G C Schito

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint The importance of the development of antibiotic resistance in Staphylococcus aureus
    G C Schito
    Institute of Microbiology, University of Genoa, Italy
    Clin Microbiol Infect 12:3-8. 2006
  2. ncbi request reprint Comparative in vitro potency of gemifloxacin against European respiratory tract pathogens isolated in the Alexander Project
    A Marchese
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Antimicrob Chemother 46:11-5. 2000
  3. ncbi request reprint The evolving threat of antibiotic resistance in Europe: new data from the Alexander Project
    G C Schito
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Antimicrob Chemother 46:3-9. 2000
  4. pmc Heterogeneous vancomycin resistance in methicillin-resistant Staphylococcus aureus strains isolated in a large Italian hospital
    A Marchese
    Institute of Microbiology, University of Genoa, Genoa, Italy
    J Clin Microbiol 38:866-9. 2000
  5. ncbi request reprint In vitro interaction between cefotetan and aminoglycosides on Staphylococcus aureus and coagulase negative staphylococci, both methicillin-susceptible and -resistant
    S Stefani
    Institute of Microbiology, University of Catania, Italy
    Chemioterapia 7:151-5. 1988
  6. ncbi request reprint Comparative activity of telithromycin against macrolide-resistant isolates of Streptococcus pneumoniae: results of two years of the PROTEKT surveillance study
    G C Schito
    University of Genoa, Italy
    J Chemother 16:13-22. 2004
  7. ncbi request reprint Trends in the activity of macrolide and beta-lactam antibiotics and resistance development. Alexander Project Group
    G C Schito
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Chemother 9:18-28. 1997
  8. ncbi request reprint Parameters characterizing the in vitro activity of cefixime, a new oral broad spectrum cephalosporin, against respiratory and urinary pathogens
    E A Debbia
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Chemother 4:131-44. 1992
  9. ncbi request reprint Antibiotic susceptibility patterns and serotypes of antibiotic resistant and/or invasive Streptococcus pneumoniae strains circulating in Italy
    A Marchese
    Institute of Microbiology, University of Genoa, Italy
    Microb Drug Resist 6:163-70. 2000
  10. ncbi request reprint Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children: influence of macrolide resistance on clinical and microbiological outcomes. Artemis-Italy Study Group
    P E Varaldo
    Institute of Microbiology, University of Ancona Medical School, Italy
    Clin Infect Dis 29:869-73. 1999

Detail Information

Publications50

  1. ncbi request reprint The importance of the development of antibiotic resistance in Staphylococcus aureus
    G C Schito
    Institute of Microbiology, University of Genoa, Italy
    Clin Microbiol Infect 12:3-8. 2006
    ..aureus, and the recently introduced oxazolidinone linezolid and the cyclic lipopeptide daptomycin are welcome additions to the ever-narrowing range of therapies effective against this pathogen...
  2. ncbi request reprint Comparative in vitro potency of gemifloxacin against European respiratory tract pathogens isolated in the Alexander Project
    A Marchese
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Antimicrob Chemother 46:11-5. 2000
    ..As resistance to currently available antimicrobial agents increases, gemifloxacin offers potential as a promising new agent for the treatment of respiratory tract infection...
  3. ncbi request reprint The evolving threat of antibiotic resistance in Europe: new data from the Alexander Project
    G C Schito
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Antimicrob Chemother 46:3-9. 2000
    ..5% and 10.4%, respectively, in 1996; 21.9% and 14.1% in 1997; 16.5% and 11.6% in 1998). Beta-lactamase production was the principal mechanism of resistance observed among isolates of Haemophilus influenzae and Moraxella catarrhalis...
  4. pmc Heterogeneous vancomycin resistance in methicillin-resistant Staphylococcus aureus strains isolated in a large Italian hospital
    A Marchese
    Institute of Microbiology, University of Genoa, Genoa, Italy
    J Clin Microbiol 38:866-9. 2000
    ..1%) gave subclones for which the vancomycin MICs were 8 mg/liter. Pulsed-field gel electrophoresis showed identical restriction patterns for both isolates, suggesting transfer of a single clone between two different patients...
  5. ncbi request reprint In vitro interaction between cefotetan and aminoglycosides on Staphylococcus aureus and coagulase negative staphylococci, both methicillin-susceptible and -resistant
    S Stefani
    Institute of Microbiology, University of Catania, Italy
    Chemioterapia 7:151-5. 1988
    ..Results were subdivided for susceptibility or resistance to the drugs used in combination. In general, when both drugs were tested against methicillin-susceptible strains the results showed synergism...
  6. ncbi request reprint Comparative activity of telithromycin against macrolide-resistant isolates of Streptococcus pneumoniae: results of two years of the PROTEKT surveillance study
    G C Schito
    University of Genoa, Italy
    J Chemother 16:13-22. 2004
    ..Clindamycin was active against >98% mef(A) but poorly active against erm(B) and erm(B)+mef(A) isolates. Telithromycin, vancomycin and linezolid were highly active (>99.5%) across all three genotypes...
  7. ncbi request reprint Trends in the activity of macrolide and beta-lactam antibiotics and resistance development. Alexander Project Group
    G C Schito
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Chemother 9:18-28. 1997
    ....
  8. ncbi request reprint Parameters characterizing the in vitro activity of cefixime, a new oral broad spectrum cephalosporin, against respiratory and urinary pathogens
    E A Debbia
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Chemother 4:131-44. 1992
    ..The new cephem seems to provide excellent opportunities for expanding oral cephalosporin therapy to a wide range of infections produced by susceptible pathogens in the adult and pediatric populations...
  9. ncbi request reprint Antibiotic susceptibility patterns and serotypes of antibiotic resistant and/or invasive Streptococcus pneumoniae strains circulating in Italy
    A Marchese
    Institute of Microbiology, University of Genoa, Italy
    Microb Drug Resist 6:163-70. 2000
    ..Penicillin, chloramphenicol, erythromycin, tetracycline, and co-trimoxazole resistance was 1.8%, 9.5%, 15.5%, 18.5%, and 21.4%, respectively...
  10. ncbi request reprint Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children: influence of macrolide resistance on clinical and microbiological outcomes. Artemis-Italy Study Group
    P E Varaldo
    Institute of Microbiology, University of Ancona Medical School, Italy
    Clin Infect Dis 29:869-73. 1999
    ....
  11. ncbi request reprint Resistance patterns of lower respiratory tract pathogens in Europe
    A Marchese
    Institute of Microbiology DI S C A T, Medical School, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Int J Antimicrob Agents 16:S25-9. 2000
    ..5%) have been evidenced. Ampicillin resistant beta-lactamase negative H. influenzae are very uncommon. Over 90% of Moraxella catarrhalis isolates are beta-lactamase producers without big differences among European countries...
  12. ncbi request reprint The beta-lactamase problem: new therapeutic options
    G C Schito
    Institute of Microbiology, University of Genoa, Medical School, Italy
    J Chemother 7:5-8. 1995
    ..In fact, the prevalence of resistance to cefetamet in the most prevalent pathogens occurring in this setting is, at present, sufficiently low to render therapeutic failures, based on this parameter, highly improbable...
  13. ncbi request reprint Epidemiology of major respiratory pathogens
    E A Debbia
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 13:205-10. 2001
    ..influenzae of about 16%. M. catarrhalis must be considered generally resistant to non-protected aminopenicillins since over 90% of these organisms produce beta-lactamases...
  14. ncbi request reprint Susceptibility of respiratory and urinary pathogens to ceftibuten and other comparative drugs: results of an Italian multicenter survey. The Italian Ceftibuten Study Group
    G C Schito
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 6:92-8. 1994
    ....
  15. ncbi request reprint Prevalence of antimicrobial resistance in Streptococcus pneumoniae circulating in Italy: results of the Italian Epidemiological Observatory Survey (1997-1999)
    A Marchese
    Institute of Microbiology, University of Genoa, Italy
    Microb Drug Resist 7:277-87. 2001
    ..Strains recovered from blood in 1999 (67) were much more susceptible to penicillin (98.5%) than respiratory pneumococci (89.8%), whereas macrolides, tetracycline, and cotrimoxazole were consistently less active (75%, 67%, 64%)...
  16. ncbi request reprint The oxazolidinones as a new family of antimicrobial agent
    A Marchese
    Institute of Microbiology, Genoa, Italy
    Clin Microbiol Infect 7:66-74. 2001
    ..Synthesis of the second-generation oxazolidinones with improved potency against Gram-positive and negative bacteria is currently under way...
  17. ncbi request reprint Do different susceptibility breakpoints affect the selection of antimicrobials for treatment of uncomplicated cystitis?
    G C Schito
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 22:345-54. 2010
    ..The use of different interpretative criteria for E. coli responsible for UTIs therefore has no influence on the decision to be taken by the physicians managing the patients...
  18. ncbi request reprint Antibacterial activity of ceftibuten, a new oral third generation cephalosporin
    E A Debbia
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 3:209-25. 1991
    ....
  19. ncbi request reprint Synergistic antibacterial interaction of cefotaxime and desacetylcefotaxime
    G Molinari
    Institute of Microbiology, Medical School, University of Genoa, Italy
    J Chemother 3:6-12. 1991
    ..These results indicate that dCTX makes an important contribution to the clinical efficacy of CTX...
  20. ncbi request reprint Role of global surveillance in combating bacterial resistance
    A Marchese
    Institute of Microbiology, School of Medicine, University of Genoa, Italy
    Drugs 61:167-73. 2001
    ....
  21. ncbi request reprint Levofloxacin, a broad spectrum anti-infective: from Streptococcus pneumoniae to Pseudomonas aeruginosa
    A M Schito
    Institute of Microbiology, School of Medicine, University of Genoa, Italy
    J Chemother 16:3-7. 2004
  22. ncbi request reprint In vitro activity of ertapenem against selected respiratory pathogens
    A Marchese
    Sezione di Microbiologia del Di S C A T, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    J Antimicrob Chemother 54:944-51. 2004
    ..Additional in vitro tests (time-kill curves with ertapenem alone and in combination with four other agents) for S. pneumoniae were carried out...
  23. ncbi request reprint The Sentinel Project: an update on the prevalence of antimicrobial resistance in community-acquired respiratory Streptococcus pneumoniae and Haemophilus spp. in Italy
    A Marchese
    Institute of Microbiology, University of Genoa, Genoa, Italy
    Int J Antimicrob Agents 26:8-12. 2005
    ....
  24. ncbi request reprint Susceptibility of Streptococcus pneumoniae to penicillin, azithromycin and telithromycin (PROTEKT 1999-2003)
    G C Schito
    Institute of Microbiology, University of Genoa Medical School, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Int J Antimicrob Agents 26:479-85. 2005
    ..pneumoniae did not change significantly over the 4 years, with an overall rate of 38.6%. Telithromycin retained good activity against S. pneumoniae (0.1% of isolates resistant), including multidrug-resistant isolates...
  25. ncbi request reprint Predicting the clinical efficacy of generic formulations of ceftriaxone
    G C Schito
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 17:33-40. 2005
    ..In contrast, most generic products failed to achieve required PK/PD levels in both investigations. As a consequence, some generic formulations of ceftriaxone may increase risks of clinical failure and/or emergence of resistant isolates...
  26. ncbi request reprint In vitro activity of prulifloxacin against Escherichia coli isolated from urinary tract infections and the biological cost of prulifloxacin resistance
    L Gualco
    Sezione di Microbiologia del DiSCAT, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Int J Antimicrob Agents 29:679-87. 2007
    ..In this transition, E. coli pays a severe biological cost that entails a general reduction of fitness, thus compromising competition with susceptible wild-type strains in the absence of the drug...
  27. ncbi request reprint Activity of moxifloxacin on biofilms produced in vitro by bacterial pathogens involved in acute exacerbations of chronic bronchitis
    S Roveta
    Sezione di Microbiologia, Di S C A T, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Int J Antimicrob Agents 30:415-21. 2007
    ....
  28. doi request reprint Activity of daptomycin on biofilms produced on a plastic support by Staphylococcus spp
    S Roveta
    Sezione di Microbiologia, Di S C A T, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Int J Antimicrob Agents 31:321-8. 2008
    ....
  29. ncbi request reprint Why fosfomycin trometamol as first line therapy for uncomplicated UTI?
    G C Schito
    Microbiology Section, Di S C A T Department, University of Genoa, Genoa, Italy
    Int J Antimicrob Agents 22:79-83. 2003
    ....
  30. ncbi request reprint Antibiotic susceptibility and serotype distribution in Streptococcus pneumoniae circulating in Italy: results of the SEMPRE surveillance study (2000-2002)
    A Marchese
    Institute of Microbiology, University of Genoa, Genoa, Italy
    Int J Antimicrob Agents 26:138-45. 2005
    ..The most common serotypes circulating are included in the heptavalent conjugate vaccine, with the exception of type 3...
  31. ncbi request reprint Incidence of lower respiratory tract infections caused by Mycoplasma, Chlamydia and Legionella: an Italian Multicenter Survey
    G C Schito
    Institute of Microbiology, University of Genoa, Chieti, Italy
    J Chemother 6:319-21. 1994
    ....
  32. ncbi request reprint Microbial epidemiology patterns of surgical infection pathogens
    E A Debbia
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 13:84-8. 2001
    ..From what has been stated, the knowledge of bacterial epidemiology and resistance represents basic support for correct therapeutic decision-making...
  33. ncbi request reprint Evolution of antibiotic resistance in gram-positive pathogens
    A Marchese
    Institute of Microbiology, University of Genoa, Italy
    J Chemother 12:459-62. 2000
    ..aureus isolated during 1997-1998, two strains (1.1%) gave subclones with vancomycin MICs of 8 mg/L. PFGE showed identical restriction patterns for both isolates, suggesting transfer of a single clone between two different patients...
  34. ncbi request reprint Microbial ecosystems as targets of antibiotic actions
    G A Meloni
    Institute of Microbiology, University of Padova, Italy
    J Chemother 3:179-81. 1991
    ..In addition an impairment of host defences can favor infections caused by microorganisms originating from resident communities whose equilibrium has been altered by the antibiotic...
  35. ncbi request reprint Antibacterial activity of the sulbactam-ampicillin combination
    F V Sessarego
    Institute of Microbiology, Faculty of Medicine and Surgery, , Genoa, Italy
    J Chemother 1:384-7. 1989
    ..The activity on the Gram-negative strains was particularly evident against enterobacteria and haemophilus. The combination of sulbactam and ampicillin provides increased activity against anaerobic strains, including Bacteroides fragilis...
  36. ncbi request reprint Antibacterial activity in vitro of tigemonam, a new oral monobactam
    G C Schito
    Institute of Microbiology, University of Genoa Medical School, Italy
    J Chemother 1:41-4. 1989
    ..When tigemonam was used in combination with netilmicin and amikacin against susceptible representative isolates of Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens and Escherichia coli, a synergistic effect was obtained...
  37. ncbi request reprint Resistance trends in Streptococcus pneumoniae (PROTEKT years 1-3 [1999-2002])
    G C Schito
    Universita di Genova, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    J Chemother 16:19-33. 2004
  38. ncbi request reprint [Recent results of multinational studies on antibiotic resistance: should we have "PROTECTion" against these resistances?]
    A Marchese
    Sezione di Microbiologia del Di S C A T, Université de Gênes, Largo R Benzi, 10 16132 Gênes, Italie
    Med Mal Infect 37:2-5. 2007
  39. ncbi request reprint Ideal microbiological and pharmacological characteristics of a quality antimicrobial agent: comparing original and generic molecules
    E Concia
    Dipartimento di Malattie Infettive, University of Verona, Italy
    J Chemother 19:609-19. 2007
    ....
  40. ncbi request reprint Is antimicrobial resistance also subject to globalization?
    G C Schito
    Istituto di Microbiologia, Universita di Genova, Italy
    Clin Microbiol Infect 8:1-8; discussion 33-5. 2002
    ..In Italy, for example, there is preference for the use of parenteral third-generation cephalosporins for some severe infections and there is a corresponding low level of penicillin-resistance among pneumococci...
  41. ncbi request reprint Efficacy of N-acetyl-cysteine in combination with thiamphenicol in sequential (intramuscular/aerosol) therapy of upper respiratory tract infections even when sustained by bacterial biofilms
    A Macchi
    Clinica di Otorinolaringoiatria, Azienda Ospedaliera Universitaria, Ospedale di Circolo e Fondazione Macchi, Varese and Institutes of Microbiology, Catholic University of Rome, Italy
    J Chemother 18:507-13. 2006
    ..Very few adverse events attributable to TGA were reported in this cohort of patients. In no case was discontinuation of treatment deemed necessary by the attending physician...
  42. ncbi request reprint Seasonal variations in nasopharyngeal carriage of respiratory pathogens in healthy Italian children attending day-care centres or schools
    P Marchisio
    Pediatric Department 1, University of Milan, Italy
    J Med Microbiol 50:1095-9. 2001
    ..However, although statistically significant, the difference was slight and had limited clinical relevance. Therefore, seasonal influence on the nasopharyngeal carriage of respiratory pathogens in healthy children was negligible...
  43. ncbi request reprint An investigation of the etiology of community-acquired lower respiratory tract infections (LRTI) and resistance to antibiotics in Italy (the EOLO Study)
    C M Sanguinetti
    Unità Operativa Complessa di Pneumologia, Az Complesso ospedaliero S Filippo Neri, Via Martinotti, Roma, Italia
    Monaldi Arch Chest Dis 57:105-6. 2002
  44. ncbi request reprint Antimicrobial susceptibility patterns of contemporary pathogens from uncomplicated urinary tract infections isolated in a multicenter Italian survey: possible impact on guidelines
    G Fadda
    Institute of Microbiology, Catholic University, Rome
    J Chemother 17:251-7. 2005
    ..The results of this survey strongly support the conclusions of recent Italian guidelines concerning the best empiric treatment of UTI in this country today...
  45. ncbi request reprint Antimicrobial susceptibility profiles of Pseudomonas aeruginosa and Staphylococcus aureus isolated in Italy from patients with hospital-acquired infections
    G Blandino
    Department of Microbiological and Gynecological Sciences, University of Catania, Via Androne, 83 8595100 Catania, Italy
    Int J Antimicrob Agents 24:515-8. 2004
    ..3% among the bronchoalveolar lavage isolates, and 42.9% among the blood isolates. These worrying results confirm the need for continuous monitoring of bacterial resistance trends in the hospitals, mainly in ICUs...
  46. ncbi request reprint Antibacterial resistance in Streptococcus pneumoniae and Haemophilus influenzae from Italy and Spain: data from the PROTEKT surveillance study, 1999-2000
    A M Schito
    Istituto di Microbiologia, Facolta di Medicina, Universita di Genova, Italy
    J Chemother 15:226-34. 2003
    ..The findings of PROTEKT 1999-2000 highlight the importance of local resistance patterns in guiding the choice of empirical antibacterials for community-acquired respiratory tract infections...
  47. ncbi request reprint Multicentre evaluation of the VITEK 2 Advanced Expert System for interpretive reading of antimicrobial resistance tests
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK
    J Antimicrob Chemother 49:289-300. 2002
    ..Further editing may be desirable (e.g. of cephalosporin results for salmonellas inferred to have ESBLs)...
  48. ncbi request reprint [Epidemiology of methicillin-resistance among Staphylococci strains isolated in risk units and effects of the vancomycin on the expression of methicillin-resistance]
    S Roveta
    Istituto di Microbiologia, Universit degli Studi di Genova, Genoa
    Infez Med 9:82-9. 2001
    ....
  49. ncbi request reprint A therapeutic approach in the treatment of infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequential treatment (systemic-inhalatory route)
    A Serra
    Department of Otorhinolaringology, University of Catania, Catania, Italy
    Int J Immunopathol Pharmacol 20:607-17. 2007
    ..The Investigator rating of treatment tolerability significantly favoured TGA in sequential treatments in comparison to the other antibiotics. No patient dropped out from the trial because of adverse events...
  50. ncbi request reprint Evaluation of spontaneous contamination of ocular medications
    A Marchese
    Institute of Microbiology 'C.A. Romanzi, University of Genoa School of Medicine, Genoa, Italy
    Chemotherapy 47:304-8. 2001
    ..As a consequence, the safe usage of these ocular medications could be extended from the recommended 3 h to at least 24 h after the first usage...