Research Topics
Species | Enrico SannaSummaryAffiliation: University of Cagliari Country: Italy Publications
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Detail Information
Publications
Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypesEnrico Sanna
Department of Experimental Biology B Loddo, Section of Neuroscience, University of Cagliari, Cittadella Universitaria, Italy
Eur J Pharmacol 451:103-10. 2002..Furthermore, zaleplon, unlike zolpidem, exhibited virtually no affinity for the peripheral type of benzodiazepine receptor...- The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous systemMario Carta
Department of Experimental Biology Bernardo Loddo, Section of Neuroscience, University of Cagliari, Cittadella Universitaria, SS 554, Km 4 5, Monserrato, Cagliari 09123, Italy
Neuropharmacology 51:805-15. 2006..Our data, consistent with clinical observations of the epileptogenic effect of this compound, suggest that TCC is a potent competitive antagonist of GABAAR function... 
Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after deliveryEnrico Sanna
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, and National Research Council, Institute of Neuroscience, 09123 Cagliari, Italy
J Neurosci 29:1755-65. 2009..These data suggest that the number of extrasynaptic GABA(A)-Rs is increased in DGGCs during late pregnancy as a consequence of the associated marked fluctuations in the brain levels of neuroactive steroids...- Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlatesEnrico Sanna
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
Eur J Pharmacol 519:31-42. 2005..These data suggest that etizolam is endowed with a reduced liability to induce tolerance and dependence compared with classical benzodiazepines... - Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampusEnrico Sanna
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
J Neurosci 24:6521-30. 2004..This novel mechanism may have a crucial role in mediating specific central effects of ethanol... - Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawalEnrico Sanna
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
J Neurosci 23:11711-24. 2003..Changes in GABA(A) receptor gene expression induced by prolonged exposure to and withdrawal of ethanol are thus associated with altered GABA(A) receptor function and pharmacological sensitivity... - Flumazenil selectively prevents the increase in alpha(4)-subunit gene expression and an associated change in GABA(A) receptor function induced by ethanol withdrawalFrancesca Biggio
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
J Neurochem 102:657-66. 2007..These observations are the first molecular and functional evidence that show a selective inhibition by flumazenil of the up-regulation of alpha(4)-subunit expression elicited by ethanol withdrawal... - Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neuronsPaolo Follesa
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
J Neurochem 94:659-71. 2005..These findings reveal complex and distinct mechanisms of regulation of the expression of GABA(A)Rs that contain the delta subunit in different neuronal types... - Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor functionMariangela Serra
Department of Experimental Biology, University of Cagliari, Cagliari, Italy
J Neurochem 98:122-33. 2006.... - Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulatorsGiovanni Biggio
Department of Experimental Biology Bernardo Loddo, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, 09123, Italy
Eur Neuropsychopharmacol 13:411-23. 2003..We report here that endogenous steroids may play a crucial role in the action of ethanol on dopaminergic neurons... - Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studiesFrancesca Biggio
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
Pharmacol Biochem Behav 84:545-54. 2006.... - Neurosteroids, GABAA receptors, and ethanol dependencePaolo Follesa
Department of Experimental Biology Bernardo Loddo, University of Cagliari, Cagliari, 09123, Italy
Psychopharmacology (Berl) 186:267-80. 2006..Ethanol may also modulate GABAAR function by increasing the de novo synthesis of neurosteroids in the brain in a manner independent of the HPA axis. This latter mechanism may play an important role in the central effects of ethanol... - Changes in expression of the delta subunit of the GABA (A) receptor and in receptor function induced by progesterone exposure and withdrawalMaria Cristina Mostallino
Research National Council CNR, Institute for Neuroscience, Cagliari, Italy
J Neurochem 99:321-32. 2006..They are consistent with the notion that this progesterone metabolite plays a key physiological role in modulation of GABAergic synapses... - GABA(A) receptor function and gene expression during pregnancy and postpartumGiovanni Biggio
Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, 09100 Cagliari, Italy
Int Rev Neurobiol 85:73-94. 2009..Such elevation in brain neuroactive steroid concentrations during pregnancy, in turn, is accompanied by alterations in both gene expression and function of synaptic and extrasynaptic GABA(A)-Rs in the hippocampus as well as other areas... - Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cellsPaolo Follesa
Department of Experimental Biology Bernardo Loddo, University of Cagliari, Cagliari, Italy
Mol Pharmacol 63:896-907. 2003..The antagonism by GHB seems not to be mediated by a direct action at GABA(A)R because GHB failed to potentiate the effects of GABA or diazepam on Cl(-) currents mediated by GABA type A receptor... - Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and functionMariangela Serra
Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
Brain Res Rev 57:520-30. 2008.... 
Stress, ethanol, and neuroactive steroidsGiovanni Biggio
Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
Pharmacol Ther 116:140-71. 2007..These data may also lead to the need for new anxiolytic, hypnotic and anticonvulsant selective drugs devoid of side effects...- Voluntary Ethanol Consumption Induced by Social Isolation Reverses the Increase of α(4)/δ GABA(A) Receptor Gene Expression and Function in the Hippocampus of C57BL/6J MiceEnrico Sanna
Section of Neuroscience, Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari Monserrato, Cagliari, Italy
Front Neurosci 5:15. 2011..We conclude that self-administration of EtOH selectively abolishes the increase of α(4) subunit but not other neurochemical, molecular, and functional modifications induced by SI prolonged mild stress... - Enhanced Sensitivity to Ethanol-Induced Inhibition of LTP in CA1 Pyramidal Neurons of Socially Isolated C57BL/6J Mice: Role of NeurosteroidsGiuseppe Talani
Section of Neuroscience, Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Monserrato Cagliari, Italy
Front Endocrinol (Lausanne) 2:56. 2011..The increase in EtOH sensitivity induced by SI may be important for the changes in the effects of EtOH on anxiety and on learning and memory associated with the prolonged stress attributable to SI... - Alpidem analogues containing a GABA or glycine moiety as new anticonvulsant agentsGiuseppe Trapani
Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
Eur J Pharm Sci 18:231-40. 2003..The results obtained suggest that compound 1 possesses interesting anticonvulsant activity and deserves further investigation as a novel lipophilic GABA derivative... - Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid estersCosimo Altomare
Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125, Bari, Italy
Eur J Pharm Sci 20:17-26. 2003.... - Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptorsMaria Paola Mascia
Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Sezione di Cagliari, Italy
Eur J Pharmacol 516:204-11. 2005..These results indicate that the pharmacological profile of TG41 is similar to that of general anesthetics which potentiate the activity of GABA(A) receptors containing the beta2 or beta3 subunit... - Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazolesBattistina Asproni
Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, Sassari, Italy
J Med Chem 48:2638-45. 2005..As for etomidate, mutation of asparagine-265 in the beta2 subunit of the GABA(A) receptor into serine reduced the ability of derivative 1i to modulate the GABA function... - Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptorsBattistina Asproni
Dipartimento Farmaco Chimico Tossicologico, Facolta di Farmacia, Universita degli Studi di Sassari, 07100 Sassari, Italy
J Med Chem 45:4655-68. 2002..These findings suggest that compound 1b may represent an interesting prototype of a novel class of drugs endowed with a neurochemical profile similar to that of atypical antipsychotics... - Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligandsGiuseppe Trapani
Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
J Med Chem 48:292-305. 2005..Compound 3 exhibited very marked effects on the peripheral and central synthesis of neuroactive steroids, while 36 (potent at subnanomolar level) showed a slight ability to affect neuroactive steroid content in the cerebral cortex... - High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-onesAndrea Carotti
Dipartimento Farmaco Chimico, , Via E. Orabona 4, I-70125, Bari, Italy
Bioorg Med Chem 11:5259-72. 2003..LDA proved to be superior to k-NN, especially in classifying PQ ligands (60-84% of success in prediction ability) into categories of efficacies which were contiguous and quite overlapped in the hyperspace of variables... - Encapsulation and release of the hypnotic agent zolpidem from biodegradable polymer microparticles containing hydroxypropyl-beta-cyclodextrinGiuseppe Trapani
Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
Int J Pharm 268:47-57. 2003..However, a need for further pharmacokinetic and pharmacodynamic studies resulted to fully evaluate the utility of this last formulation for the sustained delivery of ZP...