Alessandro Serretti

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Understanding the pharmacogenetics of selective serotonin reuptake inhibitors
    Chiara Fabbri
    University of Bologna, Institute of Psychiatry, Department of Biomedical and Neuromotor Sciences, Viale Carlo Pepoli 5, 40123 Bologna, Italy 39 051 6584233 39 051 521030
    Expert Opin Drug Metab Toxicol 10:1093-118. 2014
  2. pmc No association of a set of candidate genes on haloperidol side effects
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    PLoS ONE 7:e44853. 2012
  3. pmc Incomplete coverage of candidate genes: a poorly considered bias
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Italy
    Curr Genomics 8:476-83. 2007
  4. pmc Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways
    Paolo Olgiati
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    Int J Alzheimers Dis 2011:832379. 2011
  5. pmc No effect of serotoninergic gene variants on response to interpersonal counseling and antidepressants in major depression
    Alessandro Serretti
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    Psychiatry Investig 10:180-9. 2013
  6. ncbi Family history of major depression and residual symptoms in responder and non-responder depressed patients
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy Electronic address
    Compr Psychiatry 55:51-5. 2014
  7. ncbi Social adjustment among treatment responder patients with mood disorders
    Alessandro Serretti
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    J Affect Disord 150:961-6. 2013
  8. pmc Pharmacogenetics of antidepressant response: an update
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Bologna, Bologna, Italy
    Hum Genomics 3:257-74. 2009
  9. doi Side effects associated with psychotropic medications in patients with bipolar disorder: evidence from two independent samples
    Alessandro Serretti
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    J Psychopharmacol 27:616-28. 2013
  10. ncbi Treatment resistance in severe unipolar depression: no association with psychotic or melancholic features
    Leonardo Zaninotto
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Ann Clin Psychiatry 25:97-106. 2013

Detail Information

Publications161 found, 100 shown here

  1. ncbi Understanding the pharmacogenetics of selective serotonin reuptake inhibitors
    Chiara Fabbri
    University of Bologna, Institute of Psychiatry, Department of Biomedical and Neuromotor Sciences, Viale Carlo Pepoli 5, 40123 Bologna, Italy 39 051 6584233 39 051 521030
    Expert Opin Drug Metab Toxicol 10:1093-118. 2014
    ..Efforts in this direction are justified by the recent evidence of a favorable cost-utility of gene-guided antidepressant treatment. ..
  2. pmc No association of a set of candidate genes on haloperidol side effects
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    PLoS ONE 7:e44853. 2012
    ..This finding was not replicated in the CATIE sample. In conclusion, we did not find conclusive evidence for a major association between the investigated variations and haloperidol induced motoric side effects...
  3. pmc Incomplete coverage of candidate genes: a poorly considered bias
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Italy
    Curr Genomics 8:476-83. 2007
    ..The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed...
  4. pmc Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways
    Paolo Olgiati
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    Int J Alzheimers Dis 2011:832379. 2011
    ..Gene-gene and gene-environment interactions are prominent issues in AD genetics, but they are not specifically featured in the Alzgene database...
  5. pmc No effect of serotoninergic gene variants on response to interpersonal counseling and antidepressants in major depression
    Alessandro Serretti
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    Psychiatry Investig 10:180-9. 2013
    ..Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated...
  6. ncbi Family history of major depression and residual symptoms in responder and non-responder depressed patients
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy Electronic address
    Compr Psychiatry 55:51-5. 2014
    ..Little is known about the extent to which a family history of major depression (MD) affects residual depressive symptoms in responder and non-responder patients suffering from MD...
  7. ncbi Social adjustment among treatment responder patients with mood disorders
    Alessandro Serretti
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    J Affect Disord 150:961-6. 2013
    ..The main aim of the present work is to study several socio-demographic and clinical variables possibly influencing social adjustment in MD patients who responded to treatment...
  8. pmc Pharmacogenetics of antidepressant response: an update
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Bologna, Bologna, Italy
    Hum Genomics 3:257-74. 2009
    ..The extent of the validity of the replicated findings and the reasons for the poor results obtained from studies of the pharmacogenetics of the antidepressant response are discussed...
  9. doi Side effects associated with psychotropic medications in patients with bipolar disorder: evidence from two independent samples
    Alessandro Serretti
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    J Psychopharmacol 27:616-28. 2013
    ..Our results largely confirm in a naturalistic setting results previously observed in randomized controlled trials focusing on BD patients. ..
  10. ncbi Treatment resistance in severe unipolar depression: no association with psychotic or melancholic features
    Leonardo Zaninotto
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Ann Clin Psychiatry 25:97-106. 2013
    ..Depressive subtypes generally have been neglected in research on treatment efficacy. We studied a sample of 699 severe unipolar depressed patients to detect any association between depressive features and treatment resistance...
  11. ncbi Genetics of serotonin receptors and depression: state of the art
    Chiara Fabbri
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Viale Carlo Pepoli 5, Bologna, Italy
    Curr Drug Targets 14:531-48. 2013
    ..The reported tools may assist in the detection of multiple-loci models, which could potentially explain the high percentage of MD susceptibility ascribed to genetic factors...
  12. ncbi Effects of SORL1 gene on Alzheimer's disease. Focus on gender, neuropsychiatric symptoms and pro-inflammatory cytokines
    Paolo Olgiati
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Curr Alzheimer Res 10:154-64. 2013
    ..Sex-specific factors could modulate the association between SORL1 and AD. The influence of SORL1 variants on production of inflammatory cytokines warrants further investigation...
  13. ncbi A genetic dissection of antipsychotic induced movement disorders
    C Crisafulli
    Department of Biomorphology and Biotechnologies, Division of Biology and Genetics, University of Messina, Italy
    Curr Med Chem 20:312-30. 2013
    ..Moreover, it would increase the quality of the current treatments with APM...
  14. ncbi Catechol-o-methyltransferase and Alzheimer's disease: a review of biological and genetic findings
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    CNS Neurol Disord Drug Targets 11:299-305. 2012
    ..Taken together, these findings suggest that research should focus on the role of COMT in AD pathogenesis and on the feasibility of targeting COMT activity in AD treatment...
  15. ncbi Association of SORL1 alleles with late-onset Alzheimer's disease. findings from the GIGAS_LOAD study and mega-analysis
    Paolo Olgiati
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Curr Alzheimer Res 9:491-9. 2012
    ..Thus further examination into SORL1 SNPs and the population is necessary to determine the role of SORL1 in LOAD...
  16. ncbi The serotonin transporter gene and effectiveness of SSRIs
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy
    Expert Rev Neurother 8:111-20. 2008
    ..This article reviews the pharmacogenetic studies published to date, focusing the attention on the SERTPR...
  17. doi The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions
    A Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Mol Psychiatry 13:742-71. 2008
    ..Nevertheless, other approaches are required to disentangle conflicting findings, such as gene interaction analyses, interaction with psychosocial and environmental factors and, finally, endophenotype investigations...
  18. doi Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    J Psychiatr Res 43:519-25. 2009
    ..Serotonin has been extensively studied in relation to both personality features and suicidal behaviours...
  19. doi The socio-economical burden of schizophrenia: a simulation of cost-offset of early intervention program in Italy
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    Eur Psychiatry 24:11-6. 2009
    ..In conclusion, our study supports the use of early intervention in schizophrenia, which could allow an outcome improvement with lower direct and indirect costs...
  20. doi Common genetic, clinical, demographic and psychosocial predictors of response to pharmacotherapy in mood and anxiety disorders
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Int Clin Psychopharmacol 24:1-18. 2009
    ..Possible limitations and suggestions for future research based on a more integrated vision of human complexity are discussed...
  21. doi Lack of association between interleukin-1 alpha rs1800587 polymorphism and Alzheimer's disease in two Independent European samples
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    J Alzheimers Dis 16:181-7. 2009
    ..The effect of the IL1A on depressive symptomatology warrants further investigations, however the lack of a gene-dose relationship would suggest a false positive...
  22. ncbi Influence of TAAR6 polymorphisms on response to aripiprazole
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 33:822-6. 2009
    ....
  23. ncbi Ethical problems in pharmacogenetic studies of psychiatric disorders
    A Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Pharmacogenomics J 6:289-95. 2006
  24. ncbi Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 158:132-40. 2008
    ....
  25. ncbi Genetics of Alzheimer's disease. A rapidly evolving field
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    J Alzheimers Dis 12:73-92. 2007
    ..Genomics will provide a dynamic picture of biological processes in AD and new targets for the forthcoming anti-AD drugs...
  26. ncbi Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients
    A Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Mol Psychiatry 12:247-57. 2007
    ..0002). Response rate within 4 weeks was associated in both models (P=0.003-P<0.00001). This effect is quite robust to ethnic differences although a significant heterogeneity is present in Asian samples...
  27. ncbi Serotonin transporter gene influences the time course of improvement of "core" depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 149:185-93. 2007
    ....
  28. ncbi A neural network model for combining clinical predictors of antidepressant response in mood disorders
    Alessandro Serretti
    Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
    J Affect Disord 98:239-45. 2007
    ..The complex interactions modelled through ANN may be eventually applied at the clinical level for the individualized therapy...
  29. ncbi Catechol-O-methyltransferase gene variants in mood disorders in the Italian population
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy
    Psychiatr Genet 16:181-2. 2006
    ....
  30. ncbi Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Neurosci Lett 406:107-12. 2006
    ..In our sample IL-1A, IL-1B, TNF-alpha and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results...
  31. ncbi HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:291-9. 2007
    ..In conclusion, our study does not support the notion that HTR2C and HTR1A gene variants are major contributors to suicide-, anger-, or aggression-related behaviors in our sample...
  32. ncbi Clinical prediction of antidepressant response in mood disorders: linear multivariate vs. neural network models
    Alessandro Serretti
    Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
    Psychiatry Res 152:223-31. 2007
    ..The complex interactions modelled through ANN may eventually be applied at the clinical level for individualized therapy. However, the accuracy of prediction is still far from satisfactory from a clinical point of view...
  33. ncbi 5-HT2A SNPs and the Temperament and Character Inventory
    Alessandro Serretti
    Institute of Psychiatry University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 31:1275-81. 2007
    ..003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p=0.01) in the Italian sample. We conclude that 5-HT(2A) SNPs may marginally modulate personality traits but further studies are required...
  34. ncbi Pharmacogenetic studies in depression: a proposal for methodologic guidelines
    A Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Pharmacogenomics J 8:90-100. 2008
    ..We reviewed the state-of-the-art methodology and suggested possible guideline for future studies...
  35. ncbi HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    Curr Med Chem 14:2053-69. 2007
    ..We suggest a wider investigation of the HTR2A gene to better understand its role in psychiatric disorders, preferably complemented with the use of proteomic or metabolomic approaches...
  36. ncbi Serotonin transporter gene variants and behavior: a comprehensive review
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Curr Drug Targets 7:1659-69. 2006
    ..SERT gene variants seem therefore to modulate a wide range of aspects in both normal and affected individuals, many of which are possibly due to indirect correlations between such human features...
  37. doi TPH2 gene variants and anxiety during alcohol detoxification outcome
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Psychiatry Res 167:106-14. 2009
    ..The present preliminary results are of interest in alcoholism, given that comorbidity with anxiety represents a critical problem in treatment settings and response to detoxification...
  38. ncbi Thyroid hormones affect recovery from depression during antidepressant treatment
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyoung gi Province, Republic of Korea
    Psychiatry Clin Neurosci 63:305-13. 2009
    ..The aim of the present study was to evaluate whether thyroid hormonal changes during menopause may affect the development and the course of major depressive disorder...
  39. doi A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    J Affect Disord 128:56-63. 2011
    ..The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants...
  40. ncbi Pharmacogenetics of lithium long-term treatment: focus on initiation and adaptation mechanisms
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Neuropsychobiology 62:61-71. 2010
    ..Moreover, the pharmacogenetics reports that are not strictly associated with the mechanisms that are thought to be acutely and chronically elicited by lithium will be included in the final part of the paper...
  41. ncbi 3111T/C clock gene polymorphism is not associated with sleep disturbances in untreated depressed patients
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Chronobiol Int 27:265-77. 2010
    ..Further analysis of clock machinery will clarify the contribution of clock genes to the maintenance of mental health...
  42. ncbi Antidepressants in healthy subjects: what are the psychotropic/psychological effects?
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    Eur Neuropsychopharmacol 20:433-53. 2010
    ..In summary, antidepressants seem to exert a detectable influence also in healthy subjects...
  43. doi Novel antidepressants and panic disorder: evidence beyond current guidelines
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Neuropsychobiology 63:1-7. 2011
    ..The aim of the present review is to summarize available evidence about the efficacy and side effects of novel antidepressants for the treatment of panic disorder...
  44. doi Specificity profile of paroxetine in major depressive disorder: meta-regression of double-blind, randomized clinical trials
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    J Affect Disord 132:14-25. 2011
    ..The aim of present study was to define the most suitable sociodemographic and disease-related profile for the use of paroxetine as an antidepressant treatment...
  45. ncbi Antidepressants and body weight: a comprehensive review and meta-analysis
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    J Clin Psychiatry 71:1259-72. 2010
    ..There is evidence that antidepressant drugs may induce a variable amount of weight gain, but results are sparse and often contradictory...
  46. doi A model to incorporate genetic testing (5-HTTLPR) in pharmacological treatment of major depressive disorders
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    World J Biol Psychiatry 12:501-15. 2011
    ..To evaluate the benefit of pharmacogenetics in antidepressant treatment...
  47. doi Sexual side effects of pharmacological treatment of psychiatric diseases
    A Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Clin Pharmacol Ther 89:142-7. 2011
    ..Indeed,there is consistent evidence to suggest that a large number of psychiatric medications adversely affect one or more of the three phases of normal sexual response: desire, arousal, and orgasm...
  48. doi Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    J Clin Psychopharmacol 29:259-66. 2009
    ..The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was purposely investigated through direct inquiry and specific questionnaires...
  49. doi Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Int Clin Psychopharmacol 24:250-6. 2009
    ..Nevertheless, methodological and sample size limitations of this study do not allow definitive conclusions...
  50. doi No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Psychiatry Res 188:166-9. 2011
    ....
  51. ncbi Paroxetine for the treatment of depression: a critical update
    Sara Gibiino
    University of Bologna, Institute of Psychiatry, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    Expert Opin Pharmacother 13:421-31. 2012
    ..Paroxetine represents a widely prescribed and reliable antidepressant for the expert clinician, but the latest data do not rank it amongst the most effective and tolerable newer antidepressants...
  52. ncbi Lithium pharmacodynamics and pharmacogenetics: focus on inositol mono phosphatase (IMPase), inositol poliphosphatase (IPPase) and glycogen sinthase kinase 3 beta (GSK-3 beta)
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Curr Med Chem 16:1917-48. 2009
    ....
  53. doi A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Italy
    Int Clin Psychopharmacol 26:130-40. 2011
    ....
  54. ncbi DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
    Neurosci Lett 440:150-4. 2008
    ..008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline...
  55. ncbi Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital, Milan, Italy
    Pharmacogenetics 14:607-13. 2004
    ..We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up...
  56. ncbi Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, University of Milan School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:36-9. 2005
    ..This, together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders...
  57. ncbi Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder
    Jung Jin Kim
    Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:375-9. 2008
    ..Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted...
  58. ncbi Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Biomed Pharmacother 63:228-35. 2009
    ..Furthermore, the FSH may interfere with the mechanism of action of the antidepressant agents. Hence, larger, randomized and controlled trials are warranted to expand our understanding of this area...
  59. doi TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Eur Psychiatry 23:390-5. 2008
    ..Haplotype analysis was not informative in our sample, probably also because of the incomplete SNPs' coverage of the gene we performed. Further studies in this direction are warranted...
  60. ncbi Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, Korea
    Pharmacogenet Genomics 17:69-75. 2007
    ..In the search for further genes influencing antidepressant response we focused on the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1)...
  61. doi 5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients
    Masaki Kato
    Institute of Psychiatry, University of Bologna, Italy
    Psychiatry Res 167:97-105. 2009
    ....
  62. ncbi Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 129:36-40. 2004
    ..Thus, the previous positive association was not fully replicated for TPH. The present independent replication confirms SERTPR variants as a liability factor for antidepressant efficacy while the TPH effect is not unequivocal...
  63. ncbi Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Neuropsychobiology 47:182-6. 2003
    ..These results suggest that 5-HTTLPR may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population...
  64. ncbi Heat-shock protein-70 genes and response to antidepressants in major depression
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1006-11. 2007
    ..In conclusion, genetic variants within the genes coding for HSP-70 family proteins may affect the action of antidepressants and thus their therapeutic efficacy...
  65. ncbi Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Psychiatry Res 127:279-81. 2004
    ..We found significant differences in genotype and allele frequencies. The present study suggests that this polymorphism may confer a susceptibility to major depressive disorder in the Korean population...
  66. pmc Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Italy
    Int J Environ Res Public Health 6:1980-90. 2009
    ..Nonetheless, the marginal significance we detected could witness an informative correlation worth investigating in larger samples...
  67. ncbi Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder
    Alberto Chiesa
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Eur Arch Psychiatry Clin Neurosci 262:305-11. 2012
    ....
  68. ncbi Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity
    Cristina Cusin
    Department of Psychiatry, Vita Salute University, Raffaele del Monte Tabor, Milan, Italy
    Int J Neuropsychopharmacol 5:27-35. 2002
    ..The investigated MAOA and 5-HT-2A gene variants, therefore, do not seem to play a major role in SSRI antidepressant activity...
  69. ncbi Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita Salute San Raffaele, Milano, Italy
    Biol Psychiatry 54:687-92. 2003
    ..The short-term relapse that follows acute response to TSD has been successfully prevented by combining TSD with light therapy. The mechanism of action of this combined treatment is unknown...
  70. ncbi Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Psychopharmacology (Berl) 174:504-11. 2004
    ..The present study investigated possible genetic association between some polymorphisms possibly involved in antidepressant response and the occurrence of manic or hypo-manic switches during antidepressant treatment...
  71. doi Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul 150 713, Republic of Korea
    Eur Neuropsychopharmacol 19:806-11. 2009
    ..Explanations for these findings and possible future directions are also discussed...
  72. doi The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, Catholic University of Korea College of Medicine, Wonmi gu, Bucheon, Republic of Korea
    Neuropsychobiology 59:135-41. 2009
    ..These findings further support a role of heat shock proteins in the pathophysiology of SZ...
  73. ncbi Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Neuropsychobiology 53:9-16. 2006
    ....
  74. ncbi A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy
    Neurosci Lett 355:37-40. 2004
    ....
  75. ncbi Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders
    Laura Mandelli
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Int J Neuropsychopharmacol 10:437-47. 2007
    ..Moreover, COMT was risk factor for onset of both major depression and bipolar disorder, in conjunction with adversities...
  76. ncbi A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico, Universitario Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milano, Italy
    Neurosci Lett 368:123-6. 2004
    ....
  77. doi Clinical features, response to treatment and functional outcome of bipolar disorder patients with and without co-occurring substance use disorder: 1-year follow-up
    Marianna Mazza
    Department of Psychiatry, Bipolar Disorders Unit, Catholic University of Sacred Heart, Rome, Italy
    J Affect Disord 115:27-35. 2009
    ..The purpose of this study was to examine clinical and psychopathological features of BP with and without comorbid SUD in a real-world setting...
  78. ncbi Temperament and character of suicide attempters
    Raffaella Calati
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    J Psychiatr Res 42:938-45. 2008
    ..In conclusion, the present study reveals the difficulty to disentangle the personality profile of suicide attempters from their psychopathology. Those findings may be useful for cautions in further dissecting this complex phenotype...
  79. pmc Influence of postpartum onset on the course of mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    BMC Psychiatry 6:4. 2006
    ..To ascertain the impact of postpartum onset (PPO) on the subsequent time course of mood disorders...
  80. ncbi Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants
    Enrico Smeraldi
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
    Psychiatr Genet 16:153-8. 2006
    ..These results, although very preliminary, can represent a further step toward a better understanding of the molecular genetics of antidepressant response...
  81. doi Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The Catholic University of Korea, College of Medicine, Bucheon, Kyonggi Do, Republic of Korea
    Psychiatry Res 178:430-2. 2010
    ..Further research is needed to determine the role of DAOA on the response to antipsychotics...
  82. ncbi Relapse during a 6-month continuation treatment with fluvoxamine in an Italian population: the role of clinical, psychosocial and genetic variables
    Danilo Dotoli
    Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita Salute, Istituto Scientifico H San Raffaele Turro, Via Stamira d Ancona 20, 20127 Milan, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 30:442-8. 2006
    ..These patients could need a different psychopharmacological strategies and peculiar psychological intervention...
  83. ncbi Occurrence of cognitive impairment and dementia after the age of 60: a population-based study from Northern Italy
    Diana De Ronchi
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 19:97-105. 2005
    ..To evaluate the age, gender and education distribution of both cognitive impairment and dementia in the whole old age range of the elderly (from 61 years of age and over)...
  84. ncbi Pharmacogenetics in the treatment of depression: pharmacodynamic studies
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Hospital, Milan Italy
    Pharmacogenet Genomics 15:61-7. 2005
    ..Here, a brief overview is provided on the various pharmacogenetic studies published to date that analyse the commonest treatments for depression: antidepressants, sleep deprivation and lithium salts...
  85. ncbi Depressive syndrome in major psychoses: a study on 1351 subjects
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, School of Medicine, Via Luigi Prinetti 29, 20127 Milan, Italy
    Psychiatry Res 127:85-99. 2004
    ..We identified some symptoms that are common across all major psychoses and symptoms that are more specific to each group...
  86. ncbi No influence of FAT polymorphisms in response to aripiprazole
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The CatholicUniversity of Korea College of Medicine, Bucheon, Republic of Korea and Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC, USA
    J Hum Genet 55:32-6. 2010
    ..Our data suggest no association between investigated alleles and genotypes in FAT and response to aripiprazole. However, because several limitations characterize the present study, further investigations on larger studies are required...
  87. ncbi Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
    Francesco Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:631-5. 2007
    ..Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders...
  88. ncbi Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population
    Tae Youn Jun
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 401, Korea
    Psychiatr Genet 13:179-81. 2003
    ..The present study was aimed at examining the association between the -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder (MDD) in the Korean population...
  89. ncbi The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings
    Alessandro Serretti
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Int J Neuropsychopharmacol 7:453-60. 2004
    ..In conclusion, 5-HT1A variants could influence the antidepressant efficacy in bipolar subjects, even if results must be verified on larger samples...
  90. ncbi Pooling pharmacogenetic studies on the serotonin transporter: a mega-analysis
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 145:61-5. 2006
    ..This result supports the involvement of the SERTPR gene in response to antidepressant treatments...
  91. ncbi 5-HT 1A polymorphism and self-transcendence in mood disorders
    Cristina Lorenzi
    Department of Psychiatry P Ottonello Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Am J Med Genet B Neuropsychiatr Genet 137:33-5. 2005
    ..Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait...
  92. ncbi Clinical and demographic features of mood disorder subtypes
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Via Luigi Prinetti 29, Milan, Italy
    Psychiatry Res 112:195-210. 2002
    ..This finding may help in the search for the biological basis of mood disorders...
  93. ncbi SSRIs antidepressant activity is influenced by G beta 3 variants
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Eur Neuropsychopharmacol 13:117-22. 2003
    ..009) and this effect was independent from analyzed demographic and clinical variables. These results confirm preliminary reports and shed further light on the genetics of the response to antidepressant treatments...
  94. ncbi Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
    Psychiatr Genet 13:121-6. 2003
    ..The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach...
  95. doi Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 153:680-3. 2010
    ..001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples...
  96. doi Dysbindin gene (DTNBP1) and schizophrenia in Korean population
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Eur Arch Psychiatry Clin Neurosci 259:137-42. 2009
    ..In conclusion, the present study suggests a possible protective effect of rare DTNBP1 variants in schizophrenia, although subsequent studies in different ethnic groups are warranted...
  97. ncbi Components of self-esteem in affective patients and non-psychiatric controls
    Alessandro Serretti
    Department of Psychiatry, Istituto Scientifico H San Raffaele, Vita Salute University, Via Stamira d Ancona 20, 20127 Milano, Italy
    J Affect Disord 88:93-8. 2005
    ..8, p<0.01; SD: F=0.05, p=0.9). These findings suggest that self-esteem deficit in affective disorders might involve specific components. Implications for research and clinical practice are discussed...
  98. ncbi Antidepressant response in the elderly
    Laura Mandelli
    Department of Psychiatry, University of Bologna, Bologna, Italy
    Psychiatry Res 152:37-44. 2007
    ..Minor health problems increase the severity of depression, but they do not interfere crucially with the efficacy of antidepressant treatment. Finally, late-onset depression is associated with a positive outcome...
  99. doi Predictors of early worsening after switch to aripiprazole: a randomized, controlled, open-label study
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Clin Drug Investig 30:187-93. 2010
    ....
  100. ncbi TAAR 6 and HSP-70 variations associated with bipolar disorder
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Republic of Korea
    Neurosci Lett 465:257-61. 2009
    ..This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory...