S Seidenari

..In children the skin appears with structural characteristics, as evaluated by histology, which differ from those of adults, especially in the first years of life...

..Despite loss in image details, factor 30 compressed videomicroscopic images enable a good diagnostic accuracy...

..The most important discriminant features are target network, small globules, follicles and vessels. This classification may represent a useful tool in the follow-up of small congenital melanocytic naevi...

..We also classified small- and medium-sized congenital naevi (CN) into nine subtypes according to their macroscopic and dermoscopic aspects...

..Since elaboration of an image requires only 60s using our system, all the parameter data are available in real time and can be immediately examined by the classifier, providing an instant aid to clinical diagnosis...

..These findings suggest that patients with MTS phenotype that include colonic polyposis should be screened for MYH gene mutations...

..Semiquantitative algorithms were applied to dermoscopic images to improve the clinical diagnosis for melanoma...

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..The technique is simple and may improve cooperation between different research centers, in teleconsulting contexts or for result comparisons...

..Most MMs are sporadic, and in this setting an association with mismatch repair (MMR) gene mutations, typical of hereditary nonpolyposis colorectal cancer (HNPCC) tumours, has been proposed...

..Thus, possible early malignant melanomas (MMs) or MM precursors, lacking typical clinical characteristics, may elude the dermoscopic examination...

..Cross-sensitizations between azo dyes and para-amino compounds can partially be explained on the basis of structural affinities...

..In conclusion, our study showed that in children with suspected contact sensitization, disperse dyes should be regarded as potential triggering allergens...

..Despite the limited statistical precision of the point estimates, these findings seem to indicate that consumption of specific foods may influence melanoma risk...

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..As fibrosis and melanosis are often seen in malignant melanoma (MM), the presence of dermoscopic signs of regression may represent a clue for the diagnosis of malignancy...

..The seventh edition of the American Joint Committee on Cancer (AJCC) melanoma staging system, introduced mitotic rate (MR) as one of the primary criteria for staging thin melanoma...

..CONCLUSIONS: Our data suggest that APTs with peanuts may represent a useful integration to standard testing modalities employed for the diagnosis of peanut allergy in AD patients...

..4 compared with 2.1 in atopics. CONCLUSIONS: Although positive responses to mite patch tests are also observable in subjects without AD, their frequency and intensity are significantly lower compared with AD patients...

..The assessment of colours is essential for the diagnosis of malignant melanoma (MM), both for pattern analysis on dermoscopic images, and when employing semiquantitative methods...

..4%). Based on our data, the reticular pattern of blue regression and light brown areas can be considered a significant discriminator and a reliable predictor of MIS...

..In the skin, the generation of intracellular ceramide may also provide a link between an extracellular signal and the induction of the apoptosis programme for the elimination of damaged cells...

..The correlation between cytotoxicity and physical properties was also studied by a conductimetric assay to investigate the mechanism involved in this toxicity reduction...

..New functional parameters (water-sorption capacity and accumulated water decay) are proposed to describe more precisely the hydration kinetics of eczematous skin...

..On the basis of the above data, the skin of infants 8-24 months of age shows functional signs of immaturity. This may lead to an increased permeability and a reduced capacity for defense against chemical and microbial aggression...

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..After a rapid increase in malignant melanoma (MM) incidence in the last decades, trends of the melanoma epidemic in the recent years seemed not homogeneous...

..Patch testing represents a useful diagnostic procedure for the definition of childhood eczematous dermatitis and for the identification of agents inducing contact sensitization which is frequently associated with atopic dermatitis...

..Reflectance confocal microscopy (RCM) allows evaluation of skin lesions at high resolution...

..Further studies, using routine diagnostic testing with disperse dyes, are needed to investigate whether this increasing trend is present outside of Europe...

..These data indicate that UVB induced ceramide generation and activation of both neutral and acidic SMases, suggesting that sphingolipids metabolism may be involved in the UVB signaling pathway...

..CONCLUSION: Data indicate that patients with beta-thalassemia may undergo important alterations of connective tissues, a better understanding of which may help in preventing clinical complications...

..The color and texture matches were aesthetically good, and the nasal contour was distinct in all patients. All scars were inconspicuous and symmetrical. No patient had tenting or a flat nose...

..BRAF mutation is not a specific marker of melanocytic cancerogenesis, and it can also be involved in SGHs. In both melanocytic and non-melanocytic skin tumors, BRAF mutation is linked to early tumorigenesis events...

..In the latter, the hands may represent a 'locus minoris resistentiae', and both induction and elicitation of contact sensitization could be caused by impaired barrier function at a skin site repeatedly exposed to sensitizing garments...

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..Numerical parameters referring to malignant melanomas were significantly higher, both with respect to benign naevi and atypical naevi. The numerical parameters produced could be effectively employed for computer-aided melanoma diagnosis...

..7% sensitivity and a 100% specificity. CONCLUSION: The correct classification of all thin melanomas as such renders this approach suitable in clinical practice...

..To characterize nodular melanoma (NM) using dermoscopy, in vivo reflectance-mode confocal microscopy, and histopathologic analysis...

..To overcome subjectivity and variability in the interpretation of dermoscopic images, image analysis programs, enabling the numerical description of melanocytic lesion images, have been developed...

..In dermoscopy the presence of a blue hue is a clue for malignancy, although a blue tint is sometimes observable in benign lesions...

..We report a case of pigmented mammary Paget disease mimicking a melanoma and describe the dermoscopic, reflectance-mode confocal microscopic, histological, and immunohistochemical features...

..Reflectance confocal microscopy (RCM) has been used for over 10 years for in vivo skin imaging. However, to date no standard RCM terminology has been published...

..Owing to the visualization of cellular aspects, confocal microscopy seems useful for second level examination of clinically and dermoscopically equivocal lesions...

..Because melanoma may sometimes be difficult to differentiate from nevi with clinical atypia, many benign lesions also undergo surgical removal...

..As the VEGFR has an important impact on the pathogenesis of JNA, we suggest that a targeted therapy with monoclonal antibodies against VEGFR might lead to a specific chemoprevention and treatment of these tumors and their recurrences...

..This study confirms that the known MC1R-melanoma risk association is confined to subjects whose melanomas harbor BRAF mutations...

..We aimed at examining the association between dietary constituents and risk of cutaneous melanoma...

..In vivo confocal microscopy enables skin visualization with a quasihistopathologic resolution...

..4% vs. 93.2%). Our data suggest that combined skin prick and patch testing improves screening for egg allergy in affected children, identifying 92% of those who were challenge positive among our patients...

..Finally, a hint to the use of cytodiagnosis for basal cell carcinoma is provided...

..To characterize the microscopic aspects of the dermoscopic pigment network in vivo, by means of confocal scanning laser microscopy...

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..In conclusion, as sensitization rates to different allergens show great variations over time, periodic evaluations of patch test results in children is necessary in order to update the test trays...

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..In conclusion, based on our data, we suggest that propolis should not be used in topical products for children because of its high sensitization rate at the paediatric age...

..Moreover, cerebriform clusters were exclusively observed in five out of 20 melanomas. Confocal microscopy allowed the in vivo characterization of aspects of melanocytic nests and their exact correlation with histopathology...

..6 and 71.2% for ADAs and RDAs, respectively). CONCLUSIONS: Both methods for the automated identification of dark areas are useful for melanoma diagnosis and can be implemented in programs for image analysis...

..The efficacy of these new descriptors was tested on a data set of 510 pigmented skin lesions, composed by 85 melanomas and 425 nevi, by employing statistical methods for discrimination between the two populations...

..Asymmetry should be assessed using both dermoscopic and histopathologic analysis, and reliability in histopathologic diagnosis may be enhanced by the simultaneous evaluation of the corresponding dermoscopic images...

..851). In conclusion, for Dermatophagoides APTs, the agreement rate was similar to that of standard patch tests, and therefore APTs may be considered sufficiently reproducible to be employed as a diagnostic testing procedure...

..Spitz nevus is a benign melanocytic lesion sometimes mistakenly diagnosed clinically as melanoma...

..53). CONCLUSION: The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions...

..Thus, when pagetoid melanocytosis is observable by means of confocal microscopy, melanoma diagnosis should be considered, whereas it cannot be excluded in the absence of pagetoid cells, lacking in at least 10% of malignant lesions...

..Our aim was to examine the risk of melanoma in association with exposure to trace elements of toxicological and nutritional interest...

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..In this population, individuals carrying the R241 allele of the ICAM-1 gene appeared to show an enhanced susceptibility to cutaneous melanoma, possibly because of increased ICAM-1 expression...

..Increased public awareness regarding skin cancer probably represents the main effect of this type of campaign...