Anna Sapino

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. pmc Formalin fixation at low temperature better preserves nucleic acid integrity
    Gianni Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    PLoS ONE 6:e21043. 2011
  2. pmc Current Challenges for HER2 Testing in Diagnostic Pathology: State of the Art and Controversial Issues
    Anna Sapino
    Department of Medical Sciences, University of Turin Turin, Italy
    Front Oncol 3:129. 2013
  3. ncbi MammaPrint Molecular Diagnostics on Formalin-Fixed, Paraffin-Embedded Tissue
    Anna Sapino
    Department of Medical Sciences, University of Turin, Turin, Italy Electronic address
    J Mol Diagn 16:190-7. 2014
  4. pmc Trastuzumab with either docetaxel or vinorelbine as first-line treatment for patients with HER2-positive advanced breast cancer: a retrospective comparison
    Stefania Redana
    Institute for Cancer Research and Treatment, Division of Medical Oncology, Candiolo Italy
    BMC Cancer 10:28. 2010
  5. ncbi Patients with advanced stage breast carcinoma immunoreactive to biotinylated Herceptin are most likely to benefit from trastuzumab-based therapy: an hypothesis-generating study
    A Sapino
    Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino, Torino, Italy
    Ann Oncol 18:1963-8. 2007
  6. pmc Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Turin Medical School, Turin, Italy
    Am J Pathol 163:1313-20. 2003
  7. ncbi Which breast carcinomas need HER-2/neu gene study after immunohistochemical analysis? Results of combined use of antibodies against different c-erbB2 protein domains
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Torino Medical School, Italy
    Histopathology 43:354-62. 2003
  8. ncbi Clinical significance of neuroendocrine carcinoma of the breast
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S115-7. 2001
  9. pmc Ultrasonographically-guided fine-needle aspiration of axillary lymph nodes: role in breast cancer management
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Br J Cancer 88:702-6. 2003
  10. ncbi Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Torino, Torino, Italy
    Mod Pathol 19:599-606. 2006

Detail Information

Publications94

  1. pmc Formalin fixation at low temperature better preserves nucleic acid integrity
    Gianni Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    PLoS ONE 6:e21043. 2011
    ..In conclusion, CF preserves tissues and nucleic acids, enabling reliable gene expression profiling of fixed tissues...
  2. pmc Current Challenges for HER2 Testing in Diagnostic Pathology: State of the Art and Controversial Issues
    Anna Sapino
    Department of Medical Sciences, University of Turin Turin, Italy
    Front Oncol 3:129. 2013
    ..We will focus on the HER2 gene and on the protein, both at technical and interpretational levels...
  3. ncbi MammaPrint Molecular Diagnostics on Formalin-Fixed, Paraffin-Embedded Tissue
    Anna Sapino
    Department of Medical Sciences, University of Turin, Turin, Italy Electronic address
    J Mol Diagn 16:190-7. 2014
    ..Thus, with 580 tumor samples, MammaPrint was successfully translated to FFPE tissue. The assay has high precision and reproducibility, and FFPE results are substantially equivalent to results derived from fresh tissue. ..
  4. pmc Trastuzumab with either docetaxel or vinorelbine as first-line treatment for patients with HER2-positive advanced breast cancer: a retrospective comparison
    Stefania Redana
    Institute for Cancer Research and Treatment, Division of Medical Oncology, Candiolo Italy
    BMC Cancer 10:28. 2010
    ..We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations...
  5. ncbi Patients with advanced stage breast carcinoma immunoreactive to biotinylated Herceptin are most likely to benefit from trastuzumab-based therapy: an hypothesis-generating study
    A Sapino
    Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino, Torino, Italy
    Ann Oncol 18:1963-8. 2007
    ..We previously showed that BiotHER immunoreactivity is highly correlated with HER2 amplification and indicated that it could be associated with better clinical outcome in advanced breast cancer patients receiving trastuzumab...
  6. pmc Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Turin Medical School, Turin, Italy
    Am J Pathol 163:1313-20. 2003
    ..Taken together, these results open new perspectives on the effects of sex steroids and their antagonists on the human response in cancer and inflammation...
  7. ncbi Which breast carcinomas need HER-2/neu gene study after immunohistochemical analysis? Results of combined use of antibodies against different c-erbB2 protein domains
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Torino Medical School, Italy
    Histopathology 43:354-62. 2003
    ..Evaluation of HER2 gene amplification in breast cancers is a compelling, routine procedure. The aim of this work was to evaluate which breast carcinomas would really benefit from HER-2/neu gene analysis...
  8. ncbi Clinical significance of neuroendocrine carcinoma of the breast
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S115-7. 2001
    ..In the present work, the clinical significance of pure' NE differentiation in breast carcinoma and of its 'variants' will be analyzed...
  9. pmc Ultrasonographically-guided fine-needle aspiration of axillary lymph nodes: role in breast cancer management
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Br J Cancer 88:702-6. 2003
    ..This presurgical protocol is reliable for screening patients with LN metastases that should proceed directly to axillary dissection or adjuvant chemotherapy, thus avoiding sentinel lymph node biopsy...
  10. ncbi Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Torino, Torino, Italy
    Mod Pathol 19:599-606. 2006
    ..Conversely, the older age of patients with ER-beta-rich phyllodes tumors suggests that mechanisms, probably independent from estrogen stimulation, act on the growth of these tumors...
  11. ncbi Routine assessment of prognostic factors in breast cancer using a multicore tissue microarray procedure
    Anna Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, and Division of Pathology, Vito Fazzi Hospital, Lecce, Italy
    Virchows Arch 449:288-96. 2006
    ..In conclusion, multicore TMA may be an efficient approach in the routine study of prognostic factors in breast cancer, significantly reducing costs, time, and burden of slides necessary to accomplish these mandatory tests...
  12. ncbi Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Mod Pathol 14:768-76. 2001
    ..In addition, the possibility for using Chs or GCDFP-15 serum values in the follow-up of these patients, as demonstrated in two cases of the present series, can justify the immunophenotyping of the tumors...
  13. ncbi Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Torino Medical School, Torino, Italy
    J Pathol 194:254-61. 2001
    ..CD31 expression mainly correlates with tumour cells spreading within the ductal system. Finally, the invasive phenotype requires the co-expression of CD31 and CD44...
  14. doi Technical limits of comparison of step-sectioning,immunohistochemistry and RT-PCR on breast cancer sentinel nodes: a study on methacarn-fixed tissue
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Cell Mol Med 13:4042-50. 2009
    ..We believe that only prospective studies with quantitative mRNA analysis of specific metastatic markers on the whole lymph node can elucidate the utility of molecular assessments of SLN...
  15. ncbi Oxytocin induces proliferation and migration in immortalized human dermal microvascular endothelial cells and human breast tumor-derived endothelial cells
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Mol Cancer Res 4:351-9. 2006
    ..Altogether, these data indicate that oxytocin contributes to cell motility and growth in HMEC and B-TEC...
  16. ncbi Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Int J Oncol 21:375-8. 2002
    ..This is the first evidence that OT modulates the expression of ERalpha receptors in human neoplastic cells...
  17. doi Added value of combined gene and protein expression of CK20 and CEA in non-macroscopically involved lymph nodes of colorectal cancer
    Giuseppe D'Armento
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Int J Surg Pathol 17:93-8. 2009
    ..This approach offers a technological framework for further studies that aim to validate the clinical significance of protein/mRNA expression of tumor markers in colorectal cancer sentinel lymph nodes...
  18. ncbi Neuroendocrine differentiation in breast cancer: established facts and unresolved problems
    Luisella Righi
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Semin Diagn Pathol 27:69-76. 2010
    ..The clinical effect of neuroendocrine breast cancer is still a matter of debate; however, when compared with unselected breast cancers, NEBCs show a less aggressive clinical behavior...
  19. doi Neoadjuvant chemo-radiotherapy for locally advanced esophageal cancer: a monocentric study
    Marina Schena
    Department of Onco Hematology, Oncology Unit, San Giovanni Battista Hospital, Turin, Italy
    Tumori 98:451-7. 2012
    ....
  20. pmc Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells
    Luisella Righi
    Department of Genetics, Biology, and Biochemistry, Laboratory of Immunogenetics, University of Torino Medical School, Torino, Italy
    Am J Pathol 162:1163-74. 2003
    ..In conclusion, CD31 expression reverts the undifferentiated morphology and aggressive behavior of MDA-MB-231 cells, indicating its active role in the morphogenesis of breast ductal in situ carcinomas...
  21. doi Retrospective evaluation of clinical outcomes in patients with HER2-positive advanced breast cancer progressing on trastuzumab-based therapy in the pre-lapatinib era
    Filippo Montemurro
    Divisione di Oncologia Medica, Istituto per la Ricerca e la Cura del Cancro, Candiolo, Torino, Italy
    Clin Breast Cancer 8:436-42. 2008
    ..We sought to retrospectively compare the clinical outcomes of patients who, upon progression during an initial trastuzumab-based regimen, stopped or continued trastuzumab in addition to further chemotherapy...
  22. doi Gefitinib (ZD1839): therapy in selected patients with non-small cell lung cancer (NSCLC)?
    Diego Dongiovanni
    Medical Oncology, Centro Oncologico Ematologico Subalpino C O E S, Azienda Ospedaliera S Giovanni Battista, Turin, Italy
    Lung Cancer 61:73-81. 2008
    ....
  23. doi Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro
    Tracy A Williams
    Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
    Hypertension 55:1468-75. 2010
    ....
  24. doi Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines
    Daniele Recupero
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, Turin, Italy
    J Pathol 229:390-9. 2013
    ..Our data suggest that a reduction of the receptor steric hindrance as induced by enzymatic shedding may facilitate the binding capacity of trastuzumab...
  25. doi Epidermal growth factor receptor gene in primary tumor and metastatic sites from non-small cell lung cancer
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Thorac Oncol 4:684-8. 2009
    ..Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are capable of reducing brain and adrenal metastases. However, the EGFR status may be discordant between primary NSCLC and the corresponding metastases...
  26. doi Imatinib inhibits in vitro proliferation of cells derived from a pleural solitary fibrous tumor expressing platelet-derived growth factor receptor-beta
    Marco Prunotto
    Department of Biomedical Science and Human Oncology, University of Turin, Italy
    Lung Cancer 64:244-6. 2009
    ..With the limit of experimental findings, our results support a possible future application of imatinib as a candidate molecule in the target therapy of malignant SFTs over-expressing wild-type PDGFR...
  27. doi Micropapillary ductal carcinoma in situ of the breast: an inter-institutional study
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Mod Pathol 23:260-9. 2010
    ....
  28. ncbi Accuracy of mammography, digital breast tomosynthesis, ultrasound and MR imaging in preoperative assessment of breast cancer
    Giovanna Mariscotti
    Breast Imaging Service, Institute of Diagnostic and Interventional Radiology, University of Turin, Department of Diagnostic Imaging, Città della Salute e della Scienza Hospital, Via Genova 3, 10126 Turin, Italy
    Anticancer Res 34:1219-25. 2014
    ..To define the accuracy of digital breast tomosynthesis (DBT) and magnetic resonance imaging (MRI) added to digital mammography (DM) and ultrasound (US) in the preoperative assessment of breast cancer...
  29. ncbi Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodies
    Ada Funaro
    Department of Genetics, Biology and Biochemistry and Research Center for Experimental Medicine, University of Torino, Torino 10126, Italy
    J Clin Endocrinol Metab 88:5537-46. 2003
    ..This observation suggests that the mAb recognizes an epitope that is included in the domain of the receptor involved in the interaction with the natural ligand...
  30. ncbi Oxytocin synthesis within the normal and neoplastic breast: first evidence of a local peptide source
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Int J Oncol 28:1263-8. 2006
    ..These data altogether suggest the existence of a local OT source within the normal as well as within the neoplastic breast, and that such synthesis can be modulated by E2...
  31. doi Approaching heterogeneity of human epidermal growth factor receptor 2 in surgical specimens of gastric cancer
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, University of Turin, and Onco Haematological Department, Oncology Unit, S Giovanni Battista Hospital, 10126 Turin, Italy
    Hum Pathol 43:2070-9. 2012
    ..57). In conclusion, testing more than 1 tissue block of cancer from specimens of gastric resection provides a more reliable human epidermal growth factor receptor 2 assessment regardless of the antibody used...
  32. pmc Underuse of anthracyclines in women with HER-2+ advanced breast cancer
    Filippo Montemurro
    Division of Medical Oncology I, Fondazione del Piemonte per L Oncologia, Institute for Cancer Research and Treatment, 10060 Candiolo, Torino, Italy
    Oncologist 15:665-72. 2010
    ..A role for these compounds should be redefined in this patient subset...
  33. pmc Endothelial cell differentiation of human breast tumour stem/progenitor cells
    Benedetta Bussolati
    Department of Internal Medicine, Molecular Biotechnology Center and Research Center for Experimental Medicine, University of Torino, Italy
    J Cell Mol Med 13:309-319. 2009
    ....
  34. pmc Are breast cancer molecular classes predictive of survival in patients with long follow-up?
    Danae Pracella
    Department of Medical Sciences, Cattinara Hospital, Strada di Fiume 447, 34149 Trieste, Italy
    Dis Markers 35:595-605. 2013
    ..In conclusion, in our experience ER-positive breast tumors are better divided by classical clinical stage than molecular classification, and they need longer clinical follow-up especially in cases with lymph node involvement...
  35. pmc A collection of primary tissue cultures of tumors from vacuum packed and cooled surgical specimens: a feasibility study
    Laura Annaratone
    Department of Medical Sciences, University of Turin, Turin, Italy
    PLoS ONE 8:e75193. 2013
    ....
  36. doi Accuracy of tumour size assessment in the preoperative staging of breast cancer: comparison of digital mammography, tomosynthesis, ultrasound and MRI
    Andrea Luparia
    Istituto di Radiologia Diagnostica ed Interventistica, Universita di Torino, A O U S Giovanni Battista di Torino, Sede Molinette, Via Genova 3, 10126, Torino, Italy
    Radiol Med 118:1119-36. 2013
    ..We compared the accuracy of digital mammography (DM), digital breast tomosynthesis (DBT), ultrasound (US) and magnetic resonance imaging (MRI) for the preoperative evaluation of breast cancer size...
  37. pmc Vinorelbine-based salvage therapy in HER2-positive metastatic breast cancer patients progressing during trastuzumab-containing regimens: a retrospective study
    Filippo Montemurro
    Divisione di Oncologia Medica, AO Ordine Mauriziano Istituto per la Ricerca e la Cura del Cancro, Candiolo, Torino, Italy
    BMC Cancer 8:209. 2008
    ..We sought to document the clinical activity of vinorelbine-based salvage treatments in this clinical setting...
  38. ncbi Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem
    Gianni Bussolati
    Department of Biomedical Science and Human Oncology, University of Torino, Via Santena, Torino, Italy
    J Cell Mol Med 12:209-18. 2008
    ..Decoration of the NE might thus be regarded as a novel diagnostic parameter to define the grade of malignancy, which parallels and enhances that provided by routine histological procedures...
  39. ncbi Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, 10126 Turin, Italy
    Oncol Rep 19:1271-5. 2008
    ..These data suggest that the HER2 FISH analysis may be an effective screening test in breast cancer metastases and G3 tumors, irrespective of the hormone receptor status or presence of lymphovascular invasion...
  40. ncbi Evidence of oxytocin/oxytocin receptor interplay in human prostate gland and carcinomas
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena, I 10126 Torino, Italy
    Int J Oncol 25:899-904. 2004
    ..Altogether, the data indicate that the OT/OTR system could be involved in the control of prostate neoplastic pathology...
  41. pmc A "weighted" fluorescence in situ hybridization strengthens the favorable prognostic value of 1p/19q codeletion in pure and mixed oligodendroglial tumors
    Rebecca Senetta
    Department of Medical Sciences, University of Turin, Turin, Italy
    J Neuropathol Exp Neurol 72:432-41. 2013
    ..7 ratio cutoff) and 19q (using 0.8 ratio cutoff) arms, we created a molecular report that bears higher clinical impact and strengthens the prognostic potential of 1p/19q allelic loss...
  42. pmc High-throughput molecular analysis from leftover of fine needle aspiration cytology of mammographically detected breast cancer
    Laura Annaratone
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Transl Oncol 5:180-9. 2012
    ..These findings show that cells residual to cytologic smears of FNA are suitable for obtaining high-quality RNA for high-throughput analysis even when taken from small nonpalpable breast lesions...
  43. doi Obstructive colon metastases from lobular breast cancer: report of a case and review of the literature
    Massimiliano Mistrangelo
    Department of Digestive and Colorectal Surgery, Center of Minimally Invasive Surgery, University of Turin, Molinette Hospital, Corso A M Dogliotti 14, Turin, Italy
    Tumori 97:800-4. 2011
    ..Here we report a case of bowel obstruction caused by sigmoid metastases from breast cancer and describe its relevance to histological origin and clinical practice...
  44. doi Reliability of whole sentinel lymph node analysis by one-step nucleic acid amplification for intraoperative diagnosis of breast cancer metastases
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Ann Surg 255:334-42. 2012
    ..To assess the reliability of using the One-Step Nucleic Acid Amplification (OSNA) assay as a single test on whole sentinel lymph nodes (SLN) as a method of intraoperative diagnosis and staging of SLNs in breast cancer...
  45. doi The pathologic complete response open question in primary therapy
    Caterina Marchio
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin 10126, Italy
    J Natl Cancer Inst Monogr 2011:86-90. 2011
    ..Residual isolated tumor cells in primary tumor and in lymph nodes do not affect patient outcome...
  46. doi Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, Italy
    Breast Cancer Res Treat 124:607-17. 2010
    ..017, HR 0.521, 95%CI 0.306-0.888) and DSS (P = 0.001, HR 0.276, 95% CI 0.130-0.588). AR expression is an independent prognostic factor of better outcome in patients with ER-positive breast cancers...
  47. ncbi Isolation and characterization of human breast tumor-derived endothelial cells
    Cristina Grange
    Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy
    Oncol Rep 15:381-6. 2006
    ..Moreover, our data suggest that TEC might be more appropriate for screening antiangiogenic drugs than normal endothelial cells...
  48. doi "To be or not to be in a good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer
    Gianni Bussolati
    Department of Medical Sciences, University of Turin, Via Santena 7, 10126, Turin, Italy
    Adv Exp Med Biol 773:101-21. 2014
    ....
  49. ncbi p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis
    Sara Cabodi
    Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Cancer Res 66:4672-80. 2006
    ..Its overexpression contributes to HER2-Neu-induced breast tumorigenesis, thus identifying this protein as a putative target for clinical therapy...
  50. doi HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib
    Giorgio Valabrega
    Department of Oncological Sciences, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, TO, Italy
    Breast Cancer Res Treat 130:29-40. 2011
    ..We provide preclinical evidence that tumor cells resistant to trastuzumab and lapatinib may rely on HER2 independent pathways that can be efficiently inhibited by sorafenib...
  51. doi International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010)
    Alfredo Berruti
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Azienda Ospedaliera Universitaria San Luigi di Orbassano, Orbassano, Italy
    J Natl Cancer Inst Monogr 2011:147-51. 2011
    ..Changes in tumor biology after PST are an early phenomenon; so, an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials...
  52. pmc HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast
    Sophie Doublier
    Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena, 5 bis, 10126 Turin, Italy
    BMC Cancer 12:4. 2012
    ..To investigate whether hypoxia-inducible factor-1 (HIF-1) activation may be related to the drug resistance described in this tumor, we used MCF7 cancer cells cultured as 3-D spheroids, which morphologically simulate IMPC cell clusters...
  53. doi Columnar cell lesions associated with breast calcifications on vacuum-assisted core biopsies: clinical, radiographic, and histological correlations
    Rebecca Senetta
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Mod Pathol 22:762-9. 2009
    ....
  54. ncbi Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
    Silvia Deaglio
    Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry, the Experimental Medicine Research Center, University of Turin Medical School, Italy
    Blood 100:3782-9. 2002
    ..The tissue distribution pattern, the behavior following exposure to iron-loaded TF, and the features of the disease resulting from TFR-2 inactivation support the hypothesis that TFR-2 contributes to body iron sensing...
  55. ncbi Predicting gefitinib responsiveness in lung cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Mol Cancer Ther 6:1223-9. 2007
    ....
  56. ncbi Heterogeneous versus homogeneous genetic nature of multiple foci of in situ carcinoma of the breast
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Hum Pathol 34:1163-9. 2003
    ..Such a small subgroup of in situ cancers affecting diffusely the entire breast and originating from independent foci presents both clinical and pathogenetic interest...
  57. doi Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    Mol Nutr Food Res 54:S31-41. 2010
    ....
  58. ncbi [Rapid immunohistochemistry applied to intraoperative diagnosis: a critical analysis]
    L Viberti
    Sezione di Anatomia Patologica, Dipartimento di Scienze Biomediche e Oncologia Umana, , Via Santena 7, I-10126 Torino, Italia
    Pathologica 93:544-8. 2001
    ..Rapid IS method was performed using routine reagents and was not repeated on formalin-fixed, paraffin-embedded sections of the same cases, thus avoiding additional costs...
  59. ncbi Cytomorphologic and molecular features of hobnail variant of papillary thyroid carcinoma: case series and literature review
    Sofia Asioli
    Department of Medical Sciences, University of Turin, Torino, Italy
    Diagn Cytopathol 42:78-84. 2014
    ..Immunohistochemical and molecular results were confirmed on histological sections. Recognizing the unique cytological features of HPTC should help to avoid misdiagnosis of this rare variant...
  60. doi Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma
    Luisella Righi
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Turin, Italy
    Virchows Arch 460:415-21. 2012
    ..0062). hASH-1 expression occurs in breast cancers with NE differentiation regardless of the extent of the NE cell population, and it is restricted to a subset of tumor cells having a low proliferative potential...
  61. ncbi Anti-HER2 treatment and breast cancer: state of the art, recent patents, and new strategies
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Recent Pat Anticancer Drug Discov 4:9-18. 2009
    ..This review will focus on patents that target HER2 in anti-cancer treatment...
  62. ncbi Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case
    Donatella Pacchioni
    Department of Biomedical Science, University of Turin, Italy
    Am J Surg Pathol 31:632-6. 2007
    ..A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed...
  63. ncbi Audit system on Quality of breast cancer diagnosis and Treatment (QT): results of quality indicators on screen-detected lesions in Italy for 2006 and preliminary results for 2007
    Mariano Tomatis
    CPO Piemonte, Torino, Italy
    Epidemiol Prev 33:83-90. 2009
    ..Specialist Breast Units with adequate case volume and enough resources would provide the best setting for making audit effective in producing quality improvement with a shortening of waiting times...
  64. ncbi Steroid hormone receptor in pleural solitary fibrous tumours and CD34+ progenitor stromal cells
    Massimo Bongiovanni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    J Pathol 198:252-7. 2002
    ....
  65. doi Radical resection of a giant, invasive and symptomatic malignant Solitary Fibrous Tumour (SFT) of the pleura
    Pier Luigi Filosso
    University of Torino Italy, Department of Thoracic Surgery, San Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    Lung Cancer 64:117-20. 2009
    ..The case of a giant, invasive, radically resected malignant SFT, is described. The role of postoperative radiotherapy, to reduce the risk of recurrence, is also discussed...
  66. ncbi Quantitative detection of HHV-6 and HHV-7 in transbronchial biopsies from lung transplant recipients
    Cristina Costa
    Virology Unit, University Hospital San Giovanni Battista di Torino, Italy
    New Microbiol 34:275-80. 2011
    ..The finding of HHV-6 and/or HHV-7-DNA positivity in all the cases with ischemia-reperfusion injury suggests a possible role in favouring ?-herpesviruses reactivation, as previously described for HCMV in renal transplantation...
  67. ncbi Is detection of endocrine cells in breast adenocarcinoma of diagnostic and clinical significance?
    A Sapino
    Department of Biomedical Sciences and Human Oncology University of Torino, Torino, Italy
    Histopathology 40:211-4. 2002
  68. ncbi Oxytocin and oxytocin receptors in cancer cells and proliferation
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    J Neuroendocrinol 16:362-4. 2004
    ....
  69. ncbi Assessment of necrosis and hypoxia in ductal carcinoma in situ of the breast: basis for a new classification
    G Bussolati
    Department of Biomedical Sciences and Oncology, University of Torino, Italy
    Virchows Arch 437:360-4. 2000
    ....
  70. ncbi Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1738-45. 2001
    ..In conclusion, this study provides the first demonstration of specific GHS binding sites, other than GHS-R1, in breast cancer. These receptors probably mediate growth inhibitory effects on breast carcinoma cells in vitro...
  71. ncbi Biological relevance of oxytocin and oxytocin receptors in cancer cells and primary tumors
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S37-9. 2001
    ....
  72. ncbi Large cell neuroendocrine carcinoma of the gallbladder: report of two cases
    M Papotti
    Department of Pathology, University of Turin, Italy
    Am J Surg Pathol 24:1424-8. 2000
    ..More importantly, however, the recognition of this rare tumor type carries important clinical implications in regard to the use of chemotherapeutic agents and supplemental treatments (for example, somatostatin analogs)...
  73. pmc A modified Trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    Br J Cancer 92:1261-7. 2005
    ..Biotinylated Trastuzumab can thus be used for immunohistochemical detection of HER-2 overexpression in breast cancer, and has the potential to identify patients likely to benefit from Trastuzumab treatment...
  74. ncbi Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Cancer Res 62:2406-13. 2002
    ....
  75. ncbi Prognostic significance of the expression of immunohistochemically detectable differentiation markers in laryngeal carcinomas
    G Cortesina
    Clinica Otorinolaringoiatrica, , Italy
    Tumori 75:478-82. 1989
    ..This study indicates that the combined use of morphologic and biologic (immunohistochemical) criteria may constitute an independent parameter of primary importance in predicting the evolution of laryngeal carcinomas...
  76. pmc Inflammatory bowel disease: A proposal to facilitate the achievement of an unequivocal diagnosis
    Gabriella Canavese
    Gabriella Canavese, Isabella Castellano, Paola Cassoni, Anna Sapino, III Service of Pathology, Department of Laboratory Diagnosis, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Department of Medical Sciences, University of Torino, 10100 Torino, Italy
    World J Gastroenterol 19:426-8. 2013
    ..This new terminology could avoid ambiguous expressions that encourage the clinician to classify the patient as affected by IBD without fulfilling all of the requirements for an accurate diagnostic approach...
  77. ncbi A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
    Andrea Bertotti
    Laboratory of Molecular Pharmacology, Division of Surgical Oncology, Unit of Pathology, Institute for Cancer Research and Treatment, Torino, Italy
    Cancer Discov 1:508-23. 2011
    ..Our results suggest promising therapeutic opportunities in cetuximab-resistant patients with metastatic colorectal cancer, whose medical treatment in the chemorefractory setting remains an unmet clinical need...
  78. ncbi Calorie restriction protects against age-related rat aorta sclerosis
    Laura Castello
    Department of Clinical and Biological Sciences, University of Turin, Italy
    FASEB J 19:1863-5. 2005
    ..The protection exerted by CR against fibrosclerosis might be due to a decrease of oxidative stress, with consequent decreased MAPK activity and down-regulation of AP-1 activation and of TGFbeta1 expression and signaling...
  79. ncbi Lymphoscintigraphic localization of sentinel node in early colorectal cancer: results of a monocentric study
    Sergio Sandrucci
    Oncologic Surgery, S Giovanni Battista Hospital, University of Turin, Turin, Italy
    J Surg Oncol 96:464-9. 2007
    ..Evaluation of the feasibility of the sentinel node technique in early colorectal neoplasms and its overall accuracy in predicting nodal metastases...
  80. ncbi 34betaE12 cytokeratin immunodetection in the differential diagnosis of neuroendocrine carcinomas of the breast
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Appl Immunohistochem Mol Morphol 9:229-33. 2001
    ..HMW CK can be added to the list of markers useful in the differential diagnosis of NE from non-NE tumors...
  81. ncbi Discriminating between micrometastases and isolated tumor cells in a regional and institutional setting
    G Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Nyiri ut 38, 6000 Kecskemét, Hungary, and Department of Biological Science and Human Oncology, University of Turin, Italy
    Breast 15:347-54. 2006
    ....
  82. doi p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation
    L Damiano
    Molecular Biotechnology Centre and Department of Genetics, Biology and Biochemistry, Torino, Italy
    Oncogene 29:3677-90. 2010
    ..Therefore, p140Cap mechanistically behaves as a tumour suppressor that inhibits signalling pathways leading to aggressive phenotypes...
  83. ncbi Prostatic duct carcinoma with combined prostatic duct adenocarcinoma and urothelial carcinoma features: report of a case
    D Pacchioni
    Department of Urologic Pathology, University of Turin, Italy
    Int J Surg Pathol 12:293-7. 2004
    ..The proliferation index was high (60%), and p53 was diffusely expressed (55%). The incidence and significance of PDC with combined features is discussed with reference to literature data...
  84. ncbi A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling
    C Marchio
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    Histopathology 48:556-62. 2006
    ..To reveal architectural structure and growth patterns of tubular carcinomas (TC) and tubulo-lobular carcinomas (TLC) of the breast...
  85. ncbi Ex vivo host response to gastrointestinal cancer cells presented by autologous dendritic cells
    A Galetto
    Department of Oncology, Unity of Oncological Surgery, Azienda Ospedaliera San Giovanni, Turin, Italy
    J Surg Res 100:32-8. 2001
    ..A DC-based antitumor immunological monitoring assay with autologous tumor biopsies may allow patients to be screened to determine those who are suitable candidates for immune-based immunotherapy...
  86. ncbi Sentinel lymph node biopsy in staging small (up to 15 mm) breast carcinomas. Results from a European multi-institutional study
    Gabor Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Kecskemet, H 6000, Hungary
    Pathol Oncol Res 13:5-14. 2007
    ..With macrometastases the risk of non-SLN involvement increases, and further axillary treatment should be generally indicated...
  87. ncbi Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis
    Gabor Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Nyiri ut 38, H 6000 Kecskemet, Hungary
    Eur J Cancer 43:1407-14. 2007
    ..The opposite presentation of these factors would mandate SLN biopsy and axillary dissection, respectively...
  88. ncbi Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients
    Gabor Cserni
    Department of Surgical Pathology, Bacs Kiskun County Teaching Hospital, Nyiri ut 38, H 6000 Kecskemet, Hungary
    Am J Surg 194:288-93. 2007
    ..Two recently developed clinical prediction rules aim to anticipate the lack of nonsentinel lymph node metastases and the involvement of less than 4 lymph nodes in breast cancer patients with positive sentinel lymph nodes (SLNs)...
  89. ncbi Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance
    Eswaran Devarajan
    Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:8843-51. 2002
    ..These results suggest that the loss of caspases-3 expression may represent an important cell survival mechanism in breast cancer patients...
  90. ncbi Audit system on quality of breast cancer diagnosis and treatment (QT): results of quality indicators on screen-detected lesions in Italy in 2005 and preliminary results for 2006
    Maria Piera Mano
    CPO Piemonte, Torino
    Epidemiol Prev 32:77-84. 2008
    ..Specialist Breast Units with adequate case volume would provide the best setting for making audit effective in producing quality improvement...
  91. ncbi Audit system on quality of breast cancer diagnosis and treatment (QT): results from the survey on screen-detected lesions in Italy, 2004
    Antonio Ponti
    CPO Piemonte, Torino
    Epidemiol Prev 31:69-75. 2007
    ..Specialist Breast Units with adequate case volumes would provide the best setting for effective audits leading to quality improvement...
  92. ncbi Bronchiolar columnar cell dysplasia--genetic analysis of a novel preneoplastic lesion of peripheral lung
    Reinhard Ullmann
    Laboratory of Molecular Cytogenetics, Institute of Pathology, Auenbruggerplatz 25, 8036, Graz, Austria
    Virchows Arch 442:429-36. 2003
    ..Summarizing our data from morphological and genetic analysis, we conclude that BCCD is a preneoplasia of the bronchiolar epithelium and most probably represents an additional precursor lesion of lung adenocarcinomas...
  93. ncbi Early diagnosis, not differential treatment, explains better survival in service screening
    Eugenio Paci
    Unit of Clinical and Descriptive Epidemiology, Centre for Study and Prevention of Cancer, Research Institute of Tuscany Region, Via di San Salvi 12, 50125 Firenze, Florence, Italy
    Eur J Cancer 41:2728-34. 2005
    ..The survival analysis by specific subgroups did not support the hypothesis that the difference in prognosis was attributable to differential treatment...
  94. ncbi Insulated-tip knife endoscopic mucosal resection of large colorectal polyps unsuitable for standard polypectomy
    Alessandro Repici
    Department of Gastroenterology, IRCCS Istituto Clinico Humanitas, Milano, Italy
    Am J Gastroenterol 102:1617-23. 2007
    ..This study was conducted to evaluate the safety and efficacy in obtaining en bloc resection with It-knife EMR of large colonic lesions not resectable with standard endoscopic techniques...