Research Topics
Genomes and Genes
| Stefano SchiaffinoSummaryAffiliation: University of Padova Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Tubular aggregates in skeletal muscle: just a special type of protein aggregates?Stefano Schiaffino
Venetian Institute of Molecular Medicine VIMM, Padova, Italy Consiglio Nazionale delle Ricerche Institute of Neuroscience, Padova, Italy
Neuromuscul Disord 22:199-207. 2012....
The role of autophagy in neonatal tissues: just a response to amino acid starvation?Stefano Schiaffino
Venetian Institute of Molecular Medicine VIMM, Department of Biomedical Sciences, University of Padova, Padova, Italy
Autophagy 4:727-30. 2008..However, autophagy may have other important functions in neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress...- Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implicationsStefano Ciciliot
Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
Curr Pharm Des 16:906-14. 2010..Finally, we discuss the causes of age-dependent decline in muscle regeneration potential and the possibility of boosting regeneration in aging muscle and in muscular dystrophies... - Fibre types in skeletal muscle: a personal accountS Schiaffino
Department of Biomedical Sciences, University of Padova, Padova, Italy
Acta Physiol (Oxf) 199:451-63. 2010.... 
Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic modelsStefano Schiaffino
Venetian Institute of Molecular Medicine VIMM, Padova, Italy
Skelet Muscle 1:4. 2011..A full understanding of the operation of this pathway could help to design molecularly targeted therapeutics aimed at preventing muscle wasting, which occurs in a variety of pathologic contexts and in the course of aging...- Fiber types in mammalian skeletal musclesStefano Schiaffino
Venetian Institute of Molecular Medicine, Department of Biomedical Sciences, University of Padova, Via Orus 2, 35129 Padova, Italy
Physiol Rev 91:1447-531. 2011..The characterization of these pathways is raising increasing interest in clinical medicine, given the potentially beneficial effects of muscle fiber type switching in the prevention and treatment of metabolic diseases... - Calcineurin signaling and neural control of skeletal muscle fiber type and sizeStefano Schiaffino
Dept of Biomedical Sciences, CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, Italy
Trends Pharmacol Sci 23:569-75. 2002.... - Activity-dependent signaling pathways controlling muscle diversity and plasticityStefano Schiaffino
Department of Biomedical Sciences, University of Padova, Padova, Italy
Physiology (Bethesda) 22:269-78. 2007..The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases... - NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switchingKarl J A McCullagh
Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Institute of Neurosciences, University of Padua, 35121 Padua, Italy
Proc Natl Acad Sci U S A 101:10590-5. 2004..These results support the notion that Cn-NFAT signaling acts as a nerve activity sensor in skeletal muscle in vivo and controls nerve activity-dependent myosin switching... - Autophagy is required to maintain muscle massEva Masiero
Dulbecco Telethon Institute, 35129 Padova, Italy
Cell Metab 10:507-15. 2009..Our results suggest that inhibition/alteration of autophagy can contribute to myofiber degeneration and weakness in muscle disorders characterized by accumulation of abnormal mitochondria and inclusions... - NFAT isoforms control activity-dependent muscle fiber type specificationElisa Calabria
Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Proc Natl Acad Sci U S A 106:13335-40. 2009..Our data contribute to the elucidation of the mechanisms whereby activity can modulate the phenotype and performance of skeletal muscle... - Hybrid cardiomyocytes derived by cell fusion in heterotopic cardiac xenograftsArben Dedja
Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
FASEB J 20:2534-6. 2006..Without exception, all GFP+ cardiomyocytes also expressed donor markers, i.e., hamster membrane antigens or lacZ, so they must derive from cell fusion, not transdifferentiation... - Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activationBert Blaauw
Venetian Institute of Molecular Medicine, Via Orus 2, 35126 Padova, Italy
FASEB J 23:3896-905. 2009..We can conclude that during a fast hypertrophic growth myonuclear domain can increase without compromising muscle performance... - NFATc1 nucleocytoplasmic shuttling is controlled by nerve activity in skeletal muscleJana Tothova
Department of Biomedical Sciences, University of Padova, Padova, Italy
J Cell Sci 119:1604-11. 2006..These findings support the notion that in skeletal muscle NFATc1 is a calcineurin-dependent nerve activity sensor... - GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cellsRaffaella Di Lisi
Department of Biomedical Sciences, University of Padova, Padova, Italy
BMC Mol Biol 8:78. 2007..We have now examined the role of cTnI promoter GATA elements in skeletal muscle cells... - Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscleBert Blaauw
Department of Biomedical Sciences, CNR Institute of Neurosciences, University of Padova, Padova, Italy
Hum Mol Genet 17:3686-96. 2008..The protein levels of utrophin and dysferlin are also increased by Akt activation... - Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytesTania Zaglia
Department of Biomedical Sciences, University of Padua, Padua, Italy
J Mol Cell Cardiol 46:653-62. 2009..In addition, they are able to modulate the behavior of adult cardiomyocytes, a property that may be used to promote dedifferentiation and proliferation of cardiac cells in the damaged myocardium... - Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindlesAlberto C Rossi
Department of Biomedical Sciences, University of Padova, Padova, Italy
J Physiol 588:353-64. 2010.... - FoxO3 controls autophagy in skeletal muscle in vivoCristina Mammucari
Venetian Institute of Molecular Medicine, 35129 Padova, Italy
Cell Metab 6:458-71. 2007..These findings point to FoxO3 and Bnip3 as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved... - Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscleCristina Mammucari
Venetian Institute of Molecular Medicine, Padova, Italy
Autophagy 4:524-6. 2008..Here we discuss the major implications of our recent work... - No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in isolated fibers of adult mouse skeletal muscleBert Blaauw
Venetian Institute of Molecular Medicine, 35129 Padova, Italy
J Gen Physiol 140:235-41. 2012..We conclude that the IP(3)-IP(3)R system does not appear to affect global calcium levels in adult mouse skeletal muscle... - A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specificationGiorgia Pallafacchina
Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Center of Muscle Biology and Physiopathology, University of Padova, 35121 Padova, Italy
Proc Natl Acad Sci U S A 99:9213-8. 2002..The present results support the notion that fiber size and fiber type are regulated by nerve activity through different mechanisms... - Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical regionClaudia Sandri
Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy
Hum Genet 114:517-9. 2004..We report here that heart morphogenesis is not affected by overexpression of Sh3bgr... - Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscleMarta Murgia
Department of Biomedical Sciences, University of Padova, Italy
J Physiol 587:4319-27. 2009.... - Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiationMichela Salamon
CRIBI Biotechnology Center, Universita degli Studi di Padova, Via Ugo Bassi 58 B, 35131, Padova, Italy
J Mol Biol 326:137-49. 2003..In some cases, cardiomyocytes show a partial sarcomeric pattern of MYO18B alternating that of alpha-actinin-2. In skeletal muscle the cytoplasmic MYO18B results much more evident in the fast type fibers... - Host-derived circulating cells do not significantly contribute to cardiac regeneration in heterotopic rat heart transplantsSimonetta Ausoni
Department of Biomedical Sciences, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
Cardiovasc Res 68:394-404. 2005.... - Computational reconstruction of the human skeletal muscle secretomeStefania Bortoluzzi
Department of Biology, University of Padova, Italy
Proteins 62:776-92. 2006..In addition, better knowledge of the secretion process in skeletal muscle can be useful for future gene therapy approaches... - Clonal characterization of rat muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneityCarlo A Rossi
Stem Cell Processing Laboratory, Department of Pediatrics, University of Padua, Padova, Italy
PLoS ONE 5:e8523. 2010..By these means, novel insights on SCs heterogeneity are provided and evidences for biological readouts potentially relevant for diagnostic purposes described... - Cardiac sympathetic neurons provide trophic signal to the heart via β2-adrenoceptor-dependent regulation of proteolysisTania Zaglia
Department of Biomedical Sciences, University of Padova, Viale G Colombo 3, Padova 35121, Italy
Cardiovasc Res 97:240-50. 2013..Whether continuous input from the SNs is required for the maintenance of the cardiomyocyte size has not been determined thus far... - Adaptation of mouse skeletal muscle to long-term microgravity in the MDS missionDorianna Sandonà
Department of Biomedical Sciences, University of Padova, Padova, Italy
PLoS ONE 7:e33232. 2012.... - Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyMarco Sandri
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell 117:399-412. 2004..Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and inhibition of Foxo factors is an attractive approach to combat muscle wasting... - Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodentsMarco Testa
Department of Cardiology, Azienda Ospedaliera Sant Andrea, Via di Grottarossa 1035, 00189 Roma, Italy
J Appl Physiol 103:1412-8. 2007..In conclusion, COX-1 and COX-2 are expressed and enzymatically active in myocytes of skeletal muscles and hearts of rodents and humans. PGE(2) appears to be the main product of COX activity in striated muscles... - Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscleHoracio Moreno
Parc Científic de Barcelona and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
J Biol Chem 278:40557-64. 2003..The activity of the enhancer is maintained in adult muscle by MEF2, whereas during regeneration the operation of the enhancer depends on MEF2, myogenic transcription factors of the MyoD family, and thyroid hormone receptors... - FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cellsJinghui Zhao
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell Metab 6:472-83. 2007..These studies indicate that decreased IGF-1-PI3K-Akt signaling activates autophagy not only through mTOR but also more slowly by a transcription-dependent mechanism involving FoxO3...