Research Topics
| Leonardo-A SechiSummaryAffiliation: University of Sassari Country: Italy Publications
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Detail Information
Publications
Sardinian Type 1 diabetes patients, Transthyretin and Mycobacterium avium subspecies paratuberculosis infectionSperanza Masala
Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy
Gut Pathog 4:24. 2012..abstract:..- Interaction between Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium subspecies paratuberculosis with the enteric glia and microglial cellsSara Cannas
Dipartimento di Scienze Biomediche Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Italy
Gut Pathog 3:19. 2011..abstract:.. - Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in EnglandFarhana Kauser
Pathogen Evolution Group, Laboratory of Molecular and Cell Biology, Centre for DNA Fingerprinting and Diagnostics CDFD, Hyderabad, India
BMC Microbiol 5:32. 2005..Phylogenetic analysis was carried out based on various high-resolution genotyping techniques... - Ancestral European roots of Helicobacter pylori in IndiaS Manjulata Devi
Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
BMC Genomics 8:184. 2007..pylori. We tried to address these issues through mapping genetic origins of present day H. pylori in India and their genomic comparison with hundreds of isolates from different geographic regions... - Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity islandS Manjulata Devi
Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
BMC Genomics 7:191. 2006..pylori of native Peruvians (of Amerindian ancestry) and their genomic comparison with isolates from Spain, and Japan... - Mycobacterium avium subspecies paratuberculosis is not associated with type-2 diabetes mellitusValentina Rosu
Dipartimento di Scienze Biomediche, Sezione di Microbiologia clinica e sperimentale, viale San Pietro 43 b 07100 Sassari, Italy
Ann Clin Microbiol Antimicrob 7:9. 2008..paratuberculosis (MAP) shown a clear association of MAP with the presence of type 1 diabetes mellitus (T1DM)... - Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pyloriShaik Mahaboob Ali
Department of Microbiology, Osmania University, Hyderabad 500 007, India
Ann Clin Microbiol Antimicrob 4:20. 2005..Eugenol and cinnamaldehyde that are commonly used in various food preparations are known to possess antimicrobial activity against a wide spectrum of bacteria... - Helicobacter pylori and gastroduodenal pathology: new threats of the old friendNiyaz Ahmed
Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Ann Clin Microbiol Antimicrob 4:1. 2005..The contribution of comparative genomics to our understanding of the genome organisation and diversity of H. pylori and its pathophysiological importance to human healthcare is exemplified in this review... 
Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cellsLeonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Viale S Pietro 43 B, Sassari 07100, Italy
World J Gastroenterol 13:5731-5. 2007..To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease...- Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patientsLeonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Viale S Pietro 43 B, 07100 Sassari, Italy
World J Gastroenterol 12:7161-4. 2006.... - Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way aheadLeonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Viale S Pietro 43 B, 07100 Sassari, Italy
J Clin Microbiol 43:5275-7. 2005..Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD 2/CARD 15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis... - Immunization with DNA vaccines encoding different mycobacterial antigens elicits a Th1 type immune response in lambs and protects against Mycobacterium avium subspecies paratuberculosis infectionL A Sechi
Dipartimento di Scienze Biomediche, Sezione Microbiologia sperimentale e clinica, Facolta di Medicina, Viale S Pietro 43 B, 07100 Sassari, Italy
Vaccine 24:229-35. 2006..paratuberculosis by evaluating the expression level of INF-gamma and evaluating the presence of M. paratuberculosis and animal cell organ damage post-mortem... - Immunogenicity and cytoadherence of recombinant heparin binding haemagglutinin (HBHA) of Mycobacterium avium subsp. paratuberculosis: functional promiscuity or a role in virulence?Leonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Sassari, Italy
Vaccine 24:236-43. 2006..Since M. tuberculosis HBHA was earlier shown to be involved in dissemination of the tubercle bacilli, the immunogenicity and cytoadherent nature of this MAP protein possibly suggests functional promiscuity... - "In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosisStefania Zanetti
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, , Viale S, Pietro 43/B, 07100 Sassari, Italy
Ann Clin Microbiol Antimicrob 5:27. 2006 - PER-1 type beta-lactamase production in Acinetobacter baumannii is related to cell adhesionLeonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy
Med Sci Monit 10:BR180-4. 2004..We investigated the presence and the association of various virulence determinants in 20 Acinetobacter baumannii isolates, of which 13 were blaPER-1 positive... - Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesisLeonardo A Sechi
Dipartimento di Scienze Biomediche, Universita di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy
Clin Vaccine Immunol 15:320-6. 2008..Finding evidence of M. avium subsp. paratuberculosis involvement in T1DM is perhaps a novel finding that might serve as a foundation stone in establishing an infectious etiology for T1DM... - Mycobacterium avium subsp. paratuberculosis as a trigger of type-1 diabetes: destination Sardinia, or beyond?Pittu Sandhya Rani
Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Hyderabad, India
Gut Pathog 2:1. 2010..Systematic mechanistic insights are needed to prove this link. Unfortunately, no easy animal model(s) or in-vitro systems are available to decipher the complex immunological network that is triggered in MAP infection leading to T1DM... - Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in SardiniaLeonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, , Sassari, Italy
Am J Gastroenterol 100:1529-36. 2005..The finding of the organism colonizing a proportion of people without Crohn's disease is consistent with what occurs in other conditions caused by a primary bacterial pathogen in susceptible hosts... - Genome and transcriptome scale portrait of sigma factors in Mycobacterium avium subsp. paratuberculosisLeonardo A Sechi
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Viale S Pietro 43 B, 07100 Sassari, Italy
Infect Genet Evol 7:424-32. 2007..Thus, this first report on expression of MAP sigma factors opens the way to an extensive characterization of global gene regulation, as a key to understand strategies of survival and mechanisms of infections used by this organism... - Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutininStefania Zanetti
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Clin Diagn Lab Immunol 12:1135-8. 2005..Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls... 
Detection of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens-associated corneal ulcersAntonio Pinna
Institute of Ophthalmology, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy
Cornea 27:320-6. 2008..The purpose of this study was to report on the microbiological findings of 8 P. aeruginosa strains isolated from contact lens-associated corneal ulcers...- Quinoxalin-2-ones. Part 5. Synthesis and antimicrobial evaluation of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones variously substituted on the benzo-moietyAntonio Carta
Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
Farmaco 58:1251-5. 2003..Results of the screening showed that compounds 9b, 14b and 19b (MIC=62.5 microg/ml) and 10b (MIC=15.6 microg/ml) were the most active against Vibrio alginolyticus... - Aeromonas caviae keratitis associated with contact lens wearAntonio Pinna
Institute of Ophthalmology, University of Sassari, Sassari, Italy
Ophthalmology 111:348-51. 2004..We report the first case of bilateral contact lens-related Aeromonas caviae keratitis associated with A. caviae contamination of the contact lens case. The presence of virulence factors produced by Aeromonas species was also investigated... - Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitusDaniela Paccagnini
Dipartimento di Scienze Biomediche, Sezione di Microbiologia clinica e sperimentale, Sassari, Italy
PLoS ONE 4:e7109. 2009..Mycobacterium avium subsp. paratuberculosis (MAP) has been reported to be a possible trigger in the development of T1DM... - An outbreak of post-cataract surgery endophthalmitis caused by Pseudomonas aeruginosaAntonio Pinna
Institute of Ophthalmology, University of Sassari, Sassari, Italy
Ophthalmology 116:2321-6.e1-4. 2009..The purpose of this study was to investigate an outbreak of post-cataract surgery P. aeruginosa endophthalmitis in India... - Detection of virulence factors in a corneal isolate of Klebsiella pneumoniaeAntonio Pinna
Institute of Ophthalmology, University of Sassari, Sassari, Italy
Ophthalmology 112:883-7. 2005..To report on the microbiological findings of a Klebsiella pneumoniae strain isolated from a patient with keratitis... - Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovisPaola Molicotti
Department of Biomedical Sciences, University of Sassari, Italy
New Microbiol 31:423-7. 2008..Our results indicated that HBHA is a potential candidate for the development of a serological assay for rapid diagnosis of cattle infected with M. bovis... - In vitro efficacy of Linezolid on clinical strains of Mycobacterium tuberculosis and other mycobacteriaPaola Molicotti
Department of Biomedical Sciences, Institute of Microbiology, University of Sassari, Italy
New Microbiol 29:275-80. 2006..5 to 2 microg/ml. Linezolid can be used in combination with the standard antitubercular medications, or as an effective therapeutic alternative in infections caused by M. tuberculosis or by other species of non-tubercular mycobacteria... - Specific immunoassays confirm association of Mycobacterium avium Subsp. paratuberculosis with type-1 but not type-2 diabetes mellitusValentina Rosu
Dipartimento di Scienze Biomediche, Sezione di Microbiologia, Universita degli Studi di Sassari, Sassari, Italy
PLoS ONE 4:e4386. 2009..Rapid identification of infectious agents such as MAP in diabetic patients at the level of clinics might be helpful in deciphering the role of chronic bacterial infection in the development of autoimmune diseases such as T1DM... - Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn's disease and Johne's disease: common neural and immune pathogenicitiesAntonio M Scanu
Instituto di Clinica Chirurgica Generale, Sezione di Microbiologia Sperimentale e Clinica, Universita degli Studi di Sassari, Sassari, Italy
J Clin Microbiol 45:3883-90. 2007..paratuberculosis infection and the consumption of hand-made cheese. Mycobacterium avium subsp. paratuberculosis is a candidate pathogen in the causation of a proportion of cases of irritable bowel syndrome as well as in Crohn's disease... - Rapid identification of Mycobacterium tuberculosis Beijing genotypes on the basis of the mycobacterial interspersed repetitive unit locus 26 signatureK Rajender Rao
Pathogen Evolution Group, Laboratory of Molecular and Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD, Nacharam, Hyderabad, India
J Clin Microbiol 44:274-7. 2006..The test can also be adopted for direct application on clinical samples to save time on culturing bacilli for genotyping... - Phages specific for mycobacterial lipoarabinomannan help serodiagnosis of tuberculosisAlessandra Bua
Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy
New Microbiol 32:293-6. 2009..Our results confirm that phage display technology might be useful to develop new tools for diagnosis of tuberculosis... - Genetic affinities within a large global collection of pathogenic Leptospira: implications for strain identification and molecular epidemiologyKishore Nalam
Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
PLoS ONE 5:e12637. 2010.... - QuantiFERON TB Gold: a new method for latent tuberculosis infectionAlessandra Bua
Department of Biomedical Sciences, University of Sassari, Italy
New Microbiol 30:477-80. 2007..tuberculosis and its use alongside traditional diagnostic techniques may be an important instrument for controlling tuberculosis... - Isocitrate dehydrogenase of Helicobacter pylori potentially induces humoral immune response in subjects with peptic ulcer disease and gastritisM Abid Hussain
Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics CDFD, Hyderabad, India
PLoS ONE 3:e1481. 2008..We report immunogenic potentials of isocitrate dehydrogenase (ICD), an important house keeping protein of H. pylori... - Prevalence and characterization of Enterococcus spp. isolated from Brazilian foodsBruna C Gomes
Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av Prof Lineu Prestes 580, Bloco 13B, 05508 900 Sao Paulo, Brazil
Food Microbiol 25:668-75. 2008..faecium isolates with no virulence traits suggests their potential for biotechnological applications. In conclusion, our results showed that enterococci from Brazilian foods present important dualist aspects for food safety... - Mycobacterium tuberculosis molecular evolution in western Mediterranean Islands of Sicily and SardiniaChristophe Sola
Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Morne Joliviere, BP 484, F97165 Pointe à Pitre, Guadeloupe, France
Infect Genet Evol 5:145-56. 2005..tuberculosis complex. The results obtained are paradigmatic of the complex interplay that exists between epidemic dynamics and evolutionary genetics of M. tuberculosis... - Molecular genotyping of a large, multicentric collection of tubercle bacilli indicates geographical partitioning of strain variation and has implications for global epidemiology of Mycobacterium tuberculosisNiyaz Ahmed
Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India
J Clin Microbiol 42:3240-7. 2004..The genotypic data reported here are additionally significant for genotype-phenotype correlations and for determining whether pathogen diversity is a reflection f the host population diversity... - PCR-based detection of the Mycobacterium tuberculosis complex in urine of HIV-infected and uninfected pulmonary and extrapulmonary tuberculosis patients in Burkina FasoGabriela Torrea
Mycobacteriology Laboratory, Centre Muraz, Bobo-Dioulasso, Burkina Faso
J Med Microbiol 54:39-44. 2005..This method is not appropriate for detection of new TB cases in the routine laboratory, but it can be useful for cases where the clinical and bacteriological diagnosis of TB is not conclusive... - The cag pathogenicity island of Helicobacter pylori is disrupted in the majority of patient isolates from different human populationsFarhana Kauser
Pathogen Evolution Group, Center for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India
J Clin Microbiol 42:5302-8. 2004..Analysis of the cag-PAI genotypes with a different biogeoclimatic history will contribute to our understanding of the pathogen-host interaction in health and disease... - Antimicrobial activity of Inula helenium L. essential oil against Gram-positive and Gram-negative bacteria and Candida sppAntonella Deriu
Int J Antimicrob Agents 31:588-90. 2008 - Analysis of genomic downsizing on the basis of region-of-difference polymorphism profiling of Mycobacterium tuberculosis patient isolates reveals geographic partitioningK Rajender Rao
Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India
J Clin Microbiol 43:5978-82. 2005..This study highlights that the RDs in M. tuberculosis genomes are geographically distributed and specific and may possibly be associated with virulence spectrum... - In vitro adherence of Staphylococcus epidermidis, Serratia marcescens, and Pseudomonas aeruginosa to AcrySof intraocular lensesAntonio Pinna
J Cataract Refract Surg 31:2430-1. 2005 - Rapid diagnosis of mycobacterial infections and quantitation of Mycobacterium tuberculosis load by two real-time calibrated PCR assaysFrancesco Broccolo
Unit of Human Virology, San Raffaele Scientific Institute, Milan, Italy
J Clin Microbiol 41:4565-72. 2003..Therefore, these assays represent a fully controlled high-throughput system for the evaluation of mycobacterial burden in clinical specimens... - Antigenic profiles of recombinant proteins from Mycobacterium avium subsp. paratuberculosis in sheep with Johne's diseaseJohn P Bannantine
National Animal Disease Center, USDA Agricultural Research Service, Ames, IA 50010, USA
Vet Immunol Immunopathol 122:116-25. 2008..This study evaluated multiple M. avium subsp. paratuberculosis recombinant proteins in an ELISA-based format for sheep... - Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: an infectious trigger?Leonardo A Sechi
Clin Infect Dis 46:148-9. 2008 - Regression of microalbuminuria in type 1 diabetesCristiana Catena
N Engl J Med 349:906-8; author reply 906-8. 2003 - Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistanceClaudio Pagano
Department of Medical and Surgical Sciences, University of Padova, Via Ospedale 105, 35100 Padova, Italy
J Clin Endocrinol Metab 91:1081-6. 2006..The recently discovered hormone resistin is linked to the development of insulin resistance, but direct evidence of resistin levels in humans with nonalcoholic fatty liver disease (NAFLD) is lacking... - Insulin sensitivity in patients with primary aldosteronism: a follow-up studyCristiana Catena
Clinica Medica, University of Udine, Piazzale S. Maria della Misericordia, 1, 33100 Udine, Italy
J Clin Endocrinol Metab 91:3457-63. 2006..Treatment with surgery or aldosterone antagonists restores rapidly and persistently normal sensitivity to insulin... - Renal cysts and hypokalemia in primary aldosteronism: results of long-term follow-up after treatmentMarileda Novello
Division of Internal Medicine, Department of Experimental and Clinical Pathology and Medicine, University of Udine, Udine, Italy
J Hypertens 25:1443-50. 2007..The nature of this association could be related to hypokalemia and/or hypertension and has never been evaluated in prospective studies... - AmpliBASE MT: a Mycobacterium tuberculosis diversity knowledgebaseAhmed A Majeed
Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500076, India
Bioinformatics 20:989-92. 2004.... - Mycobacterium marinum, a further infectious agent associated with sarcoidosis: the polyetiology hypothesisOswald Moling
Division of Infectious Diseases, Ospedale Generale, Bolzano, Italy
Scand J Infect Dis 38:148-52. 2006..After this, Mycobacterium marinum-DNA was identified in the stored lung biopsies by the PCR-RFLP of the hsp65 gene...