Nicola Scichilone

Summary

Affiliation: University of Palermo
Country: Italy

Publications

  1. ncbi Diagnosis and management of asthma in the elderly
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi MIS, University of Palermo, Palermo, Italy Electronic address
    Eur J Intern Med 25:336-42. 2014
  2. pmc Safety and efficacy of montelukast as adjunctive therapy for treatment of asthma in elderly patients
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
    Clin Interv Aging 8:1329-37. 2013
  3. pmc Lung penetration and patient adherence considerations in the management of asthma: role of extra-fine formulations
    Nicola Scichilone
    Dipartimento di Biomedicina e Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Asthma Allergy 6:11-21. 2013
  4. ncbi Exhaled nitric oxide is associated with cyclic changes in sexual hormones
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy Electronic address
    Pulm Pharmacol Ther 26:644-8. 2013
  5. doi Clinical and anti-inflammatory effects of ultra-short preseasonal vaccine to Parietaria in asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Ther Adv Respir Dis 7:207-15. 2013
  6. doi Serum low density lipoprotein subclasses in asthma
    Nicola Scichilone
    Biomedical Department of Internal Medicine and Medical Specialties DiBiMIS, University of Palermo, Italy Euro Mediterranean Institute of Science and Technology, Italy Electronic address
    Respir Med 107:1866-72. 2013
  7. ncbi Allergen sensitizations in southern Italy: a 5-year retrospective study in allergic respiratory patients
    N Scichilone
    Dipartimento di Biomedicina e Medicina Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Eur Ann Allergy Clin Immunol 45:97-102. 2013
  8. ncbi Assessing and accessing the small airways; implications for asthma management
    Nicola Scichilone
    Biomedical Department of Internal and Specialist Medicine DIBIMIS, Section of Pneumology, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Pulm Pharmacol Ther 26:172-9. 2013
  9. doi Alveolar nitric oxide and asthma control in mild untreated asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Allergy Clin Immunol 131:1513-7. 2013
  10. doi Prognostic value of FEV1/FEV6 in elderly people
    Claudio Sorino
    Department of Medicine, Pneumology, Physiology and Human Nutrition, University of Palermo, Via Trabucco 180, Palermo, Italy
    Clin Physiol Funct Imaging 31:101-7. 2011

Detail Information

Publications34

  1. ncbi Diagnosis and management of asthma in the elderly
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi MIS, University of Palermo, Palermo, Italy Electronic address
    Eur J Intern Med 25:336-42. 2014
    ..The article addresses the main issues related to the diagnosis and treatment of asthma in the geriatric age. ..
  2. pmc Safety and efficacy of montelukast as adjunctive therapy for treatment of asthma in elderly patients
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
    Clin Interv Aging 8:1329-37. 2013
    ....
  3. pmc Lung penetration and patient adherence considerations in the management of asthma: role of extra-fine formulations
    Nicola Scichilone
    Dipartimento di Biomedicina e Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Asthma Allergy 6:11-21. 2013
    ....
  4. ncbi Exhaled nitric oxide is associated with cyclic changes in sexual hormones
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy Electronic address
    Pulm Pharmacol Ther 26:644-8. 2013
    ..We hypothesized that changes in the levels of sexual hormones during the menstrual cycle influence the concentration of nitric oxide in the exhaled air (FeNO) and alveolar exhaled nitric oxide (CANO)...
  5. doi Clinical and anti-inflammatory effects of ultra-short preseasonal vaccine to Parietaria in asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Ther Adv Respir Dis 7:207-15. 2013
    ..We aimed at evaluating whether the ultra-short preseasonal course of immunotherapy contributes to asthma control...
  6. doi Serum low density lipoprotein subclasses in asthma
    Nicola Scichilone
    Biomedical Department of Internal Medicine and Medical Specialties DiBiMIS, University of Palermo, Italy Euro Mediterranean Institute of Science and Technology, Italy Electronic address
    Respir Med 107:1866-72. 2013
    ..The levels of serum low-density lipoproteins (LDL) have been implicated in the inflammatory cascade in a murine model of asthma. Recent findings suggest that LDL may modulate the inflammatory state of the asthmatic airways in humans...
  7. ncbi Allergen sensitizations in southern Italy: a 5-year retrospective study in allergic respiratory patients
    N Scichilone
    Dipartimento di Biomedicina e Medicina Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Eur Ann Allergy Clin Immunol 45:97-102. 2013
    ..These observations could contribute to a proper management of chronic allergic respiratory conditions in this region...
  8. ncbi Assessing and accessing the small airways; implications for asthma management
    Nicola Scichilone
    Biomedical Department of Internal and Specialist Medicine DIBIMIS, Section of Pneumology, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Pulm Pharmacol Ther 26:172-9. 2013
    ..Formulation advancements have made for easier treatment access to the smaller airways, with the new extrafine formulations resulting in better asthma control compared with non-extrafine formulations...
  9. doi Alveolar nitric oxide and asthma control in mild untreated asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Allergy Clin Immunol 131:1513-7. 2013
    ..We postulated that the inflammatory changes of the small airways are implicated in the lack of asthma control in mild asthma...
  10. doi Prognostic value of FEV1/FEV6 in elderly people
    Claudio Sorino
    Department of Medicine, Pneumology, Physiology and Human Nutrition, University of Palermo, Via Trabucco 180, Palermo, Italy
    Clin Physiol Funct Imaging 31:101-7. 2011
    ..We evaluated whether FEV1/FEV6 is a significant predictor of mortality in elderly subjects and compared its prognostic value with that of FEV1/FVC and FEV1...
  11. pmc Is health-related quality of life associated with upper and lower airway inflammation in asthmatics?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica DIBIMIS, Sezione di Pneumologia, University of Palermo, 90146 Palermo, Italy
    Biomed Res Int 2013:539290. 2013
    ..However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL...
  12. pmc The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana, Univ of Palermo, 90146 Palermo, Italy
    J Appl Physiol (1985) 105:832-8. 2008
    ....
  13. ncbi Deep inspiration-induced changes in lung volume decrease with severity of asthma
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, 90146 Palermo, Italy
    Respir Med 101:951-6. 2007
    ..01) and to weekly salbutamol usage (r=-0.47, P=0.004). These observations provide support to the hypothesis that the attenuation of the bronchodilatory effect of DI contributes to the severity of the clinical manifestations of asthma...
  14. doi Alterations of the beneficial effect of deep inspiration in scleroderma: relationships between lung function and imaging
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana, Palermo, Italy
    Respiration 76:303-10. 2008
    ..It has been postulated that the beneficial effects of deep inspiration are dependent on the magnitude of airway distension by virtue of airway to parenchyma interdependence...
  15. pmc Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Respir Res 6:55. 2005
    ..This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments...
  16. ncbi The bronchodilatory effect of deep inspiration diminishes with aging
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, Palermo 90146, Italy
    Respir Med 98:838-43. 2004
    ..0001) and age (P=0.02) entered the model. Our data raise the hypothesis that aging is associated with reduction in DI-induced bronchodilation...
  17. doi Airway distensibility by HRCT in asthmatics and COPD with comparable airway obstruction
    Alida Benfante
    1Dipartimento di Biomedicina e Medicina Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    COPD 10:560-6. 2013
    ..Decreased airway distensibility (AD) in response to deep inspirations, as assessed by HRCT, has been associated with the severity of asthma and COPD...
  18. ncbi Effects of exercise training on airway closure in asthmatics
    Nicola Scichilone
    Department of Internal Medicine, Section of Pulmonology, DIBIMIS University of Palermo, Palermo, Italy
    J Appl Physiol (1985) 113:714-8. 2012
    ..28). This study indicates that a short course of physical training is capable of reducing airway responsiveness in mild asthmatics...
  19. doi The effect of intranasal corticosteroids on asthma control and quality of life in allergic rhinitis with mild asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Villa Sofia Cervello Hospital, Palermo, Italy
    J Asthma 48:41-7. 2011
    ..We explored whether the effect of nasal treatment on asthma control and respiratory-related quality of life (HRQoL) is mediated by inflammatory changes of the upper and lower airways...
  20. doi The impact of age on prevalence of positive skin prick tests and specific IgE tests
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica DIBIMIS, Sezione di Pneumologia, University of Palermo, Villa Sofia Cervello Hospital, Palermo, Italy
    Respir Med 105:651-8. 2011
    ....
  21. pmc Diagnosis of airway obstruction in the elderly: contribution of the SARA study
    Claudio Sorino
    Biomedical Department of Internal and Specialist Medicine, Section of Pulmonology, University of Palermo, Italy
    Int J Chron Obstruct Pulmon Dis 7:389-95. 2012
    ..70 as the criterion for confirming airway obstruction is an open issue. In this study, we compared the criteria of lower limit of normal and fixed FEV(1)/FVC for diagnosis of airway obstruction, with a focus on healthy elderly people...
  22. doi Should atopy be assessed in elderly patients with respiratory symptoms suggestive of asthma?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Expert Rev Respir Med 4:585-91. 2010
    ..For this reason, the evaluation of the atopic condition in the geriatric patient is recommended. The role of atopy as regards diagnosis, therapy and prognosis of asthma in the elderly is addressed...
  23. doi Effects of exercise training and montelukast in children with mild asthma
    Maria R Bonsignore
    Department of Medicine, Pneumology, Physiology and Nutrition, University of Palermo, Italy
    Med Sci Sports Exerc 40:405-12. 2008
    ....
  24. pmc Clinical implications of airway hyperresponsiveness in COPD
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Palermo, Italy
    Int J Chron Obstruct Pulmon Dis 1:49-60. 2006
    ..Smoking cessation has been shown to reduce AHR. Further studies are needed to elucidate whether this functional change is associated with improvement in lung function and respiratory symptoms...
  25. ncbi Spirometry reference values for women and men aged 65-85 living in southern Europe: the effect of health outcomes
    Riccardo Pistelli
    Istituto di Medicina Generale e Pneumologia, University of Palermo, Palermo, Italy
    Respiration 70:484-9. 2003
    ..Spirometry is more and more frequently used for the diagnosis of respiratory diseases in the elderly people. Unfortunately, reliable predictive values for the spirometric variables in the elderly are lacking...
  26. ncbi The mini nutritional assessment is associated with the perception of dyspnoea in older subjects with advanced COPD
    Nicola Scichilone
    DIMPEFINU, Universita di Palermo, Via Trabucco 180, 90146, Palermo, Italy
    Age Ageing 37:214-7. 2008
  27. ncbi Bronchodilatory effect of deep inspiration is absent in subjects with mild COPD
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, University of Palermo, Palermo, Italy
    Chest 125:2029-35. 2004
    ..To investigate whether the bronchodilatory effect of deep inspiration is impaired in subjects with COPD...
  28. ncbi Sleep disorders in the elderly with and without chronic airflow obstruction: the SARA study
    Vincenzo Bellia
    Istituto di Medicina Generale e Pneumologia, University of Palermo, Italy
    Sleep 26:318-23. 2003
    ....
  29. pmc Anti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics
    Nicola Scichilone
    Dipartimento Biomedico di Medicina, Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Asthma Allergy 4:19-25. 2011
    ..The ultra-short course pre-seasonal allergy vaccine, containing appropriate allergoids with the adjuvant monophosphoryl lipid A (MPL), may be effective in treating allergic symptoms...
  30. ncbi Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study
    Vincenzo Bellia
    Istituto di Medicina Generale e Pneumologia, University of Palermo, Italy
    Chest 123:1066-72. 2003
    ..This study investigated to what extent a diagnosis of COPD is erroneously made or the disease remains unrecognized in elderly asthmatic patients, and identified factors leading to misdiagnosis and underdiagnosis of asthma in such patients...
  31. doi Effects of exercise training on airway responsiveness and airway cells in healthy subjects
    Nicola Scichilone
    Dept of Internal Medicine, Div of Pulmonology DIBIMIS Univ of Palermo, Villa Sofia Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy
    J Appl Physiol (1985) 109:288-94. 2010
    ....
  32. pmc A 15-year-old boy with anterior chest pain, progressive dyspnea, and subcutaneous emphysema of the neck
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana DIMPEFINU, Sezione di Pneumologia e Medicina, University of Palermo, 90146 Palermo, Italy
    J Allergy (Cairo) 2009:496890. 2009
    ..We suggest that the diagnosis of asthma should be considered in the differential diagnosis of pneumomediastinum in adolescence...
  33. doi What proportion of chronic obstructive pulmonary disease outpatients is eligible for inclusion in randomized clinical trials?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Respiration 87:11-7. 2014
    ..We aimed to explore to what extent an unselected population of chronic obstructive pulmonary disease (COPD) outpatients would be eligible for inclusion in randomized clinical trials (RCTs)...
  34. pmc Patient perspectives in the management of asthma: improving patient outcomes through critical selection of treatment options
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana DIMPEFINU, University of Palermo, Palermo, Italy
    Patient Prefer Adherence 4:17-23. 2010
    ..The success of any anti-asthmatic treatment depends on the choice of the correct device and the adherence to therapy...