D Sacerdoti

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Noninvasive grading of the severity of portal hypertension in cirrhotic patients by echo-color-Doppler
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Ultrasound Med Biol 27:901-7. 2001
  2. pmc Role of HO/CO in the Control of Peripheral Circulation in Humans
    David Sacerdoti
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Int J Hypertens 2012:236180. 2012
  3. doi request reprint Increased EETs participate in peripheral endothelial dysfunction of cirrhosis
    David Sacerdoti
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 98:129-32. 2012
  4. doi request reprint 11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension
    David Sacerdoti
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 96:72-5. 2011
  5. ncbi request reprint 11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells
    David Sacerdoti
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 82:155-61. 2007
  6. ncbi request reprint Heme oxygenase-1 transduction in endothelial cells causes downregulation of monocyte chemoattractant protein-1 and of genes involved in inflammation and growth
    D Sacerdoti
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Cell Mol Biol (Noisy-le-grand) 51:363-70. 2005
  7. ncbi request reprint Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase
    David Sacerdoti
    Dept of Clinical and Experimental Medicine, Univ of Padova, Italy, Via Giustiniani 2, 35100 Padova, Italy
    Am J Physiol Heart Circ Physiol 291:H1999-2002. 2006
  8. ncbi request reprint Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology
    David Sacerdoti
    Department of Clinical and Experimental Medicine, Azienda Ospedaliera and University of Padova, Clinica Medica 5, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 72:51-71. 2003
  9. ncbi request reprint The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Hepatology 32:930-4. 2000
  10. pmc Haeme oxygenase mediates hyporeactivity to phenylephrine in the mesenteric vessels of cirrhotic rats with ascites
    M Bolognesi
    Clinica Medica 5, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Gut 54:1630-6. 2005

Detail Information

Publications32

  1. ncbi request reprint Noninvasive grading of the severity of portal hypertension in cirrhotic patients by echo-color-Doppler
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Ultrasound Med Biol 27:901-7. 2001
    ..066*splenic PI -0.044)*PBF]. In the second group, predicted and observed portal pressure were well correlated (r = 0.71, p = .0003). A good accuracy for the prediction of mild or severe portal hypertension was obtained...
  2. pmc Role of HO/CO in the Control of Peripheral Circulation in Humans
    David Sacerdoti
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Int J Hypertens 2012:236180. 2012
    ..In conclusion, HO/CO participates in the control of peripheral circulation, independently from NO, and is involved in vasodilatation to ACh...
  3. doi request reprint Increased EETs participate in peripheral endothelial dysfunction of cirrhosis
    David Sacerdoti
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 98:129-32. 2012
    ..In conclusion, EETs participate in the control of peripheral circulation of normal subjects and in the pathophysiology of peripheral vasodilatation of cirrhotic patients with ascites...
  4. doi request reprint 11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension
    David Sacerdoti
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 96:72-5. 2011
    ..In conclusion, 20HETE and EETs increase portal resistance; EETs, but not 20-HETE, mediate in part the pressure response to ET-1 in the portal circulation and may be involved in pathophysiology of portal hypertension...
  5. ncbi request reprint 11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells
    David Sacerdoti
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 82:155-61. 2007
    ..These findings identify a novel effect of EETs on endothelial HO-1 and indicate that the signaling pathway of EETs in endothelial cells is possibly via an increase in HO-1 expression and activity...
  6. ncbi request reprint Heme oxygenase-1 transduction in endothelial cells causes downregulation of monocyte chemoattractant protein-1 and of genes involved in inflammation and growth
    D Sacerdoti
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padova, Via Giustiniani 2, 35100 Padova, Italy
    Cell Mol Biol (Noisy-le-grand) 51:363-70. 2005
    ..5-fold. The data from this study are relevant to understanding the mechanisms underlying the pathophysiological effects of HO-1 deficiency on endothelial cell injury and inflammation...
  7. ncbi request reprint Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase
    David Sacerdoti
    Dept of Clinical and Experimental Medicine, Univ of Padova, Italy, Via Giustiniani 2, 35100 Padova, Italy
    Am J Physiol Heart Circ Physiol 291:H1999-2002. 2006
    ..We conclude that the rat mesenteric vasodilator action of 11,12-EET is mediated via an increase in HO activity and an activation of calcium-activated potassium channels...
  8. ncbi request reprint Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology
    David Sacerdoti
    Department of Clinical and Experimental Medicine, Azienda Ospedaliera and University of Padova, Clinica Medica 5, Via Giustiniani 2, 35100 Padova, Italy
    Prostaglandins Other Lipid Mediat 72:51-71. 2003
    ..They appear to be deeply involved in abnormalities related to liver diseases, particularly cirrhosis, and play a key role in the pathophysiology of portal hypertension and renal failure...
  9. ncbi request reprint The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Hepatology 32:930-4. 2000
    ..In conclusion, the assessment of hemodynamic response to drugs in terms of HVPG is the best predictor of efficacy of prophylaxis of variceal bleeding in patients treated with beta-blockers or beta-blockers plus nitrates...
  10. pmc Haeme oxygenase mediates hyporeactivity to phenylephrine in the mesenteric vessels of cirrhotic rats with ascites
    M Bolognesi
    Clinica Medica 5, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Gut 54:1630-6. 2005
    ..The aim of this study was to verify the role of haeme oxygenase in the hyporesponsiveness to phenylephrine of small mesenteric arteries in rats with CCl(4) induced cirrhosis, with and without ascites...
  11. ncbi request reprint Portal hypertension: state of the art
    A Gatta
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Ital J Gastroenterol Hepatol 31:326-45. 1999
    ..Moreover, technological developments have introduced new tools for diagnosis, such as echo-colour-Doppler, and therapy, like variceal banding and transjugular intrahepatic porto-systemic shunt...
  12. ncbi request reprint Arterioportal fistulas in patients with liver cirrhosis: usefulness of color Doppler US for screening
    M Bolognesi
    Department of Clinical and Experimental Medicine, Clinica Medica 5, Policlinico Universitario, Padova, Italy
    Radiology 216:738-43. 2000
    ....
  13. ncbi request reprint Disagreement between acute and chronic haemodynamic effects of nadolol in cirrhosis: a pathophysiological interpretation
    C Merkel
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Aliment Pharmacol Ther 22:433-9. 2005
    ..The acute effects of beta-blockers may be different from chronic; mechanisms underlying this difference are poorly elucidated...
  14. ncbi request reprint Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis
    C Merkel
    Department of Clinical Medicine, University of Padua, Italy
    Hepatology 31:324-9. 2000
    ..Side effects are few, and no deleterious effects on ascites occurrence or on survival occur after long-term use of this combination...
  15. pmc Nonalcoholic fatty liver disease (NAFLD) in nonobese patients with diabetes: Prevalence and relationships with hemodynamic alterations detected with Doppler sonography()
    S Gaiani
    Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, Italy
    J Ultrasound 12:1-5. 2009
    ..To evaluate the prevalence, severity, and hemodynamic features of nonalcoholic fatty liver disease (NAFLD) in nonobese diabetics...
  16. ncbi request reprint Role of spleen enlargement in cirrhosis with portal hypertension
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Dig Liver Dis 34:144-50. 2002
    ..The increase in spleen size is followed by an increase in splenic blood flow, which participates in portal hypertension actively congesting the portal system...
  17. ncbi request reprint Gemfibrozil improves insulin sensitivity and flow-mediated vasodilatation in type 2 diabetic patients
    A Avogaro
    University of Padova, Padova, Italy, LADSEB CNR, Padova, Italy, Parke Davis Italia, Lainate, Milan, Italy
    Eur J Clin Invest 31:603-9. 2001
    ..Endothelial dysfunction is an early feature of atherosclerosis. The relationship between insulin action and hypertriglyceridaemia on endothelial function is still debated...
  18. ncbi request reprint Acute liver rejection: accuracy and predictive values of doppler US measurements--initial experience
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, Institute of General Surgery, Clinica Medica 5, Policlinico Universitario, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Radiology 235:651-8. 2005
    ....
  19. ncbi request reprint Arteroportal fistulas between the accessory right hepatic, gastroduodenal and superior mesenteric arteries and portal vein: a difficult technical problem to overcome in liver transplantation
    Giorgio E Gerunda
    Department of Surgical and Medical Sciences, III Surgical Clinic, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Transplantation 73:417-9. 2002
    ..Fistulous communications between the accessory right hepatic (ARHA), gastroduodenal (GD), and superior mesenteric (SMA) arteries and the portal vein (PV) may represent a contraindication for liver transplantation (LT)...
  20. doi request reprint Hepatitis C virus reinfection in liver transplant patients: evaluation of liver damage progression with echo-color Doppler
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Liver Transpl 14:616-24. 2008
    ..In conclusion, the information obtainable from splanchnic Doppler parameters can be used to monitor the progression of liver fibrosis in transplant patients with HCV reinfection...
  21. ncbi request reprint Different hemodynamic patterns of alcoholic and viral endstage cirrhosis: analysis of explanted liver weight, degree of fibrosis and splanchnic Doppler parameters
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Scand J Gastroenterol 42:256-62. 2007
    ..The objective of this study was to investigate the role of the etiology of liver disease on the relationship between liver blood flow and liver pathology in endstage cirrhosis...
  22. ncbi request reprint Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    J Pharmacol Exp Ther 321:187-94. 2007
    ....
  23. ncbi request reprint Nitric oxide modulation of renal and cardiac hemodynamics in type 2 diabetes
    Michele Dalla Vestra
    Department of Medical and Surgical Sciences, Clinica Medica I, University of Padova, Via Giustiniani 2, 35128, Italy
    Eur J Endocrinol 146:687-94. 2002
    ..To evaluate endothelial function in type 2 diabetic patients with and without diabetic nephropathy...
  24. ncbi request reprint Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes
    Marco Di Pascoli
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    Biochem Biophys Res Commun 340:935-43. 2006
    ....
  25. ncbi request reprint Central nervous system alterations in liver cirrhosis: the role of portal-systemic shunt and portal hypoperfusion
    Franco Del Piccolo
    Department of Clinical and Experimental Medicine, Clinica Medica 5, University and Azienda Ospedaliera of Padova, Italy
    Metab Brain Dis 17:347-58. 2002
    ..In conclusion, portal liver hypoperfusion and decreased liver function were associated with an increased risk of central nervous system dysfunction in cirrhotic patients, whereas PUV patency per se was not...
  26. ncbi request reprint Central nervous system alterations in liver cirrhosis: the role of portal-systemic shunt and portal hypoperfusion
    Franco Del Piccolo
    Clinica Medica 5, Department of Clinical and Experimental Medicine, University and Azienda Ospedaliera of Padova, Italy
    Metab Brain Dis 18:51-62. 2003
    ..In conclusion, portal liver hypoperfusion and decreased liver function were associated with an increased risk of CNSD in cirrhotic patients, whereas PUV patency per se was not...
  27. ncbi request reprint Heme oxygenase overexpression attenuates glucose-mediated oxidative stress in quiescent cell phase: linking heme to hyperglycemia complications
    David Sacerdoti
    University of Padova, Department of Clinical and Experimental Medicine, Italy
    Curr Neurovasc Res 2:103-11. 2005
    ..These results imply that expression of HO-1 in G0/G1 cells may be a key player in decreasing cellular heme, associated with increased generation of bilirubin, and in attenuating glucose mediated oxidative stress...
  28. ncbi request reprint Role of the heme oxygenases in abnormalities of the mesenteric circulation in cirrhotic rats
    David Sacerdoti
    Department of Clinical and Experimental Medicine, University and Azienda Ospedaliera of Padova, Italy
    J Pharmacol Exp Ther 308:636-43. 2004
    ..We propose that HO is an essential component in mechanisms that modulate reactivity of the mesenteric circulation in experimental hepatic cirrhosis in rats...
  29. ncbi request reprint Alterations in thyroid Doppler arterial resistance indices, volume and hormones in cirrhosis: relationships with splanchnic haemodynamics
    Luisa Spadaro
    Department of Clinical and Experimental Medicine, Azienda Ospedaliera and University of Padua, Padua, Italy
    Ultrasound Med Biol 30:19-25. 2004
    ..01). In conclusion, thyroid is involved, primarily and secondarily, in the haemodynamic alterations of cirrhosis; a reduction in vasodilator FT3 may play a role in the pathophysiology...
  30. ncbi request reprint Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, Institute of General Surgery, Intensive Care Unit, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Hepatology 35:601-8. 2002
    ..A normal time course of portal-hepatic hemodynamics was detected in patients transplanted for acute liver failure...
  31. ncbi request reprint Effect of potassium canrenoate, an anti-aldosterone agent, on incidence of ascites and variceal progression in cirrhosis
    Luigi Bolondi
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Clin Gastroenterol Hepatol 4:1395-402. 2006
    ....
  32. ncbi request reprint Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells
    Giovanni Li Volti
    Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Italy
    Antioxid Redox Signal 7:704-10. 2005
    ..The addition of bilirubin did not restore angiogenesis. These data suggest that HO-mediated angiogenesis and cell proliferation were dependent on HO-1- and not HO-2-derived CO...