control study, we evaluated the use of the Factor VIIa-antithrombin complex (FVIIa-AT) complex assay as a hypercoagulability marker in patients with PVT...
  17. ncbi request reprint Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 96:3329-33. 2000
    ..2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications...
  18. ncbi request reprint Long-term use of oral contraceptive therapy in women with the prothrombin 20210 G-A polymorphism without thrombotic complications: a study of 13 women (12 heterozygotes and 1 homozygote)
    A Girolami
    Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua Medical School, Padua, Italy
    Thromb Res 102:205-10. 2001
    ..Occasional reports suggesting a link between this polymorphism and oral contraception-related venous thrombosis should be carefully evaluated in order to avoid premature and incorrect conclusions...
  19. ncbi request reprint The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study
    D Tormene
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Thromb Haemost 5:2193-6. 2007
    ..However, because of the different design and sample sizes of these studies the estimated risks have varied...
  20. ncbi request reprint Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein S
    F Bilora
    University of Padua Medical School, Department of Medical and Surgery Sciences, Italy
    Clin Appl Thromb Hemost 8:231-7. 2002
    ..There was also a significant falling circaseptanal rhythm on Fridays. These observations may optimize an adequate and precise anticoagulant therapy in patients with protein C or protein S deficits...
  21. ncbi request reprint Prothrombin and the prothrombin 20210 G to A polymorphism: their relationship with hypercoagulability and thrombosis
    A Girolami
    University of Padua Medical School, Department of Medical and Surgical Sciences, Italy
    Blood Rev 13:205-10. 1999
    ....
  22. ncbi request reprint The effect of pre-eclampsia on the levels of coagulation and fibrinolysis factors in umbilical cord blood of newborns
    Vincenzo Zanardo
    Department of Paediatrics, Second Chair of Internal Medicine, Padua University School of Medicine, Via Ospedale 105, 35100 Padua, Italy
    Blood Coagul Fibrinolysis 16:177-81. 2005
    ....
  23. doi request reprint Increased anticoagulant response to low-molecular-weight heparin in plasma from patients with advanced cirrhosis
    M Senzolo
    Multivisceral Transplant Unit, Department of Surgical and Gastroenterological Sciences Padua University Hospital, Padua, Italy
    J Thromb Haemost 10:1823-9. 2012
    ..Cirrhotic patients may present thrombotic complications that warrant anticoagulant therapy. However, the efficacy of low-molecular-weight heparin (LMWH) in this clinical setting is still unclear...
  24. doi request reprint Whole blood rotation thromboelastometry (ROTEM(®)) in nine severe factor V deficient patients and evaluation of the role of intraplatelets factor V
    L Spiezia
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Haemophilia 18:463-8. 2012
    ..Residual intraplatelets FV in parahaemophilia contributes significantly to thrombin generation as shown in artificially reconstituted PRP models...
  25. doi request reprint Obstetric complications and pregnancy-related venous thromboembolism: the effect of low-molecular-weight heparin on their prevention in carriers of factor V Leiden or prothrombin G20210A mutation
    Daniela Tormene
    Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua, Padua, Italy
    Thromb Haemost 107:477-84. 2012
    ..Furthermore, LMWH prophylaxis reduces the risk of pregnancy-related VTE...
  26. ncbi request reprint Postthrombotic syndrome: incidence, prevention, and management
    E Bernardi
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Semin Vasc Med 1:71-80. 2001
    ..Clinical presentation has a prognostic value, as patients with initially severe symptoms enjoy a more favorable outcome than those who progressively deteriorate over time...
  27. ncbi request reprint Activated protein C resistance in normal and pre-eclamptic pregnancies
    D M Paternoster
    Department of Obstetrics and Gynecology, Padova University, Padova, Italy
    Gynecol Obstet Invest 54:145-9. 2002
    ..Finally, this prospective study was performed to investigate the prevalence of APC-R among pregnant women and to elucidate its obstetric consequences...
  28. ncbi request reprint High prevalence of inherited thrombophilia in 'presumed peri-neonatal' ischemic stroke
    Agnese Suppiej
    Children s Hospital, University of Padua, Padua, Italy
    Eur J Haematol 80:71-5. 2008
    ..The higher prevalence of inherited thrombophilia identified in pAIS and the worse neurological outcome encourage further investigations in population-based studies...
  29. ncbi request reprint The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia
    Maria Teresa Sartori
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 9:299-307. 2003
    ..In conclusion, PAI-1 4G/5G polymorphism may influence PAI-1 expression and thrombotic risk in patients with inherited thrombophilia...
  30. ncbi request reprint The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128, Padua, Italy
    Haematologica 92:199-205. 2007
    ..The aim of this investigation was to assess the rate of recurrent VTE after withdrawal of vitamin K antagonists, and to identify clinical parameters associated with a higher likelihood of recurrence...
  31. ncbi request reprint Thrombosis and thrombophilia in children: a systematic review
    Daniela Tormene
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    Semin Thromb Hemost 32:724-8. 2006
    ..Second, the impact of prothrombotic defects in pediatric patients and the issue of routine testing for these disturbances are reviewed...
  32. doi request reprint The risk of cancer progression in women with gynecological malignancies and thrombophilic polymorphisms: a pilot case-control study
    Daniela Tormene
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Clin Appl Thromb Hemost 15:535-9. 2009
    ..Larger case-control studies in similar cohort of patients are needed to confirm these findings...
  33. ncbi request reprint Alterations in the coagulation profile in renal pig-to-monkey xenotransplantation
    Emanuele Cozzi
    Direzione Sanitaria, Padua General Hospital, University of Padua, Padua, Italy
    Am J Transplant 4:335-45. 2004
    ..This study shows that AHXR is associated with various degrees of compensated consumptive coagulopathy in our pig-to-primate model. No clear relationship was found between coagulation parameter levels and graft outcome...
  34. ncbi request reprint Effects of long-term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenografts
    Emanuele Cozzi
    Direzione Sanitaria, Padua General Hospital, Padua, Italy
    Transplantation 80:1501-10. 2005
    ..Fibrin deposition is central to the acute humoral rejection process occurring in the presence of consumptive coagulopathy when pig organs are transplanted into primates...
  35. ncbi request reprint Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 100:3484-8. 2002
    ..These risks correlate with the extent of cancer. Possibilities for improvement using the current paradigms of anticoagulation seem limited and new treatment strategies should be developed...
  36. ncbi request reprint Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial
    Paolo Prandoni
    Department of Cardiothoracic and Vascular Sciences, Clinica Medica II, Thromboembolism Unit, University of Padua, Padua, Italy
    Ann Intern Med 150:577-85. 2009
    ..The optimal duration of oral anticoagulant therapy in patients with deep venous thrombosis (DVT) of the lower extremities remains uncertain...
  37. ncbi request reprint The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study
    Daniela Tormene
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Blood 100:2403-5. 2002
    ..Accordingly, screening for thrombophilia in otherwise healthy children younger than 15 years who belong to families with inherited defects predisposing to thrombosis seems unjustified...
  38. doi request reprint Thrombin generation in Cushing's Syndrome: do the conventional clotting indices tell the whole truth?
    S Koutroumpi
    Endocrinology Unit, Department of Medicine DIMED, University of Padua, Via Ospedale, 105, 35128, Padua, Italy
    Pituitary 17:68-75. 2014
    ..The high levels of endogenous physiological anticoagulants, could possibly represent a protective mechanism against hypercoagulability seen in CS patients. ..
  39. doi request reprint Circulating microparticles of glial origin and tissue factor bearing in high-grade glioma: a potential prothrombotic role
    Maria Teresa Sartori
    Department of Cardiologic, Thoracic and Vascular Sciences, Via Giustiniani 2, Padua, Italy
    Thromb Haemost 110:378-85. 2013
    ..A contribution of TF+/GFAP- MPs to the risk of VTE is suggested. ..
  40. ncbi request reprint Severe arterial cerebral thrombosis in a patient with protein S deficiency (moderately reduced total and markedly reduced free protein S): a family study
    A Girolami
    Institute of Medical Semeiotics, University of Padua Medical School, Italy
    Thromb Haemost 61:144-7. 1989
    ..No other risk factors for thrombotic episodes were present in the family members. The patient reported was treated with ASA and dipyridamole and so far there were no relapses...
  41. doi request reprint Whole blood coagulation assessment using rotation thrombelastogram thromboelastometry in patients with acute deep vein thrombosis
    Luca Spiezia
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua, Medical School, Padua, Italy
    Blood Coagul Fibrinolysis 19:355-60. 2008
    ..Prospective studies are needed to define the potential applications of rotation thrombelastogram in the management of deep vein thrombosis patients...
  42. ncbi request reprint Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patients
    Luca Spiezia
    Department of Cardia, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale 105, 35100 Padua, Italy
    Thromb Haemost 100:1106-10. 2008
    ....
  43. ncbi request reprint Early cerebral sinovenous thrombosis in a child with acute lymphoblastic leukemia carrying the prothrombin G20210A variant: a case report and review of the literature
    Stefano Mazzoleni
    Maternity and Children s Department, Division of Pediatrics, Camposampiero Hospital, Padua, Italy
    Blood Coagul Fibrinolysis 16:43-9. 2005
    ..Data from the literature are in favor of anti-coagulant treatment, even though the efficacy and safety of thromboprophylaxis during chemotherapy in leukemic children with inherited thrombophilic conditions remain to be demonstrated...
  44. ncbi request reprint Effect of delivery modalities on the physiologic inhibition system of coagulation of the neonate
    Malida Franzoi
    Department of Pediatrics, Padua University School of Medicine, Padua, Italy
    Thromb Res 105:15-8. 2002
    ..In newborns with coagulation disorders, separate reference ranges in coagulation screening tests should be possibly needed depending on the delivery modality...
  45. ncbi request reprint Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
    Ann Intern Med 137:955-60. 2002
    ..Contributing to the controversy is uncertainty about whether residual venous thrombosis, as assessed by repeated ultrasonography over time, increases the risk for recurrent thromboembolism...
  46. pmc The long term clinical course of acute deep vein thrombosis of the arm: prospective cohort study
    Paolo Prandoni
    Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University Hospital of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
    BMJ 329:484-5. 2004
  47. doi request reprint Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes
    O Segers
    Elisabetta Castoldi, PhD, Department of Biochemistry, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands, Tel 31 43 3884160, Fax 31 43 3884159, E mail
    Thromb Haemost 111:438-46. 2014
    ..In conclusion, we have identified several SNPs that modulate thrombin generation in FV Leiden heterozygotes. These SNPs may help explain the large variability in VTE risk observed among different FV Leiden carriers. ..
  48. doi request reprint Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosis
    Luca Spiezia
    Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    Thromb Haemost 103:1188-92. 2010
    ..Further investigations are needed to verify the possible role of higher FVIIa-AT complex plasma levels in predicting hypercoagulable states and thrombosis...
  49. doi request reprint In vitro and in vivo effects of the carbon monoxide-releasing molecule, CORM-3, in the xenogeneic pig-to-primate context
    Marta Vadori
    Consorzio per la Ricerca sul Trapianto d Organi, University of Padua, Via dei Giustiniani 2, Padua, Italy
    Xenotransplantation 16:99-114. 2009
    ..Furthermore, the pharmacodynamics and pharmacotolerance of CORM-3 after administration of single and multiple doses in the primate have been assessed in view of its potential application in pig-to-primate xenotransplantation models...
  50. ncbi request reprint Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy: a randomized trial
    Giuseppe Camporese
    Unit of Angiology, University Hospital of Padua, Padua, Italy
    Ann Intern Med 149:73-82. 2008
    ..Knee arthroscopy, the most common orthopedic operation worldwide, carries a definite risk for deep venous thrombosis; however, postsurgical thromboprophylaxis is not routinely recommended...
  51. pmc Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children
    Barbara Voetsch
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Stroke 38:41-9. 2007
    ..The aim of this study is to identify polymorphisms in the GPx-3 gene, examine their relationship to arterial ischemic stroke (AIS) in a large series of children and young adults, and determine their functional molecular consequences...
  52. ncbi request reprint Isolation and characterization of an antifactor V antibody causing activated protein C resistance from a patient with severe thrombotic manifestations
    Michael Kalafatis
    Department of Chemistry, Cleveland State University, The Cleveland Clinic Foundation, Cleveland, OH 44115, USA
    Blood 99:3985-92. 2002
    ..Our data provide for the first time the demonstration of an antifactor V antibody not related to the presence of antiphospholipid antibodies, which is responsible for thrombotic rather than hemorrhagic symptoms...
  53. ncbi request reprint Folate status and homocysteine level in Italian patients aged under 60 on oral anticoagulant therapy
    Arturo Cafolla
    Haematology Department, Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy
    Ann Med 35:140-4. 2003
    ..We investigated folate status and homocysteine (Hcy) concentration in patients under 60 years on oral anticoagulant therapy (OAT) for previous venous or arterial thrombosis and in healthy blood donors...
  54. ncbi request reprint Recurrent thromboembolism in fertile women with venous thrombosis: incidence and risk factors
    Luca Spiezia
    Thromb Haemost 90:964-6. 2003
  55. ncbi request reprint An antifibrinolytic effect associated with an anti-factor V antibody in a patient with severe thrombophilia
    Mario Colucci
    Department of Biomedical Sciences, University of Bari, Italy
    Haematologica 88:1383-9. 2003
    ..Since activated protein C (APC) is also profibrinolytic we wanted to determine whether the presence of antibodies interfering with the anticoagulant activity of APC also inhibits its profibrinolytic effect...
  56. ncbi request reprint Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
    Roger J S Preston
    Department of Haematology, Division of Investigative Science, Hammersmith Campus, Imperial College London, UK
    FEBS J 272:97-108. 2005
    ..Therefore, protein C binding to sEPCR and phospholipids is broadly dependent on correct Gla domain folding, but can be selectively influenced by judicious mutation...
  57. pmc Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency
    Connie Duckers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Blood 112:3615-23. 2008
    ..Low TFPI levels decreased the FV requirement for minimal thrombin generation in FV-deficient plasma to less than 1% and might therefore protect FV-deficient patients from severe bleeding...
  58. ncbi request reprint The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S
    Valerio De Stefano
    Institute of Hematology, Catholic University, Rome, Italy
    Haematologica 91:695-8. 2006
    ..9, 95% CI 1.0-3.9); the carriers of PC or PS deficiency had a marginal increase in risk (hazard ratio 1.4, 95% CI 0.9-2.2). In conclusion, patients with AT deficiency are potential candidates for long-term oral anticoagulation...
  59. doi request reprint Thrombophilia as a predictor of persistent residual vein thrombosis
    Luca Spiezia
    Haematologica 93:479-80. 2008
    ..49 (95% CI, 0.38 to 0.63). These findings suggest that thrombophilia is an independent predictor of persistent residual vein thrombosis...
  60. ncbi request reprint Appropriateness of choice and interpretation of tests for thrombophilic defects: a practical experience
    Paolo Carraro
    Servizio di Medicina di Laboratorio, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35 100 Padua, Italy
    Clin Chim Acta 333:191-3. 2003
    ..In Italy, general practitioners tend to lack a thorough understanding of the utility of knowledge of coagulation inhibitors...
  61. doi request reprint Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies
    Guy Young
    Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA, USA
    Circulation 118:1373-82. 2008
    ..The aim of the present study was to estimate the impact of inherited thrombophilia (IT) on the risk of venous thromboembolism (VTE) onset and recurrence in children by a meta-analysis of published observational studies...
  62. ncbi request reprint Cerebral sinovenous thrombosis in children: thrombophilia and clinical outcome
    Chiara Gentilomo
    Thromb Res 121:589-91. 2008