Francesco Scaglione

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc Pharmacodynamics of levofloxacin and ciprofloxacin in a murine pneumonia model: peak concentration/MIC versus area under the curve/MIC ratios
    F Scaglione
    University of Milan School of Medicine, Milan, Italy
    Antimicrob Agents Chemother 47:2749-55. 2003
  2. doi request reprint In vitro and in vivo pharmacokinetic/pharmacodynamic activity of clofoctol
    Francesco Scaglione
    Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
    J Chemother 24:201-6. 2012
  3. doi request reprint New oral anticoagulants: comparative pharmacology with vitamin K antagonists
    Francesco Scaglione
    Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
    Clin Pharmacokinet 52:69-82. 2013
  4. ncbi request reprint Safety profile of bilastine: 2nd generation H1-antihistamines
    F Scaglione
    Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
    Eur Rev Med Pharmacol Sci 16:1999-2005. 2012
  5. ncbi request reprint Comparison of the potency of 10 different brands of Serenoa repens extracts
    F Scaglione
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Eur Rev Med Pharmacol Sci 16:569-74. 2012
  6. doi request reprint Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities
    Francesco Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 39:458-63. 2012
  7. doi request reprint Pharmacokinetics/pharmacodynamics of antibacterials in the Intensive Care Unit: setting appropriate dosing regimens
    Francesco Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Milan, Italy
    Int J Antimicrob Agents 32:294-301. 2008
  8. ncbi request reprint Influence of pharmacokinetics/pharmacodynamics of antibacterials in their dosing regimen selection
    Francesco Scaglione
    University of Milan, Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, Via Vanvitelli 32, 20129, Milan, Italy
    Expert Rev Anti Infect Ther 4:479-90. 2006
  9. ncbi request reprint Can PK/PD be used in everyday clinical practice
    Francesco Scaglione
    Department of Pharmacology, Toxicology and Chemotherapy, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 19:349-53. 2002
  10. pmc Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media
    F Scaglione
    University of Milan, Milan, Italy
    Antimicrob Agents Chemother 47:2987-9. 2003

Collaborators

Detail Information

Publications45

  1. pmc Pharmacodynamics of levofloxacin and ciprofloxacin in a murine pneumonia model: peak concentration/MIC versus area under the curve/MIC ratios
    F Scaglione
    University of Milan School of Medicine, Milan, Italy
    Antimicrob Agents Chemother 47:2749-55. 2003
    ..We conclude that for quinolones the AUC/MIC ratio best correlates with efficacy against pneumococci and that the effect of the peak/MIC ratio found in some studies could be partly explained by concentration-dependent protein binding...
  2. doi request reprint In vitro and in vivo pharmacokinetic/pharmacodynamic activity of clofoctol
    Francesco Scaglione
    Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
    J Chemother 24:201-6. 2012
    ..The area under curve/minimum inhibitory concentration (AUC/MIC) ratio is the PK/PD parameter that best correlates with in vivo clofoctol efficacy; the value of AUC/MIC required to achieve the maximum effect in this study was 75.5...
  3. doi request reprint New oral anticoagulants: comparative pharmacology with vitamin K antagonists
    Francesco Scaglione
    Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy
    Clin Pharmacokinet 52:69-82. 2013
    ..The convenience of the new OACs has translated into improvements in efficacy and safety as shown in phase III randomized trials. The new anticoagulants so far offer the greatest promise and opportunity for the replacement of VKAs...
  4. ncbi request reprint Safety profile of bilastine: 2nd generation H1-antihistamines
    F Scaglione
    Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
    Eur Rev Med Pharmacol Sci 16:1999-2005. 2012
    ..Bilastine 20 mg is similar to placebo in the driving test. Therefore, it meets the current criteria for medication used in the treatment of allergic rhinitis and urticaria...
  5. ncbi request reprint Comparison of the potency of 10 different brands of Serenoa repens extracts
    F Scaglione
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Eur Rev Med Pharmacol Sci 16:569-74. 2012
    ..Several extracts are commercially available but extraction processes vary between manufacturers and thus not all these products are equivalent in terms of active ingredient content and composition of preparations...
  6. doi request reprint Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities
    Francesco Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 39:458-63. 2012
    ....
  7. doi request reprint Pharmacokinetics/pharmacodynamics of antibacterials in the Intensive Care Unit: setting appropriate dosing regimens
    Francesco Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Milan, Italy
    Int J Antimicrob Agents 32:294-301. 2008
    ..In this review, we analyse the typical patterns of antimicrobial activity and the corresponding PK/PD parameters, with a special focus on a PK/PD dosing approach of the antimicrobial agent classes commonly utilised in the ICU setting...
  8. ncbi request reprint Influence of pharmacokinetics/pharmacodynamics of antibacterials in their dosing regimen selection
    Francesco Scaglione
    University of Milan, Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, Via Vanvitelli 32, 20129, Milan, Italy
    Expert Rev Anti Infect Ther 4:479-90. 2006
    ..This review will analyze the typical patterns of antimicrobial activity and the corresponding PK/PD parameters, with a special focus on a PK/PD dosing approach with the most commonly utilized antimicrobial agent classes...
  9. ncbi request reprint Can PK/PD be used in everyday clinical practice
    Francesco Scaglione
    Department of Pharmacology, Toxicology and Chemotherapy, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 19:349-53. 2002
    ..In our hospital, we have started a programme using this approach. Preliminary results suggest that dose optimisation leads to increased efficacy and lower costs...
  10. pmc Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media
    F Scaglione
    University of Milan, Milan, Italy
    Antimicrob Agents Chemother 47:2987-9. 2003
    ..The concentrations in cell-free fluid (C-) appear higher than those in the total fluid (C+) (as assayed traditionally)...
  11. ncbi request reprint Individualized treatment of chronic hepatitis C: from research to clinical practice
    F Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, School of Medicine, University of Milan, Italy
    J Chemother 18:5-29. 2006
  12. pmc Effect of PEX, a noncatalytic metalloproteinase fragment with integrin-binding activity, on experimental Chlamydophila pneumoniae infection
    Dario Caronzolo
    Department of Pharmacology, Chemotherapy, and Toxicology, University of Milan, Milan, Italy
    Antimicrob Agents Chemother 50:3277-82. 2006
    ..These results offer new perspectives on the treatment of C. pneumoniae infection and indicate that alpha(v)beta(3) could be a promising target for new agents developed for activity against this pathogen...
  13. doi request reprint Comparison of the potency of different brands of Serenoa repens extract on 5alpha-reductase types I and II in prostatic co-cultured epithelial and fibroblast cells
    Francesco Scaglione
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 82:270-5. 2008
    ..The aim of this study was to compare the activity of different extracts of Serenoa repens marketed in Italy...
  14. ncbi request reprint The Charta of Milan: basic criteria for the appropriate and accurate use of antibiotics: recommendations of the Italian Society of Chemotherapy
    F Scaglione
    Dipartimento de Farmacologia, Chemioterapia e Tossicologia, Universita Degli Studi de Milano, Italy
    J Chemother 21:475-81. 2009
    ..This article summarizes the recommendations drawn up by the Italian Society of Chemotherapy regarding the proper use of antimicrobial agents for infectious diseases...
  15. doi request reprint Feedback dose alteration significantly affects probability of pathogen eradication in nosocomial pneumonia
    F Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Milan, Italy
    Eur Respir J 34:394-400. 2009
    ..Measurement of drug concentrations and determination of pathogen MIC values with subsequent dose alteration significantly improves the probability of good clinical outcome and pathogen eradication in NP...
  16. doi request reprint Pharmacokinetic/pharmacodynamic (PK/PD) considerations in the management of Gram-positive bacteraemia
    Francesco Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Milan, Italy address
    Int J Antimicrob Agents 36:S33-9. 2010
    ....
  17. doi request reprint Appropriate use of antimicrobials: the peculiarity of septic patients
    Francesco Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 34:S52-4. 2009
    ..Appropriate antimicrobial therapy must be administered as early as possible in order to reduce mortality significantly...
  18. ncbi request reprint IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo
    Lorenzo Bello
    Division of Neurosurgery, Department of Neurological Sciences, University of Milan, Italy
    Neurosurgery 52:177-85; discussion 185-6. 2003
    ..This article investigates the in vitro and in vivo effects of a synthetic alphavbeta3 integrin inhibitor called IS20I on human malignant gliomas...
  19. pmc Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae
    Dario Caronzolo
    Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Milan, Italy
    Antimicrob Agents Chemother 48:4878-81. 2004
    ..001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results...
  20. ncbi request reprint Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress
    Marilou Pannacci
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Brain Behav Immun 20:546-51. 2006
    ..Moreover, G115 increases the expression of TLR4 and the release of cytokines with a different pattern compared to the stressed alone group...
  21. ncbi request reprint Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Clin Cancer Res 8:3539-48. 2002
    ..Tumors treated with PEX or PF-4/CTF were small and well delineated, with few vessels. Postsurgical administration of PEX or PF-4/CTF significantly reduces the incidence human malignant glioma recurrences for a long period of time...
  22. ncbi request reprint Influence of protein binding on the pharmacodynamics of ceftazidime or ceftriaxone against gram-positive and gram-negative bacteria in an in vitro infection model
    F Scaglione
    Department of Pharmacology, University of Milan, Italy
    J Chemother 10:29-34. 1998
    ..Moreover, only unbound drug appears to be effective, so only free drug should be considered in the pharmacokinetic-pharmacodynamic interaction...
  23. ncbi request reprint Guidelines for the diagnosis and treatment of acute and subacute rhinosinusitis in children
    S Esposito
    Institute of Pediatrics, University of Milan, Milan, Italy
    J Chemother 20:147-57. 2008
    ..These guidelines are based on the 125 that were considered truly relevant and reflect the most widely shared positions concerning the diagnosis and treatment of acute, subacute and recurrent rhinosinusitis in children...
  24. ncbi request reprint Melatonin involvement in immunity and cancer
    F Fraschini
    Department of Pharmacology, University of Milan, Italy
    Biol Signals Recept 7:61-72. 1998
    ..The means by which melatonin exerts its effects on immunity and neoplastic growth have not been elucidated. The different putative mechanisms of action of melatonin investigated so far are here briefly discussed...
  25. pmc Pharmacokinetic study of cefodizime and ceftriaxone in sera and bones of patients undergoing hip arthroplasty
    F Scaglione
    Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Italy
    Antimicrob Agents Chemother 41:2292-4. 1997
    ..Both drugs diffuse well into bone, with concentrations exceeding the MIC at which 90% of the major pathogenic infecting organisms are inhibited...
  26. ncbi request reprint Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity
    Valeria Lucini
    Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Universita degli Studi di Milano, Via Vanvitelli 32, I 20129 Milano, Italy
    J Med Chem 47:4202-12. 2004
    ..The acetamide derivative 4b produced a noticeable reduction of GTPgammaS binding at MT2 receptor, thus being among the few inverse agonists described...
  27. ncbi request reprint Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFNgamma and IL-10 plasma levels in patients with community acquired pneumonia
    G Demartini
    Dept of Pharmacology, University of Milan, Italy
    J Chemother 16:82-5. 2004
    ..In the same patients IFNgamma plasma levels decreased during treatment while IL-10 plasma levels were unaffected...
  28. ncbi request reprint Comparative activities of pefloxacin and ciprofloxacin in the treatment of chronic respiratory tract infections
    F Scaglione
    Department of Pharmacology, University of Milan, Italy
    J Chemother 7:140-5. 1995
    ..5 micrograms/ml following a single oral dose of 800 mg. Ciprofloxacin, having a shorter half-life, showed a peak of about 1 microgram/ml, 12 hours after administration (500 mg/12 hours/os)...
  29. ncbi request reprint Once-a-day cephalosporins: reality or myth?
    F Scaglione
    Department of Pharmacology, University of Milan, Italy
    J Chemother 7:13-5. 1995
    ..With beta-lactam antibiotics, however, which have a slow time-dependent antibacterial effect and do not display a PAE, the aim is to keep the antibiotic concentration above the MIC for the duration of therapy...
  30. doi request reprint Consensus document on controversial issues for the treatment of hospital-associated pneumonia
    Fabio Franzetti
    Clinica Universitaria di Malattie Infettive e Tropicali, Azienda Ospedaliera Universitaria Luigi Sacco, Universita degli Studi di Milano, Milano, Italy
    Int J Infect Dis 14:S55-65. 2010
    ..Many aspects of the treatment of HAP caused by multi-resistant Gram-positive microorganisms have been extensively studied, but controversial issues remain...
  31. ncbi request reprint Comparison of miocamycin versus amoxycillin in lower respiratory tract infections in children. Clinical response and effect on natural killer activity
    C Agostoni
    Paediatric Clinic V, S Paulo Hospital, University of Milan, Italy
    J Int Med Res 16:305-11. 1988
    ..The natural killer cell activity of patients treated with miocamycin was increased on days 7 and 10 of therapy compared with baseline. This finding did not occur in patients treated with amoxycillin...
  32. ncbi request reprint Penetration of amphotericin B in human lung tissue after single liposomal amphotericin B (AmBisome) infusion
    G Demartini
    Dept of Pharmacology, University of Milan, Italy
    J Chemother 17:82-5. 2005
    ..In lung tissue samples the lowest amphotericin B concentration (about 1 microg/g) was observed at the 10th h, then a progressive increase was observed with the highest value (2.5 microg/g) determined at the 25th h...
  33. ncbi request reprint Double-blind, multicenter, randomized trial to compare the effect of two doses of adrenocorticotropic hormone versus placebo in controlling delayed emesis after high-dose cisplatin in adult patients with cancer
    R Passalacqua
    Institute of Pharmacology, Milan, Italy
    J Clin Oncol 15:2467-73. 1997
    ..To compare, in a double-blind, placebo-controlled, randomized trial, the efficacy of two different doses of the depot formulation of adrenocorticotropic hormone (ACTH) in controlling delayed emesis after cisplatin...
  34. ncbi request reprint Pharmacokinetics of isepamicin in paediatric patients
    F Scaglione
    Department of Pharmacology, University of Milan, Italy
    J Chemother 7:63-9. 1995
    ..5 mg/kg administered once daily to children less than 16 days old and twice daily to children aged 16 days to 13 years appears to be pharmacokinetically appropriate. The drug was very well tolerated by children of all age groups...
  35. ncbi request reprint Pharmacokinetics and tissue distribution of amoxicillin plus clavulanic acid after oral administration in man
    F Fraschini
    Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy
    J Chemother 2:171-7. 1990
    ..Peak levels of amoxicillin ranged from 0.87 micrograms/g (tonsil) to 2.56 micrograms/g (lung) and of clavulanic acid from 0.20 micrograms/g (prostate) to 0.56 micrograms/g (lung) between 3 and 4 hours after dosing...
  36. ncbi request reprint In-vitro postantibiotic effects of miocamycin and erythromycin on gram-positive cocci
    F Varotto
    Clinical Research Laboratory, Istituti Clinici di Perfezionamento, Milan, Italy
    J Chemother 2:355-61. 1990
    ..Miocamycin therefore proved to possess a more evident capability to induce a PAE against the clinical isolate of Group A Streptococcus beta-haemolyticus and on Staphylococcus aureus ATCC 29213 than did erythromycin...
  37. ncbi request reprint Miocamycin distribution in tonsillar and pulmonary tissues after repeated administration
    F Scaglione
    Chair of Chemotherapy, University of Milan, Italy
    J Chemother 2:384-9. 1990
    ..3 +/- 0.61 mg/l). At the 12th hour miocamycin could still be dosed in 3 tissue samples, with values between 0.1 and 0.2 mg/kg and was found just at dosing limits in only one serum sample...
  38. ncbi request reprint Pathogen-host interaction
    F Fraschini
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy
    J Chemother 2:190-8. 1990
    ..Some antibacterial agents inhibit these parameters, whereas others can enhance some of these immune parameters to differing extents. Some antibacterial agents have a neutral effect on these parameters...
  39. ncbi request reprint Cefroxadine in the treatment of children affected by respiratory and ENT diseases. A multicentre study involving 1072 in-patients
    F Scaglione
    Department of Pharmacology, Institute of Chemotherapy, University of Milan, Italy
    Drugs Exp Clin Res 15:71-6. 1989
    ..9%), skin rash (2.2%) and glossitis (0.5%). In conclusion, cefroxadine exerts a satisfactory antibacterial action with only a few days of treatment, and it appears to be very well tolerated...
  40. ncbi request reprint Miokamycin penetration into oral cavity tissues and crevicular fluid
    F Fraschini
    Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy
    Int J Clin Pharmacol Res 9:293-6. 1989
    ..Miokamycin rapidly penetrates into tissues and fluids of oral cavity. A single oral dose of 600 mg guarantees antibacterial levels against susceptible bacteria over six hours...
  41. ncbi request reprint Long-term inhibition of glioma growth by systemic administration of human PEX
    M Pluderi
    Neurosurgery, Department of Neurological Sciences, University of Milan, Milan, Italy
    J Neurosurg Sci 47:69-78. 2003
    ..It is becoming apparent that resistance can develop over time to many types of endogenous inhibitors and seems to be influenced by the tumor type and system of delivery...
  42. ncbi request reprint Correlation between plasma and tonsillar levels of cefroxadine
    F Fraschini
    Department of Pharmacology, University of Milan, Italy
    Chemotherapy 34:8-12. 1988
    ..The time course of plasma levels is superimposable to previous studies. These findings suggest a rapid penetration of cefroxadine in tonsillar tissue and seem to confirm the clinical efficacy of the drug in ENT infections...
  43. ncbi request reprint Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients
    F Scaglione
    Dept Pharmacology, University of Milan, Italy
    J Chemother 5:228-32. 1993
    ..Clarithromycin appears to enhance the human immune response; the mechanism, pharmacodynamics, and clinical significance of this enhancement remain unknown...
  44. ncbi request reprint Kinetic profile of miocamycin in middle ear fluid and mucosa
    F Fraschini
    Department of Medical Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy
    Acta Otolaryngol 111:756-61. 1991
    ..At the following experimental times of withdrawal, the miocamycin concentration in mucosa specimens, as well as in MEF samples, proved to be markedly higher than values simultaneously found in serum...
  45. ncbi request reprint Transdermal apomorphine permeation from microemulsions: a new treatment in Parkinson's disease
    Lorenzo Priano
    Divisione di Neurologia e Neuroriabilitazione, Osp S Giuseppe, IRCCS Istituto Auxologico Italiano, Piancavallo VB, Italy
    Mov Disord 19:937-42. 2004
    ..Therefore, it seems a promising add-on treatment for uncontrolled prolonged off phases in PD patients, but chronic tolerability needs further study...