Research Topics
| P SimioniSummaryAffiliation: University of Padova Country: Italy Publications
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Publications
Circulating microparticles in carriers of factor V Leiden with and without a history of venous thrombosisElena Campello
Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Thromb Haemost 108:633-9. 2012..005). Our study results suggest that circulating MP may contribute to the development of thrombosis in carriers of FVL mutation...
Effects of long-term administration of recombinant human protein C in xenografted primatesPaolo Simioni
Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua, Padua, Italy
Transplantation 91:161-8. 2011....- Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort studyPaolo Simioni
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Via Ospedale, 105 35128 Padua, Italy
Blood 99:1938-42. 2002..Screening families of symptomatic probands with the factor V Leiden mutation has the potential to identify those asymptomatic carriers who might benefit from thromboprophylaxis during risk periods... - X-linked thrombophilia with a mutant factor IX (factor IX Padua)Paolo Simioni
Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
N Engl J Med 361:1671-5. 2009..The R338 substitution causes a gain-of-function mutation, resulting in factor IX that is hyperfunctional... - Abnormal propeptide processing resulting in the presence of two abnormal species of protein C in plasma: characterization of the dysfunctional protein C Padua3 (protein C(R-1L/propeptide))P Simioni
Department of Medical and Surgical Sciences, University of Padua, Italy
Thromb Haemost 86:1017-22. 2001..Impaired interaction of elongated APC molecules with a membrane-surface and/or factor Va which is the physiological substrate for APC, is manifested in vivo by thrombophilia... - Risk of recurrent venous thromboembolism and thrombophilia: does discrepancy make complexity or vice versa?P Simioni
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
J Thromb Haemost 1:16-8. 2003 - An underestimated combination of opposites resulting in enhanced thrombotic tendencyPaolo Simioni
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Blood 106:2363-5. 2005..Thus, failure to recognize FV deficiency in FV Leiden heterozygotes may result in an underestimate of the thrombosis risk and inadequate management of affected patients... - Inherited thrombophilia and venous thromboembolismPaolo Simioni
Department of Medical and Surgical Sciences, University of Padua, Medical School, Padua, Italy
Semin Thromb Hemost 32:700-8. 2006.... - Who should be tested for thrombophilia?Paolo Simioni
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
Curr Opin Hematol 13:337-43. 2006..The purpose of this review is to identify on the basis of available data and expert opinions who would benefit most from screening for thrombophilia... - Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variantsPaolo Simioni
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Thromb Res 117:523-8. 2006..Whether high plasma levels of sEPCR and/or the presence of the A3 haplotype increase the risk of thrombosis in carriers of other PC defects or thrombophilic conditions remains to be clarified... - The incidence of venous thromboembolism in carriers of antithrombin, protein C or protein S deficiency associated with the HR2 haplotype of factor V: a family cohort studyD Tormene
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
J Thromb Haemost 3:1414-20. 2005..0%) and none in 147 non-carriers. In family members of patients with AT, PC or PS defects the coinheritance of HR2 haplotype does not seem to increase the thromboembolic risk... - Factor V Leiden mutation and the risk of venous thromboembolism in pregnant womenD Tormene
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale Civile 105, 35128 Padua, Italy
Haematologica 86:1305-9. 2001.... - A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian familyP Simioni
Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua, Via Ospedale 105, 35100, Padua, Italy
Thromb Res 101:219-30. 2001..X Lys(408)-->Asn substitution. This is the first characterisation of a naturally occurring F.X variant with a mutation at the COOH-terminal end of the molecule... - Clinical and laboratory expression of associated thrombophilic conditions (homozygous/heterozygous factor V Leiden mutation and heterozygous prothrombin variant 20210A) in an Italian familyP Simioni
Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
Blood Coagul Fibrinolysis 11:379-84. 2000..It is likely that acquired triggering conditions play a major role in determining VTE in carriers of a mild genetic predisposition. This has to be taken into account when recommendation for thromboprophylaxis is given... - Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosisP Simioni
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
Blood 96:3329-33. 2000..2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications... - The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family studyD Tormene
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
J Thromb Haemost 5:2193-6. 2007..However, because of the different design and sample sizes of these studies the estimated risks have varied... - Long-term use of oral contraceptive therapy in women with the prothrombin 20210 G-A polymorphism without thrombotic complications: a study of 13 women (12 heterozygotes and 1 homozygote)A Girolami
Department of Medical and Surgical Sciences, Second Chair of Medicine, University of Padua Medical School, Padua, Italy
Thromb Res 102:205-10. 2001..Occasional reports suggesting a link between this polymorphism and oral contraception-related venous thrombosis should be carefully evaluated in order to avoid premature and incorrect conclusions... - Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein SF Bilora
University of Padua Medical School, Department of Medical and Surgery Sciences, Italy
Clin Appl Thromb Hemost 8:231-7. 2002..There was also a significant falling circaseptanal rhythm on Fridays. These observations may optimize an adequate and precise anticoagulant therapy in patients with protein C or protein S deficits... - Prothrombin and the prothrombin 20210 G to A polymorphism: their relationship with hypercoagulability and thrombosisA Girolami
University of Padua Medical School, Department of Medical and Surgical Sciences, Italy
Blood Rev 13:205-10. 1999.... - The effect of pre-eclampsia on the levels of coagulation and fibrinolysis factors in umbilical cord blood of newbornsVincenzo Zanardo
Department of Paediatrics, Second Chair of Internal Medicine, Padua University School of Medicine, Via Ospedale 105, 35100 Padua, Italy
Blood Coagul Fibrinolysis 16:177-81. 2005.... - Increased anticoagulant response to low-molecular-weight heparin in plasma from patients with advanced cirrhosisM Senzolo
Multivisceral Transplant Unit, Department of Surgical and Gastroenterological Sciences Padua University Hospital, Padua, Italy
J Thromb Haemost 10:1823-9. 2012..Cirrhotic patients may present thrombotic complications that warrant anticoagulant therapy. However, the efficacy of low-molecular-weight heparin (LMWH) in this clinical setting is still unclear... - Factor VIIa-antithrombin complexes in patients with non-neoplastic portal vein thrombosis with and without cirrhosisV Rossetto
Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Int J Lab Hematol 35:101-5. 2013..In this case-control study, we evaluated the use of the Factor VIIa-antithrombin complex (FVIIa-AT) complex assay as a hypercoagulability marker in patients with PVT... - Whole blood rotation thromboelastometry (ROTEM(®)) in nine severe factor V deficient patients and evaluation of the role of intraplatelets factor VL Spiezia
Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Haemophilia 18:463-8. 2012..Residual intraplatelets FV in parahaemophilia contributes significantly to thrombin generation as shown in artificially reconstituted PRP models... - Obstetric complications and pregnancy-related venous thromboembolism: the effect of low-molecular-weight heparin on their prevention in carriers of factor V Leiden or prothrombin G20210A mutationDaniela Tormene
Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua, Padua, Italy
Thromb Haemost 107:477-84. 2012..Furthermore, LMWH prophylaxis reduces the risk of pregnancy-related VTE... - Postthrombotic syndrome: incidence, prevention, and managementE Bernardi
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
Semin Vasc Med 1:71-80. 2001..Clinical presentation has a prognostic value, as patients with initially severe symptoms enjoy a more favorable outcome than those who progressively deteriorate over time... - Activated protein C resistance in normal and pre-eclamptic pregnanciesD M Paternoster
Department of Obstetrics and Gynecology, Padova University, Padova, Italy
Gynecol Obstet Invest 54:145-9. 2002..Finally, this prospective study was performed to investigate the prevalence of APC-R among pregnant women and to elucidate its obstetric consequences... - Thrombosis and thrombophilia in children: a systematic reviewDaniela Tormene
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
Semin Thromb Hemost 32:724-8. 2006..Second, the impact of prothrombotic defects in pediatric patients and the issue of routine testing for these disturbances are reviewed... - High prevalence of inherited thrombophilia in 'presumed peri-neonatal' ischemic strokeAgnese Suppiej
Children s Hospital, University of Padua, Padua, Italy
Eur J Haematol 80:71-5. 2008..The higher prevalence of inherited thrombophilia identified in pAIS and the worse neurological outcome encourage further investigations in population-based studies... - The risk of cancer progression in women with gynecological malignancies and thrombophilic polymorphisms: a pilot case-control studyDaniela Tormene
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Clin Appl Thromb Hemost 15:535-9. 2009..Larger case-control studies in similar cohort of patients are needed to confirm these findings... - Effects of long-term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenograftsEmanuele Cozzi
Direzione Sanitaria, Padua General Hospital, Padua, Italy
Transplantation 80:1501-10. 2005..Fibrin deposition is central to the acute humoral rejection process occurring in the presence of consumptive coagulopathy when pig organs are transplanted into primates... - The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patientsPaolo Prandoni
Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128, Padua, Italy
Haematologica 92:199-205. 2007..The aim of this investigation was to assess the rate of recurrent VTE after withdrawal of vitamin K antagonists, and to identify clinical parameters associated with a higher likelihood of recurrence... - Alterations in the coagulation profile in renal pig-to-monkey xenotransplantationEmanuele Cozzi
Direzione Sanitaria, Padua General Hospital, University of Padua, Padua, Italy
Am J Transplant 4:335-45. 2004..This study shows that AHXR is associated with various degrees of compensated consumptive coagulopathy in our pig-to-primate model. No clear relationship was found between coagulation parameter levels and graft outcome... - The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophiliaMaria Teresa Sartori
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
Clin Appl Thromb Hemost 9:299-307. 2003..In conclusion, PAI-1 4G/5G polymorphism may influence PAI-1 expression and thrombotic risk in patients with inherited thrombophilia... - Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosisPaolo Prandoni
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
Blood 100:3484-8. 2002..These risks correlate with the extent of cancer. Possibilities for improvement using the current paradigms of anticoagulation seem limited and new treatment strategies should be developed... - Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trialPaolo Prandoni
Department of Cardiothoracic and Vascular Sciences, Clinica Medica II, Thromboembolism Unit, University of Padua, Padua, Italy
Ann Intern Med 150:577-85. 2009..The optimal duration of oral anticoagulant therapy in patients with deep venous thrombosis (DVT) of the lower extremities remains uncertain... - The incidence of venous thromboembolism in thrombophilic children: a prospective cohort studyDaniela Tormene
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Blood 100:2403-5. 2002..Accordingly, screening for thrombophilia in otherwise healthy children younger than 15 years who belong to families with inherited defects predisposing to thrombosis seems unjustified... - Severe arterial cerebral thrombosis in a patient with protein S deficiency (moderately reduced total and markedly reduced free protein S): a family studyA Girolami
Institute of Medical Semeiotics, University of Padua Medical School, Italy
Thromb Haemost 61:144-7. 1989..No other risk factors for thrombotic episodes were present in the family members. The patient reported was treated with ASA and dipyridamole and so far there were no relapses... - Residual venous thrombosis as a predictive factor of recurrent venous thromboembolismPaolo Prandoni
Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
Ann Intern Med 137:955-60. 2002..Contributing to the controversy is uncertainty about whether residual venous thrombosis, as assessed by repeated ultrasonography over time, increases the risk for recurrent thromboembolism... - Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patientsLuca Spiezia
Department of Cardia, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale 105, 35100 Padua, Italy
Thromb Haemost 100:1106-10. 2008.... - Effect of delivery modalities on the physiologic inhibition system of coagulation of the neonateMalida Franzoi
Department of Pediatrics, Padua University School of Medicine, Padua, Italy
Thromb Res 105:15-8. 2002..In newborns with coagulation disorders, separate reference ranges in coagulation screening tests should be possibly needed depending on the delivery modality... - Whole blood coagulation assessment using rotation thrombelastogram thromboelastometry in patients with acute deep vein thrombosisLuca Spiezia
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua, Medical School, Padua, Italy
Blood Coagul Fibrinolysis 19:355-60. 2008..Prospective studies are needed to define the potential applications of rotation thrombelastogram in the management of deep vein thrombosis patients... - Early cerebral sinovenous thrombosis in a child with acute lymphoblastic leukemia carrying the prothrombin G20210A variant: a case report and review of the literatureStefano Mazzoleni
Maternity and Children's Department, Division of Pediatrics, Camposampiero Hospital, Padua, Italy
Blood Coagul Fibrinolysis 16:43-9. 2005..Data from the literature are in favor of anti-coagulant treatment, even though the efficacy and safety of thromboprophylaxis during chemotherapy in leukemic children with inherited thrombophilic conditions remain to be demonstrated... 
The long term clinical course of acute deep vein thrombosis of the arm: prospective cohort studyPaolo Prandoni
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University Hospital of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
BMJ 329:484-5. 2004- Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosisLuca Spiezia
Department of Cardiologic, Thoracic, and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
Thromb Haemost 103:1188-92. 2010..Further investigations are needed to verify the possible role of higher FVIIa-AT complex plasma levels in predicting hypercoagulable states and thrombosis... - Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy: a randomized trialGiuseppe Camporese
Unit of Angiology, University Hospital of Padua, Padua, Italy
Ann Intern Med 149:73-82. 2008..Knee arthroscopy, the most common orthopedic operation worldwide, carries a definite risk for deep venous thrombosis; however, postsurgical thromboprophylaxis is not routinely recommended... - In vitro and in vivo effects of the carbon monoxide-releasing molecule, CORM-3, in the xenogeneic pig-to-primate contextMarta Vadori
Consorzio per la Ricerca sul Trapianto d Organi, University of Padua, Via dei Giustiniani 2, Padua, Italy
Xenotransplantation 16:99-114. 2009..Furthermore, the pharmacodynamics and pharmacotolerance of CORM-3 after administration of single and multiple doses in the primate have been assessed in view of its potential application in pig-to-primate xenotransplantation models... - The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein SValerio De Stefano
Institute of Hematology, Catholic University, Rome, Italy
Haematologica 91:695-8. 2006..9, 95% CI 1.0-3.9); the carriers of PC or PS deficiency had a marginal increase in risk (hazard ratio 1.4, 95% CI 0.9-2.2). In conclusion, patients with AT deficiency are potential candidates for long-term oral anticoagulation... - Isolation and characterization of an antifactor V antibody causing activated protein C resistance from a patient with severe thrombotic manifestationsMichael Kalafatis
Department of Chemistry, Cleveland State University, The Cleveland Clinic Foundation, Cleveland, OH 44115, USA
Blood 99:3985-92. 2002..Our data provide for the first time the demonstration of an antifactor V antibody not related to the presence of antiphospholipid antibodies, which is responsible for thrombotic rather than hemorrhagic symptoms... - Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutationRoger J S Preston
Department of Haematology, Division of Investigative Science, Hammersmith Campus, Imperial College London, UK
FEBS J 272:97-108. 2005..Therefore, protein C binding to sEPCR and phospholipids is broadly dependent on correct Gla domain folding, but can be selectively influenced by judicious mutation... - Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and childrenBarbara Voetsch
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Stroke 38:41-9. 2007..The aim of this study is to identify polymorphisms in the GPx-3 gene, examine their relationship to arterial ischemic stroke (AIS) in a large series of children and young adults, and determine their functional molecular consequences... - An antifibrinolytic effect associated with an anti-factor V antibody in a patient with severe thrombophiliaMario Colucci
Department of Biomedical Sciences, University of Bari, Italy
Haematologica 88:1383-9. 2003..Since activated protein C (APC) is also profibrinolytic we wanted to determine whether the presence of antibodies interfering with the anticoagulant activity of APC also inhibits its profibrinolytic effect... - Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiencyConnie Duckers
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
Blood 112:3615-23. 2008..Low TFPI levels decreased the FV requirement for minimal thrombin generation in FV-deficient plasma to less than 1% and might therefore protect FV-deficient patients from severe bleeding... - Recurrent thromboembolism in fertile women with venous thrombosis: incidence and risk factorsLuca Spiezia
Thromb Haemost 90:964-6. 2003 - Folate status and homocysteine level in Italian patients aged under 60 on oral anticoagulant therapyArturo Cafolla
Haematology Department, Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy
Ann Med 35:140-4. 2003..We investigated folate status and homocysteine (Hcy) concentration in patients under 60 years on oral anticoagulant therapy (OAT) for previous venous or arterial thrombosis and in healthy blood donors... - Thrombophilia as a predictor of persistent residual vein thrombosisLuca Spiezia
Haematologica 93:479-80. 2008..49 (95% CI, 0.38 to 0.63). These findings suggest that thrombophilia is an independent predictor of persistent residual vein thrombosis... - Cerebral sinovenous thrombosis in children: thrombophilia and clinical outcomeChiara Gentilomo
Thromb Res 121:589-91. 2008 - Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studiesGuy Young
Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA, USA
Circulation 118:1373-82. 2008..The aim of the present study was to estimate the impact of inherited thrombophilia (IT) on the risk of venous thromboembolism (VTE) onset and recurrence in children by a meta-analysis of published observational studies... - Appropriateness of choice and interpretation of tests for thrombophilic defects: a practical experiencePaolo Carraro
Servizio di Medicina di Laboratorio, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35 100 Padua, Italy
Clin Chim Acta 333:191-3. 2003..In Italy, general practitioners tend to lack a thorough understanding of the utility of knowledge of coagulation inhibitors...