M Serra

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. ncbi request reprint Social isolation-induced changes in the hypothalamic-pituitary-adrenal axis in the rat
    M Serra
    Department of Experimental Biology, University of Cagliari, Italy
    Stress 8:259-64. 2005
  2. ncbi request reprint Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
    M Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 75:732-40. 2000
  3. ncbi request reprint Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and function
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Brain Res Rev 57:520-30. 2008
  4. ncbi request reprint Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function
    Mariangela Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 98:122-33. 2006
  5. ncbi request reprint Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 85:257-63. 2003
  6. ncbi request reprint Social isolation stress and neuroactive steroids
    M Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari 09100, Italy
    Eur Neuropsychopharmacol 17:1-11. 2007
  7. ncbi request reprint Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine
    Mariangela Serra
    Department of Experimental Biology, B Loddo, University of Cagliari, Italy
    J Psychopharmacol 16:133-8. 2002
  8. ncbi request reprint Opposite effects of short- versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain
    M Serra
    Department of Experimental Biology, University of Cagliari, 09100 Cagliari, Italy
    Psychopharmacology (Berl) 158:48-54. 2001
  9. ncbi request reprint Social isolation increases the response of peripheral benzodiazepine receptors in the rat
    Mariangela Serra
    Department of Experiemental Biology, Center for Excellence for Neurobiology of Dependence, University of Cagliari, Italy
    Neurochem Int 45:141-8. 2004
  10. pmc Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties
    E Sanna
    Department of Experimental Biology, University of Cagliari, Cittadella Universitaria Monserrato CA, Italy
    Br J Pharmacol 126:1444-54. 1999

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Social isolation-induced changes in the hypothalamic-pituitary-adrenal axis in the rat
    M Serra
    Department of Experimental Biology, University of Cagliari, Italy
    Stress 8:259-64. 2005
    ..These results suggest that social isolation increased sensitivity of the pituitary to CRF and impaired negative feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis...
  2. ncbi request reprint Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
    M Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 75:732-40. 2000
    ..The results further suggest a psychological role for neurosteroids and GABA(A) receptors in the modulation of emotional behavior and mood...
  3. ncbi request reprint Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and function
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Brain Res Rev 57:520-30. 2008
    ....
  4. ncbi request reprint Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function
    Mariangela Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 98:122-33. 2006
    ....
  5. ncbi request reprint Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 85:257-63. 2003
    ..Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration...
  6. ncbi request reprint Social isolation stress and neuroactive steroids
    M Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari 09100, Italy
    Eur Neuropsychopharmacol 17:1-11. 2007
    ....
  7. ncbi request reprint Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine
    Mariangela Serra
    Department of Experimental Biology, B Loddo, University of Cagliari, Italy
    J Psychopharmacol 16:133-8. 2002
    ....
  8. ncbi request reprint Opposite effects of short- versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain
    M Serra
    Department of Experimental Biology, University of Cagliari, 09100 Cagliari, Italy
    Psychopharmacology (Berl) 158:48-54. 2001
    ..Recent preclinical and clinical studies have shown that selective serotonin re-uptake inhibitors modulate neurosteroid synthesis in an opposite manner...
  9. ncbi request reprint Social isolation increases the response of peripheral benzodiazepine receptors in the rat
    Mariangela Serra
    Department of Experiemental Biology, Center for Excellence for Neurobiology of Dependence, University of Cagliari, Italy
    Neurochem Int 45:141-8. 2004
    ..The larger increase in neuroactive steroid concentrations induced by CB 34 and the enhanced pituitary response to this compound in isolated rats indicate that this mild stressor increases the response of PBRs...
  10. pmc Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties
    E Sanna
    Department of Experimental Biology, University of Cagliari, Cittadella Universitaria Monserrato CA, Italy
    Br J Pharmacol 126:1444-54. 1999
    ..Thus, 4-I-Pro possesses pharmacological characteristics more similar to anxiolytic and anticonvulsant drugs than to general anaesthetics...
  11. ncbi request reprint Changes in the gene expression of GABAA receptor subunit mRNAs in the septum of rats subjected to pentylenetetrazol-induced kindling
    P Follesa
    Department of Experimental Biology, University of Cagliari, 09100, Cagliari, Italy
    Brain Res Mol Brain Res 70:1-8. 1999
    ..These results suggest that long-term treatment with PTZ induces a loss of GABAA receptors in the septum...
  12. pmc 2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats
    M Serra
    Department of Experimental Biology, University of Cagliari, Italy
    Br J Pharmacol 127:177-87. 1999
    ..Our results indicate that the three CB compounds tested are specific and potent agonists at peripheral benzodiazepine receptors, and that they stimulate steroidogenesis in both the brain and periphery...
  13. ncbi request reprint Prevention of the stress-induced increase in frontal cortical dopamine efflux of freely moving rats by long-term treatment with antidepressant drugs
    L Dazzi
    Department of Experimental Biology B Loddo, University of Cagliari, 09123 Cagliari, Italy
    Eur Neuropsychopharmacol 11:343-9. 2001
    ..An attenuation of the response of mesocortical dopaminergic neurons to stress induced by long-term treatment with antidepressants might contribute to the anxiolytic effects of such drugs...
  14. ncbi request reprint Steroidogenesis in rat brain induced by short- and long-term administration of carbamazepine
    M Serra
    Department of Experimental Biology, University of Cagliari, 09100, Cagliari, Italy
    Neuropharmacology 39:2448-56. 2000
    ..These results indicate that CBZ-induced steroidogenesis might not be responsible for the anticonvulsant activity of this drug...
  15. ncbi request reprint Allopregnanolone synthesis in cerebellar granule cells: roles in regulation of GABA(A) receptor expression and function during progesterone treatment and withdrawal
    P Follesa
    Department of Experimental Biology Bernardo Loddo, University of Cagliari, Italy
    Mol Pharmacol 57:1262-70. 2000
    ..Prevention of allopregnanolone synthesis by the 5alpha-reductase inhibitor finasteride also prevented the changes in both GABA(A) receptor gene expression and receptor function elicited by progesterone treatment and withdrawal...
  16. ncbi request reprint Long-term treatment with antidepressant drugs reduces the sensitivity of cortical cholinergic neurons to the activating actions of stress and the anxiogenic drug FG 7142
    L Dazzi
    Department of Experimental Biology B Loddo and CNR Centre for Neuropharmacology, University of Cagliari, Cagliari 09123, Italy
    Neuropharmacology 41:229-37. 2001
    ..The neurochemical mechanism responsible for regulation of cholinergic neuron sensitivity might contribute to the modulation of cognitive function associated with emotional and affective disorders...
  17. ncbi request reprint Role of allopregnanolone in regulation of GABA(A) receptor plasticity during long-term exposure to and withdrawal from progesterone
    P Follesa
    Department of Experimental Biology Bernardo Loddo, CNR Center of Neuropharmacology, University of Cagliari, 09123, Cagliari, Italy
    Brain Res Brain Res Rev 37:81-90. 2001
    ....
  18. ncbi request reprint Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes
    M G Pisu
    Chair of Pharmacology, Department of Experimental Biology B Loddo, University of Cagliari, 09100, Cagliari, Italy
    Eur J Pharmacol 432:129-34. 2001
    ..3H]CB 34 is thus a potent and selective ligand for peripheral benzodiazepine receptors and should be proven useful for studies of the roles of these receptors...
  19. ncbi request reprint Reversal by flunarizine of the decrease in hippocampal acetylcholine release in pentylenetetrazole-kindled rats
    M Serra
    Department of Experimental Biology, University of Cagliari, Italy
    Biochem Pharmacol 58:145-9. 1999
    ..These data also suggest a potential therapeutic role for flunarizine in counteracting impairment of hippocampal cholinergic activity...
  20. ncbi request reprint Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the rat
    A Concas
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Pharmacol Biochem Behav 66:39-45. 2000
    ..These results suggest that neuroactive steroids may modulate the stimulant and anxiogenic effects of caffeine...
  21. ncbi request reprint Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
    J Neurosci 24:6521-30. 2004
    ..This novel mechanism may have a crucial role in mediating specific central effects of ethanol...
  22. pmc Stress, ethanol, and neuroactive steroids
    Giovanni Biggio
    Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Pharmacol Ther 116:140-71. 2007
    ..These data may also lead to the need for new anxiolytic, hypnotic and anticonvulsant selective drugs devoid of side effects...
  23. ncbi request reprint Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    Eur J Pharmacol 519:31-42. 2005
    ..These data suggest that etizolam is endowed with a reduced liability to induce tolerance and dependence compared with classical benzodiazepines...
  24. ncbi request reprint Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride
    Laura Dazzi
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 83:1103-9. 2002
    ....
  25. ncbi request reprint Neurosteroids, GABAA receptors, and ethanol dependence
    Paolo Follesa
    Department of Experimental Biology Bernardo Loddo, University of Cagliari, Cagliari, 09123, Italy
    Psychopharmacology (Berl) 186:267-80. 2006
    ..Such steroids include potent modulators of GABAAR function...
  26. ncbi request reprint Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output
    Laura Dazzi
    B Loddo Department of Experimental Biology, Centre for Neuropharmacology, University of Cagliari, 09042 Cagliari, Italy
    Brain Res 932:135-9. 2002
    ..These results suggest that endogenous allopregnanolone may modulate the excitatory response of cortical dopaminergic neurons to stressful and anxiogenic stimuli...
  27. ncbi request reprint Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder
    Maria Carolina Hardoy
    Department of Public Health, University of Cagliari, Cagliari 09100, Italy
    J Clin Psychopharmacol 26:379-84. 2006
    ..These differences did not seem to be attributable simply to drug treatment or to comorbidity with other psychiatric conditions in the patients...
  28. ncbi request reprint Maternal separation attenuates the effect of adolescent social isolation on HPA axis responsiveness in adult rats
    F Biggio
    Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09100, Italy
    Eur Neuropsychopharmacol 24:1152-61. 2014
    ..The results sustained the mismatch hypothesis stating that aversive experiences early in life trigger adaptive processes, thereby rendering an individual to be better adapted to aversive challenges later in life. ..
  29. ncbi request reprint Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice
    Carola Eva
    Dipartimento di Anatomia, Farmacologia e Medicina Legale, Sezione di Farmacologia, Universita di Torino, Torino, Italy, and Neuroscience Institute of Torino, Universita di Torino, Torino, Italy
    J Neurochem 104:1043-54. 2008
    ..Data suggest that 3alpha,5alpha-TH PROG plays an important role in the changes in NPY-Y1R signalling in the amygdala during ethanol discontinuation...
  30. ncbi request reprint Anticipation and consumption of food each increase the concentration of neuroactive steroids in rat brain and plasma
    Maria Giuseppina Pisu
    CNR Institute of Neuroscience, Cagliari, Italy
    Pharmacol Biochem Behav 85:76-81. 2006
    ..A different mechanism, insensitive to activation of such transmission, may underlie the changes in the concentrations of these neuroactive steroids during food consumption...
  31. ncbi request reprint Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands
    Angela Maria Falchi
    Department of Cytomorphology, Cittadella Universitaria, University of Cagliari, Monserrato, 09100 Cagliari, Italy
    Neuropharmacology 53:318-29. 2007
    ....
  32. ncbi request reprint Alpidem analogues containing a GABA or glycine moiety as new anticonvulsant agents
    Giuseppe Trapani
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
    Eur J Pharm Sci 18:231-40. 2003
    ..The results obtained suggest that compound 1 possesses interesting anticonvulsant activity and deserves further investigation as a novel lipophilic GABA derivative...
  33. doi request reprint Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy
    Maria Giuseppina Pisu
    CNR Institute of Neuroscience, Italy
    J Neurochem 106:2502-14. 2008
    ....
  34. doi request reprint Radiosynthesis and in vivo evaluation of N-[11C]methylated imidazopyridineacetamides as PET tracers for peripheral benzodiazepine receptors
    Katsuhiko Sekimata
    Department of Brain Sciences and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Nucl Med Biol 35:327-34. 2008
    ..Coinjection of PK11195 or unlabeled 7 significantly reduced the brain uptake of [11C]7. These results suggest that [11C]7 could be a useful radioligand for positron emission tomography imaging of PBRs...
  35. ncbi request reprint Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery
    Alessandra Oberto
    Dipartimento di Anatomia, Farmacologia e Medicina Legale, Sezione di Farmacologia, Universita di Torino, Italy
    J Neurochem 82:1272-81. 2002
    ....
  36. ncbi request reprint Neurosteroid secretion in panic disorder
    Francesca Brambilla
    Dipartimento di Scienze Neuropsichiche, Istituto Scientifico Ospedale S Raffaele, Universita Vita e Salute, Milan, Italy
    Psychiatry Res 118:107-16. 2003
    ....
  37. ncbi request reprint N-benzyl-2-(6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino)hexyl)acetamide as a new fluorescent probe for peripheral benzodiazepine receptor and microglial cell visualization
    Valentino Laquintana
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
    Bioconjug Chem 18:1397-407. 2007
    ..The obtained results indicate that compound 10 represents a new useful fluorescent probe for visualization of activated microglia and PBR...
  38. ncbi request reprint Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/LacZ transgenic mice in response to restraint stress
    Paolo Mele
    Dipartimento di Anatomia, Farmacologia e Medicina Legale, Sezione di Farmacologia, Universita di Torino, Via Pietro Giuria 12, 10125 Turin, Italy
    J Neurochem 89:1471-8. 2004
    ..Data support a role of Y1 receptors in the behavioural and neuroendocrine responses to stress...
  39. ncbi request reprint Novel L-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety
    Nunzio Denora
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
    Pharm Res 24:1309-24. 2007
    ....
  40. ncbi request reprint Physiology and gene regulation of the brain NPY Y1 receptor
    Carola Eva
    Sezione di Farmacologia, Dipartimento di Anatomia, Farmacologia e Medicina Legale, Universita di Torino, Italy Centro Rita Levi Montalcini, Universita di Torino, Italy
    Front Neuroendocrinol 27:308-39. 2006
    ..In this paper, we review the state of the art concerning Y(1)R function and gene expression, including our personal contribution to many of the subjects mentioned above...
  41. ncbi request reprint Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis
    Francesca Brambilla
    Addiction Research Center, Azienda Unita Sanitaria, Parma, Italy
    Neuropsychobiology 50:6-9. 2004
    ..PROG concentrations correlated significantly with state anxiety scores. These data suggest that neurosteroids may physiologically modulate anxiety not only in experimental animals but also in humans...
  42. ncbi request reprint Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: a preliminary study
    Palmiero Monteleone
    Department of Psychiatry, University of Naples SUN, Naples, Italy
    J Clin Psychopharmacol 24:437-40. 2004
    ....
  43. ncbi request reprint Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder
    Francesca Brambilla
    Department of Psychiatry, Sacco Hospital, Milan, Italy
    Psychiatry Res 135:185-90. 2005
    ..The plasma concentrations of progesterone and tetrahydrodeoxycorticosterone correlated with the STAI state score in patients before treatment. Our data suggest that neuroactive steroids may play a role in PD in men...
  44. ncbi request reprint Role of brain neuroactive steroids in the functional interplay between the GABA(A) and the NPY-Y1 receptor mediated signals in the amygdala
    Carola Eva
    Dipartimento di Anatomia, Farmacologia e Medicina Legale, Sezione di Farmacologia, Via Pietro Giuria 13, 10125, Universita di Torino, Torino, Italy
    Pharmacol Biochem Behav 84:568-80. 2006
    ....
  45. ncbi request reprint Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters
    Cosimo Altomare
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
    Eur J Pharm Sci 20:17-26. 2003
    ....
  46. ncbi request reprint Neurosteroids and neuroactive drugs in mental disorders
    M Giuseppina Pisu
    C N R Institute of Neuroscience, Pisa Cagliari, Italy
    Life Sci 74:3181-97. 2004
    ....
  47. ncbi request reprint Neuroanatomical and pharmacological evidence for a functional interaction between GABAergic and NPY-Y1 transmission in the amygdala of Y1R/LacZ transgenic mice
    Carola Eva
    Dipartimento di Anatomia, Farmacologia e Medicina Legale, Sezione di Farmacologia, Universita di Torino, Torino, Italy
    Crit Rev Neurobiol 16:33-41. 2004
    ..Finally, our data support a role of Y1 receptors in the behavioral and neuroendocrine responses to stress that, however, appears to be independent on the activation of the GABAergic system...
  48. ncbi request reprint Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands
    Giuseppe Trapani
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
    J Med Chem 48:292-305. 2005
    ..Compound 3 exhibited very marked effects on the peripheral and central synthesis of neuroactive steroids, while 36 (potent at subnanomolar level) showed a slight ability to affect neuroactive steroid content in the cerebral cortex...