Affiliation: University of Milan
- Sibilia V, Pagani F, Dieci E, Mrak E, Marchese M, Zarattini G, et al. Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats. Endocrine. 2013;44:790-802 pubmed publisher..Our data support a role for 5-HT in the anabolic response of the appendicular skeleton to mechanical loading. We suggest that serotonin might stimulate canonical Wnt/?-catenin-dependent bone formation to occur...