Giovanna M Scoto

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. doi request reprint Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation
    Giovanna M Scoto
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Pharmacol Biochem Behav 100:639-44. 2012
  2. ncbi request reprint Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 28:1441-6. 2007
  3. doi request reprint Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain
    Giovanna M Scoto
    Department of Pharmaceutical Sciences, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Life Sci 85:206-10. 2009
  4. doi request reprint Selective inhibition of the NOP receptor in the ventrolateral periaqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, Vle A Doria 6, 95125 Catania, Italy
    Peptides 31:696-700. 2010
  5. doi request reprint Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:957-61. 2012
  6. doi request reprint The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:66-70. 2012
  7. doi request reprint The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Neuropharmacology 71:70-82. 2013
  8. doi request reprint Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy
    J Med Chem 53:5881-5. 2010
  9. doi request reprint Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain
    Carmela Parenti
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 34:412-8. 2012
  10. doi request reprint The functional antiopioid action of the ventrolateral periaqueductal gray nociceptin/orphanin FQ and nociceptin receptor system underlies DAMGO analgesic tolerance
    Carmela Parenti
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, Italy cparenti unict it
    Pharmacology 86:138-44. 2010

Detail Information

Publications14

  1. doi request reprint Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation
    Giovanna M Scoto
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Pharmacol Biochem Behav 100:639-44. 2012
    ..Thus, it is likely that the peripheral N/OFQ/NOP receptor system contributes to the abnormal pain sensitivity in an inflammatory state...
  2. ncbi request reprint Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 28:1441-6. 2007
    ..N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG...
  3. doi request reprint Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain
    Giovanna M Scoto
    Department of Pharmaceutical Sciences, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Life Sci 85:206-10. 2009
    ..The aim of the present study was to identify the role of the vlPAG Nociceptin/Orphanin FQ/NOP receptor system in allodynia, a nociceptive behavioral response associated with chronic pain...
  4. doi request reprint Selective inhibition of the NOP receptor in the ventrolateral periaqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, Vle A Doria 6, 95125 Catania, Italy
    Peptides 31:696-700. 2010
    ..These data suggest that the N/OFQ in the vlPAG may play a key role in opioid-induced antinociceptive tolerance...
  5. doi request reprint Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:957-61. 2012
    ..The aim of this work was to determine whether the antinociceptive effect produced by LP1 was central or peripheral and to assess which opioid receptor subtypes are involved in its effects...
  6. doi request reprint The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:66-70. 2012
    ..The aim of this work was to evaluate and compare the induction of tolerance to antinociceptive effects from treatment with LP1 and morphine...
  7. doi request reprint The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Neuropharmacology 71:70-82. 2013
    ..Our studies seem to support that multitarget ligand approach should be useful for persistent pain conditions in which mechanical allodynia and thermal hyperalgesia are significant components of the nociceptive response...
  8. doi request reprint Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy
    J Med Chem 53:5881-5. 2010
    ..They exhibited in vivo anti-opioid effects on kappa opioid (KOP) receptor-mediated analgesia. Our findings demonstrate that the enantiomers display mainly sigma(1) agonist activity and that they have neuroprotective effects...
  9. doi request reprint Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain
    Carmela Parenti
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 34:412-8. 2012
    ..These results suggest a significant antinociceptive role for SP and the NK1 receptor in inflammatory pain at the supraspinal level, possibly through the release of endogenous opioids...
  10. doi request reprint The functional antiopioid action of the ventrolateral periaqueductal gray nociceptin/orphanin FQ and nociceptin receptor system underlies DAMGO analgesic tolerance
    Carmela Parenti
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, Italy cparenti unict it
    Pharmacology 86:138-44. 2010
    ..Inhibition of N/OFQ signaling can reverse and prevent the development of DAMGO tolerance in the vlPAG. The results confirm that N/OFQ acts as a functional opioid antagonist...
  11. doi request reprint Evaluation of N-substitution in 6,7-benzomorphan compounds
    Lorella Pasquinucci
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 18:4975-82. 2010
    ..LP1, possessing a mu/delta agonist profile, could represent a lead in further developing benzomorphan-based ligands with potent in vivo analgesic activity and a reduced tendency to induce side effects...
  12. doi request reprint Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties
    Agostino Marrazzo
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    J Med Chem 54:3669-73. 2011
    ..The σ(2) ligand (-)-9 displayed agonist properties in an in vitro isolated organ bath assay and antiproliferative effects on LNCaP and PC3 prostate cancer cell lines...
  13. doi request reprint A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, University of Catania, Viale A Doria, 6, 95125 Catania, Italy
    Life Sci 82:549-53. 2008
    ..This study confirms that (+/-)-PPCC plays the role of sigma agonist in this model and strengthens the hypothesis of the sigma receptor modulatory role on KOP-mediated analgesia...
  14. doi request reprint Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells
    Agostino Marrazzo
    Department of Pharmaceutical Sciences, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Eur J Med Chem 46:433-8. 2011
    ..MRJF4 was also used in combination with σ(1) agonist (+)-pentazocine and σ(2) antagonist AC927 in order to evaluate the role of σ receptor subtypes in prostate cancer cell death...