Research Topics
Species | D SansonnoSummaryAffiliation: University of Bari Country: Italy Publications
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Publications
Current and emerging therapeutic approaches in HCV-related mixed cryoglobulinemiaD Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Curr Med Chem 15:117-26. 2008..Therapy directed against chemokines and/or cytokines represents an interesting and promising future target...
Transarterial chemoembolization plus sorafenib: a sequential therapeutic scheme for HCV-related intermediate-stage hepatocellular carcinoma: a randomized clinical trialDomenico Sansonno
Liver Unit, Department of Internal Medicine and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
Oncologist 17:359-66. 2012....- Hepatitis C virus RNA and core protein in kidney glomerular and tubular structures isolated with laser capture microdissectionD Sansonno
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Clin Exp Immunol 140:498-506. 2005..The different distribution of HCV RNA and HCV-related proteins may reflect a peculiar 'affinity' of kidney microenvironments for HCV and point to distinct pathways of HCV-related damage in glomeruli and tubules... - Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relationsDomenico Sansonno
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Lancet Infect Dis 5:227-36. 2005..Emphasis, in fact, is now placed on abatement of the viral load and deletion of B-cell clonalities... - Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemiaD Sansonno
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Clin Exp Immunol 147:241-8. 2007.... - Hepatitis C virus infection, cryoglobulinaemia, and beyondD Sansonno
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
Rheumatology (Oxford) 46:572-8. 2007..Indolent lymphoproliferation might act as the starting point of chronic, multistage lymphomagenesis. An innovative therapeutic strategy is directed to 'eradication of the virus' and deletion of B-cell clonalities... - B-cell depletion in the treatment of mixed cryoglobulinemiaDomenico Sansonno
Department of Biomedical Seiences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical Sehool, Bari, Italy
Dig Liver Dis 39:S116-21. 2007..However, in view of the increased viremia in the responders, additional modes of application and combination of RTX with other agents need to be investigated... 
Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitisDomenico Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Blood 112:1620-7. 2008..Higher levels of this chemokine in the liver as well as in the skin of patients with active MC vasculitis suggest a possible interrelation between these biologic compartments...- Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damageDomenico Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
J Immunol 183:6013-20. 2009.... - Virological analysis and phenotypic characterization of peripheral blood lymphocytes of hepatitis C virus-infected patients with and without mixed cryoglobulinaemiaD Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Clin Exp Immunol 143:288-96. 2006..01). Different distribution of HCV-RNA was accompanied by evidence of an increased frequency of circulating B cells. These data indicate that MC patients are characterized distinctly by a higher quota of cell-associated viral load... - The lymphoid system in hepatitis C virus infection: autoimmunity, mixed cryoglobulinemia, and Overt B-cell malignancyF Dammacco
Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy
Semin Liver Dis 20:143-57. 2000..Current data indicate a higher prevalence of overt B-cell non-Hodgkin's lymphoma in HCV-infected patients, especially in some geographic areas... - Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assayD Sansonno
Section of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
J Viral Hepat 11:27-32. 2004..LCM-based immunoassay significantly expands our ability to investigate function-related antigens in apparently pure cell populations in HCV infection... - Non-enveloped HCV core protein as constitutive antigen of cold-precipitable immune complexes in type II mixed cryoglobulinaemiaD Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Clin Exp Immunol 133:275-82. 2003..The present data demonstrate that non-enveloped HCV core protein is a constitutive component of cryoprecipitable ICs in type II MC patients... - The cryoglobulins: an overviewF Dammacco
University of Bari Medical School, Bari, Italy, University of Foggia Medical School, Foggia, Italy
Eur J Clin Invest 31:628-38. 2001..The cryoglobulinemic syndrome is probably the consequence of pathogenic noxae that act upon the immune system of a host in which regulation of the peripheral T cell response appears to be in some way altered... - Double-filtration plasmapheresis in the treatment of leg ulcers in cryoglobulinemiaA Ramunni
Section of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy
J Clin Apher 23:118-22. 2008..02) as compared with the preapheresis values. There was improvement in the condition of ulcers in the leg during apheresis and had completely regressed by the end of the cycle... - Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patientsV Racanelli
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
J Immunol 167:21-9. 2001..These data support the concept that in chronic HCV infection the intrahepatic B cell repertoire is frequently clonally restricted and that HCV may have a direct role in sustaining in situ B cell proliferation... - B cells and HCV: an infection model of autoimmunityLoredana Sansonno
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Bari, Italy
Autoimmun Rev 9:93-4. 2009..In addition, HCV/B-cell interaction that might explain defects in humoral immunity in individuals who develop chronic virus carriage and lymphoproliferative disorders will be emphasized... - Mixed cryoglobulinemia: a model of virus-related disease in internal medicineFranco Dammacco
Department of Biomedical Seiences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical Sehool, Bari, Italy
Dig Liver Dis 39:S8-S12. 2007.... - HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocationDomenico Sansonno
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Hepatology 42:1019-27. 2005..Liver overexpression of Bcl-2 protein may occur in at least a minor proportion of HCV-infected patients... - Pegylated interferon-alpha, ribavirin, and rituximab combined therapy of hepatitis C virus-related mixed cryoglobulinemia: a long-term studyFranco Dammacco
Sections of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
Blood 116:343-53. 2010..No response occurred in remaining 5 patients of both groups. PIRR therapy is well tolerated and more effective than Peg-IFN-alpha/RBV combination in HCV-related MC. Its effect may last for more than 3 years... - Angiogenesis and anti-angiogenesis in hepatocellular carcinomaDomenico Ribatti
Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124 Bari, Italy
Cancer Treat Rev 32:437-44. 2006..Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed... - Intrahepatic B cell clonal expansions and extrahepatic manifestations of chronic HCV infectionDomenico Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Eur J Immunol 34:126-36. 2004..These findings emphasize the profound B cell function derangement in at least half of HCV-infected patients. Thus, the restriction of V gene usage has a direct impact on the clinical spectrum of HCV infection... - Monoclonal antibody treatment of mixed cryoglobulinemia resistant to interferon alpha with an anti-CD20Domenico Sansonno
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
Blood 101:3818-26. 2003..However, in view of the increased viremia in the responders, additional modes of application and combination of rituximab with other agents need to be investigated... - In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycinD Ribatti
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
Histol Histopathol 22:285-9. 2007..Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC... - Role of the HLA class II: HCV-related disordersValli De Re
CRO IRCCS, Aviano National Cancer Institute, Pordenone, Italy
Ann N Y Acad Sci 1107:308-18. 2007.... - Lack of HCV infection in malignant cells refutes the hypothesis of a direct transforming action of the virus in the pathogenesis of HCV-associated B-cell NHLsSalvatore De Vita
Division of Rheumatology, DPMSC, University of Udine, Italy
Tumori 88:400-6. 2002..Infection of B cells by HCV appears possible in some NHL subsets, but the implications remain unknown... - Mixed cryoglobulinemia syndrome as an additional autoimmune disorder associated with risk for lymphoma developmentValli De Re
Blood 111:5760. 2008