Marco Scocchi

Summary

Affiliation: University of Trieste
Country: Italy

Publications

  1. ncbi The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains
    Marco Scocchi
    Department of Life Sciences, University of Trieste, Italy
    Comp Biochem Physiol B Biochem Mol Biol 152:376-81. 2009
  2. ncbi Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics
    Marco Scocchi
    Department of Life Sciences, University of Trieste, Trieste, Italy
    Methods Mol Biol 494:161-76. 2008
  3. ncbi Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts
    Monica Benincasa
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 34127 Trieste, Italy
    J Antimicrob Chemother 58:950-9. 2006
  4. ncbi Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides
    Maura Mattiuzzo
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Mol Microbiol 66:151-63. 2007
  5. ncbi Rapid and reliable detection of antimicrobial peptide penetration into gram-negative bacteria based on fluorescence quenching
    Monica Benincasa
    Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
    Antimicrob Agents Chemother 53:3501-4. 2009
  6. ncbi Dual mode of action of Bac7, a proline-rich antibacterial peptide
    Elena Podda
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Biochim Biophys Acta 1760:1732-40. 2006
  7. ncbi The proline-rich peptide Bac7(1-35) reduces mortality from Salmonella typhimurium in a mouse model of infection
    Monica Benincasa
    Department of Life Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    BMC Microbiol 10:178. 2010
  8. ncbi Structural aspects of plant antimicrobial peptides
    Lara Padovan
    Genetic Service, IRCCS Burlo Garofolo and Department of Developmental and Reproductive Sciences, University of Trieste, 34137 Trieste, Italy
    Curr Protein Pept Sci 11:210-9. 2010
  9. ncbi Antimicrobial activity of Bac7 fragments against drug-resistant clinical isolates
    Monica Benincasa
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via Giorgieri, 1, I-34127 Trieste, Italy
    Peptides 25:2055-61. 2004
  10. ncbi Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides
    Alessandro Tossi
    Department of Life Sciences, University of Trieste, Trieste, Italy
    Methods Mol Biol 794:169-83. 2012

Collaborators

Detail Information

Publications11

  1. ncbi The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains
    Marco Scocchi
    Department of Life Sciences, University of Trieste, Italy
    Comp Biochem Physiol B Biochem Mol Biol 152:376-81. 2009
    ..The high variation in length and sequence of this region suggests the existence of a genetically unstable region similar to that found in some mammalian cathelicidins...
  2. ncbi Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics
    Marco Scocchi
    Department of Life Sciences, University of Trieste, Trieste, Italy
    Methods Mol Biol 494:161-76. 2008
    ....
  3. ncbi Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts
    Monica Benincasa
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 34127 Trieste, Italy
    J Antimicrob Chemother 58:950-9. 2006
    ....
  4. ncbi Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides
    Maura Mattiuzzo
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Mol Microbiol 66:151-63. 2007
    ....
  5. ncbi Rapid and reliable detection of antimicrobial peptide penetration into gram-negative bacteria based on fluorescence quenching
    Monica Benincasa
    Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
    Antimicrob Agents Chemother 53:3501-4. 2009
    ..Identification of peptides with the former mechanism is of considerable interest for the intracellular delivery of membrane-impermeant drugs...
  6. ncbi Dual mode of action of Bac7, a proline-rich antibacterial peptide
    Elena Podda
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    Biochim Biophys Acta 1760:1732-40. 2006
    ....
  7. ncbi The proline-rich peptide Bac7(1-35) reduces mortality from Salmonella typhimurium in a mouse model of infection
    Monica Benincasa
    Department of Life Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy
    BMC Microbiol 10:178. 2010
    ..Bac7 is a proline-rich peptide with a potent in vitro antimicrobial activity against Gram-negative bacteria. Here we investigated its activity in biological fluids and in vivo using a mouse model of S. typhimurium infection...
  8. ncbi Structural aspects of plant antimicrobial peptides
    Lara Padovan
    Genetic Service, IRCCS Burlo Garofolo and Department of Developmental and Reproductive Sciences, University of Trieste, 34137 Trieste, Italy
    Curr Protein Pept Sci 11:210-9. 2010
    ..This extends their interest from defense of important food crops also to the design of novel anti-infective compounds for both pharmaceutical and agricultural applications...
  9. ncbi Antimicrobial activity of Bac7 fragments against drug-resistant clinical isolates
    Monica Benincasa
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via Giorgieri, 1, I-34127 Trieste, Italy
    Peptides 25:2055-61. 2004
    ..In addition, when tested against fungi, the longer fragment was also active against collection strains and clinical isolates of Cryptococcus neoformans, but not towards clinical isolates of Candida albicans...
  10. ncbi Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides
    Alessandro Tossi
    Department of Life Sciences, University of Trieste, Trieste, Italy
    Methods Mol Biol 794:169-83. 2012
    ..Here, we describe how such residues can be used to modulate such key parameters as cationicity, hydrophobicity, steric factors conformational stability, and H-bonding...
  11. ncbi Structural aspects and biological properties of the cathelicidin PMAP-36
    Marco Scocchi
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Italy
    FEBS J 272:4398-406. 2005
    ..It allows the molecule to achieve an impressive charge density (+28 in 70 residues), although the significance of this feature with respect to biological activity has yet to be determined...