Enrico Sanna

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. ncbi request reprint Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes
    Enrico Sanna
    Department of Experimental Biology B Loddo, Section of Neuroscience, University of Cagliari, Cittadella Universitaria, Italy
    Eur J Pharmacol 451:103-10. 2002
  2. ncbi request reprint The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
    Mario Carta
    Department of Experimental Biology Bernardo Loddo, Section of Neuroscience, University of Cagliari, Cittadella Universitaria, SS 554, Km 4 5, Monserrato, Cagliari 09123, Italy
    Neuropharmacology 51:805-15. 2006
  3. doi request reprint Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, and National Research Council, Institute of Neuroscience, 09123 Cagliari, Italy
    J Neurosci 29:1755-65. 2009
  4. ncbi request reprint Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    Eur J Pharmacol 519:31-42. 2005
  5. ncbi request reprint Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
    J Neurosci 24:6521-30. 2004
  6. ncbi request reprint Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
    J Neurosci 23:11711-24. 2003
  7. ncbi request reprint Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons
    Paolo Follesa
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    J Neurochem 94:659-71. 2005
  8. ncbi request reprint Flumazenil selectively prevents the increase in alpha(4)-subunit gene expression and an associated change in GABA(A) receptor function induced by ethanol withdrawal
    Francesca Biggio
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    J Neurochem 102:657-66. 2007
  9. ncbi request reprint Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function
    Mariangela Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 98:122-33. 2006
  10. ncbi request reprint Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators
    Giovanni Biggio
    Department of Experimental Biology Bernardo Loddo, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, 09123, Italy
    Eur Neuropsychopharmacol 13:411-23. 2003

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes
    Enrico Sanna
    Department of Experimental Biology B Loddo, Section of Neuroscience, University of Cagliari, Cittadella Universitaria, Italy
    Eur J Pharmacol 451:103-10. 2002
    ..Furthermore, zaleplon, unlike zolpidem, exhibited virtually no affinity for the peripheral type of benzodiazepine receptor...
  2. ncbi request reprint The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
    Mario Carta
    Department of Experimental Biology Bernardo Loddo, Section of Neuroscience, University of Cagliari, Cittadella Universitaria, SS 554, Km 4 5, Monserrato, Cagliari 09123, Italy
    Neuropharmacology 51:805-15. 2006
    ..Our data, consistent with clinical observations of the epileptogenic effect of this compound, suggest that TCC is a potent competitive antagonist of GABAAR function...
  3. doi request reprint Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, and National Research Council, Institute of Neuroscience, 09123 Cagliari, Italy
    J Neurosci 29:1755-65. 2009
    ..These data suggest that the number of extrasynaptic GABA(A)-Rs is increased in DGGCs during late pregnancy as a consequence of the associated marked fluctuations in the brain levels of neuroactive steroids...
  4. ncbi request reprint Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    Eur J Pharmacol 519:31-42. 2005
    ..These data suggest that etizolam is endowed with a reduced liability to induce tolerance and dependence compared with classical benzodiazepines...
  5. ncbi request reprint Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
    J Neurosci 24:6521-30. 2004
    ..This novel mechanism may have a crucial role in mediating specific central effects of ethanol...
  6. ncbi request reprint Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
    J Neurosci 23:11711-24. 2003
    ..Changes in GABA(A) receptor gene expression induced by prolonged exposure to and withdrawal of ethanol are thus associated with altered GABA(A) receptor function and pharmacological sensitivity...
  7. ncbi request reprint Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons
    Paolo Follesa
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    J Neurochem 94:659-71. 2005
    ..These findings reveal complex and distinct mechanisms of regulation of the expression of GABA(A)Rs that contain the delta subunit in different neuronal types...
  8. ncbi request reprint Flumazenil selectively prevents the increase in alpha(4)-subunit gene expression and an associated change in GABA(A) receptor function induced by ethanol withdrawal
    Francesca Biggio
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    J Neurochem 102:657-66. 2007
    ..These observations are the first molecular and functional evidence that show a selective inhibition by flumazenil of the up-regulation of alpha(4)-subunit expression elicited by ethanol withdrawal...
  9. ncbi request reprint Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function
    Mariangela Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 98:122-33. 2006
    ....
  10. ncbi request reprint Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators
    Giovanni Biggio
    Department of Experimental Biology Bernardo Loddo, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, 09123, Italy
    Eur Neuropsychopharmacol 13:411-23. 2003
    ..We report here that endogenous steroids may play a crucial role in the action of ethanol on dopaminergic neurons...
  11. ncbi request reprint Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies
    Francesca Biggio
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
    Pharmacol Biochem Behav 84:545-54. 2006
    ....
  12. ncbi request reprint Changes in expression of the delta subunit of the GABA (A) receptor and in receptor function induced by progesterone exposure and withdrawal
    Maria Cristina Mostallino
    Research National Council CNR, Institute for Neuroscience, Cagliari, Italy
    J Neurochem 99:321-32. 2006
    ..They are consistent with the notion that this progesterone metabolite plays a key physiological role in modulation of GABAergic synapses...
  13. ncbi request reprint Neurosteroids, GABAA receptors, and ethanol dependence
    Paolo Follesa
    Department of Experimental Biology Bernardo Loddo, University of Cagliari, Cagliari, 09123, Italy
    Psychopharmacology (Berl) 186:267-80. 2006
    ..Such steroids include potent modulators of GABAAR function...
  14. doi request reprint GABA(A) receptor function and gene expression during pregnancy and postpartum
    Giovanni Biggio
    Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, 09100 Cagliari, Italy
    Int Rev Neurobiol 85:73-94. 2009
    ..Such elevation in brain neuroactive steroid concentrations during pregnancy, in turn, is accompanied by alterations in both gene expression and function of synaptic and extrasynaptic GABA(A)-Rs in the hippocampus as well as other areas...
  15. ncbi request reprint Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells
    Paolo Follesa
    Department of Experimental Biology Bernardo Loddo, University of Cagliari, Cagliari, Italy
    Mol Pharmacol 63:896-907. 2003
    ..The antagonism by GHB seems not to be mediated by a direct action at GABA(A)R because GHB failed to potentiate the effects of GABA or diazepam on Cl(-) currents mediated by GABA type A receptor...
  16. ncbi request reprint Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and function
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Brain Res Rev 57:520-30. 2008
    ....
  17. pmc Stress, ethanol, and neuroactive steroids
    Giovanni Biggio
    Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Pharmacol Ther 116:140-71. 2007
    ..These data may also lead to the need for new anxiolytic, hypnotic and anticonvulsant selective drugs devoid of side effects...
  18. pmc Involvement of the cannabinoid CB1 receptor in modulation of dopamine output in the prefrontal cortex associated with food restriction in rats
    Laura Dazzi
    Department of Life and Environmental Sciences, Section of Neuroscience and Anthropology, Centre of Excellence for the Neurobiology of Dependence, University of Cagliari, Monserrato, Cagliari, Italy
    PLoS ONE 9:e92224. 2014
    ....
  19. ncbi request reprint Increased voluntary ethanol consumption and changes in hippocampal synaptic plasticity in isolated C57BL/6J mice
    Giuseppe Talani
    Institute of Neuroscience, National Research Council, 09042, Monserrato, Cagliari, Italy
    Neurochem Res 39:997-1004. 2014
    ..In this article, we summarize some of our recent findings on the effects of SI in C57BL/6J mice on voluntary EtOH intake, regulation of GABAARs gene expression and function and hippocampal long term synaptic plasticity. ..
  20. pmc Voluntary Ethanol Consumption Induced by Social Isolation Reverses the Increase of α(4)/δ GABA(A) Receptor Gene Expression and Function in the Hippocampus of C57BL/6J Mice
    Enrico Sanna
    Section of Neuroscience, Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari Monserrato, Cagliari, Italy
    Front Neurosci 5:15. 2011
    ..We conclude that self-administration of EtOH selectively abolishes the increase of α(4) subunit but not other neurochemical, molecular, and functional modifications induced by SI prolonged mild stress...
  21. pmc Enhanced Sensitivity to Ethanol-Induced Inhibition of LTP in CA1 Pyramidal Neurons of Socially Isolated C57BL/6J Mice: Role of Neurosteroids
    Giuseppe Talani
    Section of Neuroscience, Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Monserrato Cagliari, Italy
    Front Endocrinol (Lausanne) 2:56. 2011
    ..The increase in EtOH sensitivity induced by SI may be important for the changes in the effects of EtOH on anxiety and on learning and memory associated with the prolonged stress attributable to SI...
  22. ncbi request reprint Regulatory mechanisms and the role of calcium and potassium channels controlling supercontractile crop muscles in adult Phormia regina
    Paolo Solari
    Department of Biomedical Sciences, University of Cagliari, University Campus, S P 8, I 09042 Monserrato Ca, Italy
    J Insect Physiol 59:942-52. 2013
    ....
  23. ncbi request reprint Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters
    Cosimo Altomare
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
    Eur J Pharm Sci 20:17-26. 2003
    ....
  24. ncbi request reprint Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles
    Battistina Asproni
    Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, Sassari, Italy
    J Med Chem 48:2638-45. 2005
    ..As for etomidate, mutation of asparagine-265 in the beta2 subunit of the GABA(A) receptor into serine reduced the ability of derivative 1i to modulate the GABA function...
  25. ncbi request reprint Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors
    Battistina Asproni
    Dipartimento Farmaco Chimico Tossicologico, Facolta di Farmacia, Universita degli Studi di Sassari, 07100 Sassari, Italy
    J Med Chem 45:4655-68. 2002
    ..These findings suggest that compound 1b may represent an interesting prototype of a novel class of drugs endowed with a neurochemical profile similar to that of atypical antipsychotics...
  26. ncbi request reprint Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands
    Giuseppe Trapani
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
    J Med Chem 48:292-305. 2005
    ..Compound 3 exhibited very marked effects on the peripheral and central synthesis of neuroactive steroids, while 36 (potent at subnanomolar level) showed a slight ability to affect neuroactive steroid content in the cerebral cortex...
  27. ncbi request reprint High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones
    Andrea Carotti
    Dipartimento Farmaco Chimico, Universita degli Studi, Via E Orabona 4, I 70125, Bari, Italy
    Bioorg Med Chem 11:5259-72. 2003
    ..LDA proved to be superior to k-NN, especially in classifying PQ ligands (60-84% of success in prediction ability) into categories of efficacies which were contiguous and quite overlapped in the hyperspace of variables...
  28. ncbi request reprint Alpidem analogues containing a GABA or glycine moiety as new anticonvulsant agents
    Giuseppe Trapani
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
    Eur J Pharm Sci 18:231-40. 2003
    ..The results obtained suggest that compound 1 possesses interesting anticonvulsant activity and deserves further investigation as a novel lipophilic GABA derivative...
  29. ncbi request reprint Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors
    Maria Paola Mascia
    Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Sezione di Cagliari, Italy
    Eur J Pharmacol 516:204-11. 2005
    ..These results indicate that the pharmacological profile of TG41 is similar to that of general anesthetics which potentiate the activity of GABA(A) receptors containing the beta2 or beta3 subunit...
  30. ncbi request reprint Encapsulation and release of the hypnotic agent zolpidem from biodegradable polymer microparticles containing hydroxypropyl-beta-cyclodextrin
    Giuseppe Trapani
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
    Int J Pharm 268:47-57. 2003
    ..However, a need for further pharmacokinetic and pharmacodynamic studies resulted to fully evaluate the utility of this last formulation for the sustained delivery of ZP...