A Semplicini

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi In-hospital percentage BNP reduction is highly predictive for adverse events in patients admitted for acute heart failure: the Italian RED Study
    Salvatore Di Somma
    Emergency Medicine Department, II Medical School University La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1039 Roma 00189, Italy
    Crit Care 14:R116. 2010
  2. ncbi Regulation of glomerular filtration in essential hypertension: role of abnormal Na+ transport and atrial natriuretic peptide
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, 4th Clinical Medicine, University of Padova, Italy
    J Nephrol 15:489-96. 2002
  3. ncbi Hypertension in acute ischemic stroke: a compensatory mechanism or an additional damaging factor?
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua Medical School, Via Giustiniani 2, Padua, Italy
    Arch Intern Med 163:211-6. 2003
  4. ncbi Hypertension and cerebrovascular diseases: a specific role of vascular protection for the prevention of dementia
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Italy
    J Cardiovasc Pharmacol 38:S79-82. 2001
  5. ncbi Intravenous thrombolysis in the emergency department for the treatment of acute ischaemic stroke
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua Medical School and Azienda Ospedaliera, Padua, Italy
    Emerg Med J 25:403-6. 2008
  6. ncbi G protein beta3 subunit gene 825T allele is associated with increased left ventricular mass in young subjects with mild hypertension
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Am J Hypertens 14:1191-5. 2001
  7. ncbi Problems related to short-term antihypertensive therapy in acute ischemic stroke
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Clin Exp Hypertens 28:327-34. 2006
  8. ncbi The Li+/Na+ exchange in hypertension
    Andrea Semplicini
    Clinica Medica 4, Department of Clinical and Experimental Medicine, University of Padova Medical School, Italy
    Front Biosci 8:d912-29. 2003
  9. ncbi Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Pharmacol Ther 109:274-83. 2006
  10. ncbi Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    J Hypertens 24:1115-24. 2006

Detail Information

Publications81

  1. ncbi In-hospital percentage BNP reduction is highly predictive for adverse events in patients admitted for acute heart failure: the Italian RED Study
    Salvatore Di Somma
    Emergency Medicine Department, II Medical School University La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1039 Roma 00189, Italy
    Crit Care 14:R116. 2010
    ....
  2. ncbi Regulation of glomerular filtration in essential hypertension: role of abnormal Na+ transport and atrial natriuretic peptide
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, 4th Clinical Medicine, University of Padova, Italy
    J Nephrol 15:489-96. 2002
    ....
  3. ncbi Hypertension in acute ischemic stroke: a compensatory mechanism or an additional damaging factor?
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua Medical School, Via Giustiniani 2, Padua, Italy
    Arch Intern Med 163:211-6. 2003
    ..Therefore, we investigated retrospectively the relationship between BP after ischemic stroke and neurological outcome (evaluated by means of the National Institutes of Health Stroke Scale score at day 7)...
  4. ncbi Hypertension and cerebrovascular diseases: a specific role of vascular protection for the prevention of dementia
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Italy
    J Cardiovasc Pharmacol 38:S79-82. 2001
    ..Such differences may explain the discrepant results on risk reduction for dementia observed in large intervention trials...
  5. ncbi Intravenous thrombolysis in the emergency department for the treatment of acute ischaemic stroke
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua Medical School and Azienda Ospedaliera, Padua, Italy
    Emerg Med J 25:403-6. 2008
    ....
  6. ncbi G protein beta3 subunit gene 825T allele is associated with increased left ventricular mass in young subjects with mild hypertension
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Am J Hypertens 14:1191-5. 2001
    ..Therefore we explored whether the GNB3 825T allele is associated with increased left ventricular mass index in a selected and homogeneous group of young, never treated, mild hypertensives...
  7. ncbi Problems related to short-term antihypertensive therapy in acute ischemic stroke
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Clin Exp Hypertens 28:327-34. 2006
    ..The usefulness of increasing blood pressure with vasopressive agents in selected patients with ischemic stroke deserves adequate testing with randomized clinical trials...
  8. ncbi The Li+/Na+ exchange in hypertension
    Andrea Semplicini
    Clinica Medica 4, Department of Clinical and Experimental Medicine, University of Padova Medical School, Italy
    Front Biosci 8:d912-29. 2003
    ..Regardless of its the pathophysiological significance, its measurement could be of clinical use as an intermediate phenotype of increased cardiovascular risk...
  9. ncbi Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Pharmacol Ther 109:274-83. 2006
    ....
  10. ncbi Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    J Hypertens 24:1115-24. 2006
    ..RGS2-deficient mouse line exhibits a hypertensive phenotype and a prolonged response to vasoconstrictors...
  11. ncbi Abnormalities of Gq-mediated cell signaling in Bartter and Gitelman syndromes
    L Calo
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Kidney Int 60:882-9. 2001
    ..Since PKC regulates ecNOS gene expression, we evaluated the signal transduction system involving Gq protein, PKC, and ecNOS in circulating nucleated cells from patients with BS/GS...
  12. ncbi High angiotensin II state without cardiac remodeling (Bartter's and Gitelman's syndromes): are angiotensin II type 2 receptors involved?
    L A Calò
    Department of Clinical and Experimental Medicine, Clinica Medica 4, Cagliari, Italy
    J Endocrinol Invest 32:832-6. 2009
    ....
  13. ncbi Effect of doxazosin on oxidative stress related proteins in essential hypertensive patients
    L A Calò
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    Clin Exp Hypertens 28:181-8. 2006
    ....
  14. ncbi Controlled study of the effect of angiotensin converting enzyme inhibition versus calcium-entry blockade on insulin sensitivity in overweight hypertensive patients: Trandolapril Italian Study (TRIS)
    F Galletti
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy
    J Hypertens 17:439-45. 1999
    ..The aim of this study was to evaluate the effect of trandolapril, an angiotensin converting enzyme inhibitor, on blood pressure, forearm blood flow and insulin sensitivity in comparison with nifedipine gastrointestinal therapeutic system...
  15. ncbi Blood pressure control has distinct effects on executive function, attention, memory and markers of cerebrovascular damage
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    J Hum Hypertens 25:80-7. 2011
    ..Longitudinal studies are required to unravel the effect of BP control on cognitive function, as only long-term antihypertensive treatment improves both attention and executive performance...
  16. ncbi Hyperglycemia acutely increases monocyte extracellular signal-regulated kinase activity in vivo in humans
    G Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova, 35100 Padova, Italy
    J Clin Endocrinol Metab 86:1301-5. 2001
    ..These findings may be relevant in understanding the negative role of acute hyperglycemia on monocyte pathophysiology...
  17. ncbi Effect of insulin and angiotensin II on cell calcium in human skin fibroblasts
    G Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Hypertension 37:1486-91. 2001
    ....
  18. ncbi Fibrinogen kinetics and protein turnover in hypertension: Effects of insulin
    E Kiwanuka
    Metabolism Division, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 19:789-96. 2009
    ....
  19. ncbi Control of vascular tone in the syndromes of Bartter and Gitelman
    L Calo
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Crit Rev Clin Lab Sci 37:503-22. 2000
    ..These results are also of particular interest because the derangements found in Bartter's and Gitelman's syndromes are the mirror images of those involved in the pathophysiology of hypertension...
  20. ncbi Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinase-dependent cascade
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    J Hypertens 19:599-602. 2001
    ..These results confirm the complex role played by this peptide in the regulation of zona glomerulosa cell physiology...
  21. ncbi Cyclosporin-induced endothelial dysfunction and hypertension: are nitric oxide system abnormality and oxidative stress involved?
    L Calo
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Transpl Int 13:S413-8. 2000
    ....
  22. ncbi Idiopathic hypercalciuria: O2(-)NO relationship and altered bone metabolism
    L Calo
    Dipartimento di Scienze Mediche e Chirurgiche, Università di Padova ed Azienda Ospedaliera di Padova, Italy
    J Endocrinol Invest 23:78-83. 2000
    ..A possible interaction of NO with O2-, which breaks down NO, and the role of this interaction in the pathophysiology of IH is discussed...
  23. ncbi Oxidative stress and TGFbeta in kidney-transplanted patients with cyclosporin-induced hypertension. Effect of carvedilol and nifedipine
    L Calo
    Clin Nephrol 58:103-10. 2002
    ....
  24. ncbi Comparison between nifedipine and carvedilol in the treatment of de novo arterial hypertension after liver transplantation: preliminary results of a controlled clinical trial
    A Galioto
    Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
    Transplant Proc 37:1245-7. 2005
    ..Two of the nine nonresponders to nifedipine responded to carvedilol. The efficacy of monotherapy was observed in 11 of 40 randomized patients (27.5%). Carvedilol monotherapy is as effective as nifedipine but far better tolerated...
  25. ncbi Effect of epoetin on HO-1 mRNA level and plasma antioxidants in hemodialysis patients
    L A Calò
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    Int J Clin Pharmacol Ther 41:187-92. 2003
    ..Interaction of this oxidative stress with epoetin (EPO) treatment to increase RBC number and Hb concentration remains unexplored...
  26. ncbi Ouabain-inhibiting activity of aldosterone antagonists
    A Semplicini
    Medicine Clinica, University of Padova, Italy
    Steroids 60:110-3. 1995
    ..These data suggest that aldosterone antagonists stimulate the Na+/K+ pump inhibited by endogenous ouabain and exert their antihypertensive action at least in part through this mechanism...
  27. ncbi Screening for primary aldosteronism with a logistic multivariate discriminant analysis
    G P Rossi
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Clin Endocrinol (Oxf) 49:713-23. 1998
    ..Accordingly, we investigated the usefulness of a logistic multivariate discriminant analysis (MDA) approach for PA screening...
  28. ncbi Role of insulin-like growth factor-I in primary osteoporosis: a correlative study
    L Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    J Endocrinol Invest 23:223-7. 2000
    ..In addition, nutritional caloric or proteic deficit may add to the effects of GH, age and other factors in decreasing IGF-I synthesis and therefore further contribute to the development of primary osteoporosis...
  29. ncbi Na/H and Li/Na exchange in red blood cells of normotensive and hypertensive patients with insulin dependent diabetes mellitus (IDDM)
    A Semplicini
    Institutes of Medicina Clinica and Medicina Interna, University of Padova, Italy
    Am J Hypertens 2:174-7. 1989
    ..21, n = 29). In conclusion this work confirms that Na/H and Li/Na CTT are function modes of the same transporter and that an increased activity of Na/H CTT might play a role in the blood pressure increase in IDDM...
  30. ncbi Analysis of Gq protein alpha subunit mRNA expression in human monocytes: relevance of the purification step
    L Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova Azienda Ospedaliera, Via Giustiniani, 2, 35128, Padua, Italy
    Clin Chim Acta 309:13-8. 2001
    ..In this study, we report a simple method for avoiding unwanted amplification of the Galphaq pseudogene and the use of human monocytes as a readily available source for examining Galphaq...
  31. ncbi Chronic renal failure, end-stage renal disease, and peritoneal dialysis in Gitelman's syndrome
    L Bonfante
    Department of Clinical and Experimental Medicine, Clinica Medica 4, Division of Nephrology, University of Padova, Italy
    Am J Kidney Dis 38:165-8. 2001
    ....
  32. ncbi Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2 35128 Padova, Italy
    Arterioscler Thromb Vasc Biol 27:2627-33. 2007
    ..In this study, we tested the hypothesis that rosiglitazone (RSG) is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation...
  33. ncbi Antihypertensive treatment and cognitive function: another tempest in a P pot?
    Andrea Semplicini
    J Hypertens 26:1551-2. 2008
  34. ncbi Insulin signaling, glucose metabolism, and the angiotensin II signaling system: studies in Bartter's/Gitelman's syndromes
    Paul A Davis
    Diabetes Care 29:469-71. 2006
  35. ncbi Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive oxygen species
    Paul Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven K U Leuven, Belgium
    J Hypertens 24:757-66. 2006
    ....
  36. ncbi Galphai2 expression, hypertension and insulin resistance
    Michelangelo Sartori
    J Hypertens 24:785; author reply 786. 2006
  37. ncbi Blood pressure in acute ischemic stroke and mortality: a study with noninvasive blood pressure monitoring
    Michelangelo Sartori
    Clinica Medica 4, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Blood Press Monit 11:199-205. 2006
    ....
  38. ncbi Green tea attenuates angiotensin II-induced cardiac hypertrophy in rats by modulating reactive oxygen species production and the Src/epidermal growth factor receptor/Akt signaling pathway
    Italia Papparella
    Department of Clinical and Experimental Medicine and Experimental Biomedical Sciences, University of Padova, 35128 Padova, Italy
    J Nutr 138:1596-601. 2008
    ..These results show that GTE blunts Ang II-induced cardiac hypertrophy specifically by regulating ROS production and the Src/EGFR/Akt signaling pathway activated by Ang II...
  39. ncbi Early markers of inflammation in a high angiotensin II state--results of studies in Bartter's/Gitelman's syndromes
    Paul A Davis
    Department of Nutrition, University of California, Davis, USA
    Nephrol Dial Transplant 21:1697-701. 2006
    ..0001). CONCLUSIONS: The results of this study stress the critical role played by Ang II in controlling vascular biology including inflammation-related processes as well as highlighting the utility of BS/GS in investigating these pathways...
  40. ncbi Aldosterone and refractory hypertension: a prospective cohort study
    Michelangelo Sartori
    Clinica Medica 4, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Am J Hypertens 19:373-9; discussion 380. 2006
    ..Their identification will allow a targeted therapy and a more effective BP reduction...
  41. ncbi The search for a link between inflammation and hypertension--contribution from Bartter's/Gitelman's syndromes
    Elisa Pagnin
    Nephrol Dial Transplant 21:2340-2. 2006
  42. ncbi Silencing regulator of G protein signaling-2 (RGS-2) increases angiotensin II signaling: insights into hypertension from findings in Bartter's/Gitelman's syndromes
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy
    J Hypertens 26:938-45. 2008
    ....
  43. ncbi RGS2 C1114G polymorphism and body weight gain in hypertensive patients
    Michelangelo Sartori
    Department of Angiology and Blood Coagulation, S Orsola Malpighi, University Hospital, 40138 Bologna, Italy
    Metabolism 57:421-7. 2008
    ..The RGS2 1114G allele may be considered a genetic marker that predicts an individual's predisposition to gaining weight...
  44. ncbi Intravenous thrombolysis with rt-PA in acute ischemic stroke patients aged older than 80 years in Italy
    Danilo Toni
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
    Cerebrovasc Dis 25:129-35. 2008
    ..However, little information exists on its use in elderly patients, in particular those aged >80 years, who at present are excluded from treatment...
  45. ncbi Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Via Giustiniani 2, 35128 Padova, Italy
    Free Radic Biol Med 41:473-83. 2006
    ..Pravastatin inhibited radical oxygen species production by inhibiting PKC delta. These observations offer a robust explanation for the positive effects of pravastatin treatment in patients with insulin resistance syndrome...
  46. ncbi Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat
    Italia Papparella
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, I 35128 Padua, Italy
    Cardiovasc Res 73:432-8. 2007
    ..In this study, we investigated the effects of long-term treatment with zidovudine (AZT) and vitamin C, alone and in combination, on blood pressure and on the chain of events linking oxidative stress to cardiac damage in the rat...
  47. ncbi A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients
    Gian Paolo Rossi
    For a list of author affiliations, please see the
    J Am Coll Cardiol 48:2293-300. 2006
    ..8%). The availability of AVS is essential for an accurate identification of the adrenocortical pathologies underlying PA...
  48. ncbi Usefulness and safety of early blood pressure lowering after ischemic stroke still unproven
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, Policlinico Universitario, Padova, Italy
    Am J Hypertens 20:278. 2007
  49. ncbi Prospective evaluation of the saline infusion test for excluding primary aldosteronism due to aldosterone-producing adenoma
    Gian Paolo Rossi
    DMCS Clinica Medica 4, University Hospital, Padova, Italy
    J Hypertens 25:1433-42. 2007
    ..Data on the performance of the tests used to confirm the diagnosis of primary aldosteronism (PA) are limited...
  50. ncbi Effect of doxazosin on oxidative stress-related proteins in benign prostatic hyperplasia
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy
    Urol Int 76:36-41. 2006
    ....
  51. ncbi Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Via Giustiniani, 2, 35128 Padova, Italy
    Int J Cardiol 107:54-60. 2006
    ..Carnitine has been shown to be effective in pathologic conditions characterized by increased oxidative stress and an antioxidant effect of L-carnitine and its derivatives has been described but the specific mechanism is unclear...
  52. ncbi Rho/Rho-kinase and C-reactive protein relationship in hypertension and atherosclerosis
    Lorenzo A Calo
    Nephrol Dial Transplant 21:1131-2. 2006
  53. ncbi Effects of angiotensin II and insulin on ERK1/2 activation in fibroblasts from hypertensive patients
    Michelangelo Sartori
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Am J Hypertens 17:604-10. 2004
    ..CONCLUSIONS: Angiotensin II stimulated ERK1/2 activation is increased in insulin resistant hypertensive subjects, and it may play a role in the pathogenesis of insulin resistance and accelerated cardiovascular damage...
  54. ncbi Abnormal regulation of G protein alpha(i2) subunit in skin fibroblasts from insulin-resistant hypertensive individuals
    Elisabetta Baritono
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    J Hypertens 22:783-92. 2004
    ..This suggests that G(i)-mediated signal transduction is reduced in insulin-resistant hypertension...
  55. ncbi Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes 53:1344-51. 2004
    ..This effect of insulin may contribute to the pathogenesis and progression of cardiovascular disease in the insulin resistance syndrome...
  56. ncbi Effect of manidipine on gene expression and protein level of oxidative stress-related proteins: p22phox and HO-1: relevance for antihypertensive and anti-remodeling effects
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    J Cardiovasc Pharmacol 43:531-8. 2004
    ..This effect, together with the reduction of p22(phox) mRNA production, could play a role in its protective mechanism against OxSt...
  57. ncbi G-protein beta3-subunit gene 825T allele and hypertension: a longitudinal study in young grade I hypertensives
    Michelangelo Sartori
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Hypertension 42:909-14. 2003
    ..The GNB3 825T allele may be considered a genetic marker of predisposition for hypertension...
  58. ncbi Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    Nephrol Dial Transplant 18:1518-25. 2003
    ..Therefore, we evaluated oxidative stress-related proteins in plasma and monocytes of patients with BS/GS, at baseline and after Ang II stimulation...
  59. ncbi Pseudohyperaldosteronism: pathogenetic mechanisms
    Decio Armanini
    Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy
    Crit Rev Clin Lab Sci 40:295-335. 2003
    ..Another genetic cause of pseudohyperaldosteronism is the syndrome of Liddle, which is due to a mutation of the gene encoding for beta and gamma subunits of the sodium channels...
  60. ncbi Kidney transplant in Gitelman's syndrome. Report of the first case
    Lorenzo A Calo
    Department of Clinical Medicine, 4th Medical Clinic, Medical and Surgical Sciences, Padova Hospital, Italy
    J Nephrol 16:144-7. 2003
    ....
  61. ncbi Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril
    Lorenzo A Calo
    Department of Clinical and Exprimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy
    J Cardiovasc Pharmacol 40:625-31. 2002
    ..The association of ramipril normalizes blood pressure and reduces the oxidative stress induced by both drugs...
  62. ncbi Renal vein renin measurements accurately identify renovascular hypertension caused by total occlusion of the renal artery
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy
    J Hypertens 20:975-84. 2002
    ..To assess the usefulness of indexes derived from renal vein renin measurements...
  63. ncbi Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    J Clin Endocrinol Metab 89:4153-7. 2004
    ....
  64. ncbi Rho kinase and PAI-1 in Bartter's/Gitelman's syndromes: relationship to angiotensin II signaling
    Elisa Pagnin
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    J Hypertens 22:1963-9. 2004
    ....
  65. ncbi Reduced content of alpha subunit of Gq protein content in monocytes of Bartter and Gitelman syndromes: relationship with vascular hyporeactivity
    Lorenzo Calo
    Kidney Int 61:353-4. 2002
  66. ncbi Reduced mRNA and protein content of rho guanine nucleotide exchange factor (RhoGEF) in Bartter's and Gitelman's syndromes: relevance for the pathophysiology of hypertension
    Elisa Pagnin
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Am J Hypertens 18:1200-5. 2005
    ....
  67. ncbi Bartter's and Gitelman's syndromes: a confirm in humans of the utility of Rho kinase inhibition for cardiovascular protection
    Lorenzo A Calo
    J Hypertens 23:1273-5. 2005
  68. ncbi Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism
    Alessandra Gallo
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Diabetes 54:1123-31. 2005
    ..Our data substantiate the findings of previous large intervention studies on the beneficial effect of this drug in type 2 diabetic patients...
  69. ncbi Rho kinase inhibition and vascular protection: support from studies in Bartter and Gitelman syndrome
    Lorenzo A Calo
    Arterioscler Thromb Vasc Biol 25:e34; author reply e34-5. 2005
  70. ncbi Angiotensin II-induced over-activation of p47phox in fibroblasts from hypertensives: which role in the enhanced ERK1/2 responsiveness to angiotensin II?
    Italia Papparella
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    J Hypertens 23:793-800. 2005
    ..However, the intracellular pathways leading to cell hypertrophy and hyperplasia, as well as to collagen production, are still incompletely known...
  71. ncbi Administering antihypertensive drugs after acute ischemic stroke: timing is everything
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy
    CMAJ 172:625-6. 2005
  72. ncbi Antioxidant and antiinflammatory effect of carvedilol in mononuclear cells of hypertensive patients
    Lorenzo A Calo
    Am J Med 118:201-2. 2005
  73. ncbi [C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk]
    Michelangelo Sartori
    Clinica Medica 4, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Padova
    Ann Ital Med Int 19:240-8. 2004
    ....
  74. ncbi Autonomic nervous system function in chronic hypotension associated with Bartter and Gitelman syndromes
    Michelangelo Sartori
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    Am J Kidney Dis 49:330-5. 2007
    ..This normal autonomic function suggests that other pathophysiological mechanisms, such as the characteristic vasoconstrictor abnormal cell signaling, may account for hypotension in patients with Bartter and Gitelman syndromes...
  75. ncbi L-carnitine and erythropoiesis: relationship with haeme oxygenase-1
    Lorenzo A Calo
    Nephrol Dial Transplant 20:1769-70. 2005
  76. ncbi Myocardial function in Bartter's and Gitelman's syndromes
    Roldano Scognamiglio
    Kidney Int 64:366-7; author reply 367. 2003
  77. ncbi Orthostatic hypotension and supine hypertension in primary autonomic failure
    Michelangelo Sartori
    Hypertension 45:e18; author reply e18-9. 2005
  78. ncbi Nifedipine versus carvedilol in the treatment of de novo arterial hypertension after liver transplantation: results of a controlled clinical trial
    Alessandra Galioto
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Liver Transpl 14:1020-8. 2008
    ..In responders to carvedilol, but not in responders to nifedipine, the daily dose of tacrolimus at 1 year should be reduced to 50% compared to the baseline dose to maintain the blood trough level in the therapeutic range...
  79. ncbi NADPH oxidase, superoxide overproduction and nitric oxide bioavailability in essential hypertension
    Lorenzo A Calo
    J Hypertens 23:665-6. 2005
  80. ncbi A pheochromocytoma with normal clonidine-suppression test: how difficult the biochemical diagnosis?
    Michelangelo Sartori
    Intern Emerg Med 3:61-4. 2008
  81. ncbi Callipeltin A: sodium ionophore effect and tension development in vascular smooth muscle
    Lucia Trevisi
    Department of Pharmacology and Anaesthesiology, University of Padua, Largo E. Meneghetti 2, 35131 Padua, Italy
    Biochem Pharmacol 68:1331-8. 2004
    ..It is suggested that the effect of callipeltin A on cardiac and vascular preparations is linked to a Na-ionophore action...