Research Topics
| M SantucciSummaryAffiliation: University of Florence Country: Italy Publications
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Detail Information
Publications
Recognizing hidden phenotypes in sarcomas through the electron microscopeMarco Santucci
Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
Ultrastruct Pathol 32:51-61. 2008..Occasionally, in tumors with smooth muscle, skeletal muscle, adipocytic, vascular endothelial, and Schwann cell differentiation electron microscopy may help in the differential diagnosis...
Primary cutaneous B-cell lymphomas. Current concepts. IMarco Santucci
Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
Haematologica 89:1360-71. 2004..They are defined as B-cell lymphomas originating in the skin, with no evidence of extracutaneous disease at presentation, as assessed by adequate staging procedures...- Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force WorkshopMarco Santucci
Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
Cancer 97:610-27. 2003.... - Accuracy, concordance, and reproducibility of histologic diagnosis in cutaneous T-cell lymphoma: an EORTC Cutaneous Lymphoma Project Group Study. European Organization for Research and Treatment of CancerM Santucci
Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Florence, Italy
Arch Dermatol 136:497-502. 2000..To assess the level of observer variability in the histologic identification of cutaneous T-cell lymphoma (CTCL) and its discrimination from diseases with similar histologic features... - Middle ear adenoma is an amphicrine tumor: why call it adenoma?S Ketabchi
Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Italia
Ultrastruct Pathol 25:73-8. 2001..The authors suggest that the appropriate terminology would be adeno-carcinoid or amphicrine tumor of the middle ear rather than "adenoma," a term that does not reflect its dual nature... 
Downregulation of transforming growth factor beta type II receptor in laryngeal carcinogenesisA Franchi
Department of Human Pathology and Oncology, University of Florence, Italy
J Clin Pathol 54:201-4. 2001..TGF-beta RII status was examined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of similar lesions without progression to cancer...- Inducible nitric oxide synthase expression in benign and malignant cutaneous melanocytic lesionsD Massi
Dipartimento di Patologia Umana ed Oncologia, , Firenze, Italy
J Pathol 194:194-200. 2001..These data suggest that iNOS may play a role in the malignant transformation of melanocytes and in tumour growth. In addition, iNOS may be useful as an immunohistochemical marker for malignant melanocytic lesions... - S100A13 is a new angiogenic marker in human melanomaDaniela Massi
Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
Mod Pathol 23:804-13. 2010..Therefore, S100A13 may represent a new angiogenic and prognostic marker in melanoma... - Submicroscopic and immunohistochemical profile of surface osteosarcomasA Franchi
Institute of Anatomic Pathology, University of Florence Medical School, Italy
Ultrastruct Pathol 23:233-40. 1999..Further, the myofibroblast-like cells that are present in variable numbers in these tumors are probably modified osteoblasts, since they co-express actin, osteonectin, and osteocalcin... - Italian guidelines and therapeutic algorithm for actinic keratosesR Rossi
Section of Dermatology II, University of Florence, Local Health Unit 10, Florence, Italy
G Ital Dermatol Venereol 144:713-23. 2009..The guidelines indicated by the authors have also been based on practical evaluations and their own clinical experience. The present conclusions may be modified by new findings in the field of oncologic research... - Radiation-induced cutaneous carcinoma of the head and neck: is there an early role for p53 mutations?A Franchi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Clin Exp Dermatol 31:793-8. 2006..Little is known about the molecular mechanisms underlying ionizing radiation-induced carcinogenesis of the skin... - Expression of CD44 standard and variant isoforms in parotid gland and parotid gland tumoursA Franchi
Department of Human Pathology and Oncology, University of Florence Medical School, Viale G.B. Morgagni 85, 50134 Florence, Italy
J Oral Pathol Med 30:564-8. 2001.... - Analysis of protease-activated receptor-1 and -2 in human scar formationS Materazzi
Department of Critical Care Medicine and Surgery, University of Florence, Italy
J Pathol 212:440-9. 2007.... - Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlationsAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Italy
Cancer 101:973-8. 2004..In the current study, the authors investigated whether tumor lymphangiogenesis may be related to the risk of lymph node metastasis and to clinical outcome in patients with HNSCC... - Dilation of intercellular spaces is associated with laryngo-pharyngeal reflux: an ultrastructural morphometric analysis of laryngeal epitheliumAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134, Firenze, Italy
Eur Arch Otorhinolaryngol 264:907-11. 2007..If this result will be confirmed in larger series it may provide a useful diagnostic tool for the identification of LPR... - Expression of p16 in sinonasal malignant melanomaAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
Virchows Arch 449:667-72. 2006..At variance from cutaneous melanoma, loss of p16 is not correlated with the prognosis of patients affected by sinonasal melanoma... - Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanomaDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Mod Pathol 19:246-54. 2006..These results indicate that the activation of Notch may represent an early event in melanocytic tumor growth and upregulation of Notch signaling may sustain tumor progression... - Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumorsDaniela Massi
Dipartimento di Patologia Umana ed Oncologia, Universita di Firenze, Florence 50134, Italy
Hum Pathol 38:1516-25. 2007..However, macrophages stimulated by murine melanoma cells secreted a level of NO compatible with an antitumor activity only in the presence of interferon gamma... - Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patternsAlessandro Franchi
Department of Human Pathology and Oncology, Medical School, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
Am J Surg Pathol 26:1597-604. 2002..Moreover, these findings support the hypothesis that SNUC is a separate entity from SCC and NPTC of the sinonasal tract... - Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesisDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Mod Pathol 22:21-30. 2009..Mechanistic studies are needed to address the possibility that inducible nitric oxide synthase controls lymphangiogenesis, dissemination and lymphatic borne metastases... - Expression and prognostic significance of matrix metalloproteinases and their tissue inhibitors in primary neuroendocrine carcinoma of the skinDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Hum Pathol 34:80-8. 2003..It is conceivable that future attempts to specifically block MMP-1 and MMP-3 activity may provide a novel means to inhibit invasiveness and distant spread in selected patients with PNC... - Vasculogenic mimicry has no prognostic significance in pT3 and pT4 cutaneous melanomaDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Hum Pathol 35:496-502. 2004..05). In conclusion, our results suggest that there is a mismatch between vasculogenic mimicry and tumor angiogenesis and do not support any prognostic role of vasculogenic mimicry in thick cutaneous melanoma... - Application of a filtration- and isolation-by-size technique for the detection of circulating tumor cells in cutaneous melanomaVincenzo de Giorgi
Department of Critical Care Medicine and Surgery, Dermatology Unit, University of Florence, Florence, Italy
J Invest Dermatol 130:2440-7. 2010..001). CTC detection corroborated by suitable molecular characterization may assist in the identification and monitoring of more appropriate therapies in melanoma patients... - Inducible nitric oxide synthase expression in laryngeal neoplasia: correlation with angiogenesisAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
Head Neck 24:16-23. 2002..The aim of this study was to assess whether the NO pathway may be correlated with angiogenesis in the transition from laryngeal dysplasia to invasive carcinoma... - Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 casesDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Histopathology 56:251-62. 2010..The aim was to verify whether the clinical behaviour of purely dermal LMS is different from that of LMS with minimal subcutis invasion... - Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neckAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Italy
Cancer 95:1902-10. 2002.... - Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinomaAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Firenze, Italy
Oral Oncol 45:835-8. 2009..EGFR targeted therapies could therefore be investigated prospectively in this group of tumors... - Cytokine profile and supposed contribution to scarring in cicatricial pemphigoidMarzia Caproni
Department of Dermatological Sciences, University of Florence, Italy
J Oral Pathol Med 32:34-40. 2003.... - Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinomaAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence, Italy
J Pathol 208:439-45. 2006..Taken together, our results indicate that iNOS activity may promote lymphangiogenesis and spread to lymph nodes in HNSCC, with the possible involvement of VEGF-C... - The impact of histopathologic examination of graft-versus-host disease in the era of reduced-intensity conditioning regimen: a study from the Gruppo Italiano Trapianto di Midollo OsseoDaniela Massi
Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence, Italy
Hum Pathol 42:254-68. 2011.... - Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profilesM Santucci
Dipartimento di Patologia Umana ed Oncologia, , Italy
Virchows Arch 438:457-63. 2001.... - TGF-beta isoform and receptor expression in giant cell tumor and giant cell lesions of boneA Franchi
Department of Human Pathology and Oncology, University of Florence Medical School, Italy
Appl Immunohistochem Mol Morphol 9:170-5. 2001.... - Immunohistochemical and ultrastructural investigation of neural differentiation in Ewing sarcoma/PNET of bone and soft tissuesA Franchi
Dipartimento di Patologia Umana ed Oncologia, , Italy
Ultrastruct Pathol 25:219-25. 2001.... - Microsatellite analysis in cutaneous malignant melanomaD Massi
Department of Human Pathology and Oncology, Medical Genetics Unit, University of Florence, Italy
Melanoma Res 12:577-84. 2002..Genetic analysis of metastatic lesions revealed that the same microsatellite alterations as in the primary tumour are seen, but additional genetic changes may develop during disease progression... - Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma)John Panelos
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Mod Pathol 22:959-68. 2009..Downregulation of E-cadherin and diffuse membranous beta-catenin expression suggest a dysregulation of the E-cadherin/beta-catenin complex in Merkel cell carcinoma. This may contribute to local invasion and distant metastasis... - Hyalinizing spindle cell tumor with giant rosettes and low-grade fibromyxoid sarcoma: an immunohistochemical and ultrastructural comparative investigationAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
Ultrastruct Pathol 27:349-55. 2003.... - Indolent cutaneous B-cell lymphoma: diagnosis and treatment 2012M Santucci
Divisions of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence Medical School, Florence, Italy
G Ital Dermatol Venereol 147:581-8. 2012.... - Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control studyD Massi
Department of Human Pathology and Oncology, University of Florence, I 50134 Florence, Italy
J Clin Pathol 59:166-73. 2006..Cutaneous melanoma spreads preferentially through the lymphatic route and sentinel lymph node (SLN) status is regarded as the most important predictor of survival... - Expression of protease-activated receptor-1 and -2 in orofacial granulomatosisS Ketabchi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Oral Dis 13:419-25. 2007..Protease-Activated Receptors (PARs) play a role in inflammatory diseases in diverse human tissues. The aim of the study was to investigate the expression of PAR-1, PAR-2, MMP-2, MMP-9, COX-1, and COX-2 in tissues taken from OFG patients... - Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanomaDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Hum Pathol 36:676-85. 2005..Conversely, the significance of PAR-2 up-regulation in both benign and malignant melanocytic lesions requires further research... - Tumor angiogenesis as a prognostic factor in thick cutaneous malignant melanoma. A quantitative morphologic analysisDaniela Massi
Dipartimento di Patologia Umana ed Oncologia, , Florence, Italy
Virchows Arch 440:22-8. 2002..Its prognostic significance is better assessed by quantification of vessel area, equivalent circle diameter, and microvessel branching, whereas microvessel count and vascular density do not provide significant prognostic information... - The comparative role of immunohistochemistry and electron microscopy in the identification of myogenic differentiation in soft tissue pleomorphic sarcomasAlessandro Franchi
Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
Ultrastruct Pathol 29:295-304. 2005..In conclusion, the results indicate that immunohistochemistry and electron microscopy can usefully complement each other in the classification of soft tissue pleomorphic sarcomas... - BCA-1, A B-cell chemoattractant signal, is constantly expressed in cutaneous lymphoproliferative B-cell disordersM Mori
Department of Dermatological Sciences, University of Florence Medical School, Firenze, Italy
Eur J Cancer 39:1625-31. 2003..The above findings, although only observed in a small series of patients, are in keeping with findings in MALT gastric and gastric MALT lymphomas, adding further evidence of the close similarities between CBCL and MALT lymphomas... - CDX-2, cytokeratin 7 and cytokeratin 20 immunohistochemical expression in the differential diagnosis of primary adenocarcinomas of the sinonasal tractA Franchi
Department of Human Pathology and Oncology, University of Florence, Italy
Virchows Arch 445:63-7. 2004..Staining for CDX-2 and cytokeratin 20 has potential use in separating ITACs from other primary malignant glandular neoplasms of the nasal cavities and paranasal sinuses... - Submicroscopic profile of Isospora belli enteritis in a patient with acquired immune deficiency syndromeC E Comin
Institute of Anatomic Pathology, University of Florence Medical School, Italy
Ultrastruct Pathol 18:473-82. 1994..These findings expand the current knowledge of this parasite regarding its capacity to survive in an extracellular environment and document a possible mechanism by which extraintestinal infection can take place... - Defining early mycosis fungoidesNicola Pimpinelli
Department of Dermatological Sciences, University of Florence, Florence, Italy
J Am Acad Dermatol 53:1053-63. 2005.... - Increase in FOXP3+ regulatory T cells in GVHD skin biopsies is associated with lower disease severity and treatment responseCristina Fondi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Biol Blood Marrow Transplant 15:938-47. 2009..Larger studies are required to confirm that evaluation of Tregs in minimally invasive skin biopsies assists the diagnosis and prognosis of GVHD patients... - In vivo characterization of the inflammatory infiltrate and apoptotic status in imiquimod-treated basal cell carcinomaVincenzo de Giorgi
Dipartimento di Scienze Dermatologiche, Universita degli Studi di Firenze, Florence, Italy
Int J Dermatol 48:312-21. 2009..Imiquimod use in the treatment of basal cell carcinoma (BCC) has proven to be successful in a large percentage of cases, inducing tumor regression; however, the exact cellular mechanism has not been fully clarified... - A kindred with MYH-associated polyposis and pilomatricomasSilvana Baglioni
Department of Clinical Pathophysiology, Section of Medical Genetics, University of Florence, Florence, Italy
Am J Med Genet A 134:212-4. 2005..The findings presented provide further evidence of phenotypic variability in MAP, and suggest that multiple pilomatricomas may be a useful cutaneous marker of MAP... - WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspectsGunter Burg
Department of Dermatology, University Hospital Zurich, Switzerland
J Cutan Pathol 32:647-74. 2005..These findings always have to be interpreted in the context of the clinical features and biologic behavior... - IL-4, IL-5, TGF-beta1 and IFN-gamma mRNAs detected by a new in situ amplification system in cicatricial pemphigoidMarzia Caproni
Department of Dermatological Sciences, University of Florence, Italy
Exp Dermatol 11:421-7. 2002.... - Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progressionFrancesca Bianchini
Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni 50, I 50134 Florence, Italy
Prostaglandins Other Lipid Mediat 83:320-8. 2007..On the whole, the results of in vivo and in vitro studies suggest that COX-2 expressed in TAMs appears to act as an effective biomarker of melanoma progression, and melanoma cells themselves might stimulate COX-2 in macrophages... - Photoexposition discriminates Notch 1 expression in human cutaneous squamous cell carcinomaJohn Panelos
Department of Pathology, University of Ioannina Medical School, Ioannina, Greece
Mod Pathol 21:316-25. 2008..Furthermore, Notch 1 expression was minimal in basal cell carcinoma subtypes correlated with risk of recurrence (sclerodermiform/infiltrating and baso-squamous) in comparison with nodular and superficial types... - Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 casesRein Willemze
Department of Dermatology, Leiden University Medical Center, The Netherlands
Blood 111:838-45. 2008..SPTL-ABs without associated HPS have an excellent prognosis, and multiagent chemotherapy as first choice of treatment should be questioned... - Histopathology and genetics of cutaneous T-cell lymphomaBruce R Smoller
Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Hematol Oncol Clin North Am 17:1277-311. 2003..It is hoped that greater understanding of these molecular abnormalities will permit the development of CTCL-specific therapies that alleviate suffering and prolong survival... - A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissuesAntonella Naldini
Department of Physiology, University of Siena, Italy
Diagn Mol Pathol 16:147-52. 2007..In conclusion, our study provides evidence that ribonuclease protection assay on archival specimens would be highly valuable for retrospective studies, for diagnosis or prognosis... - Prognostic factors in primary cutaneous B-cell lymphoma: the Italian Study Group for Cutaneous LymphomasPier Luigi Zinzani
Institute of Hematology and Oncology Seragnoli, University of Bologna, Bologna, Italy
J Clin Oncol 24:1376-82. 2006..Primary cutaneous B-cell lymphomas (PCBCLs) are a distinct group of primary cutaneous lymphomas with few and conflicting data on their prognostic factors... - CDX-2 homeobox gene expressionAlessandro Franchi
Am J Surg Pathol 27:1390-1. 2003 - WHO-EORTC classification for cutaneous lymphomasRein Willemze
Department of Dermatology, B1 Q 93, Leiden University Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Blood 105:3768-85. 2005.... - Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injuryDavid Gazzieri
Center of Excellence for the Study of Inflammation, University of Ferrara, Viale Pieraccini 6, 50139 Florence, Italy
Free Radic Biol Med 43:581-9. 2007....