Patrizia Saccucci

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Isolated left ventricular non compaction as possible cause of athletic training suspension: a preliminary study on screened athletes
    R Martinoli
    Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy
    J Sports Med Phys Fitness 53:240-7. 2013
  2. ncbi request reprint Association of Trp53 polymorphic variants at codon 72 with nonsyndromic mental retardation
    P Saccucci
    Division of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome, Tor Vergata, School of Medicine, Rome, Italy
    Neurosci Res 59:47-50. 2007
  3. doi request reprint Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms and mental retardation
    Patrizia Saccucci
    Division of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Nutr Neurosci 11:241-2. 2008
  4. doi request reprint Is there a role of ACP1-ADA1 genetic complex in immune reaction? Association with T1D and with past malarial morbidity
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Tor Vergata, Rome, Italy
    Am J Med Sci 340:268-70. 2010
  5. ncbi request reprint Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms
    Patrizia Saccucci
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 15:CR511-517. 2009
  6. pmc p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 18:CR712-5. 2012
  7. doi request reprint The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy
    Am J Med Sci 340:103-8. 2010
  8. doi request reprint Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?
    Maria Laura Ammendola
    Department of Surgery, University of Rome Tor Vergata School of Medicine, Rome, Italy
    Am J Obstet Gynecol 200:110.e1-5. 2009
  9. doi request reprint Acid phosphatase locus 1 genetic polymorphism and cancer grading
    Fulvia Gloria-Bottini
    Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Am J Med Sci 344:32-4. 2012
  10. doi request reprint p53 codon 72 polymorphism and coronary artery disease: evidence of association with left ventricular ejection fraction
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Italy
    Am J Med Sci 343:127-30. 2012

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Isolated left ventricular non compaction as possible cause of athletic training suspension: a preliminary study on screened athletes
    R Martinoli
    Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy
    J Sports Med Phys Fitness 53:240-7. 2013
    ..This cardiomyopathy should be considered one of the structural cardiac abnormalities responsible for sudden cardiac death...
  2. ncbi request reprint Association of Trp53 polymorphic variants at codon 72 with nonsyndromic mental retardation
    P Saccucci
    Division of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome, Tor Vergata, School of Medicine, Rome, Italy
    Neurosci Res 59:47-50. 2007
    ..5% versus 14.08%) (OR=0.42; 95% CI 0.21-0.83). These data suggest that subjects carrying the Pro allele are protected from this disease...
  3. doi request reprint Lack of association between MTHFR C677T and MTHFR A1298C genetic polymorphisms and mental retardation
    Patrizia Saccucci
    Division of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Nutr Neurosci 11:241-2. 2008
    ..Findings suggest that there is no association between MTHFR C677T and MTHFR A1298C and mental retardation in the studied Italian population and that these polymorphisms are not contributing to the aetiology of mental retardation...
  4. doi request reprint Is there a role of ACP1-ADA1 genetic complex in immune reaction? Association with T1D and with past malarial morbidity
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Tor Vergata, Rome, Italy
    Am J Med Sci 340:268-70. 2010
    ....
  5. ncbi request reprint Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms
    Patrizia Saccucci
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 15:CR511-517. 2009
    ..Observed interactions at the biochemical and clinical levels between the two systems prompted this investigation of a possible interaction concerning susceptibility to type 1 diabetes...
  6. pmc p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 18:CR712-5. 2012
    ..Since ACPACP₁ is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD...
  7. doi request reprint The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy
    Am J Med Sci 340:103-8. 2010
    ..Because it is known that the 2 systems interact and have important immunologic and metabolic functions, these 2 genes were both examined in the same sets of subjects...
  8. doi request reprint Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?
    Maria Laura Ammendola
    Department of Surgery, University of Rome Tor Vergata School of Medicine, Rome, Italy
    Am J Obstet Gynecol 200:110.e1-5. 2009
    ..Therefore, we searched for a possible association between ACP1 and leiomyomas...
  9. doi request reprint Acid phosphatase locus 1 genetic polymorphism and cancer grading
    Fulvia Gloria-Bottini
    Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Am J Med Sci 344:32-4. 2012
    ..In this article, the authors have studied the relationship between ACP(1) genotype and grade in colon and endometrium cancers...
  10. doi request reprint p53 codon 72 polymorphism and coronary artery disease: evidence of association with left ventricular ejection fraction
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Italy
    Am J Med Sci 343:127-30. 2012
    ..The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ejection fraction (LVEF) in subjects with and without coronary artery disease (CAD)...
  11. doi request reprint ACP1 genetic polymorphism and coronary artery disease: an association study
    M Banci
    Department of Cardiology, Valmontone Hospital, Rome, Italy
    Cardiology 113:236-42. 2009
    ....
  12. doi request reprint Effect of ADA1 mother-fetus and wife-husband phenotypic differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA
    Fulvia Gloria-Bottini
    Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy
    Am J Hum Biol 24:177-82. 2012
    ....
  13. ncbi request reprint Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner
    Maria Luisa Manca Bitti
    Pediatric Diabetes Unit, Tor Vergata University Hospital, Rome, Italy
    J Pediatr Endocrinol Metab 24:437-9. 2011
    ..The involvement of the *Arg/*Arg genotype in apoptosis suggests that during the autoimmune process leading to T1D, genetic factors that favor apoptosis may contribute to the onset of overt disease...
  14. doi request reprint Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy
    P Saccucci
    Department of Internal Medicine, Division of Clinical Immunology, University of Rome Tor Vergata, Rome, Italy
    Tissue Antigens 71:234-7. 2008
    ..Our data also suggest that T1D carriers of the *T1858 allele could be at increased risk for other comorbid autoimmune disorders...
  15. doi request reprint A study of acid phosphatase locus 1 in women with high fat content and normal body mass index
    Antonino De Lorenzo
    Department of Neurosciences, Human Nutrition Unit, University of Rome Tor Vergata, 00133 Rome, Italy
    Metabolism 58:351-4. 2009
    ..Because ACP(1) is present in adipocytes, the present observation suggests that F isoform may have a specific role in the regulation of quantity of adipose tissue...
  16. ncbi request reprint Association of adenosine deaminase polymorphism with mild mental retardation
    Patrizia Saccucci
    Department of Neurosciences, Pediatric Neurology Unit, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Child Neurol 21:753-6. 2006
    ..In conclusion, our findings suggest a possible role for a low-activity genotype (ADA-8Asn) (ADA(1) *2) of adenosine deaminase in the pathogenesis of mild mental retardation...
  17. ncbi request reprint Association between PTPN22 and endometriosis
    Maria Ammendola
    Division of Gynecology and Obstetrics, Department of Surgery, Hospital University of Rome Tor Vergata, School of Medicine, Rome, Italy
    Fertil Steril 89:993-4. 2008
    ..Our data show that female carriers of the PTPN22( *)T variant are significantly more susceptible to endometriosis than controls...
  18. doi request reprint Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy
    Maria Ammendola
    Department of Surgery, Division of Obstetrics and Gynecology, University of Rome, Tor Vergata School of Medicine, Rome, Italy
    Fertil Steril 90:1203-5. 2008
    ..These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes...
  19. ncbi request reprint Low molecular weight PTP-IL-4RA interaction in atopy predisposition
    Nunzio Bottini
    Department of Internal Medicine, University of Rome Tor Vergata, 135 via di Tor Vergata, I 00133 Rome, Italy
    Allergy 57:10-2. 2002
    ..Our data support the hypothesis of a direct or indirect biochemical interaction between LMPTP and IL-4RA resulting in different modulation of IL-4 signal transduction among joint genotypes...
  20. ncbi request reprint A study of Adenosine-Deaminase genetic polymorphism in rheumatoid arthritis
    G D Sebastiani
    St Camillo Hospital, Rheumatology Unit, Rome, Italy
    Int J Immunopathol Pharmacol 23:791-5. 2010
    ..Our data indicate a border line effect of ADA gene polymorphism on susceptibility to RA that need to be confirmed in other clinical settings...
  21. ncbi request reprint Lack of association between IDE genetic variability and Down's syndrome
    Carla Arpino
    Department of Neurosciences, Pediatric Neurology Unit, Tor Vergata University of Rome, Rome, Italy
    Neurosci Lett 382:93-5. 2005
    ..e., IDE 185 and IDE 199). In conclusion, the findings of our study suggest that the two IDE polymorphisms considered in the analysis do not appear to play a major role in DS-related AD...
  22. ncbi request reprint A study of three polymorphic sites of the ADA gene in children with type 1 diabetes mellitus
    P Saccucci
    Division of Biopathology of Human Polulation and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    J Pediatr Endocrinol Metab 23:283-90. 2010
    ..Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity...
  23. ncbi request reprint ACP1 and offspring sex ratio in smoking puerperae: a study at population level
    F Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Early Hum Dev 83:349-54. 2007
    ....
  24. ncbi request reprint Convulsive disorder and genetic polymorphism. Association of idiopathic generalized epilepsy with haptoglobin polymorphism
    P Saccucci
    Department of Neurosciences, School of Medicine, University of Tor Vergata, Rome, Italy
    Neurogenetics 5:245-8. 2004
    ....
  25. ncbi request reprint Autism: evidence of association with adenosine deaminase genetic polymorphism
    N Bottini
    Department of Internal Medicine, Tor Vergata University of Rome, Rome, Italy
    Neurogenetics 3:111-3. 2001
    ..00001), and in both study populations (P < 0.001 and P < 0.025). We suggest that this putative genotype-dependent reduction in ADA activity may be a risk factor for the development of autism...
  26. doi request reprint Genetic polymorphism and idiopathic generalized epilepsy. Evidence of interaction between haptoglobin and ACP1 systems
    F Gloria-Bottini
    Division of Biopathology of Human Populations and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Neuropediatrics 39:357-8. 2008
    ..This is not observed in carriers of other ACP1 types.The present data suggest an epistatic action of ACP1 concerning the effect of Hp on the susceptibility to convulsive disorders...
  27. ncbi request reprint Feto-maternal ACP1 activity ratio and intrauterine survival
    F Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Obstet Gynecol Reprod Biol 140:12-6. 2008
    ..Previous observations suggest that this may have important effects on intrauterine development and survival. The aim of the present study is to confirm previous observations and show new data...
  28. ncbi request reprint Genetic polymorphism within human growth hormone gene region and BMI in type 2 diabetes
    F Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Via Montpellier 1, I 00133, Rome, Italy
    Acta Diabetol 43:99-102. 2006
    ..BglIIA and BglIIB polymorphisms are not associated with being overweight. The present study suggests that the structural organisation of the hGH genomic area may have an important role in being overweight associated with type 2 diabetes...
  29. ncbi request reprint Functional aspects of genetic variability in the GH genomic region
    F Gloria-Bottini
    Division of Biopathology of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Endocrinol 193:85-92. 2007
    ..The functional aspects of genetic variability within the GH genomic area parallel the genetic differences observed between TD and PD versus FSS and control children...
  30. pmc Isolated left ventricular noncompaction in a case of sotos syndrome: a casual or causal link?
    Patrizia Saccucci
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Cardiol Res Pract 2011:824095. 2011
    ..Some sporadic forms of ILVNC are reported to be caused by a mutation on CSX gene, mapping on chromosome 5q35. To our knowledge, this is the first report of a patient affected simultaneously by Sotos syndrome and ILVNC...
  31. pmc Birth weight and coronary artery disease. The effect of gender and diabetes
    Maria Banci
    Department of Cardiology, Valmontone Hospital, Rome, Italy
    Int J Biol Sci 5:244-8. 2009
    ..In this paper we have analyzed the effect of gender and diabetes on the relationship between BW and CAD in the White population of Rome...
  32. ncbi request reprint Preliminary report: BGLIIA-BGLIIB haplotype of growth hormone cluster is associated with glucose intolerance in non-insulin-dependent diabetes mellitus and with growth hormone deficit in growth retardation
    E Bottini
    Department of Neurosciences, University of Rome Tor Vergata, School of Medicine, Rome, Italy
    Metabolism 51:1-4. 2002
    ..The present observation suggests that genes influencing both growth and glucose tolerance are encoded in the GH cluster...
  33. ncbi request reprint Skin testing correlates negatively with high-activity ACP1 *B/*C genotype
    E Greco
    Department of Internal Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Int Arch Allergy Immunol 145:48-53. 2008
    ..ACP1 (acid phosphatase locus 1) is a polymorphic phosphotyrosine phosphatase that interacts with IL4-RA and is involved in T cell receptor signaling...
  34. doi request reprint Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children
    Sara Piacentini
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Clin Chem Lab Med 50:311-5. 2012
    ..The aim of the present study is to analyze if some functional polymorphisms of GSTA1, GSTM1, GSTP1, GSTO2 and GSTT1 are associated with asthma in pediatric patients from Chieti (Italy)...
  35. doi request reprint A study of three polymorphic sites of ADA gene in colon cancer
    C Spina
    Department of Surgery, University of Rome Tor Vergata, Rome, Italy
    Cancer Invest 28:989-92. 2010
    ..ADA₂*2/ADA₆*2 is less represented in patients than in controls. Polymorphic sites of ADA might influence cell-mediated anti-tumor immune responses controlling adenosine level and extraenzymatic protein functions...
  36. ncbi request reprint Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome
    L di Renzo
    Department of Neuroscience, Division of Human Nutrition, University of Tor Vergata, Rome, Italy
    Int J Immunopathol Pharmacol 22:105-13. 2009
    ..Our data underscore previous findings that suggest a potential role of IL-15 cytokine in NWO syndrome...
  37. ncbi request reprint Genetic polymorphism and TH1/TH2 orientation
    N Bottini
    Department of Orthopedic Surgery and the Institute of Genetic Medicine, Unversity of Southern California, Los Angeles, CA, USA
    Int Arch Allergy Immunol 138:328-33. 2005
    ..Thus, for each genetic factor involved one would expect an opposite pattern of susceptibility towards Th1- and Th2-associated diseases...
  38. ncbi request reprint ACP1 genotype and asthma in the Chinese Han population
    Y G Liu
    Int Arch Allergy Immunol 137:263-4. 2005
  39. ncbi request reprint Genetic control of serum IgE levels: a study of low molecular weight protein tyrosine phosphatase
    N Bottini
    Experimental Medicine Unit, University of Wales, Swansea, Wales, UK
    Clin Genet 63:228-31. 2003
    ..The BC genotype is associated with the highest total ACP1 enzymatic activity. Our data suggest that one or both of the ACP1 isoforms exert an inhibitory role on some signal transduction pathway relevant for IgE hyperproduction...
  40. ncbi request reprint Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex
    N Bottini
    Burhnam Institute, La Jolla, California, USA
    Diabetes Metab Res Rev 21:353-8. 2005
    ....
  41. doi request reprint ACP1 genetic polymorphism and colon cancer
    C Spina
    Cancer Genet Cytogenet 186:61-2. 2008
  42. ncbi request reprint ADA polymorphisms and asthma: a study in the Chinese Han population
    Y Liu
    Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People s Republic of China
    J Asthma 43:203-6. 2006
    ..Our data suggest the presence of some DNA sequences influencing the susceptibility to asthma are located in the area between ADA(1) and ADA(2) sites...
  43. ncbi request reprint IL-4 receptor alpha chain genetic polymorphism and total IgE levels in the English population: two-locus haplotypes are more informative than individual SNPs
    N Bottini
    Experimental Medicine Unit, University of Wales Swansea, UK
    Clin Genet 61:288-92. 2002
    ..With regard to individual SNPs (50 478 and 551), no significant association has been observed with IgE levels or with asthma, thus confirming the higher informative value of the haplotype analysis as compared to separate study on SNPs...