Stefano Schiaffino

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Mechanisms regulating skeletal muscle growth and atrophy
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine, Padova, Italy
    FEBS J 280:4294-314. 2013
  2. doi request reprint Tubular aggregates in skeletal muscle: just a special type of protein aggregates?
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine VIMM, Padova, Italy Consiglio Nazionale delle Ricerche Institute of Neuroscience, Padova, Italy
    Neuromuscul Disord 22:199-207. 2012
  3. doi request reprint Fibre types in skeletal muscle: a personal account
    S Schiaffino
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Acta Physiol (Oxf) 199:451-63. 2010
  4. ncbi request reprint Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications
    Stefano Ciciliot
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
    Curr Pharm Des 16:906-14. 2010
  5. ncbi request reprint The role of autophagy in neonatal tissues: just a response to amino acid starvation?
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine VIMM, Department of Biomedical Sciences, University of Padova, Padova, Italy
    Autophagy 4:727-30. 2008
  6. pmc Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine VIMM, Padova, Italy
    Skelet Muscle 1:4. 2011
  7. doi request reprint Fiber types in mammalian skeletal muscles
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine, Department of Biomedical Sciences, University of Padova, Via Orus 2, 35129 Padova, Italy
    Physiol Rev 91:1447-531. 2011
  8. ncbi request reprint Activity-dependent signaling pathways controlling muscle diversity and plasticity
    Stefano Schiaffino
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Physiology (Bethesda) 22:269-78. 2007
  9. ncbi request reprint Calcineurin signaling and neural control of skeletal muscle fiber type and size
    Stefano Schiaffino
    Dept of Biomedical Sciences, CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, Italy
    Trends Pharmacol Sci 23:569-75. 2002
  10. pmc NFAT isoforms control activity-dependent muscle fiber type specification
    Elisa Calabria
    Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
    Proc Natl Acad Sci U S A 106:13335-40. 2009

Collaborators

Detail Information

Publications37

  1. doi request reprint Mechanisms regulating skeletal muscle growth and atrophy
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine, Padova, Italy
    FEBS J 280:4294-314. 2013
    ....
  2. doi request reprint Tubular aggregates in skeletal muscle: just a special type of protein aggregates?
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine VIMM, Padova, Italy Consiglio Nazionale delle Ricerche Institute of Neuroscience, Padova, Italy
    Neuromuscul Disord 22:199-207. 2012
    ..Here I suggest that tubular aggregates result from reshaping of sarcoplasmic reticulum caused by misfolding and aggregation of membrane proteins and thus represent a special type of "protein aggregates" due to altered proteostasis...
  3. doi request reprint Fibre types in skeletal muscle: a personal account
    S Schiaffino
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Acta Physiol (Oxf) 199:451-63. 2010
    ....
  4. ncbi request reprint Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications
    Stefano Ciciliot
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
    Curr Pharm Des 16:906-14. 2010
    ..Finally, we discuss the causes of age-dependent decline in muscle regeneration potential and the possibility of boosting regeneration in aging muscle and in muscular dystrophies...
  5. ncbi request reprint The role of autophagy in neonatal tissues: just a response to amino acid starvation?
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine VIMM, Department of Biomedical Sciences, University of Padova, Padova, Italy
    Autophagy 4:727-30. 2008
    ..However, autophagy may have other important functions in neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress...
  6. pmc Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine VIMM, Padova, Italy
    Skelet Muscle 1:4. 2011
    ..A full understanding of the operation of this pathway could help to design molecularly targeted therapeutics aimed at preventing muscle wasting, which occurs in a variety of pathologic contexts and in the course of aging...
  7. doi request reprint Fiber types in mammalian skeletal muscles
    Stefano Schiaffino
    Venetian Institute of Molecular Medicine, Department of Biomedical Sciences, University of Padova, Via Orus 2, 35129 Padova, Italy
    Physiol Rev 91:1447-531. 2011
    ..The characterization of these pathways is raising increasing interest in clinical medicine, given the potentially beneficial effects of muscle fiber type switching in the prevention and treatment of metabolic diseases...
  8. ncbi request reprint Activity-dependent signaling pathways controlling muscle diversity and plasticity
    Stefano Schiaffino
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Physiology (Bethesda) 22:269-78. 2007
    ..The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases...
  9. ncbi request reprint Calcineurin signaling and neural control of skeletal muscle fiber type and size
    Stefano Schiaffino
    Dept of Biomedical Sciences, CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, Italy
    Trends Pharmacol Sci 23:569-75. 2002
    ....
  10. pmc NFAT isoforms control activity-dependent muscle fiber type specification
    Elisa Calabria
    Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
    Proc Natl Acad Sci U S A 106:13335-40. 2009
    ..Our data contribute to the elucidation of the mechanisms whereby activity can modulate the phenotype and performance of skeletal muscle...
  11. pmc NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching
    Karl J A McCullagh
    Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Institute of Neurosciences, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 101:10590-5. 2004
    ..These results support the notion that Cn-NFAT signaling acts as a nerve activity sensor in skeletal muscle in vivo and controls nerve activity-dependent myosin switching...
  12. doi request reprint Autophagy is required to maintain muscle mass
    Eva Masiero
    Dulbecco Telethon Institute, 35129 Padova, Italy
    Cell Metab 10:507-15. 2009
    ..Our results suggest that inhibition/alteration of autophagy can contribute to myofiber degeneration and weakness in muscle disorders characterized by accumulation of abnormal mitochondria and inclusions...
  13. ncbi request reprint NFATc1 nucleocytoplasmic shuttling is controlled by nerve activity in skeletal muscle
    Jana Tothova
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Cell Sci 119:1604-11. 2006
    ..These findings support the notion that in skeletal muscle NFATc1 is a calcineurin-dependent nerve activity sensor...
  14. doi request reprint Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation
    Bert Blaauw
    Venetian Institute of Molecular Medicine, Via Orus 2, 35126 Padova, Italy
    FASEB J 23:3896-905. 2009
    ..We can conclude that during a fast hypertrophic growth myonuclear domain can increase without compromising muscle performance...
  15. ncbi request reprint Hybrid cardiomyocytes derived by cell fusion in heterotopic cardiac xenografts
    Arben Dedja
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    FASEB J 20:2534-6. 2006
    ..Without exception, all GFP+ cardiomyocytes also expressed donor markers, i.e., hamster membrane antigens or lacZ, so they must derive from cell fusion, not transdifferentiation...
  16. pmc GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells
    Raffaella Di Lisi
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    BMC Mol Biol 8:78. 2007
    ..We have now examined the role of cTnI promoter GATA elements in skeletal muscle cells...
  17. doi request reprint Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle
    Bert Blaauw
    Department of Biomedical Sciences, CNR Institute of Neurosciences, University of Padova, Padova, Italy
    Hum Mol Genet 17:3686-96. 2008
    ..The protein levels of utrophin and dysferlin are also increased by Akt activation...
  18. doi request reprint Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes
    Tania Zaglia
    Department of Biomedical Sciences, University of Padua, Padua, Italy
    J Mol Cell Cardiol 46:653-62. 2009
    ..In addition, they are able to modulate the behavior of adult cardiomyocytes, a property that may be used to promote dedifferentiation and proliferation of cardiac cells in the damaged myocardium...
  19. ncbi request reprint FoxO3 controls autophagy in skeletal muscle in vivo
    Cristina Mammucari
    Venetian Institute of Molecular Medicine, 35129 Padova, Italy
    Cell Metab 6:458-71. 2007
    ..These findings point to FoxO3 and Bnip3 as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved...
  20. pmc Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles
    Alberto C Rossi
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Physiol 588:353-64. 2010
    ....
  21. ncbi request reprint Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle
    Cristina Mammucari
    Venetian Institute of Molecular Medicine, Padova, Italy
    Autophagy 4:524-6. 2008
    ..Here we discuss the major implications of our recent work...
  22. doi request reprint Muscle type and fiber type specificity in muscle wasting
    Stefano Ciciliot
    Venetian Institute of Molecular Medicine VIMM, Padova, Italy
    Int J Biochem Cell Biol 45:2191-9. 2013
    ..This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  23. pmc No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in isolated fibers of adult mouse skeletal muscle
    Bert Blaauw
    Venetian Institute of Molecular Medicine, 35129 Padova, Italy
    J Gen Physiol 140:235-41. 2012
    ..We conclude that the IP(3)-IP(3)R system does not appear to affect global calcium levels in adult mouse skeletal muscle...
  24. pmc A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
    Giorgia Pallafacchina
    Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Center of Muscle Biology and Physiopathology, University of Padova, 35121 Padova, Italy
    Proc Natl Acad Sci U S A 99:9213-8. 2002
    ..The present results support the notion that fiber size and fiber type are regulated by nerve activity through different mechanisms...
  25. doi request reprint Cardiac sympathetic neurons provide trophic signal to the heart via β2-adrenoceptor-dependent regulation of proteolysis
    Tania Zaglia
    Department of Biomedical Sciences, University of Padova, Viale G Colombo 3, Padova 35121, Italy
    Cardiovasc Res 97:240-50. 2013
    ..Whether continuous input from the SNs is required for the maintenance of the cardiomyocyte size has not been determined thus far...
  26. ncbi request reprint Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region
    Claudia Sandri
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy
    Hum Genet 114:517-9. 2004
    ..We report here that heart morphogenesis is not affected by overexpression of Sh3bgr...
  27. pmc Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle
    Marta Murgia
    Department of Biomedical Sciences, University of Padova, Italy
    J Physiol 587:4319-27. 2009
    ....
  28. ncbi request reprint Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation
    Michela Salamon
    CRIBI Biotechnology Center, Universita degli Studi di Padova, Via Ugo Bassi 58 B, 35131, Padova, Italy
    J Mol Biol 326:137-49. 2003
    ..In some cases, cardiomyocytes show a partial sarcomeric pattern of MYO18B alternating that of alpha-actinin-2. In skeletal muscle the cytoplasmic MYO18B results much more evident in the fast type fibers...
  29. ncbi request reprint Computational reconstruction of the human skeletal muscle secretome
    Stefania Bortoluzzi
    Department of Biology, University of Padova, Italy
    Proteins 62:776-92. 2006
    ..In addition, better knowledge of the secretion process in skeletal muscle can be useful for future gene therapy approaches...
  30. ncbi request reprint Host-derived circulating cells do not significantly contribute to cardiac regeneration in heterotopic rat heart transplants
    Simonetta Ausoni
    Department of Biomedical Sciences, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Cardiovasc Res 68:394-404. 2005
    ....
  31. doi request reprint Mechanisms modulating skeletal muscle phenotype
    Bert Blaauw
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Compr Physiol 3:1645-87. 2013
    ..While myonuclei are in postmitotic state, satellite cells represent a reserve of new nuclei and can be involved in the adaptive response. © 2013 American Physiological Society. Compr Physiol 3:1645-1687, 2013. ..
  32. pmc Clonal characterization of rat muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneity
    Carlo A Rossi
    Stem Cell Processing Laboratory, Department of Pediatrics, University of Padua, Padova, Italy
    PLoS ONE 5:e8523. 2010
    ..By these means, novel insights on SCs heterogeneity are provided and evidences for biological readouts potentially relevant for diagnostic purposes described...
  33. pmc Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission
    Dorianna Sandonà
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    PLoS ONE 7:e33232. 2012
    ....
  34. ncbi request reprint Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents
    Marco Testa
    Department of Cardiology, Azienda Ospedaliera Sant Andrea, Via di Grottarossa 1035, 00189 Roma, Italy
    J Appl Physiol (1985) 103:1412-8. 2007
    ..In conclusion, COX-1 and COX-2 are expressed and enzymatically active in myocytes of skeletal muscles and hearts of rodents and humans. PGE(2) appears to be the main product of COX activity in striated muscles...
  35. ncbi request reprint Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle
    Horacio Moreno
    Parc Científic de Barcelona and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    J Biol Chem 278:40557-64. 2003
    ..The activity of the enhancer is maintained in adult muscle by MEF2, whereas during regeneration the operation of the enhancer depends on MEF2, myogenic transcription factors of the MyoD family, and thyroid hormone receptors...
  36. ncbi request reprint FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    Jinghui Zhao
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 6:472-83. 2007
    ..These studies indicate that decreased IGF-1-PI3K-Akt signaling activates autophagy not only through mTOR but also more slowly by a transcription-dependent mechanism involving FoxO3...
  37. pmc Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:399-412. 2004
    ..Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and inhibition of Foxo factors is an attractive approach to combat muscle wasting...