Aldo Scarpa

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. ncbi Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation
    Paolo Piacentini
    Department of Pathology, Section of Anatomic Pathology, University of Verona, Verona, Italy
    Virchows Arch 448:797-804. 2006
  2. ncbi Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients
    Aldo Scarpa
    Department of Pathology, University of Verona, Verona, Italy
    Mod Pathol 23:824-33. 2010
  3. ncbi Genetics of gastric cancer: clinical implications
    Aldo Scarpa
    Department of Pathology, University of Verona, 37134 Verona, Italy
    Suppl Tumori 2:S10-3. 2003
  4. ncbi Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study
    Daniela Cecconi
    Dipartimento di Biotecnologie, Laboratorio di Proteomica, Universita di Verona, Verona, Italy
    Proteomics 9:1952-66. 2009
  5. ncbi Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine
    Massimo Donadelli
    Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Verona, Italy
    Biochim Biophys Acta 1773:1095-106. 2007
  6. ncbi Expression of TP73L is a helpful diagnostic marker of primary mediastinal large B-cell lymphomas
    Alberto Zamo
    Department of Pathology, University of Verona, Verona, Italy
    Mod Pathol 18:1448-53. 2005
  7. ncbi Malignant pancreatic neuroendocrine tumour: lymph node ratio and Ki67 are predictors of recurrence after curative resections
    Letizia Boninsegna
    Department of Surgery, University of Verona, Verona, Italy
    Eur J Cancer 48:1608-15. 2012
  8. ncbi Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma
    Massimo Falconi
    Chirurgia Generale B Pancreas Unit, Department of Surgery, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro, 37134 Verona, Italy
    Ann Surg Oncol 15:3178-86. 2008
  9. ncbi Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors
    Giorgio Malpeli
    Department of Pathology and Diagnostics, University of Verona, Verona, Italy
    BMC Cancer 11:351. 2011
  10. ncbi Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker
    Emma Bragantini
    Dipartimento di Patologia, Sezione Anatomia Patologica, Universita di Verona, Strada Le Grazie, 8, 37134, Verona, Italy
    J Cancer Res Clin Oncol 132:45-50. 2006

Detail Information

Publications91

  1. ncbi Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation
    Paolo Piacentini
    Department of Pathology, Section of Anatomic Pathology, University of Verona, Verona, Italy
    Virchows Arch 448:797-804. 2006
    ....
  2. ncbi Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients
    Aldo Scarpa
    Department of Pathology, University of Verona, Verona, Italy
    Mod Pathol 23:824-33. 2010
    ..Ki67-based grading discerns prognosis of patients with same stage diseases...
  3. ncbi Genetics of gastric cancer: clinical implications
    Aldo Scarpa
    Department of Pathology, University of Verona, 37134 Verona, Italy
    Suppl Tumori 2:S10-3. 2003
  4. ncbi Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study
    Daniela Cecconi
    Dipartimento di Biotecnologie, Laboratorio di Proteomica, Universita di Verona, Verona, Italy
    Proteomics 9:1952-66. 2009
    ..A comparison between the patterns of proteins regulated by TSA or DAC in endocrine and ductal pancreatic cancer cell lines is also presented...
  5. ncbi Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine
    Massimo Donadelli
    Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Verona, Italy
    Biochim Biophys Acta 1773:1095-106. 2007
    ....
  6. ncbi Expression of TP73L is a helpful diagnostic marker of primary mediastinal large B-cell lymphomas
    Alberto Zamo
    Department of Pathology, University of Verona, Verona, Italy
    Mod Pathol 18:1448-53. 2005
    ..TP73L expression proved a useful diagnostic marker of primary mediastinal large B-cell lymphoma, and gave new insights in to the molecular pathways playing a role in this lymphoma...
  7. ncbi Malignant pancreatic neuroendocrine tumour: lymph node ratio and Ki67 are predictors of recurrence after curative resections
    Letizia Boninsegna
    Department of Surgery, University of Verona, Verona, Italy
    Eur J Cancer 48:1608-15. 2012
    ..In other pancreatic malignancies predictors of recurrence and the role of lymph node ratio (LNR) are well known, but both have been scarcely investigated for malignant PNETs...
  8. ncbi Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma
    Massimo Falconi
    Chirurgia Generale B Pancreas Unit, Department of Surgery, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro, 37134 Verona, Italy
    Ann Surg Oncol 15:3178-86. 2008
    ..No study has investigated the significance of the ratio between metastatic and resected/examined lymph nodes (LNR) in patients with AVC...
  9. ncbi Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors
    Giorgio Malpeli
    Department of Pathology and Diagnostics, University of Verona, Verona, Italy
    BMC Cancer 11:351. 2011
    ..The RASSF1 locus contains two CpG islands (A and C) and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter usage and alternative splicing...
  10. ncbi Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker
    Emma Bragantini
    Dipartimento di Patologia, Sezione Anatomia Patologica, Universita di Verona, Strada Le Grazie, 8, 37134, Verona, Italy
    J Cancer Res Clin Oncol 132:45-50. 2006
    ..050). While loss of Fhit correlates with poorer survival in univariate analysis, it is not an independent prognostic factor in multivariate analysis and is thus not of clinical utility...
  11. ncbi MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines
    Mario Dandrea
    Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Verona, Italy
    Nucleic Acids Res 37:6681-90. 2009
    ..Our results suggest that critical methylations located from positions -666 to -426 relative to the transcription start site of IL-6 may act as binding sites for MeCP2...
  12. ncbi Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas
    Fabrizio Comper
    Dipartimento di Patologia, Universita e Azienda Ospedaliera di Verona, Verona, Italy
    Am J Surg Pathol 33:768-74. 2009
    ..SPT shows a peculiar claudin expression profile and the highly specific pattern of claudins 5 and 7 differentiates SPT from PET, ACC, and PB...
  13. ncbi Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A
    Daniela Cecconi
    Department of Science and Technologies, Section of Biochemical Methodologies, University of Verona, Verona, Italy
    Proteomics 7:1644-53. 2007
    ..et al.., Electrophoresis 2003; Cecconi, D. et al., J. Proteome Res. 2005) and place histone-deacetylases inhibitors among the potentially most powerful drugs for the treatment of pancreatic tumors...
  14. ncbi Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells
    Patrick S Moore
    Dipartimento di Patologia, , Strada Le Grazie, 8, 37134 Verona, Italy
    Biochim Biophys Acta 1693:167-76. 2004
    ..This result was confirmed in eight additional pancreatic cancer cell lines after treatment with TSA, suggesting that this event may be a strong determinant for the induction of apoptosis by TSA...
  15. ncbi Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene
    Margherita Gaviraghi
    Department of Pathology, Section of Pathological Anatomy, University of Verona, Verona, Italy
    BMC Mol Biol 9:56. 2008
    ....
  16. ncbi Anti-viral state segregates two molecular phenotypes of pancreatic adenocarcinoma: potential relevance for adenoviral gene therapy
    Vladia Monsurro
    Department of Pathology, University of Verona Medical School, Verona, Italy
    J Transl Med 8:10. 2010
    ..Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer mortality for which novel gene therapy approaches relying on tumor-tropic adenoviruses are being tested...
  17. ncbi Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate
    Massimo Donadelli
    Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Biochim Biophys Acta 1763:917-26. 2006
    ..Finally, in vivo studies on PaCa44 cells subcutaneously xenografted in nude mice show that treatment with 100 or 200 mg/kg PDTC reduces of 30% or 60% the tumour volume, respectively, and does not cause any apparent form of toxicity...
  18. ncbi Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A
    Daniela Cecconi
    University of Verona, Department of Agricultural and Industrial Biotechnologies, Verona, Italy
    J Proteome Res 4:1909-16. 2005
    ..Our results demonstrate that the level of activation/repression of the proteins involved in these processes correlates with the growth inhibition and the apoptotic response of the cells subjected to single or combined drug treatment...
  19. ncbi Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion
    Claudio Sorio
    Dipartimento di Patologia, , Strada Le Grazie 8, 37134 Verona, Italy
    Virchows Arch 446:239-45. 2005
    ..MCC1 is sensitive to 5-fluorouracil, representing the first assessment of drug sensitivity for MCC. Finally, MCC1 is a suitable model for preclinical studies, as it grows in immunodeficient mice...
  20. ncbi RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones
    Marco Della Peruta
    Department of Pathology, University of Verona, Strada Le Grazie 8, Verona, Italy
    Mol Cancer 9:61. 2010
    ....
  21. ncbi Molecular characterization of composite mantle cell and follicular lymphoma
    Alberto Zamo
    Department of Pathology, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy
    Virchows Arch 448:639-43. 2006
    ..The light chain approach, and particularly the kappa and kappa/Kde recombination detection, proved very useful for solving the clonality issue...
  22. ncbi Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers
    Stefania Beghelli
    Department of Pathology, Section of Anatomical Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Surgery 139:347-56. 2006
    ..Immunohistochemistry may be considered sufficient, although microsatellite analysis is preferable...
  23. ncbi Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor
    Rossella Bettini
    Department of Surgery, S Cuore Don Calabria Hospital, Negrar, Verona, Italy
    Surgery 150:75-82. 2011
    ..This study analyzes the correlation between tumor size and malignancy in patients with nonfunctioning pancreatic endocrine tumors...
  24. ncbi MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases
    Vincenzo Corbo
    ARC NET Research Center Department of Pathology, University of Verona, Policlinico G B Rossi c o Piastra Odontoiatrica, Piazzale L A Scuro 10, Verona, Italy
    Endocr Relat Cancer 17:771-83. 2010
    ....
  25. ncbi Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group
    Claudio Sorio
    Department of Pathology and Diagnostics, University of Verona, Italy
    BMC Cancer 11:448. 2011
    ..It is unknown whether the level of its soluble form (suPAR) in urine may be a diagnostic-prognostic marker in these patients...
  26. ncbi The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type
    Stefano Barbi
    Department of Pathology, Section of Anatomic Pathology, University of Verona, Verona, Italy
    J Exp Clin Cancer Res 29:32. 2010
    ..The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric carcinoma and compare them with their clinical pathological correlates...
  27. ncbi Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway
    Edoardo Missiaglia
    Departments of Pathology and Surgical and Gastroenterological Sciences, University of Verona, Verona, Italy
    J Clin Oncol 28:245-55. 2010
    ..We investigated the global gene expression in a large panel of pancreatic endocrine tumors (PETs) aimed at identifying new potential targets for therapy and biomarkers to predict patient outcome...
  28. ncbi Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives
    Elisa Dalla Pozza
    Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
    Free Radic Biol Med 50:926-33. 2011
    ..These results and the consideration that DSF is already used in clinics strongly support the GEM and DSF/Zn combination as a new approach to overcoming pancreatic cancer resistance to standard chemotherapy...
  29. ncbi Allelotype of ampulla of Vater cancer: highly frequent involvement of chromosome 11
    Patrick S Moore
    Dipartimento di Patologia-Sezione di Anatomia Patologica, , Strada Le Grazie, 37134 Verona, Italy
    J Cancer Res Clin Oncol 130:339-45. 2004
    ..The resulting allelotype reveals that distinctive chromosomal alterations are present in these neoplasms, indicating that it is a tumor entity distinct from pancreatic adenocarcinoma...
  30. ncbi Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    FASEB J 22:1849-60. 2008
    ..This finding supports a possible therapeutic use of PDEs inhibitors in the earlier phases of PAH in SCD...
  31. ncbi A novel cell line and xenograft model of ampulla of Vater adenocarcinoma
    Claudio Sorio
    Dipartimento di Patologia, , Strada Le Grazie, 37134, Verona, Italy
    Virchows Arch 444:269-77. 2004
    ..Lastly, AVC1 can be readily xenografted in immunodeficient mice, making it a suitable model for pre-clinical studies...
  32. ncbi Intraductal papillary mucinous neoplasms and chronic pancreatitis
    Giorgio Talamini
    Gastroenterology and Endoscopy Unit, University of Verona, Verona, Italy
    Pancreatology 6:626-34. 2006
    ..Intraductal papillary mucinous neoplasms (IPMNs) may present with clinical and radiological pictures resembling those of chronic pancreatitis (CP)...
  33. ncbi Endocrine neoplasms of the pancreas: pathologic and genetic features
    Paola Capelli
    Department of Pathology, Section ofAnatomical Pathology, Policlinico G B Rossi, 37134 Verona, Italy
    Arch Pathol Lab Med 133:350-64. 2009
    ..The latter include more than 90% of PENs whose clinical behavior varies from indolent to malignant and cannot be predicted by their morphology...
  34. ncbi Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy
    Angela Siciliano
    Dept of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Haematologica 96:24-32. 2011
    ..Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is only partially understood...
  35. ncbi Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas
    Vincenzo Corbo
    ARC NET Research Center, University of Verona, Policlinico GB Rossi, Verona, Italy
    PLoS ONE 5:e12653. 2010
    ..Tumours of the pancreas are aggressive neoplasms for which no effective therapeutic strategy is currently available...
  36. ncbi Chromosome 3p alterations in pancreatic endocrine neoplasia
    Eliana Amato
    ARC NET Center for Applied Research on Cancer, Hospital Concern and University School of Medicine, Verona, Italy
    Virchows Arch 458:39-45. 2011
    ....
  37. ncbi Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumours
    Marco Chilosi
    Department of Pathology, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Virchows Arch 443:175-83. 2003
    ..Among lymphomas, T-cell-precursor lymphomas did not express p63, whereas most PMLBCL expressed TA-p63alpha (7/8)...
  38. ncbi Genetic abnormalities in pancreatic cancer
    Patrick S Moore
    Dipartimento di Patologia, Universita di Verona, Strada Le Grazie, 37134, Verona, Italy
    Mol Cancer 2:7. 2003
    ..These results have important implications for the development of genetic screening tests, early diagnosis, and prognostic genetic markers...
  39. ncbi Protective effects of S-nitrosoalbumin on lung injury induced by hypoxia-reoxygenation in mouse model of sickle cell disease
    Lucia De Franceschi
    Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Italy
    Am J Physiol Lung Cell Mol Physiol 291:L457-65. 2006
    ..These effects provide new insights into the possible use of NO-Alb in the treatment of acute lung injury in SCD...
  40. ncbi Low expression of ARHI is associated with shorter progression-free survival in pancreatic endocrine tumors
    Irene Dalai
    Department of Surgical and Gastroenterological Sciences, University of Verona, Verona, Italy
    Neoplasia 9:181-3. 2007
    ..ARHI is involved in PET progression. Its mRNA expression seemed to be a prognostic factor for disease outcome and, in association with the proliferative index Ki67, a predictor for a rapid tumor relapse...
  41. ncbi Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors
    Calogero Iacono
    Department of Surgery and Gastroenterology, University of Verona Medical School, Verona, Italy
    J Gastrointest Surg 11:578-88. 2007
    ..There are discordant data on factors affecting prognosis, and hence therapeutic choices, in AVAC...
  42. ncbi Ampulla of vater cancers: T-stage and histological subtype but not Dpc4 expression predict prognosis
    Stefania Beghelli
    Department of Pathology, University of Verona, Strada Le Grazie, 37134 Verona, Italy
    Virchows Arch 441:19-24. 2002
    ..Moreover, comparison of the frequencies of allelic loss on chromosomal arm 18q and the loss of Dpc4 expression (34% and 41%, respectively) is highly suggestive that DPC4 is the major target of these losses...
  43. ncbi Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine
    Daniela Cecconi
    Department of Agricultural and Industrial Biotechnologies, University of Verona, Verona, Italy
    Electrophoresis 24:4291-303. 2003
    ..The significance of some of these major changes is discussed...
  44. ncbi Family history of gastric cancer: a correlation between epidemiologic findings and clinical data
    Marco Bernini
    First Department of General Surgery, University of Verona, Ospedale Civile Maggiore Verona, P.zza Stefani n.1, 37126, Verona, Italy
    Gastric Cancer 9:9-13. 2006
    ..8% vs 55.1%, respectively). CONCLUSIONS: Stomach cancer has a relevant degree of familial aggregation and in our series of patients, this was even more pronounced for the intestinal histotype...
  45. ncbi Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways
    Maria T Scupoli
    Laboratorio Universitario di Ricerca, Medica LURM, Policlinico, G B Rossi, Piazzale L Scuro 10, 37134 Verona, Italy
    Haematologica 93:524-32. 2008
    ..We also investigated the roles of the nuclear factor-kappaB and Jun-N-terminal kinase (JNK)/activating protein (AP)-1 signaling pathways, which contribute to regulate interleukin-8 production in some cells...
  46. ncbi Microfluidic deletion/insertion analysis for rapid screening of KIT and PDGFRA mutations in CD117-positive gastrointestinal stromal tumors: diagnostic applications and report of a new KIT mutation
    Alberto Zamo
    Department of Pathology, University of Verona, Verona, Italy
    J Mol Diagn 9:151-7. 2007
    ....
  47. ncbi Application of microfluidic technology to the BIOMED-2 protocol for detection of B-cell clonality
    Alberto Zamo
    Department of Pathology and Diagnostics, Section of Anatomic Pathology, University of Verona, Verona, Italy
    J Mol Diagn 14:30-7. 2012
    ....
  48. ncbi Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Lab Invest 83:1155-63. 2003
    ..These data suggest that the disregulation of the function of atypical zeta PKC might be involved in the acquisition of an invasive and metastatic phenotype in pancreatic adenocarcinoma cells...
  49. ncbi HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Blood 106:59-66. 2005
    ..These data show that HB-EGF/HER-1 signaling is relevant to MSC biology, by regulating both proliferation and differentiation...
  50. ncbi Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review
    Giovanni Butturini
    Surgical Department, Verona University Hospital, Piazzale LA Scuro 10, Verona, Italy
    Langenbecks Arch Surg 396:363-9. 2011
    ..Acinar cell carcinomas (ACCs) are a rare pancreatic tumor group with no standardized treatment. The aim of the study is to analyze the clinical and pathologic characteristics of our series and to review the current literature...
  51. ncbi Establishment of the MAVER-1 cell line, a model for leukemic and aggressive mantle cell lymphoma
    Alberto Zamo
    Department of Pathology, University of Verona, Verona, Italy
    Haematologica 91:40-7. 2006
    ..Mantle cell lymphoma (MCL) cell lines are difficult to generate; only nine lines have been described so far and few of them have been thoroughly characterized...
  52. ncbi Immunohistochemical detection of arginine methylated proteins (MeRP) in archival tissues
    Marzia Vezzalini
    Department of Pathology and Diagnostics, University di Verona, Verona, Italy
    Histopathology 57:725-33. 2010
    ....
  53. ncbi Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer
    Davide Antonello
    Department of Pathology, Universita di Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Cancer Lett 183:179-83. 2002
    ..Likewise, no alterations in expression were found. Thus, an essential role of TIEG1 in pancreatic cancer can be excluded...
  54. ncbi Branch-duct intraductal papillary mucinous neoplasms of the pancreas: to operate or not to operate?
    Roberto Salvia
    Department of Surgery, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro 10, 37134 Verona, Italy
    Gut 56:1086-90. 2007
    ..Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) of the pancreas are reported to be less aggressive than the main-duct type. Hence, less aggressive treatment has been proposed for the former...
  55. ncbi Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells
    Massimo Donadelli
    Department of Neurological and Vision Sciences, , Verona, Italy
    Mol Carcinog 38:59-69. 2003
    ..These findings suggest that inhibitors of HDAC may represent a novel therapeutic strategy for treatment of pancreatic cancer...
  56. ncbi Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells
    Margherita Gaviraghi
    Department of Pathology, Policlinico GB Rossi, University of Verona, Italy
    Biosci Rep 31:45-55. 2011
    ..Our results also emphasize the potential therapeutic importance of pathways such as CXCR4 and hedgehog for pancreatic cancer treatment...
  57. ncbi Nonneoplastic mimickers of pancreatic neoplasms
    Giuseppe Zamboni
    Department of Pathology, University of Verona, Ospedale Sacro Cuore Don Calabria, Via Don Sempreboni 5, 37024 Negrar Verona, Italy
    Arch Pathol Lab Med 133:439-53. 2009
    ..Approximately 5% to 10% of pancreatectomies performed with the clinical diagnosis of pancreatic cancer prove on microscopic evaluation to be pseudotumors...
  58. ncbi Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A
    Daniela Cecconi
    Department of Agricultural and Industrial Biotechnologies, University of Verona, Verona, Italy
    Electrophoresis 24:1871-8. 2003
    ..The modulation of these four proteins is consistent with our observation that TSA is able to inhibit cell growth of Paca44 by causing cell cycle arrest at the G2 phase and apoptotic cell death...
  59. ncbi Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction
    Francesco Giovinazzo
    Laboratory of Translational Surgery, University Laboratories of Medical Research LURM, University of Verona, 37134 Verona, Italy
    Cell Signal 25:651-9. 2013
    ..Altogether, our findings suggest that G15 supports tumorigenic signaling in pancreas and hence it may be considered as a novel potential target for the therapy of this form of cancer...
  60. ncbi Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis
    Silvia Mattuzzi
    Dipartimento di Patologia, Universita di Verona, Verona, Italy
    J Rheumatol 34:997-1004. 2007
    ..To investigate possible associations of 9 single-nucleotide polymorphisms in the IL10, IL1B, IL1A, IL1RN, IL2, LTA, and IL6 genes with susceptibility to systemic sclerosis (SSc), and with clinical subtype of SSc patients...
  61. ncbi Pseudopapillary tumor in pediatric age: clinical and surgical management
    Nicola Zampieri
    Department of Surgical Sciences, Pediatric Surgical Unit, Policlinico G B Rossi, University of Verona, Piazzale Scuro n 1, Piazzale L A Scuro, 37134, Verona, Italy
    Pediatr Surg Int 27:1271-5. 2011
    ..Solid pseudopapillary tumors of the pancreas are rare exocrine pancreatic tumors. Through a review of pediatric cases in a single Institution, we present the clinical and surgical management of this neoplasm...
  62. ncbi Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study
    Paolo Cossu Rocca
    Department of Pathology, University of Sassari, Sassari, Italy
    Mod Pathol 20:722-8. 2007
    ..Further, S100A1 protein expression is constantly detected in the normal parenchyma of the adult and fetal kidney...
  63. ncbi Non-invasive cancer detection: strategies for the identification of novel cancer markers
    Claudio Sorio
    Department of Pathology, University of Verona, Italy
    IUBMB Life 58:193-8. 2006
    ..The purpose of this article is to discuss and help focus the strategies applying these novel technologies for the identification of potential biomarkers for early detection of cancer...
  64. ncbi Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas
    Aldo Scarpa
    Dipartimento di Patologia, Universita di Verona, Italy
    Virchows Arch 440:155-9. 2002
    ..Our data suggest that DPC4 is only rarely involved in pancreatic endocrine tumourigenesis and give further weight to the hypothesis that tumours arising from pancreatic exocrine and endocrine epithelia are genetically distinct...
  65. ncbi Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations
    Luca Frulloni
    Department of Biochemical and Surgical Sciences, University of Verona, Verona, Italy
    Pancreas 37:371-6. 2008
    ..The aim of this study was to compare clinical and radiological findings in sporadic CP with (CPgm) and without (CPwt) gene mutations...
  66. ncbi Induction of an antitumour adaptive immune response elicited by tumour cells expressing de novo B7-1 mainly depends on the anatomical site of their delivery: the dose applied regulates the expansion of the response
    Silvia Sartoris
    Dipartimento di Patologia, Sezione di Immunologia, Universita di Verona, Verona, Italy
    Immunology 110:474-81. 2003
    ..The antigen dose regulates the anatomical extent of the protective response...
  67. ncbi Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Policlinico GB Rossi, Piazzale L Scuro, 10, 37134 Verona, Italy
    Blood 102:1087-96. 2003
    ....
  68. ncbi Molecular pathology of pancreatic cancer: from bench-to-bedside translation
    Vincenzo Corbo
    ARC NET Research Centre, University Hospital of Verona, Verona, Italy
    Curr Drug Targets 13:744-52. 2012
    ....
  69. ncbi Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    Marco Chilosi
    Department of Pathology, University of Verona, Verona, Italy
    Am J Pathol 162:1495-502. 2003
    ....
  70. ncbi Sex chromosome anomalies in pancreatic endocrine tumors
    Edoardo Missiaglia
    Department of Pathology, , Italy
    Int J Cancer 98:532-8. 2002
    ..The presence of local invasion increased the risk of death almost 9 times whereas sex chromosome loss was an independent variable associated with a shorter survival period and an increased risk of death of approximately 4-fold...
  71. ncbi Acinar cell cystadenoma of the pancreas: a new entity?
    Giuseppe Zamboni
    Department of Pathology, University of Verona, Italy
    Am J Surg Pathol 26:698-704. 2002
    ..We therefore suggest the term acinar cell cystadenoma...
  72. ncbi Gene expression profiling as a tool for the identification of molecular targets
    Antonella Baron
    Department of Pathology, University of Verona, Italy
    Suppl Tumori 1:S17-20. 2002
  73. ncbi Overexpression of the Sm-like proto-oncogene in primary and metastatic pancreatic endocrine tumors
    Andrew A Gumbs
    Department of Surgical and Gastroenterological Sciences, University of Verona. Verona, Italy
    JOP 3:109-15. 2002
    ..CONCLUSIONS: Our results indicate that the cancer associated Sm-like mRNA gene may also play a role in the tumorigenesis of pancreatic endocrine tumors...
  74. ncbi SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo
    Monica Cattaneo
    1Institute for Biomedical Technologies National Research Council, Milano, Italy
    Oncogene 22:6359-68. 2003
    ..Moreover, our data provide evidence that SEL1L has an impact on the expression of genes involved in regulation of cellular growth, possibly through the TGF-beta signaling pathway...
  75. ncbi Expression profiling of microdissected pancreatic adenocarcinomas
    Tatjana Crnogorac-Jurcevic
    Cancer Research UK Molecular Oncology Unit, Imperial College School of Medicine at Hammersmith Campus, London, UK
    Oncogene 21:4587-94. 2002
    ....
  76. ncbi K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Mod Pathol 17:538-46. 2004
    ....
  77. ncbi Retrovirus-mediated herpes simplex virus thymidine kinase gene transfer in pancreatic cancer cell lines: an incomplete antitumor effect
    Eliana Greco
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Pancreas 25:e21-9. 2002
    ..CONCLUSION: Gene therapy with HSV-TK for pancreatic cancer seems effective in only a limited number of tumor-derived cell lines, and this limits its application in vivo...
  78. ncbi Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis
    Emilio Marengo
    Department of Environmental and Life Sciences, University of Eastern Piedmont, Spalto Marengo 33, 15100 Alessandria, Italy
    Anal Bioanal Chem 379:992-1003. 2004
    ..The treatment of both the cell lines with Trichostatin A therefore showed an appreciable effect on the proteomic pattern of the treated samples. Identification of some of the most relevant spots was also performed by mass spectrometry...
  79. ncbi Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas
    Giorgio Malpeli
    Dipartimento di Patologia, Sezione di Anatomia Patologica Università di Verona, Strada Le Grazie I 37134 Verona, Italy
    Haematologica 89:1091-9. 2004
    ..Thus, analysis of BCL6 may aid in clarifying the relationship between primary mediastinal B-cell lymphoma (PMBL) and other non-thymic diffuse large cell lymphomas (DLCL)...
  80. ncbi Specialized DNA arrays for the differentiation of pancreatic tumors
    Malte Buchholz
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    Clin Cancer Res 11:8048-54. 2005
    ....
  81. ncbi Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
    Asha Balakrishnan
    Laboratory of Molecular Genetics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo TO 10060, Italy
    Cancer Res 67:3545-50. 2007
    ..We also speculate that similar to other oncogenes and tumor suppressor genes, mutations affecting OBSCN could be involved in cancer predisposition...
  82. ncbi MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior
    Claudia Roldo
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA
    J Clin Oncol 24:4677-84. 2006
    ....
  83. ncbi Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells
    Graziella Bellone
    Department of Clinical Physiopathology, University of Turin, Italy
    J Immunol 177:3448-60. 2006
    ..In summary, we have identified an array of pancreatic carcinoma-derived cytokines that cooperatively affect iMo-DC activation in a manner consistent with ineffective antitumor immune responses...
  84. ncbi A microRNA expression signature of human solid tumors defines cancer gene targets
    Stefano Volinia
    Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:2257-61. 2006
    ..Our results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes...
  85. ncbi Effect of urban traffic, individual habits, and genetic polymorphisms on background urinary 1-hydroxypyrene excretion
    Pierluigi Cocco
    Dipartimento di Sanita Pubblica, Sezione di Medicina del Lavoro, Universita di Cagliari, Cagliari, and Divisione di Ematologia, Ospedale San Francesco, ASL 3, Nuoro, Italy
    Ann Epidemiol 17:1-8. 2007
    ....
  86. ncbi SEL1L a multifaceted protein playing a role in tumor progression
    Ida Biunno
    Istituto di Tecnologie Biomediche, CNR, Segrate Milano, Italy
    J Cell Physiol 208:23-38. 2006
    ..The overall architecture of SEL1L guarantees an exquisite regulation in the expression of the gene...
  87. ncbi A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expression
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Virchows Arch 447:969-77. 2005
    ..A minor subset of these tumors shows beta-catenin nuclear accumulation in association with increased expression of MMP-7, but not of cyclin D1, independent of EGFR and HER-2 gene amplification or expression...
  88. ncbi Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers
    Pierluigi Mauri
    Istituto Tecnologie Biomediche ITB CNR, Segrate, Milano, Italy
    FASEB J 19:1125-7. 2005
    ..Our finding that pancreatic cancer cells secrete a series of proteoglycans, including versican, perlecan, syndecan 1 and 4, challenges the common view that fibroblasts of tumor stroma are the sole source of these molecules...
  89. ncbi Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Cancer 103:1154-64. 2005
    ..To the authors' knowledge, little is known regarding the role of E-cadherin/beta-catenin system dysregulation in pulmonary neuroendocrine tumors...
  90. ncbi Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway
    Edoardo Missiaglia
    Cancer Research UK, Molecular Oncology Unit, Imperial College School of Medicine at Hammersmith Campus, London, UK
    Oncogene 24:199-211. 2005
    ..Finally, genome-wide demethylation induced sensitization that significantly increased response to further treatment with various chemotherapy agents...
  91. ncbi Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease
    Nathalie Sabaa
    Cardiovascular Research Center Lariboisiere, INSERM U689, Paris, France
    J Clin Invest 118:1924-33. 2008
    ..These findings in mice suggest that ETRA could be a potential new therapy for SCD, as it may prevent acute VOC and limit organ damage in sickle-cell patients...