Pierachille Santus

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc Pulmonary Rehabilitation in COPD: A Reappraisal (2008-2012)
    Pierachille Santus
    Dipartimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri, Istituto Scientifico di Milano IRCCS, Universita degli Studi di Milano, 20138 Milan, Italy
    Pulm Med 2013:374283. 2013
  2. pmc How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan
    Pierachille Santus
    Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Respiratory Unit, San Paolo Hospital, Milan, Italy
    Respir Res 13:95. 2012
  3. ncbi request reprint Varenicline and evaluated outcomes in smoking cessation programmes
    P Santus
    Universita degli Studi di Milano, Dipartimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri, Istituto Scientifico di Milano, IRCCS, Milano, Italy
    Monaldi Arch Chest Dis 79:20-6. 2013
  4. ncbi request reprint General practitioners and management of patients with respiratory diseases in a real life survey
    P Santus
    Department of Health Sciences, Rehabilitation Pneumology, Salvatore Maugeri Foundation, Scientific Rehabilitation Institute, Universita degli Studi di Milano, Milan, Italy
    Panminerva Med 54:293-8. 2012
  5. doi request reprint Doctor-patient relationship: a resource to improve respiratory diseases management
    Pierachille Santus
    Universita degli Studi di Milano, Diaprtimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri, Istituto Scientifico di Riabilitazione di Milano IRCCS, Via Camaldoli 64, 20138 Milano, Italy
    Eur J Intern Med 23:442-6. 2012
  6. doi request reprint Tiotropium: what came after the UPLIFT study
    Pierachille Santus
    Universita degli Studi di Milano, Pneumologia Riabilitativa Fondazione Salvatore Maugeri, Istituto Scientifico di Riabilitazione di Milano IRCCS, Via Camaldoli, 64, 20152 Milano, Italy
    Expert Opin Pharmacother 13:613-8. 2012
  7. doi request reprint Safety and pharmacological profile of tiotropium bromide
    Pierachille Santus
    Universita degli Studi di Milano, Clinica di Malattie dell Apparato Respiratorio, U O Pneumologia, Ospedale San Paolo, Via A Di Rudini, 8, 20142 Milano, Italy
    Expert Opin Drug Saf 8:387-95. 2009
  8. ncbi request reprint Effect of inhaled combination therapy on asthma management
    P Santus
    Institute of Lung Disease, Respiratory Unit, San Paolo Hospital, University of Milan, Italy
    Int J Clin Pharmacol Res 25:57-63. 2005
  9. ncbi request reprint Tiotropium is less likely to induce oxygen desaturation in stable COPD patients compared to long-acting beta2-agonists
    Pierachille Santus
    Unit of Respiratory Medicine, University of Milan, S Paolo Hospital, Milan, Italy
    Respir Med 101:1798-803. 2007
  10. doi request reprint Salmeterol improves fluid clearance from alveolar-capillary membrane in COPD patients: a pilot study
    Fabiano Di Marco
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, Universita degli Studi di Milano, Ospedale San Paolo, Via Antonio Di Rudini 8, 20142 Milan, Italy
    Pulm Pharmacol Ther 25:119-23. 2012

Detail Information

Publications39

  1. pmc Pulmonary Rehabilitation in COPD: A Reappraisal (2008-2012)
    Pierachille Santus
    Dipartimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri, Istituto Scientifico di Milano IRCCS, Universita degli Studi di Milano, 20138 Milan, Italy
    Pulm Med 2013:374283. 2013
    ..This would in turn increase the effectiveness of pulmonary rehabilitation in COPD patients...
  2. pmc How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan
    Pierachille Santus
    Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Respiratory Unit, San Paolo Hospital, Milan, Italy
    Respir Res 13:95. 2012
    ..We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy...
  3. ncbi request reprint Varenicline and evaluated outcomes in smoking cessation programmes
    P Santus
    Universita degli Studi di Milano, Dipartimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri, Istituto Scientifico di Milano, IRCCS, Milano, Italy
    Monaldi Arch Chest Dis 79:20-6. 2013
    ..No study has evaluated lung function. This marker could be very important as a way of evaluating, objectively, an improvement in lung function, which correlates also with subjective parameters, as dyspnea and fatigue...
  4. ncbi request reprint General practitioners and management of patients with respiratory diseases in a real life survey
    P Santus
    Department of Health Sciences, Rehabilitation Pneumology, Salvatore Maugeri Foundation, Scientific Rehabilitation Institute, Universita degli Studi di Milano, Milan, Italy
    Panminerva Med 54:293-8. 2012
    ..Aim of this study was to obtain General Practitioners (GPs) data about management and clinical setting of patients with respiratory diseases...
  5. doi request reprint Doctor-patient relationship: a resource to improve respiratory diseases management
    Pierachille Santus
    Universita degli Studi di Milano, Diaprtimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri, Istituto Scientifico di Riabilitazione di Milano IRCCS, Via Camaldoli 64, 20138 Milano, Italy
    Eur J Intern Med 23:442-6. 2012
    ..The aim of the present study was to evaluate patient's viewpoint about the different aspects involved in their respiratory diseases...
  6. doi request reprint Tiotropium: what came after the UPLIFT study
    Pierachille Santus
    Universita degli Studi di Milano, Pneumologia Riabilitativa Fondazione Salvatore Maugeri, Istituto Scientifico di Riabilitazione di Milano IRCCS, Via Camaldoli, 64, 20152 Milano, Italy
    Expert Opin Pharmacother 13:613-8. 2012
    ..Tiotropium is an anticholinergic drug that is proved to be safe, efficient and simple to handle; Respimat® technology was recently introduced as a new device for tiotropium administration...
  7. doi request reprint Safety and pharmacological profile of tiotropium bromide
    Pierachille Santus
    Universita degli Studi di Milano, Clinica di Malattie dell Apparato Respiratorio, U O Pneumologia, Ospedale San Paolo, Via A Di Rudini, 8, 20142 Milano, Italy
    Expert Opin Drug Saf 8:387-95. 2009
    ..Tiotropium is a bronchodilator of recent introduction. Objective: To discuss the clinical data on the safety and efficacy of tiotropium, a very long-acting antimuscarinic drug, available at present...
  8. ncbi request reprint Effect of inhaled combination therapy on asthma management
    P Santus
    Institute of Lung Disease, Respiratory Unit, San Paolo Hospital, University of Milan, Italy
    Int J Clin Pharmacol Res 25:57-63. 2005
    ....
  9. ncbi request reprint Tiotropium is less likely to induce oxygen desaturation in stable COPD patients compared to long-acting beta2-agonists
    Pierachille Santus
    Unit of Respiratory Medicine, University of Milan, S Paolo Hospital, Milan, Italy
    Respir Med 101:1798-803. 2007
    ..Since the three agents were similar in inducing bronchodilation, we believe that tiotropium is preferable in patients with hypoxemia caused by stable COPD because it seems to carry a smaller risk of worsening systemic hypoxemia...
  10. doi request reprint Salmeterol improves fluid clearance from alveolar-capillary membrane in COPD patients: a pilot study
    Fabiano Di Marco
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, Universita degli Studi di Milano, Ospedale San Paolo, Via Antonio Di Rudini 8, 20142 Milan, Italy
    Pulm Pharmacol Ther 25:119-23. 2012
    ....
  11. doi request reprint Close correlation between anxiety, depression, and asthma control
    Fabiano Di Marco
    Clinica di Malattie dell Apparato Respiratorio, Ospedale San Paolo, Universita degli Studi di Milano, Milano, Italy
    Respir Med 104:22-8. 2010
    ..We investigated the correlation between patients' characteristics, including anxiety and depression, and the level of asthma control evaluated by asthma control test (ACT), a self-administered validated questionnaire...
  12. doi request reprint Effect of enalapril on exercise cardiopulmonary performance in chronic obstructive pulmonary disease: A pilot study
    Fabiano Di Marco
    Clinica di Malattie dell Apparato Respiratorio, Ospedale San Paolo, Università degli Studi di, 20142 Milano, Italy
    Pulm Pharmacol Ther 23:159-64. 2010
    ..Secondary outcomes were exercise variables evaluated by the cardiopulmonary exercise test, and pulmonary function according to ACE genotyping...
  13. doi request reprint Budesonide/formoterol dry powder in asthma: an option for control as maintenance and reliever therapy
    Pierachille Santus
    Universita degli Studi di Milano, Dipartimento Toracopolmonare e Cardiocircolatorio, Fondazione Salvatore Maugeri IRCCS, Pneumologia Riabilitativa Istituto Scientifico di Milano, Via Camaldoli 64, 20138 Milan, Italy
    Expert Opin Pharmacother 11:257-67. 2010
    ..Asthma is a heterogeneous disease with various components that may contribute to symptoms. Obtaining global control of is one of the fundamental parts of the management of this disease...
  14. doi request reprint Bronchodilators modulate inflammation in chronic obstructive pulmonary disease subjects
    Pierachille Santus
    Universita degli Studi di Milano, Dipartimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri Istituto Scientifico di Milano IRCCS, Via Camaldoli 64, Milano, Italy
    Pharmacol Res 66:343-8. 2012
    ..In conclusion, tiotropium showed a better antiinflammatory activity profile when compared to formoterol in a clinical setting, reducing superoxide and LTB₄ production by peripheral neutrophils obtained from COPD subjects...
  15. pmc Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Milano, Italy
    Int J Chron Obstruct Pulmon Dis 2:27-31. 2007
    ..This review discusses the most recent data on the new fluoroquinolone prulifloxacin and critically analyses its activity and safety in the management of AECB...
  16. ncbi request reprint Effect of formoterol, tiotropium, and their combination in patients with acute exacerbation of chronic obstructive pulmonary disease: a pilot study
    Fabiano Di Marco
    Respiratory Medicine Unit, University of Milan, Ospedale San Paolo, Milano, Italy
    Respir Med 100:1925-32. 2006
    ....
  17. ncbi request reprint Anxiety and depression in COPD patients: The roles of gender and disease severity
    Fabiano Di Marco
    Respiratory Medicine Unit, University of Milan, Ospedale San Paolo, Milano, Italy
    Respir Med 100:1767-74. 2006
    ....
  18. doi request reprint Expiratory flow-limitation and heliox breathing in resting and exercising COPD patients
    Edgardo D'Angelo
    Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, Via Mangiagalli 32, 20133 Milan, Italy
    Respir Physiol Neurobiol 169:291-6. 2009
    ..Hence, the presence of TEFL has no systematic effects on the respiratory response to heliox, and the heliox-induced decrease of exercise dyspnea is not mainly due to changes in dynamic hyperinflation or TEFL...
  19. doi request reprint Anxiety and depression in asthma
    Fabiano Di Marco
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, Universita degli Studi di Milano, Ospedale San Paolo, Italy
    Curr Opin Pulm Med 17:39-44. 2011
    ..However, the implications of this correlation are still poorly understood. Here, we review the role of anxiety and depression in asthma with a focus on recent literature...
  20. ncbi request reprint Effect of inhaled bronchodilators on inspiratory capacity and dyspnoea at rest in COPD
    F di Marco
    University of Milan, San Paolo Hospital, Respiratory Unit, Milan, Italy
    Eur Respir J 21:86-94. 2003
    ..The potential advantage of formoterol needs to be tested in a larger patient population...
  21. ncbi request reprint Evaluation of the effects of zafirlukast 40 mg b.i.d. in addition to preexisting therapy of high-dose inhaled steroids on symptomatic patients with reversible respiratory obstruction: preliminary data
    S Centanni
    Institute of Lung Diseases, San Paolo Hospital, University of Milan, Italy
    Drugs Exp Clin Res 26:133-8. 2000
    ..Zafirlukast was well tolerated and accepted by patients. Further research is needed, as the small number of patients does not allow definitive conclusions to be drawn...
  22. ncbi request reprint The potential role of tocopherol in asthma and allergies: modification of the leukotriene pathway
    S Centanni
    Respiratory Unit, San Paolo Hospital, University of Milan, Milan, Italy
    BioDrugs 15:81-6. 2001
    ..The results of these studies may be useful in developing new therapeutic approaches in asthmatic/allergic patients...
  23. ncbi request reprint Atopy prevalence and spirometric performance in asymptomatic schoolchildren exposed to air pollution
    S Centanni
    Respiratory Unit, University of Milan, San Paolo Hospital, Milan, Italy
    Monaldi Arch Chest Dis 56:304-8. 2001
    ..The association between FEF75 reduction and chronic high levels of air pollution is appealing, but further confirmation studies are necessary...
  24. ncbi request reprint Bronchodilation test in COPD: effect of inspiratory manoeuvre preceding forced expiration
    P Santus
    Institute of Lung Disease, Respiratory Unit, San Paolo Hospital, Milan, Italy
    Eur Respir J 21:82-5. 2003
    ....
  25. ncbi request reprint Non-pulmonary effects induced by the addition of formoterol to budesonide therapy in patients with mild or moderate persistent asthma
    S Centanni
    Respiratory Disease Unit, University of Milan, San Paolo Hospital, Milan, Italy
    Respiration 67:60-4. 2000
    ..The present study was designed to assess the non-pulmonary effects of a 2-week treatment with the addition of formoterol to budesonide therapy in 10 patients with mild or moderate asthma...
  26. ncbi request reprint Azithromycin and lower respiratory tract infections
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Expert Opin Pharmacother 6:2335-51. 2005
    ..In addition, pharmacokinetic and pharmacodynamic properties of the drug are also considered...
  27. ncbi request reprint Effects of salmeterol on cilia and mucus in COPD and pneumonia patients
    G Piatti
    Institute of Respiratory Diseases, Ospedale Maggiore di Milano, University of Milan, Via F Sforza 35, 20122 Pad Litta, Italy
    Pharmacol Res 51:165-8. 2005
    ....
  28. doi request reprint Rapid on-site evaluation improves needle aspiration sensitivity in the diagnosis of central lung cancers: a randomized trial
    Michele Mondoni
    Respiratory Unit, San Paolo Hospital, Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Italy
    Respiration 86:52-8. 2013
    ..Rapid on-site evaluation has long been used in transbronchial needle aspiration of adenopathies and peripheral lesions, but its role in sampling central malignancies has not been substantiated yet...
  29. ncbi request reprint Comparison of the acute effect of tiotropium versus a combination therapy with single inhaler budesonide/formoterol on the degree of resting pulmonary hyperinflation
    P Santus
    Respiratory Medicine Unit, San Paolo Hospital, University of Milan, Milan, Italy
    Respir Med 100:1277-81. 2006
    ....
  30. ncbi request reprint Highlights on the appropriate use of fluoroquinolones in respiratory tract infections
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Via F Sforza 35, 20122 Milan, Italy
    Pulm Pharmacol Ther 19:11-9. 2006
    ..This review discusses the most recent data on the bacteriological and clinical activity of the new fluoroquinolones and critically analyses the risks of a potential overuse of this valuable new class of drugs...
  31. ncbi request reprint Antileukotrienes in clinical development for asthma
    Stefano Centanni
    Respiratory Unit, San Paolo Hospital, University of Milan, Via A Di Rudini 8, 20142 Milan, Italy
    Expert Opin Investig Drugs 11:49-58. 2002
    ..These drugs provide a new approach in asthmatic therapy and therefore may facilitate the compliance of daily therapy...
  32. ncbi request reprint Bronchodilating effect of oxitropium bromide in heart disease patients with exacerbations of COPD: double-blind, randomized, controlled study
    S Centanni
    Institute of Lung Disease, Respiratory Unit, San Paolo Hospital, University of Milan, Itlay
    Respir Med 96:137-41. 2002
    ..2% +/- 0.6, 31.4 +/- 2.9, -19.9 +/- 1.1. Placebo did not significantly change pulmonary function. Our data suggest that oxitropium bromide bronchodilator activity is effective in exacerbations of COPD...
  33. ncbi request reprint Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease
    P Santus
    Institute of Lung Disease, University of Milan, Respiratory Unit, San Paolo Hospital, Milano, Italy
    Monaldi Arch Chest Dis 71:15-20. 2009
    ..Altered MMP-3 activity has been described in different diseases. We investigated the role of a promoter MMP-3 polymorphism in determining susceptibility and severity of COPD...
  34. ncbi request reprint Addition of an extra dose of salmeterol Diskus to conventional dose of salmeterol Diskus in patients with COPD
    M Cazzola
    Department of Respiratory Medicine, A Cardarelli Hospital, Naples, Italy
    Respir Med 96:439-43. 2002
    ....
  35. ncbi request reprint The functional impact of adding salmeterol and tiotropium in patients with stable COPD
    M Cazzola
    Department of Respiratory Medicine, Antonio Cardarelli Hospital, Via del Parco Margherita 24, Napoli 80121, Italy
    Respir Med 98:1214-21. 2004
    ....
  36. ncbi request reprint Bronchodilator effect of an inhaled combination therapy with salmeterol + fluticasone and formoterol + budesonide in patients with COPD
    M Cazzola
    Department of Respiratory Medicine, A Cardarelli Hospital, Unit of Pneumology and Allergology, Naples, Italy
    Respir Med 97:453-7. 2003
    ..The results indicate that an inhaled combination therapy with a long-acting beta2-agonist and an inhaled corticosteroid appears to be effective in improving airway limitation after acute administration in patients suffering from COPD...
  37. ncbi request reprint A single high dose of formoterol is as effective as the same dose administered in a cumulative manner in patients with acute exacerbation of COPD
    M Cazzola
    Dipartimento di Medicina Respiratoria, Azienda Ospedaliera di Rilevanza Nazionale A Cardarelli, Unità Complessa di Pneumologia e Allergologia, Napoli, Italy
    Respir Med 97:458-62. 2003
    ..Also they did not influence SpO2. This study indicates that a single high dose offormoterol is as effective as the same dose administered in a cumulative manner in patients with acute exacerbation of COPD...
  38. ncbi request reprint Onset of action of formoterol/budesonide in single inhaler vs. formoterol in patients with COPD
    M Cazzola
    Department of Pneumology, Unit of Pneumology and Allergology, Antonio Cardarelli Hospital, Milan, Italy
    Pulm Pharmacol Ther 17:121-5. 2004
    ..This study indicates that the addition of budesonide influences the fast onset of action of formoterol, but does not induce systemic effects, in patients with stable COPD...
  39. ncbi request reprint Detection of expiratory flow limitation in COPD using the forced oscillation technique
    R L Dellaca
    TBMLab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milan, Italy
    Eur Respir J 23:232-40. 2004
    ..Within-breath respiratory system reactance provides an accurate, reliable and noninvasive technique to detect expiratory flow limitation in patients with chronic obstructive pulmonary disease...