Research Topics
Species | Iacopo SardiSummaryAffiliation: University of Florence Country: Italy Publications
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Detail Information
Publications
Loss of heterozygosity and p53 polymorphism Pro72Arg in a young patient with medulloblastomaIacopo Sardi
Unita di Oncoematologia, Ospedale Pediatrico A Meyer, I 50132 Florence, Italy
Oncol Rep 10:773-5. 2003..We identified the presence of LOH at 17p13 and Pro72Arg polymorphism in tumor DNA. These molecular findings helped us better characterize this undifferentiated tumor and led to a more aggressive therapy...- Intracavitary chemotherapy (Gliadel) and oral low-dose etoposide for recurrent anaplastic ependymomaIacopo Sardi
Neuro surgery Units, Department of Neurosurgery, University of Florence Medical School, The A Meyer Children s Hospital, Florence 50132, Italy
Oncol Rep 19:1219-23. 2008.... 
Successful treatment with a low-dose cisplatin--etoposide regimen for patients with diencephalic syndromeIacopo Sardi
Department of Pediatric Hematology Oncology, A O U Meyer Children s Hospital, viale G Pieraccini 24, 50139, Florence, Italy
J Neurooncol 109:375-83. 2012..A low-dose cisplatin-etoposide regimen is highly effective regarding tumor response and treatment of DS symptoms/cachexia without causing significant side-effects...- Monotherapy with thalidomide for treatment of spinal cord hemangioblastomas in a patient with von Hippel-Lindau diseaseIacopo Sardi
Department of Pediatric Hematology Oncology, A U O Anna Meyer Children s Hospital, Florence, Italy
Pediatr Blood Cancer 53:464-7. 2009..The antiangiogenic effect of thalidomide may be associated with the control of progressive hemangioblastoma... - Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumorsIacopo Sardi
Department of Pediatric Hematology Oncology, University of Florence, A O U Meyer Children s Hospital, 50139 Florence, Italy
Oncol Rep 22:773-9. 2009..The heterogeneous PFS in our patients treated with second line TMZ, indicates that MGMT expression alone is insufficient to predict the response to TMZ, presumably because of the DNA repair mechanisms involved... - Intracerebral atypical presentation of echinococcosis in a childIacopo Sardi
Division of Neurosurgery, A. Meyer Children's Hospital, University of Florence, Florence, Italy
Pediatr Neurosurg 44:350-2. 2008 - Emerging treatments and gene expression profiling in high-risk medulloblastomaIacopo Sardi
Department of Pediatrics, Onco hematology and Neuro surgery Units, University of Florence Medical School, A Meyer Children s Hospital, Florence, Italy
Paediatr Drugs 9:81-96. 2007.... - Detection of doxorubicin hydrochloride accumulation in the rat brain after morphine treatment by mass spectrometryIacopo Sardi
Department of Onco Hematology and Neuro Surgery Units, A Meyer Children s Hospital, viale G Pieraccini 24, 50139 Florence, Italy
Cancer Chemother Pharmacol 67:1333-40. 2011..We explored the feasibility of active modification of the blood-brain barrier protection, by using morphine pretreatment, to allow doxorubicin accumulation in the brain in an animal model... - Pediatric rhabdoid meningioma: a morphological, immunohistochemical, ultrastructural and molecular case studyAnna Maria Buccoliero
Department of Biomedicine, Careggi Hospital, Florence, Italy
Neuropathology 31:59-65. 2011..Rhabdoid meningiomas rarely occur in children. Owing to its rarity, each new case should be recorded to produce a better clinical, pathological, molecular, prognostic and therapeutic characterization of this lesion... - Merlin expression in pediatric anaplastic ependymomas real time PCR studyAnna Maria Buccoliero
Department of Human Pathology and Oncology, University of Florence, Morgagni 85, Florence, Italy
Fetal Pediatr Pathol 29:245-54. 2010..Statistical analysis did not prove significant differences. Our results suggest that NF2 alterations are not typical of intracranial anaplastic ependymomas... - Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damageValentina Cetica
Onco Hematology Unit, Department of Pediatrics, Florence Medical School, A Meyer Children s Hospital, Viale Pieraccini 24, 50139, Florence, Italy
J Neurooncol 94:195-201. 2009..This is the first study of hABH2 and hABH3 in pediatric brain tumors; further molecular investigations of their mutations and expression may help determine their role in response to chemotherapy... - Glioneuronal tumor with neuropil-like islands: clinical, morphologic, immunohistochemical, and molecular features of three pediatric casesAnna Maria Buccoliero
Pathology Unit, Anna Meyer Children s Hospital, Florence, Italy
Pediatr Dev Pathol 15:352-60. 2012..In conclusion, glioneuronal tumor with neuropil-like islands can affect children, arise in the spinal cord, and show ependymal features in its glial component. A high-dose chemoradiotherapy program is effective... - Primary cerebral myxofibrosarcoma: clinical, morphologic, immunohistochemical, molecular, and ultrastructural study of an infrequent tumor in an extraordinary localizationAnna Maria Buccoliero
Department of Biomedicine, Careggi Hospital, Florence, Italy
J Pediatr Hematol Oncol 33:e279-83. 2011..We believe each new case should be recorded to produce a better clinical, pathologic, molecular, prognostic, and therapeutic characterization of this lesion... - Infant ependymoma in a 10-year AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) experience with omitted or deferred radiotherapyMaura Massimino
Department of Pediatrics, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy
Int J Radiat Oncol Biol Phys 80:807-14. 2011..We treated 41 children under the age of 3 years with intracranial ependymoma between 1994 and 2003... - Teratoid hepatoblastomaAnna Maria Buccoliero
Department of Human Pathology and Oncology, Careggi Hospital, University of Florence, Florence, Italy
Fetal Pediatr Pathol 27:274-81. 2008..We speculate on the histogenesis of teratoid hepatoblastoma and discuss its association with chemotherapy... - Pediatric sinonasal neuroendocrine carcinoma after treatment of retinoblastomaAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, 50134 Florence, Italy
Hum Pathol 40:750-5. 2009..These tumors represent a peculiar subset of undifferentiated sinonasal neoplasms with extremely aggressive clinical behavior... 
Type A microsatellite instability in pediatric gliomas as an indicator of Turcot syndromeLaura Giunti
Medical Genetics Unit, Meyer Children s University Hospital, Florence, Italy
Eur J Hum Genet 17:919-27. 2009....- Congenital/Infantile fibrosarcoma of the colon: morphologic, immunohistochemical, molecular, and ultrastructural features of a relatively rare tumor in an extraordinary localizationAnna Maria Buccoliero
Department of Human Pathology and Oncology, University of Florence, Careggi Hospital, Firenze, Italy
J Pediatr Hematol Oncol 30:723-7. 2008..The algorithm for the diagnosis of congenital/infantile fibrosarcoma, especially outside the usual localizations, should comprise morphologic, immunohistochemical, molecular, and ultrastructural studies... - Pediatric primary anaplastic ganglioglioma: a case report and review of the literatureSilvia Scoccianti
Radiation Oncology Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
Pediatr Neurosurg 48:35-41. 2012..Prospective studies are needed to identify an appropriate chemotherapy schedule and to define biological factors in order to select those patients with a poor prognosis, who are to be treated with a more aggressive therapy... - Dedifferentiated peripheral chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of four casesAlessandro Franchi
Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, Viale G B Morgagni 85, 50134 Florence, Italy
Virchows Arch 460:335-42. 2012..PDGFRβ could represent a potential target for treatments with receptor tyrosine kinase inhibitors in peripheral DCS... - Tumour suppressor gene TP53 mutations in atypical vascular lesions of breast skin following radiotherapyRaffaella Santi
Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
Histopathology 58:455-66. 2011..The aim of the present study was to investigate alterations of tumour suppressor gene TP53 in a series of radiation-induced AVL and angiosarcomas (AS)... - Pineal germinoma morphological features in a liquid-based cerebrospinal fluid sampleAnna Maria Buccoliero
Department of Biomedicine, Careggi Hospital, Florence, Italy
Diagn Cytopathol 36:645-6. 2008 - Genetic alterations between primary head and neck squamous cell carcinoma and recurrence after radiotherapy: recurrence, genetically related cancer, or second primary?Alberto Deganello
Department of Otolaryngology Head and Neck Surgery, University of Florence, Florence, Italy
Cancer 116:1291-7. 2010..In the attempt to characterize the genetic bases of recurrent head and neck squamous cell carcinoma (HNSCC) after radiotherapy (RT), the authors compared the molecular profiles of primary tumors and recurrences... - E-cadherin mRNA expression analysis in evaluating the natural history of urothelial bladder cell carcinoma: results from a long-term follow-up studyTommaso Cai
Department of Urology, University of Florence, I 50011 Bagno a Ripoli, Florence, Italy
Oncol Rep 17:925-30. 2007..We stress that a long follow-up period is needed to evaluate the role of molecular factors in predicting prognosis in patients affected by bladder UC... - Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: relationship with clinical course at 10 years follow-upRiccardo Bartoletti
Department of Urology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy
Oncol Rep 14:251-5. 2005.... - Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancerFabio Cianchi
Department of General Surgery, Medical School, University of Florence, Florence, Italy
Clin Cancer Res 10:2694-704. 2004..We aimed at evaluating the possible interaction between the nitric oxide and COX-2 pathways, and its effect on promoting tumor angiogenesis... - Stomal recurrence following total laryngectomy: clinical and molecular analysis of a seriesRoberto Santoro
Department of Oto-neuro-ophthalmologic Surgical Sciences, University of Florence, Florence, Italy
Ann Otol Rhinol Laryngol 112:594-9. 2003..Our analysis supports the hypothesis that a subset of SRs after TL may be second primary tumors, genetically unrelated to the primary laryngeal lesion... - Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesisFabio Cianchi
Department of General Surgery, Medical School, University of Florence, Florence, Italy
Am J Pathol 162:793-801. 2003..Western and Northern blot analyses confirmed the up-regulation of the iNOS protein and gene in the tumor specimens as compared with normal mucosa. NO seems to play a role in colorectal cancer growth by promoting tumor angiogenesis... - Molecular profiling of high-risk neuroblastoma by cDNA arrayIacopo Sardi
Unita di Oncoematologia, Ospedale Pediatrico A Meyer, Via L Giordano 13, 50132 Florence, Italy
Int J Mol Med 9:541-5. 2002..Thus, the sensitive cDNA array may provide new insight into many aspects of pediatric tumors and play crucial role in the administration of adjuvant therapy of patients with neuroblastoma...