Annalisa Santucci


Affiliation: University of Siena
Country: Italy


  1. Bernardini G, Minetti M, Polizzotto G, Biazzo M, Santucci A. Pro-Apoptotic Activity of French Polynesian Padina pavonica Extract on Human Osteosarcoma Cells. Mar Drugs. 2018;16: pubmed publisher
    ..Finally, our data suggest that EPP might target different properties associated with cancer development and aggressiveness. ..
  2. Spiga O, Cicaloni V, Zatkova A, Millucci L, Bernardini G, Bernini A, et al. A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria. Comput Biol Med. 2018;103:1-7 pubmed publisher
    ..This framework may represent an online tool that can be turned into a best practice model for other rare diseases. ..
  3. Braconi D, Millucci L, Bernardini G, Santucci A. Oxidative stress and mechanisms of ochronosis in alkaptonuria. Free Radic Biol Med. 2015;88:70-80 pubmed publisher
    ..Future work should be undertaken in order to validate in vivo the results so far obtained in in vitro AKU models. ..
  4. Braconi D, Giustarini D, Marzocchi B, Peruzzi L, Margollicci M, Rossi R, et al. Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project. Osteoarthritis Cartilage. 2018;26:1078-1086 pubmed publisher
    ..Monitoring of SAA may be suggested in AKU to evaluate inflammation. Though further evidence is needed, SAA, chitotriosidase activity and PTI might be proposed as disease activity markers in AKU. ..
  5. Braconi D, Bernardini G, Santucci A. Saccharomyces cerevisiae as a model in ecotoxicological studies: A post-genomics perspective. J Proteomics. 2016;137:19-34 pubmed publisher
    ..Furthermore, a deeper knowledge of the effects of environmental pollutants on biotechnological processes associated with the use of yeasts is to be hoped. ..
  6. Laschi M, Bernardini G, Dreassi E, Millucci L, Geminiani M, Braconi D, et al. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria. ChemMedChem. 2016;11:674-8 pubmed publisher
    ..These may be promising starting points for the development of new therapeutic strategies for the treatment of AKU. ..
  7. Braconi D, Bernardini G, Paffetti A, Millucci L, Geminiani M, Laschi M, et al. Comparative proteomics in alkaptonuria provides insights into inflammation and oxidative stress. Int J Biochem Cell Biol. 2016;81:271-280 pubmed publisher
    ..Potential candidate biomarkers to assess disease severity, monitor disease progression and evaluate response to treatment were identified as well. ..
  8. request reprint
    Millucci L, Bernardini G, Marzocchi B, Braconi D, Geminiani M, Gambassi S, et al. Angiogenesis in alkaptonuria. J Inherit Metab Dis. 2016;39:801-806 pubmed
    ..This is the first report providing experimental evidences that new blood vessels are formed in AKU synovial tissues, opening new perspectives for AKU therapy. ..
  9. Braconi D, Millucci L, Bernini A, Spiga O, Lupetti P, Marzocchi B, et al. Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins. Biochim Biophys Acta Gen Subj. 2017;1861:135-146 pubmed publisher
    ..Our results provide a possible explanation for the clinically verified onset of amyloidotic processes in AKU and might lay the basis to setup proper pharmacological approaches to alkaptonuric ochronosis, which are still lacking. ..

More Information


  1. Mitri E, Millucci L, Merolle L, Bernardini G, Vaccari L, Gianoncelli A, et al. A new light on Alkaptonuria: A Fourier-transform infrared microscopy (FTIRM) and low energy X-ray fluorescence (LEXRF) microscopy correlative study on a rare disease. Biochim Biophys Acta Gen Subj. 2017;1861:1000-1008 pubmed publisher
    ..The present work proposes new strategies for filling the aforementioned gap that encompass the integration of new analytical approaches with standardized analyses. ..
  2. Millucci L, Bernardini G, Spreafico A, Orlandini M, Braconi D, Laschi M, et al. Histological and Ultrastructural Characterization of Alkaptonuric Tissues. Calcif Tissue Int. 2017;101:50-64 pubmed publisher
    ..A complete microscopic and ultrastructural analysis of different AKU tissues, coming from six differently aged patients, is here presented thus significantly contributing to a more comprehensive knowledge of this ultra-rare pathology. ..