D Sansonno

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Hepatitis C virus infection, cryoglobulinaemia, and beyond
    D Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Rheumatology (Oxford) 46:572-8. 2007
  2. ncbi request reprint Current and emerging therapeutic approaches in HCV-related mixed cryoglobulinemia
    D Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Curr Med Chem 15:117-26. 2008
  3. pmc Transarterial chemoembolization plus sorafenib: a sequential therapeutic scheme for HCV-related intermediate-stage hepatocellular carcinoma: a randomized clinical trial
    Domenico Sansonno
    Liver Unit, Department of Internal Medicine and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Oncologist 17:359-66. 2012
  4. pmc Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia
    D Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 147:241-8. 2007
  5. pmc Hepatitis C virus RNA and core protein in kidney glomerular and tubular structures isolated with laser capture microdissection
    D Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 140:498-506. 2005
  6. ncbi request reprint Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Lancet Infect Dis 5:227-36. 2005
  7. ncbi request reprint B-cell depletion in the treatment of mixed cryoglobulinemia
    Domenico Sansonno
    Department of Biomedical Seiences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical Sehool, Bari, Italy
    Dig Liver Dis 39:S116-21. 2007
  8. ncbi request reprint Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1620-7. 2008
  9. pmc Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    J Immunol 183:6013-20. 2009
  10. pmc Virological analysis and phenotypic characterization of peripheral blood lymphocytes of hepatitis C virus-infected patients with and without mixed cryoglobulinaemia
    D Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 143:288-96. 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Hepatitis C virus infection, cryoglobulinaemia, and beyond
    D Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Rheumatology (Oxford) 46:572-8. 2007
    ..Indolent lymphoproliferation might act as the starting point of chronic, multistage lymphomagenesis. An innovative therapeutic strategy is directed to 'eradication of the virus' and deletion of B-cell clonalities...
  2. ncbi request reprint Current and emerging therapeutic approaches in HCV-related mixed cryoglobulinemia
    D Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Curr Med Chem 15:117-26. 2008
    ..Therapy directed against chemokines and/or cytokines represents an interesting and promising future target...
  3. pmc Transarterial chemoembolization plus sorafenib: a sequential therapeutic scheme for HCV-related intermediate-stage hepatocellular carcinoma: a randomized clinical trial
    Domenico Sansonno
    Liver Unit, Department of Internal Medicine and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Oncologist 17:359-66. 2012
    ....
  4. pmc Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia
    D Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 147:241-8. 2007
    ....
  5. pmc Hepatitis C virus RNA and core protein in kidney glomerular and tubular structures isolated with laser capture microdissection
    D Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 140:498-506. 2005
    ..The different distribution of HCV RNA and HCV-related proteins may reflect a peculiar 'affinity' of kidney microenvironments for HCV and point to distinct pathways of HCV-related damage in glomeruli and tubules...
  6. ncbi request reprint Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Lancet Infect Dis 5:227-36. 2005
    ..Emphasis, in fact, is now placed on abatement of the viral load and deletion of B-cell clonalities...
  7. ncbi request reprint B-cell depletion in the treatment of mixed cryoglobulinemia
    Domenico Sansonno
    Department of Biomedical Seiences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical Sehool, Bari, Italy
    Dig Liver Dis 39:S116-21. 2007
    ..However, in view of the increased viremia in the responders, additional modes of application and combination of RTX with other agents need to be investigated...
  8. ncbi request reprint Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1620-7. 2008
    ..Higher levels of this chemokine in the liver as well as in the skin of patients with active MC vasculitis suggest a possible interrelation between these biologic compartments...
  9. pmc Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    J Immunol 183:6013-20. 2009
    ....
  10. pmc Virological analysis and phenotypic characterization of peripheral blood lymphocytes of hepatitis C virus-infected patients with and without mixed cryoglobulinaemia
    D Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 143:288-96. 2006
    ..01). Different distribution of HCV-RNA was accompanied by evidence of an increased frequency of circulating B cells. These data indicate that MC patients are characterized distinctly by a higher quota of cell-associated viral load...
  11. ncbi request reprint The lymphoid system in hepatitis C virus infection: autoimmunity, mixed cryoglobulinemia, and Overt B-cell malignancy
    F Dammacco
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy
    Semin Liver Dis 20:143-57. 2000
    ..Current data indicate a higher prevalence of overt B-cell non-Hodgkin's lymphoma in HCV-infected patients, especially in some geographic areas...
  12. pmc Non-enveloped HCV core protein as constitutive antigen of cold-precipitable immune complexes in type II mixed cryoglobulinaemia
    D Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 133:275-82. 2003
    ..The present data demonstrate that non-enveloped HCV core protein is a constitutive component of cryoprecipitable ICs in type II MC patients...
  13. ncbi request reprint Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay
    D Sansonno
    Section of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    J Viral Hepat 11:27-32. 2004
    ..LCM-based immunoassay significantly expands our ability to investigate function-related antigens in apparently pure cell populations in HCV infection...
  14. ncbi request reprint The cryoglobulins: an overview
    F Dammacco
    University of Bari Medical School, Bari, Italy, University of Foggia Medical School, Foggia, Italy
    Eur J Clin Invest 31:628-38. 2001
    ..The cryoglobulinemic syndrome is probably the consequence of pathogenic noxae that act upon the immune system of a host in which regulation of the peripheral T cell response appears to be in some way altered...
  15. pmc T cell receptor variable β gene repertoire in liver and peripheral blood lymphocytes of chronically hepatitis C virus-infected patients with and without mixed cryoglobulinaemia
    S Russi
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 172:254-62. 2013
    ..These results support the notion that TCR Vβ repertoire is clonally expanded in HCV-related MC with features comparable to those found in chronically HCV-infected patients without MC...
  16. ncbi request reprint Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patients
    V Racanelli
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Immunol 167:21-9. 2001
    ..These data support the concept that in chronic HCV infection the intrahepatic B cell repertoire is frequently clonally restricted and that HCV may have a direct role in sustaining in situ B cell proliferation...
  17. doi request reprint Double-filtration plasmapheresis in the treatment of leg ulcers in cryoglobulinemia
    A Ramunni
    Section of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy
    J Clin Apher 23:118-22. 2008
    ..02) as compared with the preapheresis values. There was improvement in the condition of ulcers in the leg during apheresis and had completely regressed by the end of the cycle...
  18. ncbi request reprint Mixed cryoglobulinemia: a model of virus-related disease in internal medicine
    Franco Dammacco
    Department of Biomedical Seiences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical Sehool, Bari, Italy
    Dig Liver Dis 39:S8-S12. 2007
    ....
  19. ncbi request reprint HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocation
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Hepatology 42:1019-27. 2005
    ..Liver overexpression of Bcl-2 protein may occur in at least a minor proportion of HCV-infected patients...
  20. ncbi request reprint Pegylated interferon-alpha, ribavirin, and rituximab combined therapy of hepatitis C virus-related mixed cryoglobulinemia: a long-term study
    Franco Dammacco
    Sections of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Blood 116:343-53. 2010
    ..No response occurred in remaining 5 patients of both groups. PIRR therapy is well tolerated and more effective than Peg-IFN-alpha/RBV combination in HCV-related MC. Its effect may last for more than 3 years...
  21. doi request reprint B cells and HCV: an infection model of autoimmunity
    Loredana Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Bari, Italy
    Autoimmun Rev 9:93-4. 2009
    ..In addition, HCV/B-cell interaction that might explain defects in humoral immunity in individuals who develop chronic virus carriage and lymphoproliferative disorders will be emphasized...
  22. ncbi request reprint Angiogenesis and anti-angiogenesis in hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124 Bari, Italy
    Cancer Treat Rev 32:437-44. 2006
    ..Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed...
  23. ncbi request reprint Monoclonal antibody treatment of mixed cryoglobulinemia resistant to interferon alpha with an anti-CD20
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 101:3818-26. 2003
    ..However, in view of the increased viremia in the responders, additional modes of application and combination of rituximab with other agents need to be investigated...
  24. ncbi request reprint Intrahepatic B cell clonal expansions and extrahepatic manifestations of chronic HCV infection
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Eur J Immunol 34:126-36. 2004
    ..These findings emphasize the profound B cell function derangement in at least half of HCV-infected patients. Thus, the restriction of V gene usage has a direct impact on the clinical spectrum of HCV infection...
  25. ncbi request reprint In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histol Histopathol 22:285-9. 2007
    ..Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC...
  26. ncbi request reprint Lack of HCV infection in malignant cells refutes the hypothesis of a direct transforming action of the virus in the pathogenesis of HCV-associated B-cell NHLs
    Salvatore De Vita
    Division of Rheumatology, DPMSC, University of Udine, Italy
    Tumori 88:400-6. 2002
    ..A direct oncogenetic role of HCV by direct cell infection and deregulation has only been hypothesized on the basis of the lymphotropism of the virus...
  27. ncbi request reprint Role of the HLA class II: HCV-related disorders
    Valli De Re
    CRO IRCCS, Aviano National Cancer Institute, Pordenone, Italy
    Ann N Y Acad Sci 1107:308-18. 2007
    ....
  28. doi request reprint Mixed cryoglobulinemia syndrome as an additional autoimmune disorder associated with risk for lymphoma development
    Valli De Re
    Blood 111:5760. 2008