Valeria Sibilia

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats
    Valeria Sibilia
    Department of Medical Biotechnology and Translational Medicine, Medical Pharmacology Unit, Universita degli Studi di Milano, Via Vanvitelli, 32, Milan, 20129, Italy
    Endocrine 44:790-802. 2013
  2. pmc Pharmacological characterization of the ghrelin receptor mediating its inhibitory action on inflammatory pain in rats
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Via Vanvitelli, 32, 20129, Milan, Italy
    Amino Acids 43:1751-9. 2012
  3. doi request reprint Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Via Vanvitelli, 32, 20129, Milan, Italy
    Amino Acids 42:1261-8. 2012
  4. doi request reprint TLQP-21, a VGF-derived peptide, prevents ethanol-induced gastric lesions: insights into its mode of action
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Milano, Italy
    Neuroendocrinology 92:189-97. 2010
  5. doi request reprint Linking chronic tryptophan deficiency with impaired bone metabolism and reduced bone accrual in growing rats
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milano, Italy
    J Cell Biochem 107:890-8. 2009
  6. ncbi request reprint Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milano, Milan, Italy
    J Neuroendocrinol 18:122-8. 2006
  7. ncbi request reprint Ghrelin inhibits inflammatory pain in rats: involvement of the opioid system
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli, 32, 20129 Milan, Italy
    Neuropharmacology 51:497-505. 2006
  8. ncbi request reprint Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat
    V Sibilia
    Department of Pharmacology, Chemoterapy, and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    J Endocrinol Invest 29:RC31-4. 2006
  9. ncbi request reprint Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Italy
    Pharmacol Res 55:418-25. 2007
  10. ncbi request reprint Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy
    Peptides 25:2163-70. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats
    Valeria Sibilia
    Department of Medical Biotechnology and Translational Medicine, Medical Pharmacology Unit, Universita degli Studi di Milano, Via Vanvitelli, 32, Milan, 20129, Italy
    Endocrine 44:790-802. 2013
    ..Our data support a role for 5-HT in the anabolic response of the appendicular skeleton to mechanical loading. We suggest that serotonin might stimulate canonical Wnt/β-catenin-dependent bone formation to occur...
  2. pmc Pharmacological characterization of the ghrelin receptor mediating its inhibitory action on inflammatory pain in rats
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Via Vanvitelli, 32, 20129, Milan, Italy
    Amino Acids 43:1751-9. 2012
    ....
  3. doi request reprint Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Via Vanvitelli, 32, 20129, Milan, Italy
    Amino Acids 42:1261-8. 2012
    ..The central inhibitory effect of TLQP-21 on gastric acid secretion is mediated by endogenous somatostatin and prostaglandins and requires the integrity of sensory nerve fibres...
  4. doi request reprint TLQP-21, a VGF-derived peptide, prevents ethanol-induced gastric lesions: insights into its mode of action
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Milano, Italy
    Neuroendocrinology 92:189-97. 2010
    ..TLQP-21, a peptide derived from the vgf gene, has been reported to play a role in the regulation of rat gastric motility, but its influence on gastric mucosal integrity is unknown...
  5. doi request reprint Linking chronic tryptophan deficiency with impaired bone metabolism and reduced bone accrual in growing rats
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milano, Italy
    J Cell Biochem 107:890-8. 2009
    ....
  6. ncbi request reprint Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milano, Milan, Italy
    J Neuroendocrinol 18:122-8. 2006
    ..The observation that CST-14 binds both GHR-S and somatostatin receptors, whereas CST-8 specifically displaces only ghrelin binding, indicates that CST-8 behaves as a GHS-R(1a) antagonist...
  7. ncbi request reprint Ghrelin inhibits inflammatory pain in rats: involvement of the opioid system
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli, 32, 20129 Milan, Italy
    Neuropharmacology 51:497-505. 2006
    ..c.), did not antagonize antinociception elicited by i.p. ghrelin. Overall these data indicate that ghrelin exerts an inhibitory role on inflammatory pain through an interaction with the central opioid system...
  8. ncbi request reprint Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat
    V Sibilia
    Department of Pharmacology, Chemoterapy, and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    J Endocrinol Invest 29:RC31-4. 2006
    ..In all, our results indicate that the anorexigenic effect of obestatin is of little account and that the peptide does not modify energy metabolism in the long-term administration...
  9. ncbi request reprint Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Italy
    Pharmacol Res 55:418-25. 2007
    ..These results indicate that ticlopidine exerts dual effects during the development and healing of gastric lesions induced by EtOH...
  10. ncbi request reprint Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy
    Peptides 25:2163-70. 2004
    ..Semiquantitative RT-PCR assay of gastric NOS mRNA isoforms revealed that the reduction in iNOS-derived NO and the increase of constitutive-derived NO are relevant for the gastroprotection of Hexa against ethanol-induced gastric damage...
  11. ncbi request reprint Long-term effects on bone of postnatal immunization against GHRH in female and male rats
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Centre of Excellence of Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, Italy
    J Endocrinol 177:93-100. 2003
    ..These data indicate that transient GHRH deprivation induces an osteopenic effect in female rats which is not evident in male rats...
  12. ncbi request reprint Bone effects of hexarelin, a GH-releasing peptide, in female rats: influence of estrogen milieu
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32 20129 Milan, Italy
    Eur J Endocrinol 146:855-62. 2002
    ....
  13. ncbi request reprint Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Italy
    Neuroendocrinology 75:92-7. 2002
    ..The fact that very low doses of ghrelin and GHS inhibit gastric secretion, provide evidence for a tonic inhibitory role of the peptides in the central control of gastric secretory function...
  14. ncbi request reprint The influence of sex and gonadectomy on the growth hormone and corticosterone response to hexarelin in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Italy
    Life Sci 68:321-9. 2000
    ..We suggest that gender-specific patterns in the regulation of the hypothalamus-pituitary function could be responsible for the GH and corticosterone sexually differentiated responses to HEXA...
  15. ncbi request reprint Amylin compared with calcitonin: competitive binding studies in rat brain and antinociceptive activity
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milan, Italy
    Brain Res 854:79-84. 2000
    ..It is therefore suggested that the central inhibitory activity of AMY on pain perception involves interaction with sCT receptors whereas the selective AMY binding sites subserve other (as yet unknown) functions...
  16. ncbi request reprint Hexarelin, a growth hormone - releasing peptide, counteracts bone loss in gonadectomized male rats
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Italy
    Growth Horm IGF Res 9:219-27. 1999
    ..The evidence that HEXA, unlike GH, inhibits bone resorption indicates that other mechanisms contribute to the bone sparing effect of HEXA...
  17. pmc Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milan, Italy
    Br J Pharmacol 154:688-97. 2008
    ..We investigated the role of prostaglandins (PG) and the possible interplay between PGs and nitric oxide (NO) in ghrelin gastroprotection against ethanol (EtOH)-induced gastric lesions...
  18. ncbi request reprint Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action
    V Sibilia
    Department of Pharmacology, Chemotherapy, and Medical Toxicology, University of Milan, 20129 Milan, Italy
    Endocrinology 144:353-9. 2003
    ..The gastroprotective effect of ghrelin is mediated by endogenous NO release and requires the integrity of sensory nerve fibers...
  19. ncbi request reprint Endocrine effects of centrally injected nociceptin in the rat
    Carmela Netti
    Department of Pharmacology, Chemotheraphy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Brain Res 938:55-61. 2002
    ..Pretreatment with OFQ (23 microg/rat, i.c.v.) attenuated the GH secretion induced by morphine (1 mg/kg, given by intra-arterial injection), thus showing a negative interaction between OFQ and morphine in the control of GH secretion...
  20. ncbi request reprint Sympathectomy alters bone architecture in adult growing rats
    F Pagani
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
    J Cell Biochem 104:2155-64. 2008
    ..These data indicate that guanethidine-induced sympathectomy caused a negative balance of bone metabolism, leading to decreased mass by regulating deposition rather than resorption during modeling and remodeling of bone...
  21. ncbi request reprint Effects of amylin and salmon calcitonin on beta-endorphin-induced growth hormone and prolactin secretion in the rat
    F Pagani
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy
    Neuroendocrinology 68:220-8. 1998
    ....
  22. ncbi request reprint Different skeletal regional response to continuous brain infusion of leptin in the rat
    F Guidobono
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy
    Peptides 27:1426-33. 2006
    ..The results demonstrate that long-term central infusion of leptin activates bone remodeling with a negative balance. Leptin induces distinct responses in the different structure of bone and in the axial and appendicular skeleton...
  23. ncbi request reprint The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat
    F Guidobono
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129, Milano, Italy
    Peptides 21:1537-41. 2000
    ..Additional mechanisms could involve noradrenergic alpha(2) receptors as the peptide gastroprotective activity is reduced from 67% to 20% by the alpha(2) antagonist yohimbine...
  24. ncbi request reprint GH-releasing peptides and bone
    D Cocchi
    Department of Biomedical Sciences and Biotechnologies, University of Milano, Italy
    J Endocrinol Invest 28:11-4. 2005
    ..These results would indicate that only osteoblasts from fetal bone express functional receptors responsive to ghrelin and GHS...
  25. ncbi request reprint Acylated and unacylated ghrelin protect MC3T3-E1 cells against tert-butyl hydroperoxide-induced oxidative injury: pharmacological characterization of ghrelin receptor and possible epigenetic involvement
    Elisa Dieci
    Department of Medical Biotechnology and Translational Medicine, Medical Pharmacology Unit, Universita degli Studi di Milano, Via Vanvitelli, 32, 20129, Milan, Italy
    Amino Acids 46:1715-25. 2014
    ..In conclusion, our data demonstrate that ghrelin and DAG promote survival of MC3T3-E1 cell exposed to t-BHP-induced oxidative damage. Such effect is independent of GHS-R1a and is likely mediated by a common ghrelin/DAG binding site...
  26. ncbi request reprint Ghrelin in gastroenteric pathophysiology
    V Locatelli
    Department of Experimental and Environmental Medicine and Biotechnology, University of Milano Bicocca, Monza, Italy
    J Endocrinol Invest 28:843-8. 2005
    ..Given its prevailing role in physiological and pathophysiological gastric function, the discovery of ghrelin will open new perspectives and potential clinical implications in the gastroenteric field...